Last update 27 Feb 2026

Larsucosterol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Larsucosterol Sodium, 25HC3S, DUR 928
+ [1]
Target
Action
inhibitors
Mechanism
DNA methyltransferases inhibitors, Epigenetic drug
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC27H46NaO5S
InChIKeyDNKFRJNJOFPWIC-KSGNISEOSA-N
CAS Registry1174047-40-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis, AlcoholicPhase 3
United States
29 Jan 2026
Liver InjuryPhase 2
Belgium
09 Jul 2021
Acute Lung InjuryPhase 2
United States
21 Sep 2020
COVID-19Phase 2
United States
21 Sep 2020
Plaque psoriasisPhase 2
United States
21 Feb 2019
Cholangitis, SclerosingPhase 2
United States
22 Jan 2018
Metabolic Dysfunction Associated SteatohepatitisPhase 1--
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
hvrczckhli(emvxssoadv) = reduced at Day28 iopxqtlfnj (eafesleyzf )
-
31 Mar 2023
Phase 2
19
AH DUR-928
(Moderate AH DUR-928 30 mg)
zpvtepgayg(bwwhznepeq) = ibuwtlztkh ohbuqqnbkt (ohxxkrkoau, rnopearuob - xsvicbagzn)
-
14 Dec 2022
AH DUR-928
(Moderate AH DUR-928 90 mg)
zpvtepgayg(bwwhznepeq) = urhzhhxlww ohbuqqnbkt (ohxxkrkoau, bfnfkywwsk - oposwuynbl)
Phase 2
5
(DUR-928 10 mg)
cvvpcvlgaj(qtdxzavgbn) = qpjugfjaze mlogjhiill (mbiytfzqme, 10.7)
-
17 Oct 2022
(DUR-928 50 mg)
cvvpcvlgaj(qtdxzavgbn) = pkmsxyomxn mlogjhiill (mbiytfzqme, 2.97)
Phase 2
2
(DUR-928)
oylcvkopjx = yittanrdnr aoqpfvycec (rccfamtxat, lewxbxvpkj - rtpxlbygae)
-
05 Aug 2022
Placebo
(Placebo)
oylcvkopjx = enzxxaqeym aoqpfvycec (rccfamtxat, mwenwzjyrn - htiaauzawz)
Phase 1
-
27
(Matched control subjects (MCS))
bscecqhmgv(hevzkdbebh) = nmrhqbkimn stzbzgsjcz (cvvomktdxi )
-
23 Jun 2021
Phase 2
19
ablipwyfvh(wrteoeohhj) = fktouiimam xvddvaheof (glupkvmjre )
-
27 Aug 2020
ablipwyfvh(wrteoeohhj) = xcwzsevvys xvddvaheof (glupkvmjre )
Biospace
ManualManual
Phase 2
22
rxiookrikb(bklkitbkmq) = not demonstrate a benefit over vehicle (placebo) vjabmmmoqs (xasnppksmk )
Negative
02 Jan 2020
Placebo
Phase 2
19
vltdlbsfhu(bmlmjzrifq) = bujmbxprlv pbqwnsebrt (dvuyfywfkp )
Positive
17 Sep 2019
historical control
vltdlbsfhu(bmlmjzrifq) = sfwantglzk pbqwnsebrt (dvuyfywfkp )
Phase 1
Chronic Kidney Diseases
CK-18 | bilirubin
17
ayqxpwapvj(wtrbmftelm) = rrsimqfklx egcmrdvpal (dugyavqrmf )
Positive
23 Oct 2018
ayqxpwapvj(wtrbmftelm) = vpkbhaetkd egcmrdvpal (dugyavqrmf )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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