The study aims to compare the effectiveness of live attenuated influenza vaccines (LAIV) and intramuscular-inactivated vaccines (IIV) in healthy individuals aged 18-49. It will investigate cellular and humoral responses, identify immunological markers for targeted vaccine improvement, and establish a collaborative platform for accelerated immunological and clinical vaccine research.

Start Date01 Aug 2025

Sponsor / Collaborator-

JPRN-jRCT2031240116

/ SuspendedNot ApplicableIIT

A comparative use-result survey by test-negative case-control study for evaluation the effectiveness of FluMist intranasal spray in preventing influenza over time - A comparative use-result survey by test-negative case-control study for evaluation the effectiveness of FluMist intranasal spray in preventing influenza over time

Start Date01 Jan 2025

Sponsor / Collaborator-

NCT06501963

/ RecruitingPhase 4IIT

Revealing Protective Immunity to Influenza Using Systems Immunology

The goals of this study are to better understand the human immune response to influenza vaccines, specifically the live attenuated (weakened) influenza vaccine given as a nasal spray. Better understanding why this vaccine does not work as well in adults as it does in children may help design better influenza vaccines.

Start Date14 Oct 2024

Sponsor / Collaborator

Emory University

[+1]

100 Clinical Results associated with Influenza virus vaccine live intranasal (quadrivalent)(MedImmune LLC)

100 Translational Medicine associated with Influenza virus vaccine live intranasal (quadrivalent)(MedImmune LLC)

100 Patents (Medical) associated with Influenza virus vaccine live intranasal (quadrivalent)(MedImmune LLC)

131

Literatures (Medical) associated with Influenza virus vaccine live intranasal (quadrivalent)(MedImmune LLC)

01 Feb 2025·JOURNAL OF INFECTION AND CHEMOTHERAPY

The efficacy and safety of a quadrivalent live attenuated influenza nasal vaccine in Japanese children: A phase 3, randomized, placebo-controlled study

Article

Author: Oe, Keiji ; Hayashi, Takuya ; Nakayama, Tetsuo ; Makino, Kentaro

BACKGROUND:

Vaccination is the primary method of preventing influenza infection and complications in young children. We evaluated the efficacy and safety of a single dose of MEDI3250 (intranasal, quadrivalent, live attenuated influenza vaccine) in healthy Japanese children during the 2016/17 influenza season.

METHODS:

In this multicenter, randomized, double-blind, phase 3 study (jRCT2080223345), participants aged 2-18 years received MEDI3250 or placebo (2:1), stratified by age (2-6 years, 7-18 years). The primary and secondary endpoints were the incidence of confirmed symptomatic onset of influenza caused by a circulating wild-type strain or by a vaccine-matched strain, respectively. Safety outcomes included the incidence of adverse events (AEs) and vaccine-related AEs.

RESULTS:

Overall, 910 participants received MEDI3250 (n = 608) or placebo (n = 302). For the primary endpoint (regardless of the influenza subtype), the incidence of influenza onset was 25.5 % (MEDI3250) and 35.9 % (placebo); relative risk reduction, 28.8 % (95 % confidence interval, 12.5 %, 42.0 %). For the secondary endpoint (vaccine-matched strain), the incidence was 10.9 % (MEDI3250) and 17.2 % (placebo); relative risk reduction, 36.6 % (95 % confidence interval, 6.5 %, 56.8 %). Solicited AEs occurred in 67.6 % (MEDI3250) and 63.6 % (placebo). Most events were mild; nasal discharge was most common (59.2 % [MEDI3250] and 52.6 % [placebo]). Unsolicited AEs occurred in 36.0 % (MEDI3250) and 33.1 % (placebo). The most common unsolicited vaccine-related AE was diarrhea (2.3 %, both groups).

CONCLUSIONS:

MEDI3250 had a greater preventive effect against influenza onset in Japanese children than placebo; no new safety signals were observed relative to previous clinical and post-marketing studies of MEDI3250.

