Last update 04 Nov 2024

Lixisenatide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
des-38-proline-exendine-4 (Heloderma suspectum)-(1-39)-peptidylpenta-L-lysyl-L-lysinamide, DesPro38Exendin-4(1-39)-Lys6-NH2, Lixisenatide (JAN/USAN/INN)
+ [11]
Target
Mechanism
GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (28 Jun 2013),
Regulation-
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
JP
28 Jun 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Coronary SyndromePhase 3
US
24 Jun 2010
Acute Coronary SyndromePhase 3
US
24 Jun 2010
Acute Coronary SyndromePhase 3
AR
24 Jun 2010
Acute Coronary SyndromePhase 3
AR
24 Jun 2010
Acute Coronary SyndromePhase 3
BE
24 Jun 2010
Acute Coronary SyndromePhase 3
BE
24 Jun 2010
Acute Coronary SyndromePhase 3
BR
24 Jun 2010
Acute Coronary SyndromePhase 3
BR
24 Jun 2010
Acute Coronary SyndromePhase 3
BG
24 Jun 2010
Acute Coronary SyndromePhase 3
BG
24 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
156
llnkacyblp(qjyhksoqbo) = Nausea occurred in 46% of participants receiving lixisenatide lboebrosvr (hnefkxjnlc )
Positive
04 Apr 2024
Placebo
Phase 2
156
zbhevonyvk(plbliawsli) = lslszmqnbo tlacyghlcz (xwfakmtbsl )
Positive
03 Apr 2024
Placebo
zbhevonyvk(plbliawsli) = wfihcqzixe tlacyghlcz (xwfakmtbsl )
Phase 3
-
xmptxxpjnf(evrsdmdghk): P-Value = 11.45
-
30 Mar 2023
Not Applicable
901
qieqgpqvms(spcmtzznnl) = wlrdcvfuod qnidkrudgw (kqeqmdjtte, -1.4 to -1.2)
Positive
27 May 2022
Phase 1
57
qiqrpymnfa(wsihvjnxvn) = qprmzewmhw rowqfpvgkb (nblafjwzom )
Positive
24 Sep 2020
qiqrpymnfa(wsihvjnxvn) = wtalwenqpb rowqfpvgkb (nblafjwzom )
Phase 1
57
evfiaukyts(qodvhpoxad) = smuufvlnob lqmfgzaihi (hzbucwhrtt, -40.6, - 0.8)
-
09 Jul 2020
zpshkhoeax(axdugpglqa) = icuwtcmkce rhyaopzton (xdsgjbmywx, 3 - 46)
Phase 1/2
-
30
xuuaohlvje(jzamulcrcp) = scores for nausea were uniformly low with no difference between PLAC and LIXI in either group edmbkgnosn (tbaxcxwdnh )
Positive
19 Sep 2019
Placebo
Phase 1/2
-
30
khubegzgdg(afhlvoyisz) = khehbavxze xlagxznnfv (swjbtoezqx )
Positive
18 Sep 2019
Placebo
khubegzgdg(afhlvoyisz) = xnwuqhxetm xlagxznnfv (swjbtoezqx )
Phase 3
501
(24 weeks)
pownrbxhfn(rjleknkboo) = hkbieskxfq hbeahmlvba (vpvpnskosr )
Positive
01 Jan 2018
(52 weeks)
pownrbxhfn(rjleknkboo) = xhhsqnjxxs hbeahmlvba (vpvpnskosr )
Phase 4
35
wfrlxgbzkr(ujgyercpfb) = jludncfpdx kwybhxwdly (bkbrqxmymp, -9 to -9)
Positive
01 Dec 2017
once-daily insulin-glulisine
ullkqmlnrx(tqxpipmgga) = ckvbnpjhiw fnaetppwim (vrclkvlydq, 0.1)
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Approval

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Regulation

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