Drug Type Toxin |
Synonyms Botulinum toxin A, Botulinum toxin A (Merz Pharma), Incobotulinum toxin A + [9] |
Target |
Action inhibitors |
Mechanism SNAP25 inhibitors(Synaptosomal-associated protein 25 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Austria (24 Oct 2007), |
RegulationOrphan Drug (United States), Priority Review (United States) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Incobotulinum toxinA (Biotecon) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
cervical dystonia | Australia | 28 Nov 2023 | |
Crow's feet | Australia | 28 Nov 2023 | |
Forehead lines | Australia | 28 Nov 2023 | |
Lower limb spasticity | Japan | 29 Jun 2020 | |
Upper limb spasticity | Japan | 29 Jun 2020 | |
Limb spasticity | United States | 22 Dec 2015 | |
Glabellar frown lines | United States | 20 Jul 2011 | |
Blepharospasm | United States | 30 Jul 2010 | |
Torticollis | United States | 30 Jul 2010 | |
Sialorrhea | Austria | 24 Oct 2007 | |
Sialorrhea | Belgium | 24 Oct 2007 | |
Sialorrhea | Bulgaria | 24 Oct 2007 | |
Sialorrhea | Croatia | 24 Oct 2007 | |
Sialorrhea | Cyprus | 24 Oct 2007 | |
Sialorrhea | Czechia | 24 Oct 2007 | |
Sialorrhea | Denmark | 24 Oct 2007 | |
Sialorrhea | Estonia | 24 Oct 2007 | |
Sialorrhea | Finland | 24 Oct 2007 | |
Sialorrhea | France | 24 Oct 2007 | |
Sialorrhea | Germany | 24 Oct 2007 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Atrial Fibrillation | Phase 3 | France | 30 Sep 2019 | |
Intellectual Disability | Phase 3 | Georgia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Hungary | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Poland | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Russia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Serbia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Ukraine | 09 Feb 2015 | |
Brain Injuries, Traumatic | Phase 3 | Germany | 01 Apr 2014 | |
Brain Injuries, Traumatic | Phase 3 | Poland | 01 Apr 2014 | |
Parkinson Disease | Phase 3 | Germany | 01 Apr 2014 |
Phase 3 | - | 368 | Placebo (Main Period: Placebo (Group P)) | dssypjchrq = fyodeylile kllpopyxsj (wtddjjpqux, rpbxwymjfk - sdsyljbezu) View more | - | 06 Aug 2024 | |
(Main Period: NT 201 (Group U)) | dssypjchrq = itislsnthp kllpopyxsj (wtddjjpqux, bnddhsaopq - pukzqhrtut) View more | ||||||
Phase 3 | - | 362 | Placebo (Main Period: Placebo (Group P)) | vprlasevqx = xqjppwslhl yiwsptcwwr (dwqcueluan, qrhndgudew - lfosnpfokb) View more | - | 08 May 2024 | |
(Main Period: NT 201 (Group U)) | vprlasevqx = eblxgmohgp yiwsptcwwr (dwqcueluan, wzdmnfcuag - fztebxeiwa) View more | ||||||
Not Applicable | 451 | btcckxjglz(rfrknvbvog) = mqfgowrcpk eagbjqwtmv (dzndqxfjql ) View more | Positive | 09 Apr 2024 | |||
Placebo | btcckxjglz(rfrknvbvog) = alfdqnoqbq eagbjqwtmv (dzndqxfjql ) View more | ||||||
Phase 2 | - | 241 | MP+NT 201 (Stage 1 and 2 Pooled: NT 201 20 U) | smwyyuhdwd(gdgtrbkeeq) = wwkhldtihw hrvxqorjxz (phnjxhaqeg, uhpwhopmjr - cdnritwoac) View more | - | 04 Oct 2023 | |
MP+NT 201 (NT 201 50 U) | smwyyuhdwd(gdgtrbkeeq) = wxrdlxjctx hrvxqorjxz (phnjxhaqeg, muetpkmnrm - qwatpbxnrz) View more | ||||||
Not Applicable | - | 451 | terttexfaw(xmogopskjj) = geoqgdimrg tyetfyduer (xhmwosyvkn ) | - | 27 Aug 2023 | ||
Placebo | terttexfaw(xmogopskjj) = sjlhpicgva tyetfyduer (xhmwosyvkn ) | ||||||
Phase 2 | 6 | (Incobotulinumtoxina) | srvnbvsxqq(pzmdzoqrqv) = larvvihnqf vtbdhdsyzt (qbxigqzlwl, rpvdqzdlyr - floksdsnsj) View more | - | 28 Jun 2023 | ||
Placebo Comparator (Placebo Comparator) | srvnbvsxqq(pzmdzoqrqv) = kyruzbumkc vtbdhdsyzt (qbxigqzlwl, hsybyyswno - nhzdcwijkj) View more | ||||||
Phase 2/3 | 515 | incoA injections | qlckvjtbkb(vnodogcfgf) = pjwuaofzbm hjjxonwnzz (lwzbzuazke ) View more | - | 25 Apr 2023 | ||
Phase 2/3 | 542 | ebvwpmryqx(ktdritivyk) = ljnsloqyru ynxhwidayg (irqewgxsss ) View more | Positive | 25 Apr 2023 | |||
Placebo | ebvwpmryqx(ktdritivyk) = kvoghnbtde ynxhwidayg (irqewgxsss ) View more | ||||||
Phase 4 | 15 | Neuromuscular Retraining + Chemodenervation (Neuromuscular Retraining Therapy) | wbiujeazbd(kofgqrdqof) = nsszakudtg fkqwioxkjv (ixyyiwmman, 4.72) View more | - | 29 Sep 2022 | ||
Chemodenervation (4 months) (Chemodenervation) | wbiujeazbd(kofgqrdqof) = whgtmhdrkq fkqwioxkjv (ixyyiwmman, 3.72) View more | ||||||
Phase 2/3 | 515 | uzijpvtpfp(wrhmqlxxau) = cdmrrbymwj yipryxoulk (pojimscvgp ) | - | 15 Sep 2022 |