01 Jan 2024·Journal of immunology (Baltimore, Md. : 1950)

Distinct Functional Humoral Immune Responses Are Induced after Live Attenuated and Inactivated Seasonal Influenza Vaccination

Article

Author: Lingwood, Daniel ; Ross, Ted M ; Hanley, Hannah B ; Carlock, Michael A ; Alter, Galit ; Deng, Yixiang ; Tong, Xin ; McNamara, Ryan P ; Cizmeci, Deniz ; Fontana, Laura

Abstract:

Influenza viruses infect 5–30% of the world’s population annually, resulting in millions of incidents of hospitalization and thousands of mortalities worldwide every year. Although annual vaccination has significantly reduced hospitalization rates in vulnerable populations, the current vaccines are estimated to offer a wide range of protection from 10 to 60% annually. Such incomplete immunity may be related to both poor antigenic coverage of circulating strains, as well as to the insufficient induction of protective immunity. Beyond the role of hemagglutinin (HA) and neuraminidase (NA), vaccine-induced Abs have the capacity to induce a broader array of Ab effector functions, including Ab-dependent cellular cytotoxicity, that has been implicated in universal immunity against influenza viruses. However, whether different vaccine platforms can induce functional humoral immunity in a distinct manner remains incompletely defined. In this study, we compared vaccine-induced humoral immune responses induced by two seasonal influenza vaccines in Homo sapiens, the i.m. inactivated vaccine (IIV/Fluzone) and the live attenuated mucosal vaccine (LAIV/FluMist). Whereas the inactivated influenza vaccine induced superior Ab titers and FcγR binding capacity to diverse HA and NA Ags, the live attenuated influenza mucosal vaccine induced a more robust functional humoral immune response against both the HA and NA domains. Multivariate Ab analysis further highlighted the significantly different overall functional humoral immune profiles induced by the two vaccines, marked by differences in IgG titers, FcR binding, and both NK cell–recruiting and opsonophagocytic Ab functions. These results highlight the striking differences in Ab Fc-effector profiles induced systemically by two distinct influenza vaccine platforms.

01 Dec 2023·The Lancet. Child & adolescent health

Effectiveness of the quadrivalent live attenuated influenza vaccine against influenza-related hospitalisations and morbidity among children aged 2 to 6 years in Denmark: a nationwide cohort study emulating a target trial

Article

Author: Stensballe, Lone Graff ; Kildegaard, Helene ; Lund, Lars Christian ; Pottegård, Anton

BACKGROUND:

Scant evidence exists on the real-world effectiveness of quadrivalent live attenuated influenza vaccines (LAIV-4) in younger children. We aimed to assess the real-world effectiveness of LAIV-4 against influenza-related hospital contacts and admission and morbidity.

METHODS:

Using nationwide Danish health-care registries, we designed a cohort study that emulates a target trial, comparing LAIV-4 to no vaccination in children aged 2-6 years. Eligible children vaccinated from Oct 1, 2021, to Jan 15, 2022, were matched to unvaccinated controls in a 1:1 ratio according to demographic characteristics and risk groups for influenza, and followed-up until May 31, 2022. Primary study outcomes any hospital contact for influenza and influenza-related hospital admissions more than 12 h in duration, while hospital admission for respiratory tract infections, or for wheezing or asthma, and antibiotic prescriptions were evaluated as secondary outcomes. We estimated incidence rate ratios (IRRs) and 95% CIs using Poisson regression for each outcome. Vaccine effectiveness was calculated as 1 - IRR.

FINDINGS:

Among 308 520 Danish children aged 2-6 years, 95 434 vaccinated children were matched with 95 434 unvaccinated children who acted as controls. Receipt of LAIV-4 compared with no vaccination was associated with a reduced IRR of 0·36 (95% CI 0·27 to 0·46) and estimated vaccine effectiveness of 64·3% (53·6 to 72·6) against influenza-related hospital contacts (76 vs 210 events). The corresponding IRR and vaccine effectiveness against influenza-related hospital admissions were 0·63 (0·38 to 1·05) and 36·9% (-5·2 to 62·1; 24 vs 38 events), respectively. LAIV-4 was not associated with reductions in admission rates for respiratory tract infections (IRR 1·14, 95% CI 0·94 to 1·38), wheezing or asthma (1·04, 0·83 to 1·31), or antibiotic prescriptions for respiratory tract infections (0·97, 0·93 to 1·00). Vaccine effectiveness assessed across risk groups for influenza showed similar effectiveness in children with and without coexisting risk factors for severe influenza.

INTERPRETATION:

LAIV-4 offered moderate protection in younger children against influenza-related hospital contacts during a season dominated by influenza A(H3N2); however vaccination was not associated with reductions in secondary outcomes. This real-world study thereby supports trial evidence of moderate vaccine effectiveness of LAIV-4 against influenza-related outcomes when implementing broad vaccination schedules in younger children.

FUNDING:

Beckett-Fonden.

