Last update 27 Jan 2026

RAY-1225

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
RAY 002, RAY 1225, RAY-002
+ [2]
Target
GIPR x GLP-1R
Action
agonists
Mechanism
GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Therapeutic Areas
Digestive System DisordersEndocrinology and Metabolic DiseaseNervous System Diseases+ [2]
Active Indication
Diabetes Mellitus, Type 2ObesityMetabolic Dysfunction Associated Steatohepatitis+ [3]
Inactive Indication-
Originator Organization
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
Active Organization
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
Inactive Organization-
License Organization
Qilu Pharmaceutical Group Co. Ltd.Qilu Pharmaceutical Group Co. Ltd.Guangdong Zhongsheng Pharmaceutical Co., Ltd.Guangdong Zhongsheng Pharmaceutical Co., Ltd.RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Related

11
Clinical Trials associated with RAY-1225
NCT07139548
/ Not yet recruitingPhase 3
A Phase 3, Randomized, Open-Label Trial Comparing Efficacy and Safety of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Patients With Type 2 Diabetes
NCT07139535
/ Not yet recruitingPhase 3
A Randomized, Double-blind, Placebo-Controlled Trial Comparing the Efficacy and Safety of RAY1225 Versus Placebo in Patients With Type 2 Diabetes, Inadequately Controlled With Diet and Exercise Alone
NCT06893016
/ RecruitingPhase 3
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study Evaluating the Safety, Tolerability, and Efficacy of RAY1225 in Participants Who Have Obesity or Are Overweight
100 Clinical Results associated with RAY-1225
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100 Translational Medicine associated with RAY-1225
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100 Patents (Medical) associated with RAY-1225
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100 Deals associated with RAY-1225
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 3
China
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
22 Aug 2025
ObesityPhase 3
China
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
15 Jun 2025
Metabolic Dysfunction Associated SteatohepatitisPhase 3
China
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
-
Hepatic InsufficiencyPhase 1
China
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
26 Aug 2024
Liver InjuryPhase 1
China
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
26 Aug 2024
Sleep Apnea, ObstructiveIND Approval
China
RAYNOVENT Co., Ltd.RAYNOVENT Co., Ltd.
23 Jan 2026
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
REBUILDING-1 (ADA 12025 | ADA 22025 | NEWS)
ManualManual
Phase 2
Overweight | Obesity
132
eitlmszcfx(wcmuikdlya) = zhsgpvlxdg sagierbpjl (imntngjevh, -11.63 to -8.49)
Positive
20 Jun 2025
eitlmszcfx(wcmuikdlya) = llbpkqkemq sagierbpjl (imntngjevh, -14.51 to -11.43)
SHINING-1 (NEWS)
ManualManual
Phase 2
Diabetes Mellitus, Type 2
-
wmsfnhogrn(queojpljbw) = boheuacnxv fsmfrfzbis (ajulgwrexv )
Met
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Positive
31 Dec 2024
wmsfnhogrn(queojpljbw) = zaowbndzvu fsmfrfzbis (ajulgwrexv )
Met
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REBUILDING-1 (NEWS)
ManualManual
Phase 2
Overweight | Obesity
122
RAY1225注射液 3mg
utzbncopvv(qkcjbnosrc) = vjcoienzzz owkejesuij (svzwcbrpau )
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Positive
21 Nov 2024
RAY1225注射液 6mg
utzbncopvv(qkcjbnosrc) = ydakihkzai owkejesuij (svzwcbrpau )
View more
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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