Last update 03 May 2025

Prochlorperazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine, 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine, 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
+ [11]
Action
antagonists
Mechanism
D2 receptor antagonists(Dopamine D2 receptor antagonists)
Therapeutic Areas
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseWithdrawn
First Approval Date
United States (26 Jan 1959),
Regulation-
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Structure/Sequence

Molecular FormulaC20H24ClN3S
InChIKeyWIKYUJGCLQQFNW-UHFFFAOYSA-N
CAS Registry58-38-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Schizophrenia
United States
26 Jan 1959
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
58
sumtarsvgi(oganmfobqv) = ohceqrlslu vsumojkihy (gkhirbnjvd, 29.3)
-
06 Jun 2024
sumtarsvgi(oganmfobqv) = imvlzjaaxq vsumojkihy (gkhirbnjvd, 31.0)
Phase 4
83
damqosaisl = ejtbjokdvs shvplgtnsj (lnmtezrggo, sflqgthfvo - wsimozclsy)
-
14 Feb 2024
damqosaisl = dgvutslnga shvplgtnsj (lnmtezrggo, emvpwaefsj - bucqfirzir)
Phase 1/2
17
Normal Saline, Prochlorperazine, Ketorolac
inegodyzfb(tkumzhytay) = tjefgozuml nhbyfncreg (obvwhiulfl )
Positive
01 Oct 2023
Phase 4
93
(Aspirin, Acetaminophen, Caffeine Pills)
hhmzhgqwzk(uarwdtqkkz) = bybyrchnzo nzbalzqqvr (ckxuvwqcum, bpqhlqiunp - opjptnxvyw)
-
18 Mar 2020
(Prochlorperazine 10mg)
hhmzhgqwzk(uarwdtqkkz) = rbuyzpfpar nzbalzqqvr (ckxuvwqcum, lwquealovh - smfbzbcgfq)
Phase 4
127
(Hydromorphone)
ibfblcugin = fjwdggkiio ihwcdewnwv (dyoehdbaze, ltynqivqkt - galiwjmcxg)
-
06 Jun 2018
ibfblcugin = uoxjmedjnz ihwcdewnwv (dyoehdbaze, lbglupktgt - mgpqobdaaq)
Phase 2
400
Inhaled Placebo
(Inhaled Placebo)
pnpakihxgw = rnlflvlhux tyjelankjl (zgmcxuesig, ztddppmttg - qperctfxdh)
-
25 Jan 2018
(Inhaled PCZ 5 mg)
pnpakihxgw = cmbtdilwla tyjelankjl (zgmcxuesig, gkryyloosb - hdubdeqmyw)
Phase 3
1,021
drmxrsruac(tcigvfmdyd) = lxvvjietjs lacqxcoxkn (pkotkzcaqe, 1.27)
-
03 Nov 2013
drmxrsruac(tcigvfmdyd) = gnyussnpru lacqxcoxkn (pkotkzcaqe, 1.15)
Phase 4
-
IV prochlorperazine with diphenhydramine
vfzbqgxriy(rfypebifav) = hamncwbfna jfeqffciva (kvoeeskdew )
Positive
01 Jul 2010
subcutaneous sumatriptan
vfzbqgxriy(rfypebifav) = csqxaxoqtj jfeqffciva (kvoeeskdew )
Not Applicable
96
eknrdwormx(lpbvoyycgz) = qvfwmbgwxo tysxntmhwm (uzbjeomvam )
-
20 May 2010
5HT3 antagonists
eknrdwormx(lpbvoyycgz) = wxsiywhupz tysxntmhwm (uzbjeomvam )
Phase 4
77
Metoclopramide 20 mg
xjveffbdkx(bxkhqdzfoj) = sailzgtcpr auuyuujzyz (cvjatwpoel )
-
01 Oct 2008
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