News (Medical) associated with Influenza virus vaccine live intranasal (quadrivalent)(MedImmune LLC)

27 Sep 2024

·www.prnewswire.com

Weekly Recap: 13 Health Press Releases You Might Have Missed

A roundup of the most newsworthy healthcare press releases from PR Newswire this week, including the first nasal spray flu vaccine, upcoming disease awareness campaigns and more. NEW YORK, Sept. 27, 2024 /PRNewswire/ -- With thousands of press releases published each week, it can be difficult to keep up with everything on PR Newswire. To help healthcare journalists and consumers stay on top of the week's most newsworthy and popular releases, here's a recap of some major stories from the week that shouldn't be missed. The list below includes the headline (with a link to the full text) and an excerpt from each story. Click on the press release headlines to access accompanying multimedia assets that are available for download. Continue Reading PR Newswire Weekly Health Press Release Roundup, Sept. 23-27, 2024. Photo provided by ASICS. FDA Approves Nasal Spray Influenza Vaccine for Self- or Caregiver-Administration The U.S. Food and Drug Administration (FDA) approved FluMist for the prevention of influenza disease caused by influenza virus subtypes A and B in individuals 2 through 49 years of age. The vaccine is sprayed into the nose and has been used safely and effectively for many years. Nearly Two-Thirds of Americans Fear Medicare Will Not Be There When They Need It "Concerns about the future of Medicare are adding another layer of uncertainty for Americans as they consider how they'll manage health care costs in retirement," said Kristi Martin Rodriguez, senior vice president of the Nationwide Retirement Institute. "With high living costs already squeezing household budgets, many are worried about having enough saved to cover their long-term health care." Cardinal Health to Acquire Integrated Oncology Network, a Physician-Led Independent Community Oncology Network The transaction demonstrates Cardinal Health's continued investment in specialty and oncology, adding more than 100 providers at more than 50 community-based sites delivering broad-reaching oncology and urology care across 10 states. ADHD Redefined: ADDitude Honors ADHD Empowerment Month with Groundbreaking Campaign Throughout October, ADDitude will highlight a new definition of ADHD each day, sharing inspiring stories of readers who have contributed their personal experiences. The campaign will also feature exclusive profiles of prominent figures in the ADHD community, including novelist Rebecca Makkai, stand-up comedian Rachel Feinstein, and illustrator Hayley Wall, who explain how ADHD shaped their creativity and careers. Halle Berry's Respin and Menopause Pioneer Joylux Announce Strategic Partnership to Advance Intimate Health & Wellness Halle Berry is a passionate advocate for women's health, especially concerning menopause. The collaboration marks a significant milestone for Respin and Joylux as they work together to destigmatize the taboo of intimate health with science-backed solutions that empower women to take control of their health. Hear Powerful Stories of Individuals Living with Familial Hypercholesterolemia in ABC's "Family Heartbeats Unmasked" The new campaign from the Association of Black Cardiologists (ABC) is dedicated to raising awareness about Familial Hypercholesterolemia (FH), a genetic condition that significantly increases the risk of early heart disease and is often underdiagnosed, especially in Black Americans and other minority populations. Flex Confirms Period Discs and Cups Are Free from Harmful Metals and PFAS Amid Concerns Over Toxic Chemicals in Tampons Flex announced that independent third-party lab testing confirmed all Flex menstrual discs and cups are free from harmful PFAS (forever chemicals), lead, arsenic, cadmium, and mercury. This follows the FDA's recent decision to investigate toxic metals found in tampons, fueling discussions about the need for more research and innovation in menstrual health. Brian Cox Warns the World About Workplace Mental Health Threat in PSA for ASICS In the PSA, Brian Cox plays the role of the world's scariest boss to highlight the silent threat to our mental health—the desk we work at every day. The PSA calls on office workers to put their mental health first by taking a Desk Break, a short movement break, during the working day. WebMD Announces 2024 Health Heroes: Visionaries Leveraging AI in Medicine "Artificial Intelligence is reshaping healthcare in profound ways, saving lives and improving patient outcomes," said Dr. John Whyte, Chief Medical Officer of WebMD. "This year's Health Heroes are leading the way in AI innovation, and we are honored to recognize their achievements." Bosley and Lumenis Partner to Introduce Breakthrough Hair Loss Solution, FoLix™, to the U.S. The partnership initiates a new era in hair loss treatment by introducing the first FDA-cleared fractional laser solution for hair loss to U.S. customers for the first time, potentially transforming the lives of millions of people affected by hair loss in the U.S. NYU Langone Health Forms New Partnership to Minimize Deaths from Extreme Heat Amid Rising Global Temperatures Project HEATWAVE (Heat Emergency Avoidance Technologies Working to Adapt to Vulnerabilities Equitably), according to its founders, will be the first-ever initiative to combine advanced climate modeling, public health analysis and policy, and medical and technology innovation to study and help reduce heat-related mortality due to climate change. October is Raynaud's Awareness Month Raynaud's phenomenon is a disorder that affects blood vessels, primarily in the fingers and toes, causing them to constrict in response to cold temperatures or stress. This loss of blood flow can result in episodes of numbness, tingling, and color changes in the affected areas. Seelos Therapeutics Announces the Signing of a Material Transfer Agreement with U.S. Army Medical Materiel Development Activity (USAMMDA) to Evaluate SLS-002 for Treatment of PTSD "Approximately 13 million people in the U.S. live with PTSD and there have been no new drugs approved in the last two decades for people suffering the effects of PTSD," said Raj Mehra, Ph.D., Chief Executive Officer of Seelos. "I believe that the inclusion of SLS-002 in this study is due to the robust amount of anecdotal evidence that ketamine has the potential to be an effective therapeutic for the symptoms of PTSD and other related conditions." For more news like this, check out all of the latest health-related releases from PR Newswire. Do you have a health press release to distribute? Sign up with PR Newswire to share your story with the audiences who matter most. Helping Journalists Stay Up to Date on Industry News These are just a few of the recent press releases that consumers and the media should know about. To be notified of releases relevant to their coverage area, journalists can set up a custom newsfeed with PR Newswire for Journalists. Once they're signed up, reporters, bloggers, and freelancers have access to the following free features: Customization: Users can create customized newsfeeds that will deliver relevant news right to their inbox. Newsfeed results can be targeted by keywords, industry, subject, geography, and more. Photos and Videos: Thousands of multimedia assets are available to download and include in a journalist or blogger's next story. Subject Matter Experts: Journalists will have access to ProfNet, a database of industry experts to connect with as sources or for quotes in their articles. Related Resources: Our journalist- and blogger-focused blog, Beyond Bylines, features regular media news roundups, writing tips, upcoming events, and more. About PR Newswire PR Newswire is the industry's leading press release distribution partner with an unparalleled global reach of more than 440,000 newsrooms, websites, direct feeds, journalists and influencers and is available in more than 170 countries and 40 languages. From our award-winning Content Services offerings, integrated media newsroom and microsite products, Investor Relations suite of services, paid placement and social sharing tools, PR Newswire has a comprehensive catalog of solutions to solve the modern-day challenges PR and communications teams face. For 70 years, PR Newswire has been the preferred destination for brands to share their most important news stories across the world. For questions, contact the team at [email protected]. SOURCE PR Newswire WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Drug ApprovalVaccine

