A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lirentelimab in Adult Subjects With H-1 Antihistamine Refractory Chronic Spontaneous Urticaria

This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of subcutaneous lirentelimab (AK002) in adult subjects with H-1 antihistamine refractory chronic spontaneous urticaria. Subjects who complete the randomized, double-blind, placebo-controlled treatment period may have the option to enroll in an open-label extension period and receive up to 6 doses of subcutaneous lirentelimab.

Start Date26 Oct 2022

Sponsor / Collaborator

Allakos, Inc.

NCT05155085

/ TerminatedPhase 2

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneous Lirentelimab in Adult Subjects With Moderate-to-Severe Atopic Dermatitis Inadequately Controlled by Topical Treatments

This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of subcutaneous lirentelimab (AK002), given every 2 weeks for 7 doses, in adult subjects with moderate-to-severe AD inadequately controlled by topical treatments. Subjects who complete the randomized, double-blind, placebo-controlled treatment period may have the option to enroll in an open-label extension period and receive up to 7 doses of subcutaneous lirentelimab.

Start Date27 Jun 2022

Sponsor / Collaborator

Allakos, Inc.

NCT05152563

/ WithdrawnPhase 3

A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamic Effect of Subcutaneous AK002 in Subjects With Moderate to Severe Eosinophilic Gastritis and/or Eosinophilic Duodenitis

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, tolerability, and pharmacodynamic effect of subcutaneous lirentelimab (AK002), given monthly for 6 doses, in subjects with moderate to severe Eosinophilic Gastritis and/or Eosinophilic Duodenitis who have an inadequate response with, lost response to, or were intolerant to standard therapies.

Start Date01 Dec 2021

Sponsor / Collaborator

Allakos, Inc.

100 Clinical Results associated with Antolimab

100 Translational Medicine associated with Antolimab

100 Patents (Medical) associated with Antolimab

Literatures (Medical) associated with Antolimab

01 Feb 2024·Current allergy and asthma reports

Mast Cell–Targeting Therapies in Mast Cell Activation Syndromes

Review

Author: Toscano, Alessandro ; Ebo, Didier G ; Van Gasse, Athina ; Sabato, Vito ; Beyens, Michiel

PURPOSE OF REVIEW:

Provide an overview of the expanding landscape of mast cell (MC)-targeting treatments in mast cell activation syndromes (MCAS).

RECENT FINDINGS:

Tyrosine-kinase inhibitors (TKIs) targeting wild-type and mutated KIT can efficiently induce MC depletion. Avapritinib and midostaurin can also temper IgE-mediated degranulation. Avapritinib has been recently approved by the FDA for the treatment of indolent systemic mastocytosis (ISM). Targeting activation pathways and inhibitory receptors is a promising therapeutic frontier. Recently, the anti Siglec-8 antibody lirentelimab showed promising results in ISM. MCAS is a heterogeneous disorder demanding a personalized therapeutic approach and, especially when presenting as anaphylaxis, has not been formally captured as outcome in prospective clinical trials with TKI. Long-term safety of TKI needs to be addressed. New drugs under investigation in diseases in which non-neoplastic MCs play a pivotal role can provide important inputs to identify new efficient and safe treatments for MCAS.

01 Nov 2023·Gut

Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis

Article

Author: Black, Christopher J ; Barberio, Brigida ; Del Corso, Giulio ; de Bortoli, Nicola ; Ford, Alexander C ; Savarino, Edoardo ; Visaggi, Pierfrancesco

Background:

There is currently no recommendation regarding preferred drugs for active eosinophilic oesophagitis (EoE) because their relative efficacy is unclear. We conducted an up-to-date network meta-analysis to compare proton pump inhibitors, off-label and EoE-specific topical steroids, and biologics in EoE.

Methods:

We searched MEDLINE, Embase, Embase Classic and the Cochrane Central Register of Controlled Trials from inception to June 2023. We included randomised controlled trials (RCTs) comparing efficacy of all drugs versus each other, or placebo, in adults and adolescents with active EoE. Results were reported as pooled relative risks with 95% CIs to summarise effect of each comparison tested, with drugs ranked according to P score

Results:

Seventeen RCTs were eligible for systematic review. Of these, 15 studies containing 1813 subjects with EoE reported extractable data for the network meta-analysis. For histological remission defined as ≤6 eosinophils/high-power field (HPF), lirentelimab 1 mg/kg monthly ranked first. For histological remission defined as ≤15 eosinophils/HPF, budesonide orally disintegrating tablet (BOT) 1 mg two times per day ranked first. For failure to achieve symptom improvement, BOT 1 mg two times per day and budesonide oral suspension (BOS) 2 mg two times per day were significantly more efficacious than placebo. For failure to achieve endoscopic improvement based on the EoE Endoscopic Reference Score, BOT 1 mg two times per day and BOS 1 mg two times per day or 2 mg two times per day were significantly more efficacious than placebo.

