A Multi-Center, Single-Dose and Repeat-Dose Over Eight Weeks, Sequential Cohort Study to Evaluate Safety and Tolerability As Well As Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% Administered Subcutaneously in Subjects with Alpha1-Antitrypsin Deficiency

The purpose of this study is to evaluate the safety and tolerability of 72 milligrams per kilogram (mg/kg) and 180 mg/kg Alpha-1 15%, administered as a single-dose subcutaneous (SC) infusion and subsequently as weekly SC infusions over 8 weeks in participants with Alpha1-Antitrypsin Deficiency (AATD).

Start Date13 Aug 2021

Sponsor / Collaborator

Grifols Therapeutics, Inc.

NCT04547140

/ TerminatedPhase 2

A Multicenter, Randomized, Double-blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of Liquid Alpha1-Proteinase Inhibitor (Human) Plus Standard Medical Treatment (SMT) Versus Placebo Plus SMT in Hospitalized Subjects With COVID-19

The purpose of the study is to determine if Liquid Alpha1-Proteinase Inhibitor (Human) (Liquid Alpha1-PI) plus SMT can reduce the proportion of participants dying or requiring intensive care unit (ICU) admission on or before Day 29 or who are dependent on high flow oxygen devices or invasive mechanical ventilation on Day 29 versus placebo plus SMT in hospitalized participants with COVID-19.

Start Date29 Jan 2021

Sponsor / Collaborator

Grifols Therapeutics, Inc.

NCT04495101

/ CompletedPhase 2

A Multicenter, Randomized, Open-label, Parallel Group Pilot Study to Evaluate the Safety and Efficacy of Prolastin Plus Standard Medical Treatment (SMT) Versus SMT Alone in Hospitalized Subjects With COVID-19

The primary objective of the study is to determine if Prolastin plus SMT can reduce the proportion of subjects dying or requiring intensive care unit (ICU) admission on or before Day 15 or who are dependent on invasive mechanical ventilation on Day 15 versus SMT alone in hospitalized subjects with Coronavirus disease 2019 (COVID-19).

Start Date29 Jul 2020

Sponsor / Collaborator

Instituto Grifols SA

100 Clinical Results associated with Alpha1-proteinase inhibitor(Grifols SA)

100 Translational Medicine associated with Alpha1-proteinase inhibitor(Grifols SA)

100 Patents (Medical) associated with Alpha1-proteinase inhibitor(Grifols SA)

1,328

Literatures (Medical) associated with Alpha1-proteinase inhibitor(Grifols SA)

01 Jun 2025·Current Radiopharmaceuticals

Apigenin's Influence on Inflammatory and Epigenetic Responses in Rat Lungs After Radiotherapy

Article

Author: Hassanzadeh, Leila ; Ramezani, Fatemeh ; Janzadeh, Atousa ; Hajimirzaei, Pooya ; Nikoofar, Alireza ; Paydar, Reza ; Gorjipour, Fazel ; Hamblin, Michael R ; Rajabinasab, Fatemeh ; Moayer, Fariborz

Introduction::

The lung is a moderately radio-sensitive organ. When cells are damaged due to accidental radiation exposure or treatment, they release molecules that lead to the recruitment of immune cells, accumulating inflammatory cytokines at the site of damage. Apigenin (Api) is a natural flavonoid known for its anti-inflammatory properties. In this study, we investigated the radioprotective properties of Api in the lung.

Methods::

Thirty-six Wistar rats were randomly assigned to nine groups: control, radiation (Rad), CMC+Rad, Api10+Rad, and Api20+Rad. Api was administered with an intraperitoneal injection for 7 days, after which the rats were irradiated with 6 Gy whole-body X-ray. At 6 and 72 hours post-irradiation, the rats were euthanized, and their lung tissue was extracted.

Results::

Radiation led to increased alveolar wall thickness and the infiltration of macrophages and lymphocytes. Furthermore, the expression levels of inflammatory factors such as a nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-ĸB), Glycogen synthase kinase-3 beta (GSK-3β), transforming growth factor-beta1 (TGF-β1), and epigenetic factors including DNA methyltransferase 3a (DNMT3a) and Histone deacetylase 2 (HDAC2) were elevated in the lung tissue following radiation. Meanwhile, the expression level of IκB-α decreased. However, administration of Api (at both 10&20 mg/kg) reversed the adverse effects of radiation.