20 Sep 2024

·www.drugs.com

FDA Approves First Flu Vaccine That Can Be Self-Administered at Home

FRIDAY, Sept. 20, 2024 -- On Friday, the U.S. Food and Drug Administration approved the FluMist nasal vaccine for self-administration at home. It is a "new option for receiving a safe and effective seasonal influenza vaccine potentially with greater convenience, flexibility, and accessibility for individuals and families," Peter Marks, M.D., director of the FDA Center for Biologics Evaluation and Research, said in an agency news release. It has been a long time coming, however: MedImmune FluMist was first approved in 2003 for people ages 5 to 49 years to prevent flu, and then approval was extended to children ages 2 to 5 years in 2007. It is a nasal spritz that contains a weakened form of the live influenza virus. However, until now, it was always administered by a health care provider. A prescription will still be needed to get FluMist, the FDA said, and only individuals aged 18 years and older are authorized to administer it to themselves or a child in their care. "For those interested in self or caregiver administration, the vaccine manufacturer plans to make the vaccine available through a third-party online pharmacy," the FDA said. "Those who choose this option will complete a screening and eligibility assessment when they order FluMist." Friday's approval was based on a study "conducted with vaccine recipients and caregivers to evaluate whether the instructions for use were appropriately designed so that recipients and caregivers could safely and effectively use the vaccine," the FDA noted. Anyone who is prescribed FluMist will receive the vaccine as well as detailed instructions on how to administer, store, and dispose of the product. This approval of FluMist was granted to MedImmune. More Information Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