Conclusions:

Although this network meta-analysis supports the efficacy of most available drugs over placebo for EoE treatment, significant heterogeneity in eligibility criteria and outcome measures among available trials hampers the establishment of a solid therapeutic hierarchy.

25 Oct 2023·The British journal of dermatology

A study of the safety and effectiveness of lirentelimab as a treatment for people with indolent systemic mastocytosis.

Article

News (Medical) associated with Antolimab

12 Mar 2025

·www.globenewswire.com

Allakos Provides Business Update and Reports Fourth Quarter 2024 Financial Results

SAN CARLOS, Calif., March 12, 2025 (GLOBE NEWSWIRE) -- Allakos Inc. (the “Company”) (Nasdaq: ALLK), a biotechnology company that has been developing antibodies for the treatment of allergic, inflammatory and proliferative diseases, today provided a business update and reported financial results for the fourth quarter ended December 31, 2024. Recent Allakos Events Reported topline data from the Phase 1 study of AK006 in patients with chronic spontaneous urticaria in January 2025.Announced in January 2025 that the Company was discontinuing further development of AK006, restructuring operations to reduce costs and exploring strategic alternatives. Cash Guidance Allakos ended the fourth quarter of 2024 with $80.8 million in cash, cash equivalents and investments. Allakos’ financial outlook, restructuring activities and estimated cash outlook as reported by the Company in January 2025 remain unchanged. The Company estimates that cash used in restructuring activities to close out AK006 development, including severance and contractual payments to vendors, will be approximately $34 million to $38 million. The Company also estimates that a significant majority of these restructuring costs will be paid over the first and second quarters of 2025. The Company estimates it will have cash, cash equivalents and investments in a range of approximately $35 million to $40 million at June 30, 2025. Fourth Quarter 2024 Financial Results Allakos ended the fourth quarter of 2024 with $80.8 million in cash, cash equivalents and investments resulting in a net decrease in cash, cash equivalents and investments of $11.9 million during the fourth quarter of 2024. Research and development expenses were $14.8 million in the fourth quarter of 2024 compared to $53.8 million in the fourth quarter of 2023, a decrease of $39.0 million. This quarter over quarter decrease is due to halting lirentelimab development and includes a $31.2 million decrease in contract research and manufacturing costs, $6.7 million of decreased compensation costs and a $1.1 million decrease in other research and development expenses. General and administrative expenses were $9.8 million for the fourth quarter of 2024 compared to $11.2 million for the fourth quarter of 2023, a decrease of $1.4 million. The quarter over quarter change included $2.9 million of decreased compensation costs offset by a $1.5 million increase primarily from professional and other general costs associated with the termination of our office lease. Allakos reported net income of $0.4 million in the fourth quarter of 2024 compared to a net loss of $62.6 million in the fourth quarter of 2023. The gain in the fourth quarter of 2024 was primarily attributed to the $23.9 million gain on lease amendment recognized as a result of the lease termination agreement entered into during the fourth quarter of 2024. About Allakos Allakos is a clinical stage biotechnology company that has been developing therapeutics that target immunomodulatory receptors present on immune effector cells involved in allergy, inflammatory and proliferative diseases. