Last update 09 Dec 2024

HER2Bi-armed activated T cells(Karmanos Cancer Institute)

Overview

Basic Info

Drug Type
T-lymphocyte cell therapy
Synonyms
Anti-CD3 x Anti-HER2/Neu Armed Activated T Cells, Anti-CD3 x Anti-Her2/neu Bispecific Antibody-Armed Activated T Cells
Mechanism
CD3 modulators(T cell surface glycoprotein CD3 modulators), HER2 modulators(Receptor protein-tyrosine kinase erbB-2 modulators)
Active Indication-
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenocarcinoma of prostatePhase 2
US
07 Jun 2018
Adenocarcinoma of prostatePhase 2
US
07 Jun 2018
Metastatic castration-resistant prostate cancerPhase 2
US
07 Jun 2018
Metastatic castration-resistant prostate cancerPhase 2
US
07 Jun 2018
Metastatic Prostate CarcinomaPhase 2
US
07 Jun 2018
Metastatic Prostate CarcinomaPhase 2
US
07 Jun 2018
Triple Negative Breast CancerPhase 2
US
01 Jul 2010
Triple Negative Breast CancerPhase 2
US
01 Jul 2010
HER2-negative breast cancerPhase 2
US
08 Mar 2010
Locally Advanced Unresectable Breast CarcinomaPhase 2
US
08 Mar 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
43
iiegaqaonp(ubfuqcmita) = egdtzcwqtt vlcqnvtwtg (hqghhzkbrs, fxanosdpng - ahuqkeearw)
-
23 Dec 2022
Phase 2
15
Laboratory Biomarker Analysis+HER2Bi-Armed Activated T Cells+pembrolizumab
pmnkcxoqsg(bugttteihs) = mrthzxecpo bpmjgebpqm (mzlkficvgo, gqtttsjyqy - xgkeiomakk)
-
15 Nov 2022
Phase 2
12
yaoudilczk(tkvflqewkw) = dgqwuepvyt walufzdgcf (fzqbjbpmwf )
Positive
13 Feb 2020
Phase 2
Metastatic HER2-Negative Breast Carcinoma
HER2-negative | HR Positive | PR Positive
32
ypijnzxswe(njqoidkasz) = nifwsadtzq ejxjfpumcw (vhrmrbhtlw )
Positive
02 Jun 2019
ypijnzxswe(njqoidkasz) = yvmqoyahan ejxjfpumcw (vhrmrbhtlw )
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Approval

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Regulation

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