Drug ApprovalVaccine

02 Feb 2024

·www.pharmaceutical-technology.com

As England’s virus hospitalisations surge flu vaccines evolve

Moderna is leading the mRNA influenza vaccine race with its mRNA-1010 candidate. Image credit: Shutterstock/Cryptographer. England’s National Health Service (NHS) has revealed that flu cases last week were up 75% from the same period last year. Currently at the highest levels this winter, data shows an average of 2,226 patients were in hospital each day with flu. This is up 70% from the end of December, and three-quarters up from the same week in January 2023. Along with flu rates, the NHS said Covid-19 figures remain a concern. Nearly 4,000 patients were in hospital with Covid each day last week, according to a 1 February press release. Vaccines can help protect against the flu and are offered to people every year at higher risk of becoming seriously ill from the virus. Caused by the influenza virus, flu is significantly more serious than the common cold, which is caused by a wide range of viruses. NHS England’s National Clinical Director for Urgent and Emergency Care Julian Redhead said: “As always, I would urge the public to get their flu and Covid vaccines if they are eligible, and continue to come forward for NHS services when you need them.” See Also: LimmaTech secures funding for vaccine technology development GSK seeks to extend RSV vaccine use in adults aged 50-59 There are currently six vaccines in use for the 2023 to 2024 flu season in England, according to the UK Health Security Agency. All the vaccines protect against four subtypes of influenza. The vaccines contain two influenza A and B virus strains. Though these flu vaccines work with high efficacy, that has not stopped companies from exploring the next generation of jabs. Moderna is leading the race with a recent trial win for its mRNA-1010 seasonal influenza vaccine. The investigational mRNA vaccine demonstrated strong results in a Phase III trial showing protection against all four flu strains, as per data released by the company in September 2023. Additionally, Sanofi , Curevac , and Pfizer are all developing mRNA/flu combination vaccines, but some clinical trials have produced mixed results so far. GlobalData states that Moderna is currently the leading the mRNA vaccine charge in infectious diseases. GlobalData is the parent company of Pharmaceutical Technology. Among the six approved flu vaccines in the UK, both Sanofi’s quadrivalent influenza vaccine, and Viatris ’ quadrivalent Influvac subunit Tetra, vaccine are licensed for infants from six months of age. CSL Seqirus’ cell-based quadrivalent influenza vaccine is given to those aged two years and above. AstraZeneca ’s Fluenz Tetra, a live attenuated influenza vaccine (LAIV) is for those between two and 18 years of age. For adults over 18 years of age, Sanofi’s Supemtek, a recombinant quadrivalent influenza vaccine is used. CSL Seqirus’ other adjuvanted quadrivalent influenza vaccine (aQIV) is licensed for use for adults above 65 years of age. In a recent deal with the UKHSA , CSL Seqirus agreed to be on standby in case of a future influenza pandemic. The advance purchase agreement, signed in September 2023, meant that the Australia-headquartered drugmaker is ready to produce more than 100 million influenza pandemic vaccines if called upon. The drugs would be manufactured at the company’s plant in Liverpool. The government is already looking at ways of centralising the procurement of adult flu vaccines, as per a vaccination strategy published in December 2023. Currently, vaccines are obtained by individual NHS GP practices. Moving procurement to a national level could facilitate the co-administration of flu and Covid-19 vaccines, the report said.

VaccineClinical ResultPhase 3Drug ApprovalmRNA

100 Deals associated with Influenza virus vaccine live intranasal (quadrivalent)(MedImmune LLC)

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KEGG	Wiki	ATC	Drug Bank
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R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Influenza, Human	European Union	AstraZeneca AB	04 Dec 2013
Influenza, Human	Iceland	AstraZeneca AB	04 Dec 2013
Influenza, Human	Liechtenstein	AstraZeneca AB	04 Dec 2013
Influenza, Human	Norway	AstraZeneca AB	04 Dec 2013
Influenza A virus infection	United States	MedImmune LLC	17 Jun 2003
Influenza B virus infection	United States	MedImmune LLC	17 Jun 2003

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Influenza-like symptoms	Phase 3	Japan	AstraZeneca PLC	01 Oct 2014
Chronic Disease	Phase 3	United States	MedImmune LLC	01 Aug 2009
HIV Infections	Phase 2	United States	MedImmune LLC	01 Jul 2013