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements include, but are not limited to, Allakos’ expectations regarding its financial position and guidance, including estimated costs of restructuring activities to close out AK006 development, the timing of payment of such restructuring costs, and estimated ending second quarter 2025 cash, cash equivalents and investments; restructuring activities and plans; and exploration of strategic alternatives. Such statements are based on Allakos’ current views about its plans, intentions, expectations, strategies and prospects only as of the date of this release and are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from those set forth in or implied by such forward-looking statements, including but not limited to: uncertainties related to Allakos’ ability to realize the contemplated benefits of its restructuring activities and related reduction in force; Allakos’ ability to accurately forecast financial results, including restructuring and other costs and expenses; availability of suitable third parties with which to conduct contemplated strategic alternative transactions; whether Allakos will be able to pursue strategic alternative transactions, or whether any transaction, if pursued, will be completed on attractive terms; whether Allakos’ cash resources will be sufficient to fund its foreseeable and unforeseeable operating expenses and capital expenditure requirements; Allakos’ ability to maintain the listing of its common stock on Nasdaq; general economic and market conditions, both domestic and international; risks associated with volatility and uncertainty in the capital markets for biotechnology companies; and other risks. Information regarding the foregoing and additional risks may be found in the section entitled “Risk Factors” in documents that Allakos files from time to time to with the SEC. These documents contain and identify important factors that could cause the actual results for Allakos to differ materially from those contained in Allakos’ forward-looking statements. Any forward-looking statements contained in this press release speak only as of the date hereof, and Allakos specifically disclaims any obligation to update any forward-looking statement, except as required by law. These forward-looking statements should not be relied upon as representing Allakos’ views as of any date subsequent to the date of this press release. Source: Allakos Inc. Investor Contact:Adam Tomasi, PresidentAlex Schwartz, VP Strategic Finance and Investor Relationsir@allakos.com Media Contact:media@allakos.com ALLAKOS INC. UNAUDITED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME AND LOSS (in thousands, except per share data) Three Months Ended Twelve Months Ended December 31, December 31, 2024 2023 2024 2023 Operating expenses Research and development $14,819 $53,801 $79,939 $150,908 General and administrative 9,837 11,182 38,822 45,148 Impairment of long-lived assets — — 27,347 — Gain on lease amendment (23,883) — (23,883) — Total operating expenses 773 64,983 122,225 196,056 Loss from operations (773) (64,983) (122,225) (196,056)Interest income 1,104 2,382 6,450 10,347 Other expense, net 45 50 (43) 8 Net income (loss) 376 (62,551) (115,818) (185,701)Unrealized gain (loss) on investments (198) 122 86 334 Comprehensive income (loss) $178 $(62,429) $(115,732) $(185,367)Net income (loss) per common share: Basic and diluted $0.00 $(0.71) $(1.30) $(2.14)Weighted-average number of common shares outstanding: Basic 89,445 87,567 88,791 86,798 Diluted 90,400 87,567 88,791 86,798 ALLAKOS INC. UNAUDITED CONDENSED BALANCE SHEETS (in thousands) December 31, December 31, 2024 2023 Assets Current assets: Cash and cash equivalents $17,753 $66,440 Investments 63,067 104,354 Prepaid expenses and other current assets 4,766 9,095 Total current assets 85,586 179,889 Property and equipment, net 10,827 33,369 Operating lease right-of-use assets — 24,136 Other long-term assets 188 6,216 Total assets $96,601 $243,610 Liabilities and stockholders’ equity Current liabilities: Accounts payable $5,490 $1,764 Accrued expenses and other current liabilities 12,294 34,814 Total current liabilities 17,784 36,578 Operating lease liabilities, net of current portion — 38,215 Total liabilities 17,784 74,793 Stockholders’ equity: Common stock 90 88 Additional paid-in capital 1,312,886 1,287,156 Accumulated other comprehensive gain (loss) 136 50 Accumulated deficit (1,234,295) (1,118,477)Total stockholders’ equity 78,817 168,817 Total liabilities and stockholders’ equity $96,601 $243,610

