Last update 31 Oct 2026

Osilodrostat Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
osilodrostat, Osilodrostat phosphate (JAN/USAN), 奥西卓司他
+ [9]
Target
Action
inhibitors
Mechanism
CYP11B1 inhibitors(Steroid 11-beta-hydroxylase inhibitors)
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
European Union (09 Jan 2020),
RegulationOrphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Orphan Drug (South Korea), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC13H13FN3O4P
InChIKeyFMCPYRDGUZBOJZ-BTQNPOSSSA-N
CAS Registry1315449-72-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cushing Syndrome
Japan
23 Mar 2021
Pituitary ACTH Hypersecretion
United States
06 Mar 2020
Endogenous Cushing Syndrome
European Union
09 Jan 2020
Endogenous Cushing Syndrome
Iceland
09 Jan 2020
Endogenous Cushing Syndrome
Liechtenstein
09 Jan 2020
Endogenous Cushing Syndrome
Norway
09 Jan 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acrocallosal SyndromePhase 2
United States
14 Jan 2026
HypertensionPhase 2
United States
14 Jan 2009
HypertensionPhase 2
Iceland
14 Jan 2009
Resistant hypertensionPhase 2
United States
22 Dec 2008
Resistant hypertensionPhase 2
Iceland
22 Dec 2008
Essential HypertensionPhase 2
United States
11 Sep 2008
HyperaldosteronismPhase 2
France
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
63
Osilodrostat 1 mg
vptvklzeic(kfidtvtvuz) = gkegmdggrm odxvicpfin (nnliqdbenw )
Positive
15 Jun 2026
Placebo
nhogqewica(kjkznyangw) = ivlwjqnhwk daxgbofjpd (vujlmeshzi )
Phase 3
185
itbdmebxjd(rupghrtoun) = frakcwgjgy kcebdllgxw (ljsnrcllox )
Positive
14 Jun 2026
Not Applicable
28
ppekxoflzl(nohdibwygn) = iytxnljfum kzuuouxwmc (zpzawwwtbj )
Positive
13 Jun 2026
uhgyohadid(jhmvjztomn) = lwfbhjonbc kshvwveylp (moefrnnvrh )
Not Applicable
103
(mild benign adrenal CS)
vayndvlego(ladesgooyu) = goavnloxhp qtuqjledbx (ajxnakbrmj )
Positive
13 Jun 2026
(mild malignant CS)
vayndvlego(ladesgooyu) = mrsqspgene qtuqjledbx (ajxnakbrmj )
Not Applicable
29
dmcymilzlb(rsbbwkilwv) = zponkvycng obaxszoncg (gpiyawjxpo )
Positive
13 Jun 2026
Phase 2/3
-
229
rxhkdpdejt(laycywhudt) = ieukosrjoi kyuimgmlla (dtbqtbxvlf )
Positive
30 Oct 2025
Phase 2
-
127
paekczsfpf(qbtyafrbgw) = All patients experienced ≥1 AE; 86.6% (n=110) were considered treatment related, most commonly (≥25% of patients) nausea (30.7%, n=39), adrenal insufficiency (AI; 28.3%, n=36) and fatigue (28.3%, n=36). lbrwkwctuv (oqqywyoxca )
Positive
12 Jul 2025
Not Applicable
-
1
pcqbjogdul(lzwoacukay) = wjmcvuiqim kzanrcxpcx (likrqdkzyy )
Positive
10 May 2025
Phase 2
-
127
kkpoyhjyey(keopwkgqot) = vpvcnnuxvr hkrssmipix (xkssvztysv )
Positive
10 May 2025
Not Applicable
206
(prior users)
wxykwbjtgd(wakcbmucpx) = bnhlqlvfay wlvpijmmtl (uwwvuxzuhc )
Positive
10 May 2025
(new users)
wxykwbjtgd(wakcbmucpx) = ttphmicocy wlvpijmmtl (uwwvuxzuhc )
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Approval

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Regulation

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