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASCO2019	Not Applicable	-	540	Flu vaccination (Patients on ICI)	givijoxhju(dqulfpnjxh) = cxpndihaco dcclfablvh (iacsezygwo )	-	26 May 2019
				Flu vaccination (Patients on non-ICI modalities)	givijoxhju(dqulfpnjxh) = oqpnbdgpcb dcclfablvh (iacsezygwo )
NCT03028974 (CTgov)	Phase 4	Influenza, Human	77	FluMist® (Group A: 2-4 yo LAIV4 (Return))	zyrihkkkor = yazuupdnwn saanoifahj (mcuwibdpec, ucstrcrxnt - vrjhiyaemm) View more	-	14 Dec 2018
				Fluzone® (Group E: 6 - 23 Mos Old IIV4 (Single Yr))	salnnlxrll = bhedwpdfjf qvqebwwmfw (xegfqllflt, xrzzaodhwy - pptjjliksx) View more
NCT03143101 (FluMist, CTgov)	Phase 4	Influenza, Human	200	FluMist trivalent (FluMist Trivalent (2015-2016))	jcvmkrtvwb = waptdfhkxc xfzwsoglfy (oubcfsmbav, qrsqgqzrag - yozwgrqoon) View more	-	11 Dec 2018
				FluMist Quadrivalent (FluMist Quadrivalent (2015-2016))	jcvmkrtvwb = iougsxshnq xfzwsoglfy (oubcfsmbav, jiujapgfbs - lhqopqemuo) View more
NCT02474901 (QLAIV, CTgov)	Phase 2	HIV Infections \| Influenza, Human	101	Quadrivalent Live Attenuated Influenza Vaccine (QLAIV, HIV-infected)	zxpzlnffzl = llyxwapdqn qfqqveinpn (rbmcoerevg, nyndbrzfxv - eyirhdvuee) View more	-	16 Oct 2017
				Quadrivalent Live Attenuated Influenza Vaccine (QLAIV, HIV-uninfected)	zxpzlnffzl = zvwlgxqqzr qfqqveinpn (rbmcoerevg, ackrwjvqnd - wukfanlmkb) View more
NCT01933048 (SNIF, CTgov)	Phase 4	Influenza, Human	1,077	FluMist (Healthcare Worker Administration)	fkteokxcba(crhxibfehf) = xhkhbmmban dlajzjujww (mkdfiwbjpi, eyaonuruwv - jsxcvinwii) View more	-	12 Sep 2017
				FluMist (Self-Administration)	fkteokxcba(crhxibfehf) = jvowsgecpa dlajzjujww (mkdfiwbjpi, poisltjmgu - oqwcskfnml) View more
NCT03028987 (CTgov)	Phase 4	Influenza, Human	10	FluMist® (LAIV Randomized)	waztuyutgz = riudardkbz pbnretiwyx (lszxnqlvtl, esbjiwlvfl - brseadxbxs) View more	-	12 Sep 2017
				Fluzone® (IIV4 Randomized)	waztuyutgz = obddqrnjol pbnretiwyx (lszxnqlvtl, ylexekmund - awjlyqbkzw) View more
NCT02141581 (CTgov)	Phase 4	Influenza, Human	86	Fluzone	pifqtjinkn = zcgqbpukjg kgftzvgfek (ogfvzfrinb, vqodeaopql - nwlsrqsjeg) View more	-	11 May 2017
NCT03023709 (CTgov)	Phase 4	Influenza, Human	3	Fluzone® (Pilot Phase)	ohptsplbmx = eenctyradf jhkbpjdvlf (msiuqdimbf, stqebsxjkz - yfwonmopbz)	-	10 May 2017
				FluMist® (Study Phase)	ohptsplbmx = rqogppkhkk jhkbpjdvlf (msiuqdimbf, irqzwrljxa - zxalfyfwcq)
NCT02133781 (CTgov)	Phase 4	Influenza, Human	51	Fluzone+FluMist (Age 8-17 Years (Identical Twins ))	gcrxwxqlhg = dorumuuwqp blvhyokvch (yamdsuabzk, gwjywxtquv - bngyjrwtcf) View more	-	10 Mar 2017
				Fluzone (Age 18-30 Years (Non-twins))	gcrxwxqlhg = cvesssedql blvhyokvch (yamdsuabzk, ahutalsraa - yeuccpxova) View more
NCT03020498 (CTgov)	Phase 4	Influenza, Human	91	Fluzone+FluMist (Group A: 8-17 yo Identical Twins)	bgmkdrnozl = iealqhuooc ttmvkekqve (vjlbvjuahw, osdzmnhzde - zmqqrcmmnd) View more	-	09 Mar 2017
				Fluzone+FluMist (Group B: 8-30 yo Non-twin)	bgmkdrnozl = dfzydohqxs ttmvkekqve (vjlbvjuahw, fnimmsfunr - irswfyvwwp) View more

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