Financial Statement

06 Nov 2024

·www.globenewswire.com

Allakos Provides Business Update and Reports Third Quarter 2024 Financial Results

SAN CARLOS, Calif., Nov. 06, 2024 (GLOBE NEWSWIRE) -- Allakos Inc. (the “Company”) (Nasdaq: ALLK), a biotechnology company developing antibodies for the treatment of allergic, inflammatory and proliferative diseases, today provided a business update and reported financial results for the third quarter ended September 30, 2024. Recent Allakos Events Reported safety, pharmacokinetics (PK), and pharmacodynamic (PD) results from the Phase 1 trial of subcutaneous (SC) AK006 in healthy volunteers. Bioavailability of subcutaneous AK006 was approximately 77%.Subcutaneous administered AK006 showed an estimated half-life of 12-22 days.Consistent with the IV formulation, skin biopsies taken from subcutaneous AK006 treated healthy volunteers showed high levels of receptor occupancy confirming AK006 reaches skin tissue mast cells.The 720 mg dose of AK006 showed 98% receptor occupancy at day 113 suggesting the potential for infrequent dosing.Single and multiple doses of IV AK006 and single dose subcutaneous AK006 up to 720 mg were well tolerated with a favorable safety profile. Completed enrollment of over 30 patients in the randomized, double-blind, placebo-controlled Phase 1 trial of intravenous (IV) AK006 in patients with chronic spontaneous urticaria. Data from these patients expected in early Q1 of 2025. Upcoming Allakos Anticipated Milestones Report randomized double-blind, placebo-controlled data on over 30 patients from the Phase 1 trial of AK006 in patients with CSU in early Q1 of 2025. Cash Guidance Allakos ended the third quarter of 2024 with $92.7 million in cash, cash equivalents and investments. Allakos’ financial outlook, restructuring activities and estimated cash runway as reported by the Company in January 2024 remain unchanged. The Company reiterates that it expects the restructuring activities will extend the cash runway into mid-2026 and to end 2024 with total cash, cash equivalents and investments in its previously stated $81 to $86 million guidance range. The Company has substantially completed its exit of the lirentelimab development program. Third Quarter 2024 Financial Results Allakos ended the third quarter of 2024 with $92.7 million in cash, cash equivalents and investments resulting in a net decrease in cash, cash equivalents and investments of $30.4 million during the third quarter of 2024. Approximately $18 million of this third quarter decrease was paid in connection with exiting the lirentelimab development program. Research and development expenses were $10.9 million in the third quarter of 2024 compared to $36.7 million in the third quarter of 2023, a decrease of $25.8 million. This quarter over quarter decrease is attributed to $16.4 million of lower contract research and development costs, primarily due to halting lirentelimab development and includes a $4.6 million decrease relating to a change in estimated manufacturing costs upon resolution of the related work orders with the vendor, $5.7 million of decreased compensation costs and a $3.7 million decrease in other research and development expenses. General and administrative expenses were $8.9 million for the third quarter of 2024 compared to $11.5 million for the third quarter of 2023, a decrease of $2.6 million. The quarter over quarter change included $2.4 million of decreased compensation costs and $0.2 million of decreased other general and administrative expenses. Allakos reported a net loss of $18.4 million in the third quarter of 2024 compared to $45.6 million in the third quarter of 2023. Net loss per basic and diluted share was $0.21 for the third quarter of 2024 compared to $0.52 in the third quarter of 2023. About Allakos Allakos is a clinical stage biotechnology company developing therapeutics that target immunomodulatory receptors present on immune effector cells involved in allergy, inflammatory and proliferative diseases. Activating these immunomodulatory receptors allows for the direct targeting of cells involved in disease pathogenesis and, in the setting of allergy and inflammation, has the potential to result in broad inhibition of inflammatory cells. The Company’s most advanced product candidate is AK006. AK006 targets Siglec-6, an inhibitory receptor expressed on mast cells. Mast cells are widely distributed in the body and play a central role in the inflammatory response. Inappropriately activated mast cells have been identified as key drivers in a number of severe diseases affecting the gastrointestinal tract, eyes, skin, lungs and other organs. In preclinical studies, AK006 appears to provide deep mast cell inhibition and, in addition to its inhibitory activity, reduce mast cell numbers. For more information, please visit the Company’s website at www.allakos.com. