Ozanimod Hydrochloride

Ventoux Bio July 22, 2026 Dupuytren's Information, Events We have now studied VEN-201 in human Dupuytren’s tissue from several individual donors, and the early results are genuinely encouraging. Across these samples, VEN-201 has shown consistent signs of acting on the biological processes that drive the disease, exactly the direction we hoped to see. What gives us particular confidence is that consistency. Seeing the same direction of effect across tissue from different people, despite the natural variation from one person to the next, is an important early signal that we may be engaging the true drivers of the disease rather than seeing a one-off result. It is still early, and there is real work ahead before this reaches patients, but this is the kind of human-anchored evidence that strengthens our conviction and helps open doors with research and funding partners. Out of respect for the scientific process, we are sharing these findings at a high level for now, with more detail to follow as the work matures. Our focus now is to build on these findings: studying additional donor tissue to further test what we are seeing, deepening our understanding of how VEN-201 works, and advancing the preparation needed to move toward a first clinical study. Each of these steps brings us closer to testing VEN-201 in patients, and each one depends on continued support. This is the question closest to my own heart and the one I receive the most from fellow patients. Our current estimate is roughly 18 months to a first clinical study, and reaching that milestone depends heavily on funding. Here is the honest part. Dupuytren’s affects millions of people, yet it has long been underfunded for how common and life-altering it is, and today’s climate is especially hard for early-stage research. Many investors now wait to commit until a therapy is already being tested in humans, which leaves promising pre-clinical programs like ours in a real gap. We are pushing hard to reach that in-human stage, and it is truly within sight. That final stretch is where community support matters most. Any and all help, whether you run with me, donate, or invest, moves us from promising science into the clinic and closer to the day patients can join a study. There are three ways to be part of this, whichever fits you best: Run with Me. This October I am running the 25k at the Lake Hodges Trail Festival in San Diego and I would love for you to join our team and run with me. Our team name is the Dupuytren’s & Ledderhose Run Collective, more info below. Donate. If you would rather cheer from the sidelines (near or far), every dollar donated does directly to our Dupuytren’s research at Ventoux Biosciences. Please donate and / or share with fellow patients impacted by this disease. Invest. We have a crowdfunding campaign now open and anyone can invest. WeFunder is a regulated investment crowdfunding platform where everyday investors can invest in Ventoux and receive equity, an ownership stake in the company, rather than making a donation. Investment minimum is $100. Company News Dupuytren's Information Events Johnny Randel is a senior finance executive who has more than 30 years of experience in financial institutions including over 17 in private equity. Mr. Randel recently retired as the Chief Financial Officer (“CFO”) of StepStone Group. Inc (Nasdaq: STEP), a global private markets specialist firm delivering tailored investment solutions, advisory services, and impactful, data-driven insights to the world’s investors with $678B of capital responsibility. Mr. Randel spent over 13 years leading the corporate and investment finance and accounting teams and was the CFO for the lead up and execution of the company’s initial public offering in 2020. Previously, Mr. Randel held the role of Chief Financial Officer and Chief Operating Officer at Citigroup Private Equity overseeing financial and operational activities for the company and its coinvestment, mezzanine, and fund of fund investment programs. Mr. Randel also held a previous role as Assistant Treasurer within Citigroup Inc.’s Treasury department where he managed rating agency relationships and fixed income client relations. Mr. Randel also held various finance roles supporting corporate finance and strategy over the course of his career. Mr. Randel received his B.G.S. from the University of Kansas and MBA from the University of Southern California. Mr. Cravets is an industry leader in biostatistics with extensive experience in program design and analysis. He currently serves as the Senior Vice President of Biometrics at Gossamer Bio. Prior to joining Gossamer Bio, Mr. Cravets was Vice President of Biometrics at Heron Therapeutics Inc. from 2016 to 2018, where he played a key role in the late-stage development programs for Zynrelef for the treatment post-surgical pain and Cinvanti for the prevention of chemotherapy induced nausea and vomiting. Before joining Heron, Mr. Cravets was Executive Director of Biometrics at Receptos Inc. from 2014 to 2016, where he built the biostatistics and data management functions while contributing to mid- and late-stage development programs for ozanimod (Zeposia) in multiple sclerosis (MS) and inflammatory bowel diseases (IBD). Before joining