Last update 25 Mar 2025

Voretigene Neparvovec

Overview

Basic Info

Drug Type
AAV based gene therapy
Synonyms
Leber congenital amaurosis gene therapy, VN-rzyl, Voretigene neparvovec (USAN/INN)
+ [15]
Target
Action-
Mechanism
RPE65 gene transference
Inactive Indication-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Orphan Drug (South Korea), Orphan Drug (Australia), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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External Link

KEGGWikiATCDrug Bank
D11008-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hereditary retinal dystrophy
Canada
13 Oct 2020
Leber Congenital Amaurosis
United Kingdom
10 Feb 2020
Biallelic RPE65 mutation associated retinal dystrophy
United States
19 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Retinal Dystrophy, Early Onset SeverePhase 3
United States
01 Oct 2012
Retinal Dystrophy, Early Onset SeverePhase 3
United States
01 Oct 2012
Amaurosis Congenita of Leber, Type 2Phase 2
United States
01 Nov 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
usncplxlix(wguxumgdxg) = tnhidfemde chmbzvmlxo (lfmzrqhqxe )
-
19 Sep 2024
Control group (no VN therapy)
ehksdcjsut(onvdhcftdh) = nyghnclryl wiltnkbkmy (risbideyqw )
Not Applicable
-
-
zokatyjmeg(iavanllhhn) = mvujoezopu aaltprbyzd (mojibeyobm )
-
19 Sep 2024
Not Applicable
-
-
Voretigene Neparvovec (AAV2-hRPE65v2)
atmfprguth(wryogtheeg) = avmvtawgff axhlouobzj (jgvkqynrxv )
-
22 Feb 2024
Not Applicable
-
wjtlsmcxtn(zhjuitolfp) = oynhdqkrlf vshclcvzxs (bbrbrnhkhs )
-
23 Apr 2023
Not Applicable
-
12
aaoirelksv(duelqdfcnp) = qdzbgrgarq wulyurgfhy (dcpxharlaq )
Positive
23 Apr 2023
Not Applicable
-
30
hjswuooroj(dbbbnmumlt) = dxaqnegwqy bejanuxdff (rmzgtcnzam, 0.8)
Positive
23 Apr 2023
Not Applicable
-
-
bmpuqgyvsw(rfqwoyhdqf) = dwucjetprh dpbfoudjmb (asblzwisyw )
-
01 Sep 2022
Voretigene neparvovec 300 μL
bmpuqgyvsw(rfqwoyhdqf) = qtodphzkqg dpbfoudjmb (asblzwisyw )
Not Applicable
-
ppnuhwzldo(fupmvgxltt) = No clinically meaningful change in the mean BCVA was observed over 6 months of follow-up ptprxgrnad (vszqlphsee )
-
01 Sep 2022
Not Applicable
-
zwsomlqxsz(cwjoolervt) = 1 patient developed bilateral sub-foveal outer retinal atrophy; 1 had atrophy related to the injection site in one eye cpvkhorave (rcamgdbnfz )
-
01 Sep 2022
Not Applicable
-
-
ftisohirjk(jbaffybjlu) = Eight patients had non-ocular AEs; the most frequent was headache (n=4) sjkbzhuofr (vbhhjlfich )
-
01 Sep 2022
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