Conclusion::

Api administration mitigated radiation-induced lung damage by reversing inflammatory and epigenetic changes.

01 May 2025·PHYTOMEDICINE

Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop

Article

Author: Huang, Yihan ; Zhao, Chenrui ; Ji, Xiaolan ; Zheng, Guodong ; Wang, Na ; Liu, Rui ; Zhang, Tao ; Luo, Shiqiong ; Gong, Ling

PURPOSE:

The aim of this study was to investigate the therapeutic effect of API on UC via the regulation of PAMP-MRGPRX2-mediated mast cells (MCs) degranulation.

BACKGROUND:

The pro-inflammatory positive feedback loop mediated by Mas-related G-protein-coupled receptor X2 (MRGPRX2) and its endogenous ligand, PAMP-12, is associated with ulcerative colitis (UC) progression. However, the therapeutic strategies that target MRGPRX2 in the treatment of UC are less reported. Apigenin (API), a natural flavonoid, can relieve inflammation.

METHOD:

A dextran sodium sulfate (DSS)-induced mouse UC model was used to elucidate the therapeutic effects of API. Animal behavior assessment, serological assays, and histological analysis were performed in wild-type (WT) and MC MrgprB2-conditional knockout (CKO) mouse model. mRNA sequencing analysis, PCR, ELISA, and western blotting were performed in vitro and in vivo to elucidate the mechanism underlying the effect of API by a PAMP-12 triggered MC degranulation model.

RESULTS:

MC degranulation via MrgprB2 was critical for the persistence of inflammation in colitis. API attenuated colonic tissue damage, splenomegaly, and myeloperoxidase (MPO) activity in the colonic tissues. It also ameliorated colonic crypt structure damage and inflammatory cell infiltration. Moreover, API suppressed MCs degranulation, and the level of carboxypeptidases A3 (CPA3), in DSS-induced colitis, thereby blocking the pro-inflammatory positive feedback loop induced by PAMP-MrgprB2. Lastly, API effectively inhibited PAMP-12-triggered mast cell degranulation by regulating Akt1/XBP-1S/CHOP/TXNIP and NF-κB/IL-1β signaling pathways.

CONCLUSION:

API alleviates inflammatory symptoms in UC by suppressing PAMP-MRGPRX2/B2 mediated MC sustained degranulation feedback loop.

01 May 2025·Biomaterials advances

Erythrocyte membrane vesicles as drug delivery systems: A systematic review of preclinical studies on biodistribution and pharmacokinetics

Review

Author: Kostevšek, Nina

This systematic review aims to summarize the development of erythrocyte membrane vesicles (EMVs) as drug delivery carriers, with a focus on elucidating their fate in terms of biodistribution and pharmacokinetics in preclinical studies. The PubMed database was systematically reviewed to search for original peer-reviewed published studies on the use of EMVs for drug delivery to summarize the preclinical findings, following the PRISMA guidelines. A total of 142 articles matched the selection criteria and were included in the review. For each study, the following parameters were extracted: type of active pharmaceutical ingredient (API) encapsulated into EMVs, EMVs-API formulation method and final particle size, EMVs surface modifications for active targeting, cell lines and animal models used in the study, crucial treatment data, biodistribution data and finally, where applicable, data about the EMVs circulation time and blood half-life. EMVs size did not vary significantly among the different formulation methods. A complete list of cell lines and animal models used is provided. Circulation times and data for blood half-life were grouped per animal type. For the most commonly used animal type, BALB/c mice, the average half-life of EMV-API was calculated to be 10.4 h, and in all cases, up to a 10-fold increase was observed compared with that of free API. Surface modifications did not drastically change the circulation time but did improve target tissue accumulation. The most critical weaknesses in the analysed studies were identified. Key points for future studies are provided to fill the current knowledge gaps and improve the quality of publications.

