A Phase I Clinical Trial Assessing the Safety, Feasibility and Immunologic Correlates of Allogeneic HPV-specific Cluster of Differentiation 4 (CD4)+ T Cells in Advanced HPV16-associated Malignancies

In this study, haploidentical relatives of a patient with recurrent or metastatic HPV 16-associated malignancy will be vaccinated with a therapeutic human papillomavirus (HPV) vaccine series to generate HPV-specific leukocytes. The cancer patient with recurrent or metastatic HPV16+ cancer will then be randomized to one of two arms: 1) non-myeloablative allogeneic bone marrow transplant or 2) cluster of differentiation 8 (CD8)-depleted donor lymphocyte infusion.

Start Date18 Oct 2023

Sponsor / Collaborator

The Sidney Kimmel Comprehensive Cancer Center

[+1]

NCT05132803

/ WithdrawnPhase 1IIT

A Feasibility Trial to Assess Intratumoral Injection of TA-CIN With Anti-PD-1 Therapy for Recurrent HPV16-associated Cancers

The primary to assess the safety and tolerability of TA-CIN and anti-PD-1 therapy in patients with recurrent HPV16-associated cancers and to assess the feasibility of IT injection of TA-CIN in patients with recurrent HPV16-associated cancers undergoing treatment with anti-PD-1 therapy.

Start Date01 Aug 2021

Sponsor / Collaborator

The Sidney Kimmel Comprehensive Cancer Center

NCT04398524

/ Active, not recruitingPhase 2

A Phase II Study of Cemiplimab, an Anti-PD-1 Monoclonal Antibody, and ISA101b Vaccine in Patients With Recurrent/Metastatic HPV16 Positive Oropharyngeal Cancer Who Have Experienced Disease Progression With Prior Anti-PD-1 Therapy

This will be an open-label, phase 2 study in which subjects will receive ISA101b and cemiplimab.

Start Date01 Jul 2021

Sponsor / Collaborator

ISA Pharmaceuticals BV

[+1]

100 Clinical Results associated with ISA-101

100 Translational Medicine associated with ISA-101

100 Patents (Medical) associated with ISA-101

Literatures (Medical) associated with ISA-101

13 Oct 2023·Clinical cancer research : an official journal of the American Association for Cancer Research

Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men.

Article

Author: Gosens, Karien C M ; Krebber, Wilhelmus J T A ; Welters, Marij J P ; Quint, Wim G V ; Richel, Olivier ; van Noesel, Carel J M ; van der Burg, Sjoerd H ; de Vries, Henry J C ; Boekestijn, Sanne ; Loof, Nikki M ; Melief, Cornelis J M ; van der Wal, Allard C ; Prins, Jan M

PURPOSEAnal cancer is increasing in HIV+ men who have sex with men (MSM). Treatment options for its precursor, high-grade anal intraepithelial neoplasia (HGAIN), are suboptimal. In this phase I to II dose-finding study, we assessed the safety and efficacy of the human papillomavirus type 16 (HPV16) synthetic long peptide vaccine (SLP-HPV-01) in HIV+ MSM with HPV16-positive HGAIN.PATIENTS AND METHODSFour dosage schedules (1-5-10; 5-10-20; 10-20-40; and 40-40-40-40 μg) of SLP-HPV-01 were administered intradermally with a 3-week interval in 10 patients per dose level (DL). In each dose group, 5 patients also received 1 μg/kg pegylated IFNα-2b subcutaneously. Primary endpoints were safety and regression of HGAIN at 3, 6, and 12 months.RESULTSEighty-one of 134 screened patients (60%) had HPV16-negative HGAIN lesions, leaving 53 eligible patients. Thirteen patients were excluded, leaving 40 men. The vaccine was well tolerated. One patient developed a generalized rash. The highest dosage level induced the strongest immune responses. There was no indication for stronger reactivity in the IFNα groups. Up to 18 months of follow-up, 8/38 intention-to-treat patients had a complete clinical and histologic response and one had a partial response (in total 9/38, 23.7%). At the highest dosage level, the clinical response was 4/10 (40%). Stronger immune responses were detected among clinical responders.CONCLUSIONSThe highest DL is safe, immunogenic, and associated with clinical responses to HPV16-induced lesions. However, as the majority of HGAIN is caused by the other HPV types, further studies should aim at pan-HPV vaccination to prevent or treat HGAIN.