Receptos, Mr. Cravets was the head of biostatistics at Ardea Biosciences from 2011-2014, building the biostatistics function while also making significant contributions to the designs and analyses of late-stage studies of lesinurad (Zurampic) for the treatment of gout. From 2003-2011 Mr. Cravets served in roles of increasing responsibility in the biostatistics group at Biogen Idec Inc., contributing to the successful regulatory approvals of rituximab (Rituxan) in both rheumatoid arthritis (RA) and chronic lymphocytic leukemia (CLL). From 1996 to 2003, Mr. Cravets was in the biostatistics group at Amgen, Inc., working on multiple products across various neurology, rheumatology, cardiovascular, and bone disease indications. Mr. Cravets began his career in the pharmaceutical products division of Abbott Laboratories in 1994 after completing his master’s degree in statistics at the University of Michigan and his bachelor’s degree in mathematics at UCLA. Dr. Satish is a trained biotechnologist with several years of experience in cell and molecular biology. Dr. Satish’s interest has been in skin research with a special focus on skin inflammation, infection, and fibrosis. The other arm of Dr. Satish’s research has been to study the molecular determinants of palmar fascial disease, Dupuytren’s contracture. Her long-term interest has been to develop therapeutic agents to help alleviate the pain and distress of patients with Dupuytren’s. Her studies on Dupuytren’s disease were funded by a private donor, which moved the research forward to study this disease in an animal model, which was not feasible earlier. Dr. Satish’s research on Dupuytren has identified small molecules that can be used as a target to intervene with the progression and development of the disease. Dr. Satish received her Ph.D. from a prestigious institute in India and did her post-doctoral training at the University of Pittsburgh. Currently, Dr. Satish serves as a faculty at the Division of Asthma Research, Cincinnati Children’s Hospital; named as the top hospital in the US. At Cincinnati Children’s, Dr. Satish researches Atopic Dermatitis, a chronic inflammatory skin disease affecting children and adults. Dr. Satish has published over 50 articles in peer-reviewed journals, review articles and book chapters. Dr. Denkler is an accomplished, board certified plastic surgeon with expertise in aesthetic and reconstructive surgery. Dr. Denkler is a clinical professor of plastic surgery at UCSF and has a private practice in Marin County. He is internationally renowned for his use of multiple approaches in treating the debilitating and disabling effects of palmar fibromatosis (Dupuytren disease). Dr. Denkler is an expert in needle aponeurotomy (NA), a minimally invasive procedure that uses subcutaneous needles to release the contracture as well as use of subcutaneous injection of collagenase. He has treated over 10,000 Dupuytren’s fingers, authored >35 publications and book chapters, presented internationally and domestically and is often cited for expert opinion in national and international news discussing Dupuytren’s. HIs pioneering investigational work documenting the safety of epinephrine with local anesthesia contributed to the origination of “wide-awake hand surgery”. Dr. Denkler trained at prestigious medical institutions in the United States and Europe. He attended Baylor College of Medicine in Houston, Texas, followed by residency training in plastic and reconstructive surgery with the Cronin, Bauer, and Biggs group, also in Houston. Additionally, Dr. Denkler completed a hand surgery fellowship with Dr. Eugene Kilgore in San Francisco and one year of fellowship training in craniofacial surgery with Dr. Paul Tessier in Paris, France. Daiva Bajorunas MD is an endocrinologist with more than 25 years of experience in the biopharmaceutical industry. She has a strong interest in advancing therapeutic options for conditions of significant unmet medical need. For the past decade, Daiva has been engaged as a consultant to the pharmaceutical industry, currently as Founder and Principal, DBMD Consulting, and previously as Chief Medical Officer / Chief Scientific Officer for Vault Bioventures. She has provided her expertise to enhance large, mid-size and small pharmaceutical company product development, clinical/regulatory, and life cycle strategies for both drugs and devices, including oral, transdermal, injectable and inhalative delivery systems, working across multiple therapeutic areas and geographies. She has considerable experience chairing Data Safety Monitoring Boards. In the past she held various R&D positions of increasing responsibility at Rhone-Poulenc Rorer, BMS, Aventis (acquired by Sanofi), and Kos Pharmaceuticals (acquired by Abbott). Before she joined industry, she held academic appointments at Memorial Sloan-Kettering Cancer Center and Cornell University Medical College (CUMC), and was Director of Clinical Care, Endocrinology Service, Memorial Hospital (MH), New York, NY. Daiva received her MD degree at the University of Michigan Medical School, did her residency training at St. Vincent’s Hospital & Medical Center in NY, her metabolism fellowship at Stanford University Medical Center, CA and her endocrinology fellowship at MH/CUMC, NY.