News (Medical) associated with Alpha1-proteinase inhibitor(Grifols SA)

12 Sep 2024

·healthcare-digital.com

Grifols & Orange Business Launch Egypt Plasma Project

Grifols' Cairo project is part of a national initiative to achieve self-sufficiency in plasma-derived medicines. Grifols & Orange Business Complete landmark phase of Data Centre for Plasma Derivatives Facility, designed to boost healthcare in Egypt Global healthcare company Grifols is working with French telecoms giant Orange to create a sustainable supply of essential therapeutics for life-threatening diseases in Egypt. Orange Business – the enterprise division of telecoms company, Orange Group – has completed the initial stage of a new data centre and communications infrastructure in Cairo, for Grifols Egypt for Plasma Derivatives (GEPD). GEPD is a joint venture between Grifols and Egypt's National Service Projects Organisation (NSPO), which manufactures military and civilian products and provides contracting services. The project is part of a national initiative to achieve self-sufficiency in plasma-derived medicines -- vital treatments extracted from blood plasma for various serious medical conditions. Partnership to boost Egyptian healthcare Grifols, a specialist in plasma-derived medicines, is seeking to interconnect critical healthcare facilities, including a plasma laboratory, co-location data centre, plasma warehouse, 20 plasma donation centres, and a state-of-the-art manufacturing facility. Orange Business is providing co-location services, which allows GEPD to house its servers in Orange's data centre. The company is also supplying communication services and support with equipment procurement. The networked healthcare infrastructure is designed to ensure efficient operations and “the timely delivery of plasma-derived medicines to patients in need”, said Dr Ahmed Serag, Chief Strategy and Projects Officer at GEPD. Kristof Symons, CEO International at Orange Business, said: "Our technical skills, experienced resources, and global knowledge were pivotal in enabling Grifols to replicate its global business model in Egypt. This project shows how Orange Business can support its customers in creating a positive impact in today's society." About Grifols Multinational healthcare company Grifols was founded in 1940 in Barcelona, Spain employs 24,000 people worldwide, and specialises in the production of plasma-derived medicines and the development of diagnostic solutions. Its core activities include plasma collection, the manufacture of protein therapies derived from plasma, and fractionation, a process that separates a mixture into two or more fractions with different chemical and physical properties. Grifols is conducting clinical trials for its Alzheimer's treatment , a plasma-based therapy aimed at slowing cognitive decline in patients with mild to moderate Alzheimer's disease. The company is also researching treatments for liver diseases and immunodeficiencies. Among Grifols' products are Gamunex, an immune globulin therapy used to treat primary immunodeficiency, and Prolastin, used in the treatment of alpha-1 antitrypsin deficiency. The firm also produces albumin solutions for fluid replacement and coagulation factors for haemophilia treatment. In the diagnostic sector, Grifols offers blood typing systems and infectious disease screening tools. The company operates a network of plasma donation centres, primarily in the US, which form a crucial part of its supply chain for plasma-derived therapies.

15 Nov 2023

·www.globenewswire.com

Grifols Completes Cohort 1 in Clinical Study of Alpha-1 15%, Evaluating First-in-Human Subcutaneous Dosing Option for Patients with Alpha1-Antitrypsin Deficiency