01 Mar 2023·Seminars in Immunopathology

Combination immunotherapy with synthetic long peptides and chemotherapy or PD-1 blocker for cancers caused by human papilloma virus type 16

Review

Author: Melief, Cornelis J M ; van der Gracht, Esmé ; Wiekmeijer, Anna-Sophia

Therapeutic vaccination of premalignant conditions and of different stages of cancer can be accomplished with several platforms including DNA vaccines, RNA vaccines, synthetic long peptides (SLP), and recombinant viruses. We successfully used a therapeutic vaccine composed of SLP covering the complete sequence of the two oncogenic proteins E6 and E7 of human papillomavirus type 16 (HPV16) as monotherapy in patients with premalignant disease. However, combination treatment might be required in patients with (advanced) cancer because of the hostile cancer microenvironment for T cells in established HPV16+ cancer, often associated with systemic immunosuppression. In patients with late-stage recurrent or metastatic HPV16+ cancers, we have therefore combined treatment with the SLP vaccine, called ISA101b, with either standard-of-care chemotherapy or with immune checkpoint inhibition with anti-PD-1 monoclonal antibody. A strong vaccine-induced interferon gamma-producing T cell response to HPV16 E6/E7 was associated with significantly better survival. In a second phase 1/2 study, patients with recurrent or metastatic HPV16+ oropharyngeal cancer were treated with the combination of ISA101b and anti-PD-1 (nivolumab). In this trial, the clinical overall response rate (ORR) in 22 patients was 36%, twice the ORR in the nivolumab registration trial for this category of patients, and 2/22 patients had a complete clinical response that is ongoing after 4 1/2 years. Other promising strategies for late-stage cancer recipients are the infusion of expanded tumor-infiltrating lymphocytes or the infusion of T cell receptor transduced T cells, both directed against HPV16.

01 Feb 2022·Journal for ImmunoTherapy of CancerQ2 · MEDICINE

ISA101 and nivolumab for HPV-16⁺cancer: updated clinical efficacy and immune correlates of response

Q2 · MEDICINE

ArticleOA

Author: Feng, Lei ; Massarelli, Erminia ; Barrese, Tomas Z ; Wang, Jing ; Wistuba, Ignacio ; Johnson, Faye M ; Melief, Cornelis J M ; Curran, Michael A ; Glisson, Bonnie S ; Rodriguez Canales, Jaime ; Sousa, Luana Guimaraes de ; Chin, Renee L ; Rajapakshe, Kimal ; Ferrarotto, Renata ; William, William ; Wang, Qi ; Coarfa, Cristian ; Lee, Jack

BackgroundThe combination of ISA101, a human papilloma virus (HPV) 16 peptide vaccine, and nivolumab showed a promising response rate of 33% in patients with incurable HPV-16+cancer. Here we report long-term clinical outcomes and immune correlates of response.MethodsPatients with advanced HPV-16+cancer and less than two prior regimens for recurrence were enrolled to receive ISA101 (100 µg/peptide) on days 1, 22, and 50 and nivolumab 3 mg/kg every 2 weeks beginning day 8 for up to 1 year. Baseline tumor samples were stained with multiplex immunofluorescence for programmed death-ligand 1 (PD-L1), programmed cell death protein-1 (PD-1), CD3, CD8, CD68, and pan-cytokeratin in a single panel and scanned with the Vectra 3.0 multispectral microscope. Whole transcriptome analysis of baseline tumors was performed with Affymetrix Clariom D arrays. Differential gene expression analysis was performed on responders versus non-responders.ResultsTwenty-four patients were followed for a median of 46.5 months (95% CI, 46.0 months to not reached (NR)). The median duration of response was 11.2 months (95% CI, 8.51 months to NR); three out of eight (38%) patients with objective response were without progression at 3 years. The median and 3-year overall survival were 15.3 months (95% CI, 10.6 months to 27.2 months) and 12.5% (95% CI, 4.3% to 36%), respectively. The scores for activated T cells ((CD3+PD-1+)+(CD3+CD8+PD-1+)), activated cytotoxic T cells (CD3+CD8+PD-1+), and total macrophage ((CD68+PD-L1−)+(CD68+PD-L1+)) in tumor were directly correlated with clinical response (p<0.05) and depth of response with the two complete response patients having the highest degree of CD8+T cells. Gene expression analysis revealed differential regulation of 357 genes (≥1.25 fold) in non-responders versus responders (p<0.05). Higher expression of immune response, inflammatory response and interferon-signaling pathway genes were correlated with clinical response (p<0.05).ConclusionsEfficacy of ISA101 and nivolumab remains promising in long-term follow-up. Increased infiltration by PD-1+T cells and macrophages was predictive of response. Enrichment in gene sets associated with interferon-γ response and immune infiltration strongly predicted response to therapy. A randomized trial is ongoing to test this strategy and to further explore correlates of immune response with combined nivolumab and ISA101, versus nivolumab alone.Trial registration numberNCT02426892.