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements include, but are not limited to, Allakos’ expected timing of reporting data from its clinical trial of AK006; cash guidance and runway; and restructuring. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from current expectations and beliefs, including but not limited to: Allakos’ stages of clinical drug development; Allakos’ ability to timely initiate and complete clinical trials for AK006; Allakos’ ability to obtain required regulatory approvals for its clinical trials; uncertainties related to the enrollment of patients in its clinical trials; Allakos’ ability to demonstrate sufficient safety and efficacy of its product candidates in its clinical trials; uncertainties related to the success of clinical trials, regardless of the outcomes of preclinical testing or early-stage trials; Allakos’ ability to obtain regulatory approvals to market its product candidates; market acceptance of Allakos’ product candidates; uncertainties related to the projections of the size of patient populations suffering from the diseases Allakos is targeting; Allakos’ ability to advance additional product candidates beyond AK006; uncertainties related to Allakos’ ability to realize the contemplated benefits of its restructuring and related reduction in force; Allakos’ ability to accurately forecast financial results; Allakos’ ability to obtain additional capital to finance its operations, research and drug development; Allakos’ ability to maintain the listing of our common stock on Nasdaq; general economic and market conditions, both domestic and international; domestic and international regulatory obligations; and other risks. Information regarding the foregoing and additional risks may be found in the section entitled “Risk Factors” in documents that Allakos files from time to time to with the SEC. These documents contain and identify important factors that could cause the actual results for Allakos to differ materially from those contained in Allakos’ forward-looking statements. Any forward-looking statements contained in this press release speak only as of the date hereof, and Allakos specifically disclaims any obligation to update any forward-looking statement, except as required by law. These forward-looking statements should not be relied upon as representing Allakos’ views as of any date subsequent to the date of this press release. Source: Allakos Inc. Investor Contact:Adam Tomasi, PresidentAlex Schwartz, VP Strategic Finance and Investor Relationsir@allakos.com Media Contact:media@allakos.com ALLAKOS INC.UNAUDITED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS(in thousands, except per share data) Three Months Ended Nine Months Ended September 30, September 30, 2024 2023 2024 2023 Operating expenses Research and development $10,874 $36,749 $65,120 $97,107 General and administrative 8,876 11,461 28,985 33,966 Impairment of long-lived assets — — 27,347 — Total operating expenses 19,750 48,210 121,452 131,073 Loss from operations (19,750) (48,210) (121,452) (131,073)Interest income 1,392 2,590 5,346 7,965 Other expense, net (14) (6) (88) (42)Net loss (18,372) (45,626) (116,194) (123,150)Unrealized gain (loss) on investments 325 87 284 212 Comprehensive loss $(18,047) $(45,539) $(115,910) $(122,938)Net loss per common share: Basic and diluted $(0.21) $(0.52) $(1.31) $(1.42)Weighted-average number of commonshares outstanding: Basic and diluted 89,024 87,115 88,571 86,539 ALLAKOS INC.UNAUDITED CONDENSED BALANCE SHEETS(in thousands) September 30, December 31, 2024 2023 Assets Current assets: Cash and cash equivalents $10,449 $66,440 Investments 82,266 104,354 Prepaid expenses and other current assets 4,438 9,095 Total current assets 97,153 179,889 Property and equipment, net 15,733 33,369 Operating lease right-of-use assets 9,880 24,136 Other long-term assets 1,668 6,216 Total assets $124,434 $243,610 Liabilities and stockholders’ equity Current liabilities: Accounts payable $3,964 $1,764 Accrued expenses and other current liabilities 12,017 34,814 Total current liabilities 15,981 36,578 Operating lease liabilities, net of current portion 35,710 38,215 Total liabilities 51,691 74,793 Stockholders’ equity: Common stock 89 88 Additional paid-in capital 1,306,991 1,287,156 Accumulated other comprehensive gain (loss) 334 50 Accumulated deficit (1,234,671) (1,118,477) Total stockholders’ equity 72,743 168,817 Total liabilities and stockholders’ equity $124,434 $243,610

