Tryptophan

USA News Group News Commentary Issued on behalf of Oncolytics Biotech Inc. VANCOUVER, BC, Jan. 22, 2025 /PRNewswire/ -- USA News Group News Commentary – Big developments are expected this week at the 2025 ASCO Gastrointestinal Cancers Symposium, running January 23-25 in San Francisco. This year's event is particularly critical as researchers highlight the alarming rise in cancer rates among people under 50, with gastrointestinal cancers leading the increase. Colorectal and pancreatic cancers, two of the top three deadliest cancer types, remain significant concerns as pancreatic cancer mortality continues to climb. Among the innovators presenting at the symposium are Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Agenus Inc. (NASDAQ: AGEN), Guardant Health, Inc. (NASDAQ: GH), Xilio Therapeutics, Inc. (NASDAQ: XLO), and RenovoRx, Inc. (NASDAQ: RNXT). Continue Reading Pelareorep Factsheet (PRNewsfoto/USA News Group) The article continued: According to USD Analytics' recently introduced study, the Global Pancreatic Cancer Treatment Market is expected to soar in the upcoming years, growing at a 7.6% CAGR. Analysts at Precedence Research project that the global stomach cancer treatment market will grow at a 12.54% CAGR to US17.6 billion by 2034. Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), a leading clinical-stage company specializing in immunotherapy for oncology, today shared details about the data it will present at the ASCO GI symposium. The presentations will highlight pelareorep, an innovative immunotherapy that trains the immune system to target cancer by turning "cold" tumors—typically resistant to treatment—into "hot" tumors that respond better to therapy. In relapsed anal cancer, 4 out of 12 evaluable patients achieved a partial response for a response rate of 33%, and one patient achieved a remarkable complete response, meaning their cancer became undetectable and remained so for over 15 months. To put this into perspective, similar treatments typically achieve response rates of only 10-24%. This underscores pelareorep's potential to deliver life-changing results in some of the toughest-to-treat cancers. "In relapsed anal cancer, the efficacy signal that was initially reported continues to outperform historical control trials with the inclusion of additional patients," said Thomas Heineman, M.D., Ph.D., Chief Medical Officer for Oncolytics Biotech. "Importantly, the complete response we observed previously continued beyond the 12 months initially reported. Together, these results point to a clinically meaningful synergy between pelareorep and checkpoint inhibitors like atezolizumab." In pancreatic cancer, pelareorep has also demonstrated strong potential to improve outcomes for patients with this aggressive disease. The upcoming ASCO GI presentation will feature new safety data showing that pelareorep can be combined with modified FOLFIRINOX, another widely used chemotherapy regimen for patients with pancreatic cancer. "Our new safety data indicate its ability to also be combined with modified FOLFIRINOX, thus expanding its potential to benefit patients with metastatic pancreatic cancer," added Dr. Heineman. "We will continue to provide updates on the safety and efficacy of pelareorep-based combination therapy from these cohorts as they become available." This builds on prior results from the GOBLET study, where pelareorep, combined with atezolizumab, gemcitabine, and nab-paclitaxel, achieved a 62% objective response rate—more than double historical averages of 25%. These findings were pivotal in earning pelareorep FDA Fast Track designation in 2022, highlighting its promise to fill the critical unmet need for more effective pancreatic cancer therapies. The ability to pair pelareorep with modified FOLFIRINOX represents an important step forward in expanding treatment options for metastatic pancreatic cancer. These results not only highlight pelareorep's versatility but also its potential to enhance outcomes across multiple standard-of-care therapies. "I am quite pleased by these recent updates from the GOBLET study as they continue to provide potential new treatment options for patients in need of alternatives while maintaining a manageable safety profile," said Dirk Arnold, M.D., Ph.D., Director of Asklepios Tumorzentrum Hamburg, and primary investigator of the GOBLET trial. "I've been especially impressed with the ability of pelareorep-based therapies to work across multiple challenging cancer indications and with multiple standards of care, including chemotherapy and checkpoint inhibitors, so I look forward to additional data readouts that can help improve the treatment paradigm." As Oncolytics Biotech advances its clinical programs and prepares for pivotal studies, the growing body of evidence continues to solidify pelareorep as a transformative therapeutic option for patients in desperate need of effective treatments. CONTINUED… Read this and more news for Oncolytics Biotech at: In other recent industry developments and happenings in the market include: Agenus Inc. (NASADAQ: AGEN), a leader in immuno-oncology, recently announced it too will share five presentations at ASCO GI's symposium featuring botensilimab (BOT, an Fc-enhanced anti-CTLA-4 antibody) plus balstilimab (BAL, an anti-PD-1 antibody), and showcasing BOT/BAL's consistent activity in microsatellite stable (MSS) colorectal cancer (CRC), which accounts for over 80% of CRC cases and has limited treatment options, as well as its efficacy in microsatellite instability-high (MSI-H) CRC. Additionally, one presentation will feature BOT/BAL and