News (Medical) associated with ISA-101

13 May 2024

·www.prnewswire.com

SCG Cell Therapy Presented New Preclinical Data in an Oral Presentation at ASGCT 2024 Annual Meeting Highlighting Superior Tumor Inhibition of its Immunoswitch Armored HPV-TCR T Cell Therapy (SCG142) against a Broad Range of HPV-associated Cancers

SINGAPORE, May 12, 2024 /PRNewswire/ -- SCG Cell Therapy Pte Ltd (SCG), a clinical-stage biotechnology company developing novel immunotherapies for infectious diseases and their associated cancers, announced first preclinical data of its novel human papillomavirus (HPV)-specific T cell receptor-engineered T (TCR T) cell therapy armored with an TGFβRII-41BB immunoswitch – SCG142 – in an oral presentation at the American Society of Gene & Cell Therapy (ASGCT) Annual Meeting in Baltimore, Maryland. In preclinical studies, SCG142 demonstrated superior CD8+ and CD4+ TCR T cell proliferation and tumor inhibition both in-vitro and in-vivo compared to conventional TCR T without immunoswitch, including tumor rechallenge models. Importantly, SCG142 functionality is CD8 co-receptor independent, transferring desired effector functions also to CD4+ T cells and promoting longer persistence and improved proliferation of T cells. In addition, SCG142 exhibited high functional avidity and can recognize both genotypes HPV-16 and HPV-52, with a favorable safety profile with no alloreactivity or off-target toxicity in relevant toxicology models. "SCG142 is a novel and differentiated HPV-specific TCR T cell therapy with preclinical efficacy in various tumor types with expression of HPV-16- and HPV-52 genotypes. We're excited to demonstrate that armoring the TCR-T cells with the chimeric switch receptor didn´t change the favorable safety profile but helped to overcome the immune inhibitory signal of TGF-β, which can be crucial for effective treatment of solid tumors", said Dr. Susanne Wilde, Head of Preclinical Research of SCG Cell Therapy. "These promising results underscore the potential of SCG142 to provide new solutions for patients in a variety of HPV-16- and HPV-52 expressing cancers. Based on these encouraging data, we are eagerly advancing SCG142 towards clinical trials", she added. About SCG142 SCG142, an autologous HPV-specific TCR T cell therapy holding the promise as the best-in-class product. Utilizing SCG's proprietary GianTCRTM technology, high affinity and high avidity natural TCRs can be isolated to target against intracellular antigens presented through major histocompatibility complex (MHC) in solid tumors. Study results showed that SCG142, a fully natural HPV specific TCR armoured with chimeric switch receptor, has the potential to specially target HPV-16 and HPV-52-positive tumor cells in various HPV-related tumor types, generating CD8 co-receptor independent T cell functionality and sustained anti-tur activity. About Human Papillomavirus and Cancers Human papillomavirus (HPV) infection is the most common sexually transmitted infection. Nearly all sexually active people are infected with HPV and around half of these infections occur with a high-risk HPV type, which can lead to cancer development.1 As such, HPV infection accounts for more than 90% of anal and cervical cancers, about 70% of vaginal and vulvar cancers, and 60% of penile and oropharyngeal cancers, and it causes an estimated 630,000 cancers worldwide each year2x. About SCG Cell Therapy SCG is a leading biotechnology company focusing on the development of novel immunotherapies in infections and its associated cancers. The company targets the most common cancer-causing infections: helicobacter pylori, HPV, HBV and EBV, and develops a broad and unique pipeline of TCR-based cellular immunotherapy products against infection- associated cancers. With the proprietary GianTCRTM TCR screening platform, in house viral vector production and AutoCellTM, a fully closed and automatic cell therapy manufacturing system, the company covers the entire value chain from new target research and discovery, manufacturing, and clinical development. For more information about SCG, please visit us at . [1] HPV and cancer. National Cancer Institute. (2023, October 18) [2] Basic information about HPV and cancer. Centers for Disease Control and Prevent (2023, September 12) SOURCE SCG Cell Therapy Pte Ltd

