Delving into the Latest Updates on Heat shock protein 10(Invion Ltd.) with Synapse

Overview

Basic Info

Drug Type

Recombinant protein

Synonyms

Chaperonin 10, Chaperonin-10, Heat shock protein 10

+ [10]

Target-

Mechanism

Immunomodulators

Therapeutic Areas

Immune System DiseasesNervous System DiseasesDigestive System Disorders+ [2]

Active Indication

Colitis, UlcerativeMultiple SclerosisPsoriasis+ [2]

Inactive Indication

Plaque psoriasis

Originator Organization

Invion Ltd.

Active Organization

Invion Ltd.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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INTRODUCTIONGlioblastoma (GBM) is associated with a poor prognosis. This review will discuss different directions of treatment, mostly regarding immunotherapies and combinatorial approaches.DEVELOPMENTStandard treatment for newly diagnosed GBM is maximal and safe surgical resection followed by concurrent radiochemotherapy (RCT) based on temozolomide, allowing 14.6 months median survival. Nowadays, no combination with molecular-targeted therapy had significantly improved prognosis. Phases I and II data are emerging, highlighting the potential efficacy of associations with other therapies. Studies have suggested the potential of targeting tumor stem cells, at less partially responsible for resistance to RCT. There is now some evidence that immunotherapy is also relevant for brain tumors. Treatment strategies have mainly explored vaccines strategies, such as the dendritic cell, heat shock protein or EGFRvIII vaccines. Of the work initiated in melanoma, immune checkpoints inhibitors have exhibited stimulating results. Others trials have demonstrated potential of autologous stimulated lymphocytes. Moreover, strong data indicates that radiation therapy has the potential to promote immunogenicity and create a sort of in situ personalized vaccine.CONCLUSIONThese data provide strong evidence to support the potential of associating combinatorial targeted and/or immunotherapeutic regimens in patients with GBM that may change patient outcome.

01 Feb 2015·Experimental and Therapeutic MedicineQ4 · MEDICINE

Recombinant Cpn 0810 stimulates proinflammatory cytokine expression and apoptosis in human monocytes

Q4 · MEDICINE

Article

Author: Chen, Yuyu ; Wu, Yimou ; Liu, Liangzhuan ; Chen, Lili ; You, Xiaoxing ; Wu, Baiping ; Zhang, Qiugui

The aim of the present study was to express the recombinant Chlamydophila pneumoniae (C. pneumoniae) protein, Cpn 0810, in Escherichia coli (E. coli) BL21, and investigate the effects of Cpn 0810 on inflammatory and apoptotic processes in human monocytic (THP-1) cells. An ELISA was performed to detect the levels of the proinflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6. In addition, Hoechst 33258 staining and annexin V binding analyses were performed to measure the rates of apoptosis. Purified glutathione S-transferase (GST)-Cpn 0810 recombinant proteins were obtained from the E. coli BL21 cells carrying the pGEX6p-2/Cpn 0810 plasmid, and were shown to stimulate the expression of TNF-α and IL-6 in the THP-1 cells in a dose- and time-dependent manner. TNF-α and IL-6 levels peaked at 24 h after GST-Cpn 0810 stimulation. Furthermore, GST-Cpn 0810 significantly promoted the apoptosis of THP-1 cells. In conclusion, recombinant GST-Cpn 0810 was shown to stimulate the expression of TNF-α and IL-6, inhibit proliferation and induce apoptosis in THP-1 cells. Therefore, Cpn 0810 may interact with host cells following C. pneumoniae infection, functioning as an important pathogenic factor.

01 Apr 2012·Nephrology Dialysis TransplantationQ2 · MEDICINE

Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice

Q2 · MEDICINE

Article

Author: Onkar P. Kulkarni ; Claudia Kantner ; Miklós Sárdy ; Hans-Joachim Anders ; Richard Brown ; Daniel Lambert ; Mi Ryu ; Dean Naylor

BACKGROUNDSystemic lupus erythematosus (SLE) is still treated with global immunosuppressants with serious toxicities. We hypothesized that endogenous immunosuppressive molecules might be able to control SLE manifestations more specifically. Heat shock protein 10, or chaperonin 10 (Cpn10), is a secretory molecule that can suppress innate and adaptive immunity.METHODSRecombinant human Cpn10 (100 μg per mouse) was given intraperitoneally to healthy-appearing female MRL-(Fas)lpr mice from 12 to 22 weeks of age. At the age of 22 weeks, mice were analysed for treatment outcome by harvesting organs, plasma and urine.RESULTSCpn10 entirely prevented cutaneous lupus lesions as compared to vehicle-treated mice. Cpn10 also suppressed lupus nephritis as evident from serum creatinine levels, albuminuria and the scores of disease activity and chronicity. Autoimmune lung disease was unaffected by Cpn10 treatment while overall survival of mice was prolonged. Cpn10 did not have any major effects on either dendritic cell or B-cell counts except T cells in spleen, plasma interferon-gamma, tumour necrosis factor-alpha, interleukin-10, anti-nuclear autoantibody levels or markers of lymphoproliferation.CONCLUSIONSIn summary, recombinant Cpn10 selectively prevents cutaneous lupus and suppresses nephritis in MRL-(Fas)lpr mice without affecting the underlying systemic autoimmune process. Hence, Cpn10 might be useful for the treatment of skin and kidney manifestations of SLE.

100 Deals associated with Heat shock protein 10(Invion Ltd.)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Plaque psoriasis	Phase 3	AU	Invion Ltd.	-
Colitis, Ulcerative	Phase 2	-	Invion Ltd.	-
Multiple Sclerosis	Phase 2	-	Invion Ltd.	-
Psoriasis	Phase 2	-	Invion Ltd.	-
Rheumatoid Arthritis	Phase 2	-	Invion Ltd.	-
Systemic Lupus Erythematosus	Phase 2	-	Invion Ltd.	-
Colitis, Ulcerative	Preclinical	AU	-	-
Multiple Sclerosis	Preclinical	AU	Invion Ltd.	-
Rheumatoid Arthritis	Preclinical	AU	Invion Ltd.	-
Rheumatoid Arthritis	Preclinical	NZ	Invion Ltd.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01838694 (CTgov)	Phase 1/2	Systemic Lupus Erythematosus	30	Placebo (Placebo)	jwsdbgrngw(yoiaiqxgzc) = klpmziplmt tutjlpypaz (fbsaqpdluf, kunqfluiyi - hebjjheirk) View more	-	30 Jan 2017
				Ala-Cpn10 (Ala-Cpn10)	mtjgcyfcem(xlyfaxhufh) = whhtabhjgb dlkxqztbpz (fudvdmzxba, zseraqgtyw - ppxceuhxdw) View more