invariant natural killer T cells (iNKTs) in patients with refractory gastric cancer. "These presentations will highlight BOT/BAL's potential to benefit patients across colorectal cancer treatment settings, including the neoadjuvant, late-line, and first-line settings," said Dr. Garo Armen, Chairman and CEO of Agenus. "We aim to transform outcomes at every stage of disease and deliver renewed hope for patients worldwide." ALX Oncology Holdings Inc. (NASDAQ: ALXO), a clinical-stage biotechnology company advancing therapies that boost the immune system to treat cancer and extend patients' lives, also recently announced that updated results from its Phase 2 ASPEN-06 clinical trial were accepted for oral presentation at ASCO GI 2025. ASPEN-06 is a global clinical trial testing evorpacept, ALX Oncology's innovative therapy designed to block the "don't eat me" signal used by cancer cells to evade the immune system. The study is evaluating evorpacept in combination with trastuzumab, CYRAMZA® (ramucirumab), and paclitaxel (a combination known as TRP) compared to TRP alone in patients with HER2-positive gastric or gastroesophageal junction cancer who have previously received anti-HER2 treatments. This approach aims to enhance the effectiveness of existing therapies and improve outcomes for patients with this aggressive cancer type. Xilio Therapeutics, Inc. (NASDAQ: XLO), a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology therapies for people living with cancer, recently announced its plans to present initial data from its ongoing Phase 2 trial for vilastobart (XTX101), a tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4, in combination with atezolizumab (Tecentriq®) in patients with metastatic microsatellite stable colorectal cancer (MSS CRC) at the ASCO GI Symposium. In addition, the company also announced preliminary data from Phase 1 dose escalation for XTX301, an investigational tumor-activated IL-12. "We are encouraged by the early evidence of responses in patients with cold tumors, including MSS colorectal cancer, reported for the combination of vilastobart and atezolizumab in Phase 1C dose escalation earlier this year, and we look forward to sharing initial Phase 2 data for the combination in MSS CRC at ASCO GI in January," said Katarina Luptakova, M.D., Chief Medical Officer of Xilio. "In addition, the preliminary Phase 1 data we reported today for XTX301, our tumor-activated IL-12, highlight its promising clinical profile, including no dose-limiting toxicities reported to date and consistent interferon gamma signaling observed throughout treatment cycles." RenovoRx, Inc. (NASDAQ: RNXT), a life sciences company developing novel targeted oncology therapies and commercializing RenovoCath®, a novel, FDA-cleared delivery platform, also announced that three of its abstracts were accepted to be presented at several upcoming industry conferences, including ASCO GI 2025. RenovoRx is pioneering a novel therapy platform called TAMP, which delivers chemotherapy directly to the tumor through the arterial wall, potentially reducing side effects and improving treatment effectiveness compared to standard intravenous therapy. Their ongoing Phase III TIGeR-PaC trial, evaluating this approach with their FDA-cleared RenovoCath device, is expected to complete patient enrollment and a key interim analysis by mid-2025. "These abstracts support the potential for our TAMP therapy platform to provide a meaningful advancement in the standard of care for cancer treatment," said Ramtin Agah, MD, Chief Medical Officer and Founder of RenovoRx. "TAMP focuses on drug concentration optimization in tumors by delivering therapies with our RenovoCath delivery system. This targeted approach to cancer treatment is designed to enable physicians to isolate segments of the vascular anatomy closest to tumors and ensure precise therapeutic delivery, while potentially minimizing a therapy's toxicities versus the standard of care. Specifically, our approach enables physicians to utilize RenovoCath to use pressure to force chemotherapy across the arterial wall near the tumor site to bathe the target tumor." Source: CONTACT: USA NEWS GROUP [email protected] (604) 265-2873 DISCLAIMER: Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. USA News Group is a wholly-owned subsidiary of Market IQ Media Group, Inc. ("MIQ"). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice commencing immediately and ongoing. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material, including this article, which is disseminated by MIQ has been approved by Oncolytics Biotech Inc.; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles. While all information is believed to be reliable, it is not guaranteed by us to be accurate. 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Common July 4 Pet Anxiety Treatment Leads to Accidental Overdose MINNEAPOLIS, July 2, 2024 /PRNewswire/ -- Many people use calming chews to relieve their pet's anxiety, especially during the July 4 holiday. Not only can the sound of fireworks scare your pet, but a change in routine or sudden influx of visitors can cause pets great distress. While these supplements can help calm your pet, they can also be dangerous if taken in too great of a quantity. Continue Reading It was anything but relaxing when Elton overdosed on calming chews and had to be rushed to the veterinary hospital for treatment. "I had just moved to a new apartment, and I ran out to do some grocery shopping," explained Jacque Dickson, who lives with her dogs Elton and Chubbs in Greensboro, North Carolina. "My father had recently bought a bottle of