Cell TherapyImmunotherapyClinical ResultAACRASCO

17 Apr 2024

·www.pharmaceutical-technology.com

Ultimovacs downsizes to funnel funds to cancer vaccine programme

Ultimovac’s UV1 works by inducing T cell response against telomerase reverse transcriptase (hTERT) – a protein that provides the limitless self-renewal hallmark in cancer progression. Image Credit: CI Photos / Shutterstock. Ultimovacs has implemented cash-saving strategies, including a 40% workforce reduction, to extend its reserves into Q4 2025. The operational adjustments are expected to provide a cash runway beyond the anticipated top-line readout from the next two Phase II trials – the FOCUS trial in Q3 this year, and the DOVACC trial in H1 2025. The UV1 cancer vaccine development programme has suffered some setbacks. The company has reported topline data from two Phase II trials, NIPU and INITIUM, for the vaccine used in combination with PD1 inhibitors in two cancer indications, with both trials failing to meet primary endpoints. The Phase II NIPU trial (NCT04300244) evaluated UV1 in combination with Bristol Myers Squibb’s checkpoint inhibitors Opdivo (nivolumab) and Yervoy (ipilimumab) as a second-line treatment in mesothelioma patients. The study failed to meet its primary endpoint of progression-free survival (PFS). The Phase II INITIUM trial (NCT02275416) also evaluated the UV1, Opdivo and Yervoy combination but in patients with unresectable or metastatic malignant melanoma. The study also failed to meet primary endpoints, with the company deciding to stop pursuing the therapy in this indication. See Also: NIH team develops AI tool to predict cancer drug response SGN-1 by Guangzhou Huajin Pharmaceutical Technology for Peritoneal Cancer: Likelihood of Approval Despite this, Ultimovacs expects positive readouts from the next two trials. The Phase II FOCUS trial (NCT05075122) evaluates the combination treatment of UV1 vaccine with MSD’s Keytruda (pembrolizumab) as a first-line treatment in patients with PD-L1 positive head and neck squamous cell carcinoma. The combination has been successful in the Phase I trial (NCT03538314), with an observed 67% overall survival rate at a three-year follow-up. While the company expects positive data in Q3 this year, it is prepared to wait for data readout from the DUVACC trial before deciding on the fate of UV1 should the FOCUS trial fail, said Ultimovac’s CEO Carlos de Sousa in a business update webcast today. The Phase II DUVACC trial (NCT04742075) evaluates UV1 in combination with AstraZeneca’s checkpoint inhibitor Infinzi (duvalumab) and Lynparza (olaparib), a poly-ADP ribose polymerase (PARP) inhibitor, as a second line treatment in patients with BRCA negative ovarian cancer. The trial is currently recruiting patients, with 40% of the total expected enrolment completed as of Q4 2023. UV1 is also being evaluated in an investigator-led Phase II LUNGVAC trial (NCT05344209). The study investigates the combination therapy of UV1 and Sanofi and Regeneron’s Libtayo (cemiplimab) as a first-line therapy in patients with advanced or metastatic non-small cell lung cancer. The trial started recruitment in October 2022 and reached only 15% enrolment as of Q4 2023. The topline data from the trial is expected in H1 2026. GlobalData forecasts therapeutic cancer vaccines as the weakest immuno-oncology agent class with relatively low global sales of up to $4bn by 2028, compared to checkpoint modulators sales reaching $120bn by 2028. GlobalData is the parent company of Pharmaceutical Technology . Other cancer vaccines in development include Transgene and Japanese NEC Corporation’s cancer vaccine, TG4050 , for the treatment of head and neck cancers and ISA Pharmaceuticals’ cancer vaccine, ISA101b , for treating oropharyngeal cancer.