Study designed to demonstrate impact of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% (Alpha-1 15%), an alpha1 antitrypsin treatment, compared with Liquid Alpha1-Proteinase Inhibitor (Human) intravenousThis first in-human subcutaneous approach to treating alpha1-antitrypsin deficiency, if proven successful in clinical trials, could give patients the convenience and flexibility to administer their medication from home BARCELONA, Spain, Nov. 15, 2023 (GLOBE NEWSWIRE) -- Grifols (MCE: GRF, MCE: GRF.P NASDAQ: GRFS), one of the world’s leading producers of plasma-derived medicines, today announced that it has completed Cohort 1 of its Phase 1/2 study (NCT04722887) evaluating Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% (Alpha-1 15%), a subcutaneous (SC) alpha1 antitrypsin (AAT) treatment being compared to Liquid Alpha1-Proteinase Inhibitor (Human) intravenous (IV). Alpha1-antitrypsin deficiency (also known as alpha-1) is an underdiagnosed1 genetic disorder that occurs when a patient has low levels of AAT, a protective protein that safeguards the lungs. Augmentation therapy with IV AAT is the standard medical treatment option for patients with severe AAT deficiency and emphysema. If proven successful in clinical trials, a SC option could provide alpha-1 patients the ability to independently administer AAT therapy from home, allowing for greater convenience and flexibility. In this multi-center, single-dose and repeat-dose study over eight weeks, Cohort 1 has been completed and demonstrated no safety issues with Alpha-1 15% that would prevent the study from moving forward into Cohort 2. “A subcutaneous option would be a first for alpha-1 patients, providing more freedom when it comes to managing their AAT deficiency by allowing patients to administer their medication from the comfort of their own home. We are pleased to announce this milestone during Alpha-1 Awareness Month, contributing to raising further visibility about this rare disease,” said Jörg Schüttrumpf, Chief Scientific Innovation Officer, Grifols. “We look forward to moving this study into Cohort 2. Grifols has a strong commitment to the alpha-1 community and continues to innovate to find additional treatment options for patients living with this disease, in addition to more convenient alpha-1 testing alternatives such as AlphaID™ At Home, our recently launched direct-to-consumer genetic health risk service.” “During Alpha-1 Awareness month, we are excited to share this exciting news to the Alpha-1 community of a new clinical trial advancement in Alpha-1. We are thrilled that Grifols has completed Cohort 1 in clinical study of Alpha-1 15% and moving forward into Cohort 2. This study evaluating first-in-human subcutaneous dosing option for Alpha-1 patients could provide a new option that could easily be administered from their own homes,” said Scott Santarella, Alpha-1 Foundation President and CEO. About Grifols Grifols is a global healthcare company founded in Barcelona in 1909 committed to improving the health and well-being of people around the world. A leader in essential plasma-derived medicines and transfusion medicine, the company develops, produces and provides innovative healthcare services and solutions in more than 110 countries. Patient needs and Grifols’ ever-growing knowledge of many chronic, rare and prevalent conditions, at times life-threatening, drive the company’s innovation in both plasma and other biopharmaceuticals to enhance quality of life. Grifols is focused on treating conditions across a broad range of therapeutic areas: immunology, hepatology and intensive care, pulmonology, hematology, neurology and infectious diseases. A pioneer in the plasma industry, Grifols continues to grow its network of donation centers, the world’s largest with over 390 across North America, Europe, Africa and the Middle East and China. As a recognized leader in transfusion medicine, Grifols offers a comprehensive portfolio of solutions designed to enhance safety from donation to transfusion, in addition to clinical diagnostic technologies. It provides high-quality biological supplies for life-science research, clinical trials, and for manufacturing pharmaceutical and diagnostic products. The company also supplies tools, information and services that enable hospitals, pharmacies and healthcare professionals to efficiently deliver expert medical care. Grifols, with more than 24,000 employees in more than 30 countries and regions, is committed to a sustainable business model that sets the standard for continuous innovation, quality, safety and ethical leadership. In 2022, Grifols’ economic impact in its core countries of operation was EUR 9.6 billion. The company also generated 193,000 jobs, including indirect and induced. The company’s class A shares are listed on the Spanish Stock Exchange, where they are part of the Ibex-35 (MCE:GRF). Grifols non-voting class B shares are listed on the Mercado Continuo (MCE:GRF.P) and on the U.S. NASDAQ through ADRs (NASDAQ:GRFS). For more information, please visit www.grifols.com MEDIA CONTACT:Media Press Officemedia@grifols.com Tel. +34 93 571 00 02 INVESTORS: Investors Relations Department & Sustainabilityinversores@grifols.com - investors@grifols.com Tel. +34 93 571 02 21 LEGAL DISCLAIMER The facts and figures contained in this report that do not refer to historical data are “future projections and assumptions”. Words and expressions such as “believe”, “hope”, “anticipate”, “predict”, “expect”, “intend”, “should”, “will seek to achieve”, “it is estimated”, “future” and similar expressions, insofar as they relate to the Grifols group, are used to identify future projections and assumptions. These expressions reflect the assumptions, hypotheses, expectations and predictions of the management team at the time of writing this report, and these are subject to a number of factors that mean that the actual results may be materially different. The future results of the Grifols group could be affected by events relating to its own activities, such as a shortage of supplies of raw materials for the manufacture of its products, the appearance of competitor products on the market, or changes to the regulatory framework of the markets in which it operates, among others. At the date of compiling this report, the Grifols group has adopted the necessary measures to mitigate the potential impact of these events. Grifols, S.A. does not accept any obligation to publicly report, revise or update future projections or assumptions to adapt them to events or circumstances subsequent to the date of writing this report, except where expressly required by the applicable legislation. This document does not constitute an offer or invitation to buy or subscribe shares in accordance with the provisions of the following Spanish legislation: Royal Legislative Decree 4/2015, of 23 October, approving recast text of Securities Market Law; Royal Decree Law 5/2005, of 11 March and/or Royal Decree 1310/2005, of 4 November, and any regulations developing this legislation. In addition, this document does not constitute an offer of purchase, sale or exchange, or a request for an offer of purchase, sale or exchange of securities, or a request for any vote or approval in any other jurisdiction. The information included in this document has not been verified nor reviewed by the external auditors of the Grifols group 1 American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168(7):818-900. doi:10.1164/rccm.168.7.818

