Last update 17 Apr 2025

SAR-440234

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
SAR 440234, SAR440234
Target
CD123 x CD3
Action
modulators, stimulants
Mechanism
CD123 modulators(Interleukin-3 receptor subunit alpha modulators), CD3 stimulants(T cell surface glycoprotein CD3 stimulants)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [1]
Active Indication-
Inactive Indication
High Risk Myelodysplastic SyndromePre B-cell acute lymphoblastic leukemiaRefractory acute myeloid leukemia
Originator Organization
SanofiSanofi
Active Organization-
Inactive Organization
SanofiSanofi
Drug Highest PhaseDiscontinuedPhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with SAR-440234
NCT03594955
/ TerminatedPhase 1/2
An Open-label, First-in-human, Dose Escalation Study of SAR440234 Administered as Single Agent by Intravenous Infusion in Patients With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), or High Risk Myelodysplasia (HR-MDS)
100 Clinical Results associated with SAR-440234
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100 Translational Medicine associated with SAR-440234
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100 Patents (Medical) associated with SAR-440234
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100 Deals associated with SAR-440234
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
High Risk Myelodysplastic SyndromePhase 2
United States
SanofiSanofi
24 Oct 2018
High Risk Myelodysplastic SyndromePhase 2
France
SanofiSanofi
24 Oct 2018
Pre B-cell acute lymphoblastic leukemiaPhase 2
United States
SanofiSanofi
24 Oct 2018
Pre B-cell acute lymphoblastic leukemiaPhase 2
France
SanofiSanofi
24 Oct 2018
Refractory acute myeloid leukemiaPhase 2
United States
SanofiSanofi
24 Oct 2018
Refractory acute myeloid leukemiaPhase 2
France
SanofiSanofi
24 Oct 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03594955 (CTgov)
Phase 1/2
High Risk Myelodysplastic Syndrome | Pre B-cell acute lymphoblastic leukemia | Refractory acute myeloid leukemia
7
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07 Apr 2022
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Biosimilar

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Regulation

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