Phase 2VaccineClinical ResultPhase 1

12 Dec 2023

·www.prnewswire.com

ISA Pharmaceuticals reports highlights of randomized Phase 2 cancer vaccine trial in head & neck cancer

Study indicates clear route to market despite not meeting the primary endpoint of 6 months' overall response rate (ORR) in the entire population In a predefined subgroup of patients there was a doubling of ORR (51.9% vs 26.7% for placebo) and improved overall survival which sets the stage for a confirmatory Phase 3 trial OEGSTGEEST, The Netherlands, Dec. 12, 2023 /PRNewswire/ -- ISA Pharmaceuticals B.V. (ISA), a clinical-stage immunotherapy company, today announced positive anti-tumor response data with ISA101b, an HPV16 directed therapeutic cancer vaccine given in combination with Libtayo®, an anti-PD1 checkpoint inhibitor (CPI). The data were generated in the OpcemISA trial, a large scale randomized double blind study that is ongoing in patients with advanced oropharyngeal cancer (OPC), a type of head and neck cancer. It is the first time that the combination of a tumor-specific therapeutic vaccine and a CPI has generated such high response rates, albeit in a predefined subpopulation of metastatic cancer patients. ISA101b is a therapeutic cancer vaccine targeting cancers caused by the human papillomavirus type 16 (HPV16). More than 60 percent of head-and-neck cancers are HPV16-related, and incidence rates are going up. ISA101b elicits a powerful and targeted T-cell immune response to the HPV16 virus. OPC is a solid cancer with a high unmet medical need that does not always respond to immunotherapy. Best responses in the OpcemISA trial are found in a subcategory of patients with characteristics suitable for immunostimulatory treatments. Study design & results A total of 199 first- and second-line patients with recurrent/metastatic HPV16+ OPC were enrolled in the OpcemISA trial. Patients were randomized to receive either ISA101b plus CPI, or placebo plus CPI. The primary endpoint was the objective response rate (ORR) at 6 months, confirmed by independent central review. The secondary endpoints included drug safety, progression free survival (PFS) and overall survival (OS). Further details can be found at clinicaltrials.gov (NCT03669718). Whereas the addition of ISA101b to the CPI led to a doubling of the ORR (from 26.7% to 51.9%) in a large subgroup of patients, the study as a whole did not meet this primary endpoint. Patients in the aforementioned subgroup, predefined based on a validated biomarker, also showed a clear overall survival benefit compared to the placebo arm. ISA101b was well tolerated. Gerben Moolhuizen, Chief Executive Officer of ISA, said, "Recurrent and/or metastatic head and neck cancer is notoriously difficult to treat. Patients suffering from this terrible disease need new treatment options. In our OpcemISA study, ISA101b shows compelling results in a large, predefined subset of patients. This provides us with a clear development path to make ISA101b a treatment option for these patients." Phase 3 and beyond ISA is preparing for a confirmatory Phase 3 trial in this subpopulation of patients. This subgroup represents an important proportion of head and neck cancer patients, and an attractive commercial opportunity. The OpcemISA trial was part of a clinical collaboration between ISA and Regeneron. Regeneron has elected not to exercise its option on the ISA101b asset. ISA is currently in discussions with potential partners with interest in ISA101b and ISA's technology platform in general. About ISA Pharmaceuticals ISA Pharmaceuticals is an immunotherapy company developing treatments for various cancers and infectious diseases. ISA has best-in-class technology to stimulate and activate the human immune system, specifically T cells, to fight diseased or infected cells. Its lead asset ISA101b is in late-stage clinical trials for human papillomavirus type 16 (HPV16)-induced cancers in a collaboration with biotechnology company Regeneron. Other assets are in preclinical stage development and include immunotherapies to treat patients that suffer from cancers that over-express PRAME or chronic hepatitis B. For more information, please visit . About ISA101b ISA101b immunotherapy targets human papillomavirus type 16 (HPV16) positive cancers. It induces strong and specific T-cell immune responses to the HPV16 virus, and (re-)establishes a powerful and targeted T-cell immune response against infected and/or cancerous cells and tissues. ISA101b is using ISA's proprietary Synthetic Long Peptide (SLP®) technology.. In September 2021 ISA101b was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for the treatment of recurrent and metastatic HPV16 positive oropharyngeal cancer (OPC). SOURCE ISA Pharmaceuticals

