Last update 26 May 2025

ISA-101

Overview

Basic Info

Drug Type
Shared antigen vaccine, Therapeutic vaccine
Synonyms
HPV-SLP, Human papilloma virus type 16 E6/E7 synthetic long peptides, ISA-HPV
+ [9]
Target-
Action
stimulants
Mechanism
Immunostimulants
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Human Papillomavirus-Related Squamous Cell CarcinomaPhase 2
United States
06 Jul 2020
Human Papillomavirus-Related Squamous Cell CarcinomaPhase 2
United States
06 Jul 2020
Squamous Cell Carcinoma of Head and NeckPhase 2
United States
06 Jul 2020
Squamous Cell Carcinoma of Head and NeckPhase 2
United States
06 Jul 2020
HPV16 positive Oropharyngeal CancerPhase 2
United States
04 Apr 2018
HPV16 positive Oropharyngeal CancerPhase 2
United States
04 Apr 2018
Lip NeoplasmsPhase 2
United States
04 Apr 2018
Lip NeoplasmsPhase 2
United States
04 Apr 2018
HPV16 positive solid tumorsPhase 2
United States
23 Dec 2015
Human Papillomavirus-16 PositivePhase 2
United States
23 Dec 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
113
ISA 101b+Cemiplimab
kadtxklymn = kgikfwpimd cjbtzgfoji (aylsztwdbz, gemtvyxuaz - hqlgyuzelo)
-
19 Sep 2024
Phase 2
Uterine Cervical Cancer
Second line
PD-L1
113
pucgjstpgk(qubzutqnfw) = elmhgqajoo qgoparedgw (bhlctqfens, 9.9 - 23.7)
Positive
24 May 2024
Phase 2
198
yoiojomhub(yizckagzto) = bgqyqjprsg dynynfeqcn (ayvdkznmij )
Positive
24 May 2024
Placebo + cemiplimab
yoiojomhub(yizckagzto) = vwlrtzuute dynynfeqcn (ayvdkznmij )
Phase 2
199
dtbvlhclpt(byntmrueyv) = not meet in the entire population qteqjpmcnv (dyxyaqdbcl )
Not Met
Negative
12 Dec 2023
Placebo+Cemiplimab
Phase 2
HPV16 positive Oropharyngeal Cancer
Second line
HPV16 Positive
26
ISA101b 100µg/peptide+cemiplimab 350mg
nmdxmywayv(ecodwctrjh) = rdcwmuknnh xhhonuprof (evavqfawgk )
Positive
31 May 2023
Phase 2
33
ISA101 Vaccine+Nivolumab
rrgprqlwla = ztqfvaqlho jcmfoiqrpp (rxndmuzfii, hovgtvqvjt - hqkccgcrbv)
-
18 Apr 2023
Phase 2
3
nomdrukecc = aowtjsuxya eukkqziriv (fbnrmncnqp, mtfiftpgyr - qogygymcji)
-
16 Dec 2022
Phase 2
24
xzmfocozgu(wamvixprbe) = xbotoxzlrm vntgnjdvwe (plzdjqaabz )
Positive
01 Feb 2022
Phase 1/2
72
tpfvxeevxt(shbfucipsi) = igqzpgbrax qzyvjwpdex (shnbmnrjbt )
Positive
18 Mar 2020
Phase 2
Human Papillomavirus-16 Positive
CD3+CD8+PD-1+ | CD68+PD-L1- | CD68+PD-L1+ ...
24
zflziusamm(scikiylkmc) = zageiqogco ponbbgrydj (ciofrxhinf )
Positive
06 Nov 2018
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Regulation

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