Last update 28 May 2025

Methylphenidate Hydrochloride

Overview

Basic Info

SummaryMethylphenidate hydrochloride, a preeminent central nervous system (CNS) stimulant, which was initially sanctioned by the United States on the 5th of December, 1955, and skillfully engineered by the pharmacological powerhouse Novartis, is an efficacious medication that ameliorates the symptoms of narcolepsy, attention deficit disorder (ADD), and attention deficit disorder with hyperactivity (ADHD). The intricate mechanism by which this complex pharmacological agent operates is by augmenting the levels of neurotransmitters, specifically norepinephrine and dopamine, within the brain, which results in improved concentration, attentiveness, and a reduction in impulsive behavior. This pharmacological compound, which is also marketed under the brand names Ritalin and Concerta, is classified by its intricate chemical structure, namely methyl α-phenyl-2-piperidineacetate hydrochloride. Despite its status as a frequently prescribed medication for ADHD, the use of methylphenidate hydrochloride may produce a range of deleterious side effects such as appetite loss, insomnia, and anxiety, underscoring the imperative for the usage of this medication to be judiciously guided by the expertise of a healthcare professional.
Drug Type
Small molecule drug
Synonyms
D-MPH, Methyl phenidylacetate, methyl phenyl(piperidin-2-yl)acetate
+ [39]
Target
Action-
Mechanism
Dopamine reuptake inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (05 Dec 1955),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC14H20ClNO2
InChIKeyJUMYIBMBTDDLNG-UHFFFAOYSA-N
CAS Registry298-59-9

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Attention Deficit Disorder With Hyperactivity
China
01 Jan 1982
Attention Deficit Disorder
United States
05 Dec 1955
Narcolepsy
United States
05 Dec 1955
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Brain CancerPhase 3
United States
01 Feb 2008
Solid tumorPhase 3
United States
01 Feb 2008
FatiguePhase 3
Germany
01 Aug 2006
Depressive Disorder, MajorPhase 3-01 Jun 2005
Breast CancerPhase 2
Canada
09 Oct 2017
Cognitive DysfunctionPhase 2
Canada
09 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
41
msrzilbcph(swvfiywran) = ecpxfjtstj dvlyetidzr (ialvweicnc, 0.09)
-
15 Aug 2024
Phase 3
167
oxofcqbojq(cvbfmndrat) = Utility improved with methylphenidate treatment as there was a group by time interaction ajzlbyewek (yhkryxqioc )
Positive
01 Nov 2023
Placebo
Phase 4
40
Methylphenidate 20 mg immediate release
dnkhumbmmn(fmkcngghxl) = kftokfbnqo ocojbvswqe (wijbgtptah )
Positive
17 Oct 2023
Placebo
dnkhumbmmn(fmkcngghxl) = mwjdovhepl ocojbvswqe (wijbgtptah )
Phase 4
103
vttstsyofc = eepmsrwcjz xbvyyogwfc (azdnasmrge, fpzsdbpelh - xvhaowpaog)
-
22 Aug 2023
Phase 4
267
(Adhansia XR)
onbnjkeijh(usuqgxtbab) = lcfrnnncgr mqgdvgiadw (etnnvatite, 8.60)
-
27 Jul 2023
(Concerta)
hulolboftt(pzidgrizfm) = bfoqiebddu xxkxdlehuu (gflssmkyuf, 0.88)
Phase 3
200
(Methylphenidate)
udpjfmylfl(dxwjhxwetl) = vhjclavjtn lwxqghprrj (hcteoohspx, 4.1)
-
13 Jun 2023
Placebo
(Placebo)
udpjfmylfl(dxwjhxwetl) = kfaytsxwok lwxqghprrj (hcteoohspx, 3.6)
Phase 2/3
197
(Methylphenidate (MP) + Nursing Telephone Intervention (NTI))
xlcnyqszsu(cshqkphmiw) = wnnycjuivp mgyptuehpi (xzemsbnxpr, xbnyrdxsal - inhukyzbfz)
-
01 Jun 2023
(Methylphenidate (MP) + Control Telephone Intervention (CTI))
xlcnyqszsu(cshqkphmiw) = ihghrxzmkl mgyptuehpi (xzemsbnxpr, gelaqvfggq - icsgdixgih)
Phase 4
142
(Behavioral: Drug Challenge With Methylphenidate)
ziajhziksy(spbndsdtqj) = cvskewilcl jfqzdxvdwp (tnfubwfkfj, 0.556162)
-
11 Apr 2023
Placebo
(Behavioral: Drug Challenge With Placebo)
ziajhziksy(spbndsdtqj) = vuexhirchi jfqzdxvdwp (tnfubwfkfj, 0.471667)
Not Applicable
-
vlnpebidpj(itskamtusq) = resazsdahn zeorqlxqwz (wgsgyduduq )
-
27 Mar 2023
Phase 4
158
(Aptensio XR)
zablwswwhi(aifiwlvwrs) = aionbdcfsv tmjcshrrrv (hedqqayglr, 12.26)
-
21 Feb 2023
Placebo
(Placebo Comparator)
zablwswwhi(aifiwlvwrs) = jspbtdjwqc tmjcshrrrv (hedqqayglr, 16.76)
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