Clinical ResultImmunotherapyPhase 3Fast TrackPhase 2

100 Deals associated with ISA-101

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Oropharyngeal Neoplasms	Phase 2	-	Shin Nippon Biomedical Laboratories, Ltd.	-
Oropharyngeal Neoplasms	Phase 2	-	The University of Texas MD Anderson Cancer Center	-
Oropharyngeal Neoplasms	Phase 2	-	Bristol Myers Squibb Co.	-
Vulvar Neoplasms	Phase 2	-	Bristol Myers Squibb Co.	-
Vulvar Neoplasms	Phase 2	-	Shin Nippon Biomedical Laboratories, Ltd.	-
Vulvar Neoplasms	Phase 2	-	The University of Texas MD Anderson Cancer Center	-
Vulvar Neoplasms	Phase 2	-	ISA Pharmaceuticals BV	-
Recurrent Cervical Cancer	Discovery	Belgium	ISA Pharmaceuticals BV	01 Sep 2013
Uterine Cervical Cancer	Discovery	Germany	ISA Pharmaceuticals BV	01 Sep 2013
Vulvar intraepithelial neoplasia	Discovery	Netherlands	ISA Pharmaceuticals BV	20 Mar 2008

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04646005 (CTgov)	Phase 2	Recurrent Cervical Cancer \| Metastatic Cervical Carcinoma	113	Cemiplimab+ISA 101b	(pqsmcjvfpt) = vrbvgwdhaj cdoifzcnoh (uufkvzjfss, lgzsdoqyzq - cnhcuevmsu) View more	-	19 Sep 2024
NCT04646005 (ASCO2024) Manual	Phase 2	Uterine Cervical Cancer Second line PD-L1	113	Cemiplimab 350 mgISA101b	(nbuqxbhgwl) = lqvxyxipuy ikszabkhfr (zyimqpsnvj, 9.9 - 23.7) View more	Positive	24 May 2024
NCT03669718 (OpcemISA, ASCO2024)	Phase 2	HPV16 positive Oropharyngeal Cancer HPV16-positive	198	ISA101b + cemiplimab	(znxejlnaml) = yodbucclap hvvfvrrczl (bmtnfzbduy ) View more	Positive	24 May 2024
NCT03669718 (OpcemISA, ASCO2024)	Phase 2	HPV16 positive Oropharyngeal Cancer HPV16-positive	198	Placebo + cemiplimab	(znxejlnaml) = rztjcupqaz hvvfvrrczl (bmtnfzbduy ) View more	Positive	24 May 2024
NCT03669718 (OpcemISA , PRNewswire) Manual	Phase 2	Oropharyngeal Neoplasms	199	ISA101b+Cemiplimab	(svvfbxgczx) = not meet in the entire population kxxkwsjqsr (xiclfjjjxs ) Not Met View more	Negative	12 Dec 2023
NCT03669718 (OpcemISA , PRNewswire) Manual	Phase 2	Oropharyngeal Neoplasms	199	Placebo+Cemiplimab		Negative	12 Dec 2023
NCT02426892 (Pubmed \| J Immunother Cancer) Manual	Phase 2	Human Papillomavirus-16 Positive HPV-16 positive	24	Nivolumab+ISA 101	(cfhmtyupcn) = wymhvmdudn lrrsrmwwtv (pmuzfmzlfm ) View more	Positive	01 Feb 2022
NCT02128126 (Pubmed \| Sci Transl Med) Manual	Phase 1/2	Neoplasms	72	ISA 101	zhibjbuogm(ycnkwiukce) = zjwonoezuf wgnqolnnxi (qeumwqduyy )	Positive	18 Mar 2020
P157 (SITC2018)	Phase 2	Human Papillomavirus-16 Positive CD3+CD8+PD-1+ \| CD68+PD-L1- \| CD68+PD-L1+ ... View more	24	ISA101	vqknwzgqqx(pmoouhotqv) = qxmiawscoq dehafyrxdw (lsncniodoi ) View more	Positive	06 Nov 2018
ISA-HPV-01-12 (AACR2014)	Not Applicable	Metastatic Cervical Carcinoma	-	HPV16 SLP ISA101 vaccine + carboplatin-paclitaxel + type I interferon	snumdoovyf(pxteyrydqv) = abpqvbvrty yviarflbkk (kvsyediixe )	-	01 Oct 2014
ASCO2005	Phase 2	Neoplasms	-	Autologous PBMCs pulsed with HPV16 E6 (PBMCs pulsed with HPV16 E6)	(okhncpdjmr) = Six patients had grade III toxicity (mainly anemia), which most likely is due to the disease yguikiwmbu (oeecjczmra ) View more	-	01 Jun 2005

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