23 Oct 2023

·www.prnewswire.com

Body Kitchen Announces Commitment to Seafood Ingredients in Green-Lipped Mussel & Elastin Supplements

Marine nutraceuticals, Pro Elastin and Pro Mobility, tackle skin elasticity and joint health CRANBURY, N.J., Oct. 23, 2023 /PRNewswire/ -- Body Kitchen, a premium natural supplement company dedicated to promoting well-nourished bodies, announced its commitment to using first-class, sustainably harvested ingredients in its popular and expanding lineup of marine nutraceuticals, including: Pro Elastin – skin elasticity formula features Prolastin®, bio-diverse marine elastin peptides from Boulogne-sur-Mer, France. Pro Mobility – joint health formula features Biolane™ pollution-free whole green-lipped mussel extract from New Zealand. The leading brand in elastin supplements, Body Kitchen was first-to-market with a high-potency, marine elastin peptide formula delivering optimal absorption without a 'fishy' odor. An advanced extraction process uses enzymes in place of chemicals to preserve the proprietary peptides' naturally high levels of antioxidants. Following the success of Pro Elastin, the company released Pro Mobility with whole green-lipped mussel extract, flash-frozen to retain its naturally occurring nutrient profile, including omega-3 fats, amino acids, vitamins, and minerals. Aquatic ingredients contain bioactive molecules not found in alternative sources, often with better digestibility and tolerance. State-of-the-art technologies preserve optimal potency and freshness, creating palatable, consumer-first ingredients that are sustainably produced and harvested. "Seafood provides some of the most nutritious, concentrated sources of macro and micro-nutrients," says Ravi Gogineni, VP of Product Development. "Through our sourcing of high-quality, efficacious, sustainably harvested marine ingredients from around the world, we can make their health benefits a reality for millions of people." In the next 10 years, the global marine supplements market is predicted to swell 8.1%, according to market research provider, Fact.MR. Body Kitchen is buoyed by deep industry knowledge, global partnerships, and economies of scale, making its marine nutraceuticals an appealing choice for consumers seeking the health benefits of fish in palatable, convenient forms. The company operates an ever-evolving portfolio of premium supplement brands, including its namesake Body Kitchen, Pro-Mobility, and Exceed. Driven by a core set of values that prioritizes quality, science and innovation, the family-run company is focused on being inclusive of a wide range of health challenges, consumer preferences, and market segments. Body Kitchen's Pro Elastin and Pro Mobility are available on the store site and on Amazon. Press Contact Brooke Place 630-414-1047 SOURCE Body Kitchen

100 Deals associated with Alpha1-proteinase inhibitor(Grifols SA)

External Link

KEGG	Wiki	ATC	Drug Bank
-	Alpha1-proteinase inhibitor(Grifols SA)	B02AB02	DB00058

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Alpha 1-Antitrypsin Deficiency	Japan	OrphanPacific, Inc.	22 Jan 2021
Pulmonary Emphysema	United States	Grifols Therapeutics, Inc.	02 Dec 1987

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
HIV Infections	Phase 3	United States	Grifols Biologicals, Inc.	01 Apr 2012
COVID-19	Phase 2	Spain	Instituto Grifols SA	29 Jul 2020
Diabetes Mellitus, Type 1	Phase 2	United States	Grifols Therapeutics, Inc.	01 Mar 2014
Cystic Fibrosis	Phase 2	-	Grifols Therapeutics, Inc.	01 Dec 2003
Emphysema	Phase 2	Denmark	Grifols Therapeutics, Inc.	01 Dec 2003
Emphysema	Phase 2	Sweden	Grifols Therapeutics, Inc.	01 Dec 2003
Emphysema	Phase 2	United Kingdom	Grifols Therapeutics, Inc.	01 Dec 2003