Financial StatementPhase 1Clinical Result

07 Aug 2024

·www.globenewswire.com

Allakos Provides Business Update and Reports Second Quarter 2024 Financial Results

SAN CARLOS, Calif., Aug. 07, 2024 (GLOBE NEWSWIRE) -- Allakos Inc. (the “Company”) (Nasdaq: ALLK), a biotechnology company developing antibodies for the treatment of allergic, inflammatory and proliferative diseases, today provided a business update and reported financial results for the second quarter ended June 30, 2024. Recent Allakos Events Initiated the randomized, double-blind, placebo-controlled Phase 1 trial of intravenous (IV) AK006 in patients with chronic spontaneous urticaria.Completed dosing in the randomized, double-blind, placebo-controlled subcutaneous (SC) AK006 cohort in healthy volunteers.Reported safety, pharmacokinetics (PK), and pharmacodynamic (PD) results from the Phase 1 trial of IV AK006 in healthy volunteers.Presented preclinical data at the 2024 European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress on mast cell inhibition with AK006. Upcoming Allakos Anticipated Milestones Report safety, PK, and PD results from the Phase 1 trial of SC AK006 in healthy volunteers in Q3 2024.Report randomized double-blind, placebo-controlled data from the Phase 1 trial of AK006 in patients with CSU at year end 2024. Cash GuidanceAllakos ended the second quarter of 2024 with $123.1 million in cash, cash equivalents and investments. Allakos’ financial outlook, restructuring activities and estimated cash runway as reported by the Company in January 2024 remain unchanged. The Company reiterates that the restructuring activities will extend the cash runway into mid-2026 and continues to expect to end 2024 with total cash, cash equivalents and investments in the range of $81 to $86 million. The Company reiterates that an estimated $30 million of closeout, severance and other costs will be paid in 2024 in connection with exiting the lirentelimab development program, of which we have spent $13 million to date in the first six months of 2024. Approximately $1 million of these payments were made in the second quarter of 2024. Second Quarter 2024 Financial ResultsAllakos ended the second quarter of 2024 with $123.1 million in cash, cash equivalents and investments resulting in a net decrease in cash, cash equivalents and investments of $16.2 million during the second quarter of 2024. Research and development expenses were $19.4 million in the second quarter of 2024 compared to $27.3 million in the second quarter of 2023, a decrease of $7.9 million. This quarter over quarter decrease is attributed to $2.5 million of lower contract research and development costs, primarily due to halting lirentelimab development, $2.5 million of decreased compensation costs and a $2.9 million decrease in other research and development expenses. General and administrative expenses were $9.2 million for the second quarter of 2024 compared to $10.5 million for the second quarter of 2023, a decrease of $1.3 million. The quarter over quarter change included $0.7 million of decreased compensation costs and $0.6 million of decreased other general and administrative expenses. Allakos reported a net loss of $26.7 million in the second quarter of 2024 compared to $35.1 million in the second quarter of 2023. Net loss per basic and diluted share was $0.30 for the second quarter of 2024 compared to $0.41 in the second quarter of 2023. About AllakosAllakos is a clinical stage biotechnology company developing therapeutics that target immunomodulatory receptors present on immune effector cells involved in allergy, inflammatory and proliferative diseases. Activating these immunomodulatory receptors allows for the direct targeting of cells involved in disease pathogenesis and, in the setting of allergy and inflammation, has the potential to result in broad inhibition of inflammatory cells. The Company’s most advanced product candidate is AK006. AK006 targets Siglec-6, an inhibitory receptor expressed on mast cells. Mast cells are widely distributed in the body and play a central role in the inflammatory response. Inappropriately activated mast cells have been identified as key drivers in a number of severe diseases affecting the gastrointestinal tract, eyes, skin, lungs and other organs. In preclinical studies, AK006 appears to provide deep mast cell inhibition and, in addition to its inhibitory activity, reduce mast cell numbers. For more information, please visit the Company’s website at www.allakos.com. Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements include, but are not limited to, Allakos’ expected timing of reporting data from its clinical trial of AK006; cash guidance and runway; and restructuring. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from current expectations and beliefs, including but not limited to: Allakos’ stages of clinical drug development; Allakos’ ability to timely initiate and complete clinical trials for AK006; Allakos’ ability to obtain required regulatory approvals for its clinical trials; uncertainties related to the enrollment of patients in its clinical trials; Allakos’ ability to demonstrate sufficient safety and efficacy of its product candidates in its clinical trials; uncertainties related to the success of clinical trials, regardless of the outcomes of preclinical testing or early-stage trials; Allakos’ ability to obtain regulatory approvals to market its product candidates; market acceptance of Allakos’ product candidates; uncertainties related to the projections of the size of patient populations suffering from the diseases Allakos is targeting; Allakos’ ability to advance additional product candidates beyond AK006; uncertainties related to Allakos’ ability to realize the contemplated benefits of its restructuring and related reduction in force; Allakos’ ability to accurately forecast financial results; Allakos’ ability to obtain additional capital to finance its operations, research and drug development; Allakos’ ability to maintain the listing of our common stock on Nasdaq; general economic and market conditions, both domestic and international; domestic and international regulatory obligations; and other risks. Information regarding the foregoing and additional risks may be found in the section entitled “Risk Factors” in documents that Allakos files from time to time with the SEC. These documents contain and identify important factors that could cause the actual results for Allakos to differ materially from those contained in Allakos’ forward-looking statements. Any forward-looking statements contained in this press release speak only as of the date hereof, and Allakos specifically disclaims any obligation to update any forward-looking statement, except as required by law. These forward-looking statements should not be relied upon as representing Allakos’ views as of any date subsequent to the date of this press release. Source: Allakos Inc. Investor Contact:Adam Tomasi, PresidentAlex Schwartz, VP Strategic Finance and Investor Relationsir@allakos.com Media Contact:Denise Powelldenise@redhousecomms.com ALLAKOS INC. UNAUDITED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (in thousands, except per share data) Three Months Ended Six Months Ended June 30, June 30, 2024 2023 2024 2023 Operating expenses Research and development $19,422 $27,280 $54,246 $60,358 General and administrative 9,211 10,537 20,109 22,505 Impairment of long-lived assets — — 27,347 — Total operating expenses 28,633 37,817 101,702 82,863 Loss from operations (28,633) (37,817) (101,702) (82,863)Interest income 1,959 2,697 3,954 5,375 Other expense, net (2) — (74) (36)Net loss (26,676) (35,120) (97,822) (77,524)Unrealized gain (loss) on investments (11) (171) (41) 125 Comprehensive loss $(26,687) $(35,291) $(97,863) $(77,399)Net loss per common share: Basic and diluted $(0.30) $(0.41) $(1.11) $(0.90)Weighted-average number of common shares outstanding: Basic and diluted 88,644 86,646 88,342 86,246 ALLAKOS INC. UNAUDITED CONDENSED BALANCE SHEETS (in thousands) June 30, December 31, 2024 2023 Assets Current assets: Cash and cash equivalents $26,496 $66,440 Investments 96,625 104,354 Prepaid expenses and other current assets 4,805 9,095 Total current assets 127,926 179,889 Property and equipment, net 16,590 33,369 Operating lease right-of-use assets 10,228 24,136 Other long-term assets 1,714 6,216 Total assets $156,458 $243,610 Liabilities and stockholders’ equity Current liabilities: Accounts payable $16,119 $1,764 Accrued expenses and other current liabilities 19,761 34,814 Total current liabilities 35,880 36,578 Operating lease liabilities, net of current portion 36,579 38,215 Total liabilities 72,459 74,793 Stockholders’ equity: Common stock 89 88 Additional paid-in capital 1,300,200 1,287,156 Accumulated other comprehensive gain (loss) 9 50 Accumulated deficit (1,216,299) (1,118,477)Total stockholders’ equity 83,999 168,817 Total liabilities and stockholders’ equity $156,458 $243,610

