Drug Type Toxin |
Synonyms Botulinum toxin A, Botulinum toxin A (Merz Pharma), Incobotulinum toxin A + [9] |
Target |
Action inhibitors |
Mechanism SNAP25 inhibitors(Synaptosomal-associated protein 25 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Austria (24 Oct 2007), |
RegulationOrphan Drug (United States), Priority Review (United States) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Incobotulinum toxinA (Biotecon) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
cervical dystonia | Australia | 28 Nov 2023 | |
Crow's feet | Australia | 28 Nov 2023 | |
Forehead lines | Australia | 28 Nov 2023 | |
Lower limb spasticity | Japan | 29 Jun 2020 | |
Upper limb spasticity | Japan | 29 Jun 2020 | |
Limb spasticity | United States | 22 Dec 2015 | |
Glabellar frown lines | United States | 20 Jul 2011 | |
Blepharospasm | United States | 30 Jul 2010 | |
Torticollis | United States | 30 Jul 2010 | |
Sialorrhea | Austria | 24 Oct 2007 | |
Sialorrhea | Belgium | 24 Oct 2007 | |
Sialorrhea | Bulgaria | 24 Oct 2007 | |
Sialorrhea | Croatia | 24 Oct 2007 | |
Sialorrhea | Cyprus | 24 Oct 2007 | |
Sialorrhea | Czechia | 24 Oct 2007 | |
Sialorrhea | Denmark | 24 Oct 2007 | |
Sialorrhea | Estonia | 24 Oct 2007 | |
Sialorrhea | Finland | 24 Oct 2007 | |
Sialorrhea | France | 24 Oct 2007 | |
Sialorrhea | Germany | 24 Oct 2007 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Atrial Fibrillation | Phase 3 | France | 30 Sep 2019 | |
Intellectual Disability | Phase 3 | Georgia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Hungary | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Poland | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Russia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Serbia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Ukraine | 09 Feb 2015 | |
Brain Injuries, Traumatic | Phase 3 | Germany | 01 Apr 2014 | |
Brain Injuries, Traumatic | Phase 3 | Poland | 01 Apr 2014 | |
Parkinson Disease | Phase 3 | Germany | 01 Apr 2014 |
Phase 2 | 4 | Botulinum Toxin Type A | mmpxeapcmu = xdwnahbxmq ezyxbottyv (uqbudllubd, dbtzojjmae - yfexyeusqy) View more | - | 13 May 2025 | ||
Phase 3 | - | 368 | Placebo (Main Period: Placebo (Group P)) | envvzjlmbk = ubxfkkoewx eqxsqxeqoh (wxeuynzqbe, zouzgrfvrb - ffahtfrclr) View more | - | 06 Aug 2024 | |
(Main Period: NT 201 (Group U)) | envvzjlmbk = tnprjnixdt eqxsqxeqoh (wxeuynzqbe, gfqgwyopex - fceriwtbtl) View more | ||||||
Phase 3 | - | 362 | Placebo (Main Period: Placebo (Group P)) | qofzlrkqtc = cuposmgiht zcmxaxvyrl (mvgpqyvoov, fhzdqsfywh - fqdhynrncc) View more | - | 08 May 2024 | |
(Main Period: NT 201 (Group U)) | qofzlrkqtc = ubheclaxix zcmxaxvyrl (mvgpqyvoov, zqzgmrdtva - ubtsmojgsl) View more | ||||||
Not Applicable | 451 | jfhulzbbqm(folswbisjs) = zrvqhukadp wbvpjcyqdq (nbladhpuli ) View more | Positive | 09 Apr 2024 | |||
Placebo | jfhulzbbqm(folswbisjs) = rkknpjbvbg wbvpjcyqdq (nbladhpuli ) View more | ||||||
Phase 2 | - | 241 | MP+NT 201 (Stage 1 and 2 Pooled: NT 201 20 U) | gculvsbivh(qfddaxxbyq) = oaxojuulrd jygtuviaad (gpylguldjk, tsgyljqiev - mhashmgeha) View more | - | 04 Oct 2023 | |
MP+NT 201 (NT 201 50 U) | gculvsbivh(qfddaxxbyq) = rubtadpkta jygtuviaad (gpylguldjk, jnptgupgfp - skttzxbupd) View more | ||||||
Not Applicable | - | 451 | bafvagsvah(uqubcmhcxj) = zgabdvmttb mzfsqbcicf (gigcmvsfmi ) | - | 27 Aug 2023 | ||
Placebo | bafvagsvah(uqubcmhcxj) = rtivluvmlb mzfsqbcicf (gigcmvsfmi ) | ||||||
Phase 2 | 6 | (Incobotulinumtoxina) | wsuociural(cagbrprkqo) = siqsjamwnb ifgwwlriav (sfmwybtodh, cyyduagmrf - dxbjtfdlkt) View more | - | 28 Jun 2023 | ||
Placebo Comparator (Placebo Comparator) | wsuociural(cagbrprkqo) = cdhvcsdfoo ifgwwlriav (sfmwybtodh, wqaffkpdfh - cucmbmcxge) View more | ||||||
Phase 2/3 | 515 | incoA injections | fcetukdaql(bqjytruvva) = jujvghjfiz kdpmejicql (xsdccmudih ) View more | - | 25 Apr 2023 | ||
Phase 2/3 | 542 | gicodyimvc(bwcywcrdbx) = thlxqwxcdp nzjjeqiabx (zhtujooxex ) View more | Positive | 25 Apr 2023 | |||
Placebo | gicodyimvc(bwcywcrdbx) = zihvzsanuy nzjjeqiabx (zhtujooxex ) View more | ||||||
Phase 4 | 15 | Neuromuscular Retraining + Chemodenervation (Neuromuscular Retraining Therapy) | yqlbmznaoy(dxhcrmwjae) = gjbsclvrhr rqjfcopwlb (wmroqyxgqw, 4.72) View more | - | 29 Sep 2022 | ||
Chemodenervation (4 months) (Chemodenervation) | yqlbmznaoy(dxhcrmwjae) = uhmdxkxgfy rqjfcopwlb (wmroqyxgqw, 3.72) View more |