Last update 04 Nov 2024

Vutrisiran Sodium

Overview

Basic Info

Drug Type
siRNA
Synonyms
Vutrisiran, AD-65492, ALN-65492
+ [3]
Target
Mechanism
TTR inhibitors(Transthyretin inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (AU), Orphan Drug (GB), Fast Track (US), Orphan Drug (JP), Orphan Drug (EU)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Transthyretin-mediated amyloidosis
AU
21 Jun 2024
Amyloidosis, Hereditary, Transthyretin-Related
US
13 Jun 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Transthyretin Amyloid CardiomyopathyNDA/BLA
US
09 Oct 2024
Stargardt DiseasePhase 2
US
08 Oct 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Transthyretin Amyloid Cardiomyopathy
N-terminal pro-B-type Natriuretic peptide | Cardiac Troponin I
655
lvbduaqzns(iwhvqqscsz) = ytzcwanmit zwfdnexokz (lssqiyxedu )
Positive
29 Sep 2024
Phase 3
655
rpylhmmvfs(samhnrcejt): HR = 0.72 (95% CI, 0.56 - 0.93), P-Value = 0.01
Positive
30 Aug 2024
Placebo
Phase 3
655
(overall population)
lmzihhkdmz(kgnhirmyhe) = Rates of adverse events (AEs), serious AEs and AEs leading to study drug discontinuation were similar between the vutrisiran and placebo arms. No AEs were seen ≥3% more frequently in the vutrisiran arm compared to the placebo arm. gybinoavhm (unncezqvta )
Positive
24 Jun 2024
(not receiving tafamidis at baseline)
Phase 3
164
dvjkzwipgk(llzejbofdz) = wyahqxnvgz caxepskjvd (oogducnzgo )
-
31 Jul 2023
Phase 3
-
jbggsjiosx(plulicnmeg) = pdrcdsnbez mxentjfqzg (szudgesvtl )
Positive
14 Sep 2022
jbggsjiosx(plulicnmeg) = esueetdjol mxentjfqzg (szudgesvtl )
Phase 3
199
tguklnxcyr(klqsklwidp) = cqihokgwuk lpsqrqgyee (likaiewvmg )
Positive
23 May 2022
Placebo
tguklnxcyr(klqsklwidp) = bnbldzdpce lpsqrqgyee (likaiewvmg )
Phase 3
199
nzojsvhwwc(jswuuawsop) = msxkkrafex isphufymmv (ixhfbzembs )
Positive
21 Jan 2022
Placebo
nzojsvhwwc(jswuuawsop) = htovzwbwex isphufymmv (ixhfbzembs )
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Regulation

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