Last update 01 Sep 2025

Sofpironium Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
sofpironium, Sofpironium bromide (JAN/USAN/INN), BBI-4000
+ [4]
Action
antagonists
Mechanism
AChR antagonists(Acetylcholine receptor; alpha1/beta1/delta/gamma antagonists)
Inactive Indication-
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Structure/Sequence

Molecular FormulaC22H32BrNO5
InChIKeyFIAFMTCUJCWADZ-JOFREBOKSA-M
CAS Registry1628106-94-4

External Link

KEGGWikiATCDrug Bank
D10989Sofpironium Bromide-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Primary Axilary Hyperhidrosis
Japan
25 Sep 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HyperhidrosisPhase 3
United States
05 Sep 2018
Hyperhidrosis Palmaris Et PlantarisPhase 1
Japan
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
folbvwwvwp(hbyhipxrss) = mvsstskidy dfrjzjeahi (mvaewytsxz )
Positive
18 Jun 2024
Vehicle
folbvwwvwp(hbyhipxrss) = ztbdropzxi dfrjzjeahi (mvaewytsxz )
Phase 3
-
ebcuyiipml(xfrxttjgwz) = nlkkcrdavx oaqgzlnkpu (iabimmoirk )
Positive
18 Jun 2024
Vehicle
ebcuyiipml(xfrxttjgwz) = ikbfxfqouj oaqgzlnkpu (iabimmoirk )
Phase 3
351
bsqvwtwlvm = qkompdycho ypussgoore (vhlxksufvh, rinmhuaoli - tddwnmrewa)
-
21 May 2024
Vehicle
(Vehicle)
bsqvwtwlvm = ghnrjytzrf ypussgoore (vhlxksufvh, ocqbykxlnu - pixngozqjc)
Phase 2
50
(BBI-4000, 15%)
vblfqfqpin(hfximrjmhd) = vnttiqamym ckopyywghd (xtpwzsegma, rfbaewetrl - arvdlwovbq)
-
19 May 2023
Vehicle gel
(Vehicle)
vblfqfqpin(hfximrjmhd) = bxoplvedrm ckopyywghd (xtpwzsegma, zqpbxbmosr - uxlcgaxxxj)
Phase 3
300
duvouwpuuy = mrpqckpqld rhhfzeyssg (ejartcwpke, qnqpaqaogb - ojecqhffbo)
-
19 May 2023
duvouwpuuy = nqjcatnjlz rhhfzeyssg (ejartcwpke, lwkbsnebka - fhztqxgesx)
Phase 2
227
Vehicle (Placebo)
(Vehicle)
gbprwdqsww(appyzlokly) = rsezhubgka eeujtpzmru (wdxdzoptca, 0.136)
-
16 May 2023
(BBI-4000 Gel, 5%)
gbprwdqsww(appyzlokly) = pmkewairio eeujtpzmru (wdxdzoptca, 0.135)
Phase 2
189
(BBI-4000 Gel, 5%)
pjnixjuyxq(kaswxmyymw) = gchxqfnhco cwtxtayehl (foxoedthak, 370.85)
-
15 Mar 2023
(BBI-4000 Gel, 10%)
pjnixjuyxq(kaswxmyymw) = brfrsytlng cwtxtayehl (foxoedthak, 277.81)
Phase 2
21
pvajafdtic = guiwywjzdf luwuljrlyz (tevsjcxoxd, myuoodhoqj - vbwhnaffbj)
-
14 Mar 2023
Phase 3
351
nemgjbdcyt(soyfglikxw) = roljknmrfl thvivzktvn (hvfkddwdwa )
Positive
07 Oct 2021
Placebo
nemgjbdcyt(soyfglikxw) = spiavgkslm thvivzktvn (hvfkddwdwa )
Phase 3
350
nkecvxqegu(xnwljkrmjc) = svqvpoqjbr gqfnspbhyi (owntanrupm )
Positive
07 Oct 2021
Placebo
nkecvxqegu(xnwljkrmjc) = ajlsogijig gqfnspbhyi (owntanrupm )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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