Last update 01 Nov 2024

SAR-440234

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
Target
CD123 x CD3
Mechanism
CD123 modulators(Interleukin-3 receptor subunit alpha modulators), CD3 modulators(T cell surface glycoprotein CD3 modulators)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases
Active Indication
Acute Myeloid LeukemiaLymphoid LeukemiaMyelodysplastic Syndromes
Inactive Indication
High Risk Myelodysplastic SyndromePre B-cell acute lymphoblastic leukemiaRefractory acute myeloid leukemia
Originator Organization
SanofiSanofi
Active Organization
SanofiSanofi
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with SAR-440234
NCT03594955 / TerminatedPhase 1/2
An Open-label, First-in-human, Dose Escalation Study of SAR440234 Administered as Single Agent by Intravenous Infusion in Patients With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), or High Risk Myelodysplasia (HR-MDS)
100 Clinical Results associated with SAR-440234
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100 Translational Medicine associated with SAR-440234
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100 Patents (Medical) associated with SAR-440234
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100 Deals associated with SAR-440234
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
LeukemiaPhase 2
FR
SanofiSanofi
24 Oct 2018
LeukemiaPhase 2
US
SanofiSanofi
24 Oct 2018
Acute Myeloid LeukemiaPhase 2-
SanofiSanofi
-
Lymphoid LeukemiaPhase 2-
SanofiSanofi
-
Myelodysplastic SyndromesPhase 2-
SanofiSanofi
-
High Risk Myelodysplastic SyndromePreclinical
FR
SanofiSanofi
24 Oct 2018
Pre B-cell acute lymphoblastic leukemiaPreclinical
FR
SanofiSanofi
24 Oct 2018
Pre B-cell acute lymphoblastic leukemiaPreclinical
US
SanofiSanofi
24 Oct 2018
Refractory acute myeloid leukemiaPreclinical
US
SanofiSanofi
24 Oct 2018
Refractory acute myeloid leukemiaPreclinical
FR
SanofiSanofi
24 Oct 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03594955 (CTgov)
Phase 1/2
High Risk Myelodysplastic Syndrome | Pre B-cell acute lymphoblastic leukemia | Refractory acute myeloid leukemia
7
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07 Apr 2022
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Approval

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Regulation

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