Oral PDE4 inhibitors have demonstrated efficacy in Phase 2 studies of ulcerative colitis cAMPfield's lead candidate is prifemilast, a potentially best-in-class PDE4 inhibitor for the treatment of IBD, in-licensed from Newsoara Biopharma Co., Ltd. (Newsoara) Founded by Mountainfield Venture Partners in partnership with executives who played key roles in the development and/or commercialization of Humira®, Entyvio®, Otezla® and Zeposia® Series A led by Frazier Life Sciences and included Deep Track Capital, Forbion, Abingworth, Venrock, Longitude Capital, Novo Holdings and RA Capital cAMPfield initiating global Phase 2 trials in moderate-to-severe ulcerative colitis and Crohn's disease SAN DIEGO, June 18, 2026 /PRNewswire/ -- cAMPfield Therapeutics, Inc., a clinical-stage biopharmaceutical company formed to develop well-tolerated and highly effective oral medicines for immune-mediated inflammatory diseases, has launched with a $180 million Series A financing to advance prifemilast (HY1999/HPP737), a once-daily oral PDE4 inhibitor, for the treatment of inflammatory bowel disease (IBD). The Series A financing was supported by top tier investors led by Frazier Life Sciences, and included Deep Track Capital, Forbion, Abingworth, Venrock, Longitude Capital, Novo Holdings, and RA Capital. Recent proof-of-concept data support the therapeutic potential of PDE4 inhibition in ulcerative colitis and underscore this mechanism's potential to address persistent unmet needs in IBD. To advance a next-generation PDE4 inhibitor with the potential to deliver improved efficacy and tolerability, Mountainfield Venture Partners founded cAMPfield Therapeutics based on an exclusive license to global rights outside of Greater China from Newsoara to prifemilast (originally developed and licensed to Newsoara by vTv Therapeutics Inc.). Prifemilast is an investigational, once-daily PDE4B-selective inhibitor that has an extensive development history in the United States and China, with more than 700 clinical trial participants dosed to date, including more than 250 participants with 52 weeks of exposure. Prifemilast has shown more selective inhibition of PDE4B, the subtype most strongly associated with beneficial anti-inflammatory activity, vs PDE4D, a subtype believed to contribute to dose-limiting adverse effects. Prifemilast has been well-tolerated, with treatment discontinuation rates comparable to those observed for participants on placebo. It has also demonstrated robust efficacy in a Phase 3 trial for plaque psoriasis, an immune-mediated inflammatory disease with overlapping inflammatory pathways, cytokine networks, and genetic risk factors with IBD. Taken together, the extensive clinical experience with prifemilast supports its potential to deliver the combination of efficacy, tolerability, and convenience needed to establish a new standard of care in IBD. Building on these encouraging clinical data, cAMPfield is initiating a global Phase 2b trial with prifemilast in moderate-to-severe ulcerative colitis and a global Phase 2 trial in Crohn's disease. "Despite the availability of more than a dozen approved therapies for IBD, most patients fail to achieve deep and durable remission, while others discontinue or switch treatments because of limitations in safety or long-term effectiveness," said Bill Gerhart, CEO of cAMPfield Therapeutics. "Supported by the clinical validation of PDE4 inhibition, the best-in-class potential of prifemilast, and our team's deep experience in IBD drug development, we aim to establish prifemilast as the treatment of choice for patients and physicians seeking robust disease control with a convenient once-daily, well-tolerated oral therapy." cAMPfield was founded by Mountainfield Venture Partners, a biopharmaceutical company creation firm, in partnership with industry leaders who have played key roles in the development and commercialization of important therapies for IBD and other immune-mediated inflammatory diseases. The company's founders include Asit Parikh, formerly Head of Gastroenterology at Takeda Pharmaceuticals and development leader of Entyvio; Keith Usiskin, formerly VP and Head of Gastroenterology at Celgene / Bristol Myers Squibb and development leader of Otezla and Zeposia for IBD; and Mark Stenhouse, formerly COO of Prometheus Biosciences (developer of tulisokibart) and VP of U.S. Sales and Marketing at