Delving into the Latest Updates on Acteoside with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

HMGB1 x NLRP3 x TLR4

Action

inhibitors, antagonists

Mechanism

HMGB1 inhibitors(High Mobility Group Protein B1 inhibitors), NLRP3 inhibitors(NACHT, LRR and PYD domains-containing protein 3 inhibitors), TLR4 antagonists(Toll like receptor 4 antagonists)

Therapeutic Areas

Nervous System DiseasesCardiovascular DiseasesEndocrinology and Metabolic Disease+ [1]

Active Indication

Diabetic NephropathiesParkinson DiseaseIschemic stroke

Inactive Indication-

Originator Organization-

Active Organization

Chinese PLA Academy of Military Medical Sciences

Beijing University of Traditional Chinese MedicineDongzhimen Hospital

+ [3]

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC29H36O15

InChIKeyFBSKJMQYURKNSU-ZLSOWSIRSA-N

CAS Registry61276-17-3

A comprehensive characterization strategy for the intelligent analysis of multiple chemical components in Yangxinshi Tablet (YXST) was established. The strategy developed the deep learning-assisted mass defect filtering intelligent classification, preferred ions capture list and active exclusion (DLA-MDF-PIL-AE) data acquisition mode by online comprehensive two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (2DLC-Q-TOF-MS/MS). Firstly, the online 2DLC-Q-TOF-MS/MS system was constructed and the orthogonality was evaluated. Secondly, the user interface for deep learning-assisted MDF intelligent classification technology was developed and applied to compounds classification to generate preferred ion capture lists of various types compounds. Finally, molecular networking (MN), associated neutral loss (NL) fragments, and characteristic diagnosis ion (CDI) were utilized for the automatic and manual annotation of compounds, respectively. As a result, a total of 228 compounds including 80 flavanoids, 52 alkaloids, 36 phenolic acids, 15 terpenoids, 17 saponins and 28 others were preliminary identified from YXST and source attribution was assigned to them. Furthermore, 39 compounds were simultaneously quantified by ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-MS/MS) method. Conclusively, the proposed integrated strategy proved to be a powerful method for characterizing multiple components in complex natural products.

01 Jun 2025·Separation and Purification Technology

Molecularly imprinted composite membranes with the dual imprinted network for highly selective separation of acteoside

Author: Fan, Yingying ; Chen, Chen ; Li, Xueqin ; Fang, Mujin ; Cheng, Yun ; Li, Kui

Acteoside (ACT) is the main active ingredient in phenylethanoid glycosides (PhGs) and it has anti-inflammatory, liver-protecting, and memory-enhancing functions.It remained a challenge to develop an imprinted membrane with high permselectivity for separation of ACT from PhGs.In this paper, ACT was used as a template mol. to design dual imprinted molecularly imprinted composite membranes (DIMICMs).The dual imprinted network structure was constructed and played a vital role in DIMICMs.On one hand, ACT imprinted network was formed on the surface of ACT-KH570/PDA/CMK-3@PVDF, and it can recognize and adsorb ACT.On the other hand, the imprinted filler ACT-KH570/PDA/CMK-3 was mixed with PVDF powder to construct the ACT imprinted network in the membrane, and the imprinted network can further recognize and accommodate the ACT.The dual imprinted network acted synergistically for dual recognition of ACT.The result showed that the DIMICMs had the high permselectivity (β = 14.61), selectivity (α = 4.64) and rebinding capacity (105.58 mg/g).The designed approach of DIMICMs with a dual imprintednetwork provided a strategy for the separation of natural products.

01 May 2025·International Journal of Biological Macromolecules

Study on the synergistical effects of characteristic compounds in Osmanthus black tea against xanthine oxidase based on multispectral analysis combined with in silico studies

Article

Author: Quan, Wei ; Kang, Manjun ; Liu, Zhonghua ; Li, Cui ; Tao, Tiantian ; Li, Wenlan ; Li, Maiquan ; Zhu, Mingzhi ; Liu, Xia ; Fu, Peitao

With the worldwide prevalence of hyperuricemia (HUA), safe and effective natural xanthine oxidase (XOD) inhibitors are in need. This research was aimed to reveal the promising XOD inhibitors in Osmanthus black tea. Here, the combination index (CI) values for TF3 and acteoside were below 0.9, confirming the synergistic inhibitory effects on XOD. Further research confirmed that TF3-acteoside was stronger in inducing static quenching of XOD fluorescence than TF3 or acteoside. Besides, the secondary structure of XOD was significant changed by TF3-acteoside, specifically a decrease in the content of α-Helix and random coil, accompanied by an increase in β-Sheet and β-Turn contents, ultimately its structural stability and rigidity was enhanced. Molecular docking and molecular dynamics simulation analysis verified that TF3-acteoside stably bound to XOD by multiple hydrogen bonds. This study will lay important theoretical basis for the advancement of novel XOD inhibitors and the application of osmanthus black tea in lowering uric acid (UA).

100 Deals associated with Acteoside

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetic Nephropathies	Preclinical	China	Dongzhimen Hospital	01 Sep 2024
Diabetic Nephropathies	Preclinical	China	Beijing University of Traditional Chinese Medicine	01 Sep 2024
Parkinson Disease	Preclinical	China	People's Liberation Army Air Force Military Medical University	01 Jul 2024
Parkinson Disease	Preclinical	China	Chinese PLA Academy of Military Medical Sciences	01 Jul 2024
Ischemic stroke	Preclinical	China	Xinjiang Medical University	01 Feb 2024
Ischemic stroke	Preclinical	China	Xijing Hospital	01 Feb 2024