calming chews for Chubbs, who can be anxious. The bottle was in an unopened box, but the dogs managed to get into it and consume the entire bottle of more than 160 chews. My first call was to the pet emergency room, and they had me call Pet Poison Helpline before I even left the house." By calling first, the toxicology experts at Pet Poison Helpline were able to start developing a recommended treatment plan based on Elton and Chubbs' individual situations that could be ready when Dickson arrived at the clinic. "After talking with the experts at Pet Poison Helpline, they determined that Chubbs was not in danger because of his size," Dickson explained. "He's a fit cattle dog, but he's 65 pounds. Because Elton is only 10 pounds, they recommended I take him into the hospital for treatment and observation." As soon as Dickson arrived at Carolina Veterinary Specialists in Greensboro, the medical team was ready to start treatment. The Pet Poison Helpline team had determined that Elton had consumed a dangerous level of the product, which contains tryptophan. The toxicologists were concerned with Elton developing hypernatremia due to the number of chews he ingested, potentially causing a fluid shift that results in increased sodium concentrations. There was also a concern for serotonin syndrome to develop, which causes numerous neurologic and cardiovascular signs, due to the amount of L-tryptophan ingested. With this in mind, the specialists at Pet Poison Helpline recommended an antiemetic, electrolyte monitoring, intravenous fluids and monitoring for serotonin syndrome, a condition that happens when there is too much serotonin in the body. "The dedicated team at Carolina Veterinary Specialists took great care of Elton," said Dr. Renee Schmid, a senior veterinary toxicologist and director of Veterinary Medicine at Pet Poison Helpline. "He was closely monitored overnight and went home the next day, where Ms. Dickson could monitor both him and Chubbs for any additional symptoms or changes in behavior." Accidental medication poisoning is only one of the risks facing pets during the July 4 holiday. An even greater threat is pets being terrified by the loud fireworks explosions or getting out of the house and into other dangers such as being hit by a car. Pet Poison Helpline has partnered with AKC Reunite, the nation's largest not for profit pet recovery service, offering its 24/7 toxicology expertise as an optional, unlimited benefit for its members to add to their pet's lifetime protection. "According to AKC Reunite, more pets go missing during the July 4th weekend than any other time of the year," said Dr. Schmid. "To help prevent problems with your pet, AKC Reunite has six tips for protecting your pet this Independence Day." Tip 1: Establish a Place of Sanctuary Make sure your dog or cat always has access to a comfortable, quiet and safe place to get away from the noise. Either a closet, under a piece of furniture or in his crate. Tip 2: Make Toys and Long-Lasting Treats Available Keep toys and long-lasting treats in your pet's safe area to make the area more fun and to provide distractions from loud noises and flashes. Tip 3: Exercise Earlier in the Day is Key Make time to exercise your pet during daylight hours; then, keep them safely indoors before the fireworks begin. Tip 4: Turn Up the Music, but Not Too Loud At dusk, close your windows and curtains and turn on music or the television to muffle the loud noises that accompany social gatherings and the booming thunder from fireworks. Tip 5: Watch Their Body Language: Pets convey fear by shivering, cowering, tucking their tail between the legs, and averting their eyes. Looming over a fearful dog will only make it more anxious; and unless a dog is likely to get hurt it is often best to leave a fearful dog alone because its behavior when scared is uncertain. Overall, you know your pet best, and recognizing the cues they give you through their body language will help to determine the best way to make them as comfortable as possible. "Enjoy the July 4th festivities with your family and friends, but don't forget about your furry loved ones," Dr. Schmid said. "Taking a few precautions can help protect your pet from a variety of dangers." Pet Poison Helpline created Toxin Tails to educate the veterinary community and pet lovers on the many types of poisoning dangers facing pets, both in and out of the home. All the pets highlighted in Toxin Tails have been successfully treated for the poisoning and fully recovered. About Pet Poison Helpline Pet Poison Helpline®, your trusted source for toxicology and pet health advice in times of potential emergency, is available 24 hours, seven days a week for pet owners and veterinary professionals who require assistance treating a potentially poisoned pet. We are an independent, nationally recognized animal poison control center triple licensed by the Boards of Veterinary Medicine, Medicine and Pharmacy providing unmatched professional leadership and expertise. Our veterinarians and board-certified toxicologists provide treatment advice for poisoning cases of all species, including dogs, cats, birds, small mammals, large animals and exotic species. As the most cost-effective option for animal poison control care, Pet Poison Helpline's fee of $85 per incident includes follow-up consultations for the duration of the case. Based in Minneapolis, Pet Poison Helpline is available in North America by calling 800-213-6680. Additional information can be found online at . Contact: Dr. Renee Schmid Pet Poison Helpline® (952) 806-3803 [email protected] SOURCE Pet Poison Helpline