AbbVie with responsibility for Humira commercialization. The company is led by Chief Executive Officer Bill Gerhart, a Senior Advisor at Mountainfield Venture Partners. Prior to cAMPfield, Gerhart served as Chief Executive Officer of Kinevant, Respivant, Patara Pharma, Elevation Pharmaceuticals, and Mpex Pharmaceuticals, where he helped build and lead companies developing innovative therapies for inflammatory, respiratory, rare, and infectious diseases. Throughout his career, he has advanced multiple clinical-stage programs and led successful strategic transactions resulting in approved and commercialized therapies for patients with serious diseases. About Inflammatory Bowel Disease Inflammatory Bowel Disease, which includes ulcerative colitis and Crohn's disease, is an immune-mediated inflammatory disease that affects more than 2.4 million people in the United States and remains an area of substantial unmet need. Although numerous therapies are available, remission remains elusive for many, and treatment discontinuation, loss of response, and safety concerns continue to drive frequent therapy switching. While injectable biologics have grown in use, many patients and clinicians prefer the convenience and familiarity of oral therapies. However, currently approved oral therapies for IBD are limited by poor tolerability, safety concerns and/or modest efficacy. About Phosphodiesterase 4 Inhibitors Inhibiting phosphodiesterase 4 (PDE4) increases intracellular cyclic adenosine monophosphate (cAMP), which in turn reduces pro-inflammatory cytokines, increases anti-inflammatory cytokines, and modulates fibrotic pathways. PDE4 inhibitors are a validated class of medicines for treating immune-mediated inflammatory and fibrotic diseases, with regulatory approvals thus far in plaque psoriasis, psoriatic arthritis, Behcet's disease, COPD and pulmonary fibrosis. PDE4 inhibitors have also demonstrated clinically meaningful efficacy in Phase 2 studies of ulcerative colitis, but none have yet been advanced to Phase 3 studies or regulatory approvals. While effective, the clinical use of earlier generation PDE4 inhibitors has been limited by poor tolerability that results from the inhibition of multiple isoforms, or subtypes, of PDE4. About cAMPfield Therapeutics cAMPfield Therapeutics is a clinical-stage biopharmaceutical company focused on developing well-tolerated and highly effective oral medicines for immune-mediated inflammatory diseases, including inflammatory bowel disease. cAMPfield was founded by Mountainfield Venture Partners in partnership with executives who played key roles in the development and/or commercialization of Entyvio, Humira, Otezla and Zeposia. cAMPfield holds exclusive global development and commercialization rights to prifemilast outside Greater China through a license agreement with Newsoara. The company is headquartered in San Diego, California. For more information, visit . About Newsoara Biopharma Co., Ltd. Newsoara Biopharma Co., Ltd. (Newsoara) is a clinical-stage biopharmaceutical company founded in 2018 with headquarters in Shanghai, China. Newsoara focuses on discovering and developing innovative, targeted therapies to treat autoimmune diseases, cancer, and metabolic disorders. About vTv Therapeutics Inc. vTv Therapeutics Inc. (vTv) is a late-stage biopharmaceutical company focused on developing oral, small molecule drug candidates intended to help treat people living with diabetes and other chronic diseases. vTv's clinical pipeline is led by cadisegliatin, currently in a US Phase 3 trial, a potential first-in-class oral glucokinase activator being investigated for the treatment of type 1 diabetes. About Mountainfield Venture Partners Mountainfield Venture Partners is a biopharmaceutical company creation firm that builds new companies around development-stage drug candidates with the potential to transform patient care. Mountainfield forms its companies around in-licensed drug candidates, world-class leadership teams, and syndicated capital raises from top-tier life science institutional investors. For more information, visit . Media and Investor Contact Rayne Rodgers [email protected] cAMPfield Therapeutics All third-party product names, company names, and logos are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them. SOURCE cAMPfield Therapeutics 21% more press release views with Request a Demo