Financial StatementPhase 1Clinical ResultImmunotherapy

100 Deals associated with Antolimab

External Link

KEGG	Wiki	ATC	Drug Bank
-	Antolimab	-	-

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Eosinophilic Esophagitis	Phase 3	United States	Allakos, Inc.	06 Jul 2020
Eosinophilic Esophagitis	Phase 3	Australia	Allakos, Inc.	06 Jul 2020
Eosinophilic Esophagitis	Phase 3	Netherlands	Allakos, Inc.	06 Jul 2020
Eosinophilic Duodenitis	Phase 3	United States	Allakos, Inc.	18 Jun 2020
Eosinophilic Enteropathy	Phase 3	United States	Allakos, Inc.	18 Jun 2020
Moderate Atopic Dermatitis	Phase 2	United States	Allakos, Inc.	27 Jun 2022
Moderate Atopic Dermatitis	Phase 2	Germany	Allakos, Inc.	27 Jun 2022
Severe Atopic Dermatitis	Phase 2	United States	Allakos, Inc.	27 Jun 2022
Severe Atopic Dermatitis	Phase 2	Germany	Allakos, Inc.	27 Jun 2022
Chronic Urticaria	Phase 2	United States	Allakos, Inc.	23 Jan 2018

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05528861 (MAVERICK, CTgov)	Phase 2	Chronic Urticaria	127	AK002 (AK002 SC 300 mg (Main Study))	ptdyppnhim(qzzyohnomx) = breoolhwjx rpvzoqanwz (daahxqaztm, 1.9) View more	-	27 Sep 2024
				Placebo (Placebo (Main Study))	ptdyppnhim(qzzyohnomx) = hmxnnlkblc rpvzoqanwz (daahxqaztm, 2.0) View more
NCT05155085 (ATLAS, CTgov)	Phase 2	Moderate Atopic Dermatitis \| Severe Atopic Dermatitis	131	AK002 (AK002 SC 300 mg (Main Study))	euhmsvkkvr = fdihzaxbbl dfspwidmaw (zukskdglmx, xrhwfmuivx - vhpdrtgewp) View more	-	24 Sep 2024
				Placebo (Placebo (Main Study))	euhmsvkkvr = exkazmrvau dfspwidmaw (zukskdglmx, bbjihczvjz - pvmjnrthpu) View more
NCT04620811 (CTgov)	Phase 3	Eosinophilic Enteropathy \| Eosinophilic Duodenitis	159	Lirentelimab (AK002) (Main Study Placebo to Extension Study 3.0 mg/kg of Lirentelimab (AK002))	mtkggaqzjy = qzvcuvaoli cakgyqsytw (xyqftbsnvd, tbdvbwwixa - gzpcwvfytw) View more	-	18 Apr 2024
				Lirentelimab (Main Study Active to Extension Study 3.0 mg/kg of Lirentelimab (AK002))	mtkggaqzjy = mvzknwjysp cakgyqsytw (xyqftbsnvd, phesyhjbrm - wkywecolsr) View more
NCT03664960 (CTgov)	Phase 2	Eosinophilic Enteropathy \| Eosinophilic Duodenitis	58	Placebo+AK002 (Main Study Placebo to Extension Study 1 to 3.0 mg/kg of AK002)	wnqscvqfuc = tthnepemab igpzeyelpl (rtukupevje, fqbqlmtefa - ahdwdmfkpq) View more	-	28 Feb 2024
				AK002 (Main Study Active to Extension Study 1 to 3.0 mg/kg of AK002)	wnqscvqfuc = kecuvmixon igpzeyelpl (rtukupevje, vkeaimjhdt - jiimzjityz) View more
NCT03496571 (ENIGMA, CTgov)	Phase 2	Eosinophilic Enteropathy	65	AK002 (1 mg/kg of AK002)	youfrcffyc(existvevqs) = pgsxtsblon khyhwrqmdy (tjicemkmxv, kxdzvtbxte - jiogqeargw) View more	-	17 Jan 2024
				AK002 (3 mg/kg of AK002)	youfrcffyc(existvevqs) = ivzrxrmgbh khyhwrqmdy (tjicemkmxv, ewjsdskpzf - bhdqjevmnt) View more
NCT05528861 (MAVERICK, GlobeNewswire) Manual	Phase 2	Chronic Urticaria	123	Lirentelimab	lzckxbcesr(wxttonvied) = efkqvfabsi ypgphaerzm (ufefoxieyt ) View more	Negative	16 Jan 2024
				Placebo	lzckxbcesr(wxttonvied) = rpesybixci ypgphaerzm (ufefoxieyt ) View more
NCT05155085 (ATLAS, GlobeNewswire) Manual	Phase 2	Dermatitis, Atopic	122	Lirentelimab	qyztldtapf(ggpkysfwvq) = ptjzcptlrq yjlvjswwyj (ilvpgzaxfk ) Not Met View more	Negative	16 Jan 2024
				Placebo	qyztldtapf(ggpkysfwvq) = ppheewzsin yjlvjswwyj (ilvpgzaxfk ) Not Met View more
NCT04322604 (ENIGMA 2, CTgov)	Phase 3	Eosinophilic Enteropathy \| Eosinophilic Duodenitis	181	lirentelimab (AK002) (3 mg/kg of Lirentelimab (AK002))	zxebjymkqt = zoddgzzusy jvkzzjvind (fytcplfllu, cvkoybohjq - csqkhlhfib) View more	-	02 Jan 2024
				Placebo (Placebo)	zxebjymkqt = wajsnxindf jvkzzjvind (fytcplfllu, lmiaqrgwhb - qxbiajrhpt) View more
NCT04856891 (EoDyssey, CTgov)	Phase 3	Eosinophilic Enteropathy \| Eosinophilic Duodenitis	94	AK002 (3.0 mg/kg of Lirentelimab (AK002))	xzpybbylus = txtplciglr eyodyupnaj (fitbtggpez, jmbspfkvlo - tcqreylqry) View more	-	02 Jan 2024
				Placebo (Placebo)	xzpybbylus = bircipjvaa eyodyupnaj (fitbtggpez, anemnhgtny - hqbvvpibjc) View more
NCT04322708 (KRYPTOS, CTgov)	Phase 2/3	Eosinophilic Esophagitis	277	lirentelimab (AK002) (1 mg/kg of Lirentelimab (AK002))	gpsdfceqdv = qhishmpjjh htqthsnxvi (unmbppkhxx, yxltyfjwby - ivpprasgul) View more	-	02 Jan 2024
				lirentelimab (AK002) (3 mg/kg of Lirentelimab (AK002))	gpsdfceqdv = ckxzfjlqbl htqthsnxvi (unmbppkhxx, llmjwtttee - iqbfbzqqed) View more

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