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02947087 (CTgov)	Phase 1/2	Pancreatitis, Chronic	48	Prolastin-C (Prolastin-C)	kwualvodxd(luldlecmqq) = lmemuuzahe pdhiighjgi (qxtyjtyxxd, 42) View more	-	09 May 2023
				Placebo (Placebo)	kwualvodxd(luldlecmqq) = xefhzhiiqs pdhiighjgi (qxtyjtyxxd, 78) View more
NCT04547140 (CTgov)	Phase 2	COVID-19	57	Standard Medical Treatment	cgeyhpfmnz = dvdcevolcq rosetxduqy (mpboltkgrm, vvmbifvwbb - lsrwmjmsqw) View more	-	22 Mar 2023
JPRN-JapicCTI-163194 \| NCT02870348 (GTI1401-OLE, Pubmed \| Respir Investig) Manual	Phase 1/2	Alpha 1-Antitrypsin Deficiency	4	Alpha1-proteinase inhibitor	ntptyqwfft(ozlcqneebz) = skrurouvdv rjjsbxqhyu (ukybyemcci ) View more	Positive	12 Aug 2022
ATS2022	Not Applicable	COVID-19	-	IV AAT	dppuuhtlrh(lbhdlehyxg) = nsptzhnzsc bgquueklkt (quulhnylfj, d7: 217.7+/ - 168.7) View more	-	15 May 2022
				Placebo	dppuuhtlrh(lbhdlehyxg) = whhzizyvon bgquueklkt (quulhnylfj, d7: 348.2+/ - 264.0) View more
NCT02870348 (GTI1401-OLE, CTgov)	Phase 1/2	Alpha 1-Antitrypsin Deficiency	4	Alpha-1 MP	wgcxewtnwl = rbmjozhiuj dhxusdnmoh (yxchbnpcuk, blexxvgyfo - didhwqnkod) View more	-	21 Mar 2022
NCT02093221 (CTgov)	Phase 2	Diabetes Mellitus, Type 1	76	180 mg/kg Alpha1-PI (Alpha1-PI 180 mg/kg/wk, 26 Weeks)	ojgxqonhtt(augmecdeid) = wzaddsftuv drbmyxfxnf (zavksujrzi, 27.7184) View more	-	19 Apr 2018
				180 mg/kg Alpha1-PI (180 mg/kg/wk Alpha1-PI, 13 Weeks)	ojgxqonhtt(augmecdeid) = yiaddytuss drbmyxfxnf (zavksujrzi, 28.9450) View more
NCT02282527 (CTgov)	Phase 2/3	Alpha 1-Antitrypsin Deficiency	32	Alpha1-PI (Liquid Alpha₁-PI)	jqhgfkvdla(edgotcnnrs) = gbddqrsfak eeuezkfwhm (sladxcojko, 23.041) View more	-	13 Mar 2017
				Prolastin-C (Prolastin-C)	jqhgfkvdla(edgotcnnrs) = ejvcimqpqp eeuezkfwhm (sladxcojko, 25.230) View more
NCT01936896 (VCU-α1RT \| VCU-Alpha1RT, CTgov)	Phase 1/2	ST Elevation Myocardial Infarction \| Acute myocardial infarction	10	Alpha 1-Antitrypsin	quyaevarkv(gagwepzfke) = qeajqjcvtv mksxktunlq (pscmhrxvvi, vwbbpqqirq - qyqtbanivu) View more	-	12 Feb 2016
NCT00295061 (Pubmed)	Phase 3	Alpha 1-Antitrypsin Deficiency	24	Prolastin-C	oxgfwsyfhp(jcvzzqisol) = vmgjmpobhs snhbzfaycw (wzpmjqxyno )	-	30 Sep 2010
				Prolastin	oxgfwsyfhp(jcvzzqisol) = dryomjaile snhbzfaycw (wzpmjqxyno )

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