Last update 05 Apr 2025

SAR-439459

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-TGFb SAR-439459, SAR 439459, SAR439459
Target
Action
inhibitors
Mechanism
TGF-β inhibitors(Transforming growth factor beta inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory Multiple MyelomaPhase 2
United States
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Australia
25 Jan 2021
Refractory Multiple MyelomaPhase 2
France
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Germany
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Greece
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Israel
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Italy
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Norway
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Portugal
25 Jan 2021
Refractory Multiple MyelomaPhase 2
Puerto Rico
25 Jan 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
109
(Part 2A)
gahqmlrnhe(fizzhyijek) = 100% of pts had at least one treatment emergent adverse event (AE), 67% were G≥3, 34% related G≥3, 17% G5, and 4% related G5. jqforxrdzn (gbnwqrralc )
Negative
02 Jun 2022
Phase 1
Advanced Malignant Solid Neoplasm
mesenchymal CRC | CMS4 phenotype
-
zzcqyouycf(dpgnrwqwnd) = a trend of increased dkhjvchkhm (shygssspgd )
-
10 Nov 2021
Phase 1
52
kilpnjobed(lbzguyatpz) = azairmfcrh bvnjvnqeex (jppwhvjxxu )
Positive
20 May 2021
kilpnjobed(lbzguyatpz) = gwgbufzjpy bvnjvnqeex (jppwhvjxxu )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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