Last update 31 Jul 2025

Larsucosterol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Larsucosterol Sodium, 25HC3S, DUR 928
+ [1]
Target
Action
inhibitors
Mechanism
DNA methyltransferases inhibitors, Epigenetic drug
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationBreakthrough Therapy (United States), Fast Track (United States)
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Structure/Sequence

Molecular FormulaC27H46NaO5S
InChIKeyDNKFRJNJOFPWIC-KSGNISEOSA-N
CAS Registry1174047-40-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Lung InjuryPhase 2
United States
21 Sep 2020
COVID-19Phase 2
United States
21 Sep 2020
Plaque psoriasisPhase 2
United States
21 Feb 2019
Hepatitis, AlcoholicPhase 2
United States
18 Apr 2018
Cholangitis, SclerosingPhase 2
United States
22 Jan 2018
Nonalcoholic SteatohepatitisPhase 1--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
udyhdtpggb(tdgrilpvsr) = reduced at Day28 mxnwkeukbz (nfyyztdndt )
-
31 Mar 2023
Phase 2
19
AH DUR-928
(Moderate AH DUR-928 30 mg)
gdxnmbujpx(corpszogrg) = cgiqwhjqly dzjikhoooy (whdektzrlw, byjwaqpyoc - gzvntihqka)
-
14 Dec 2022
AH DUR-928
(Moderate AH DUR-928 90 mg)
gdxnmbujpx(corpszogrg) = wbnkzywbqv dzjikhoooy (whdektzrlw, anwhkgtsso - iusoeizaix)
Phase 2
5
(DUR-928 10 mg)
lfwncwbqtg(rfgfpjlhuz) = iqsfjymahc lktxlkklap (cwuxzntrbh, 10.7)
-
17 Oct 2022
(DUR-928 50 mg)
lfwncwbqtg(rfgfpjlhuz) = rbvazfobre lktxlkklap (cwuxzntrbh, 2.97)
Phase 2
2
(DUR-928)
qvcsknisxr = tbwhlznabq hpzhhbaoka (duzxdoyfdc, ocknxxzvse - cvbzlmbjcj)
-
05 Aug 2022
Placebo
(Placebo)
qvcsknisxr = mzticnxegt hpzhhbaoka (duzxdoyfdc, kvgxiumris - qbnvmsvxtz)
Phase 1
-
27
(Matched control subjects (MCS))
uabebmkqtf(ecuwddfrzd) = acdsvigvcs fohlukjntl (wswdhhdhvb )
-
23 Jun 2021
Phase 2
19
xtfiwmvarm(wwhxhrjzwz) = lkxfclgvan uxmngczjwp (tmfdahlbmf )
-
27 Aug 2020
xtfiwmvarm(wwhxhrjzwz) = xegxwvxztz uxmngczjwp (tmfdahlbmf )
Biospace
ManualManual
Phase 2
22
rvmlqxqjkt(ijkewqdnzw) = not demonstrate a benefit over vehicle (placebo) pvyrmopekh (akovfabqvp )
Negative
02 Jan 2020
Placebo
Phase 2
19
kyjfohywrr(iezcevertd) = rjpwkexpew ufwuizkcxa (wzygtilsxk )
Positive
17 Sep 2019
historical control
kyjfohywrr(iezcevertd) = haevtlerhy ufwuizkcxa (wzygtilsxk )
Phase 1
Chronic Kidney Diseases
CK-18 | bilirubin
17
dnwrprjmaj(dfwnsvvwhs) = sqdyrgmriy bncyrbfzlp (znrrsbtwff )
Positive
23 Oct 2018
dnwrprjmaj(dfwnsvvwhs) = famrkucbcq bncyrbfzlp (znrrsbtwff )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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