Preservation and Transfer of Hepatitis B Virus Immunity After Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation in Adult Sickle Cell Disease Patients (Protect Study)

Sickle cell disease (SCD) patients ending with mixed mononuclear chimerism after non-myeloablative HSCT with alemtuzumab/TBI conditioning will probably preserve their immune response to vaccinations administered prior to the transplantation and will therefore not need to be revaccinated. Furthermore, SCD patients after haploidentical HSCT might benefit from adoptive transfer of immunity from their donors.
To test the first hypothesis, patients undergoing alemtuzumab/TBI HSCT will be vaccinated with a hepatitis B virus (HBV) vaccine before the transplant. To test the second hypothesis, haploidentical and matched related donors will be vaccinated prior to stem cell donation against HBV. Neither the patient nor the donor may previously have been immunized against HBV in all cohorts. Post-transplantation, the investigators will be able to evaluate whether SCD patients preserve their pre-transplant immune response in the post-transplantation period. Furthermore, the investigators will determine whether donors transfer their immunity to HSCT recipients with SCD disease.

Start Date08 Jun 2021

Sponsor / Collaborator

Academic Medical Center University of Amsterdam

NCT04326803

/ Unknown statusPhase 4IIT

Hepatitis B Virus (HBV) Infection in Haitian Immigrants in Chile: Determination of HBV Genotypes, Viral Escape Mutants and Host Factors Influencing Response to Vaccination

International migration to Chile has sharply increased since 2010. Particularly, Haitian migration now totals approximately 200.000 people. Preliminary results show a high prevalence of hepatitis B infection in this population. Approximately 35% of adult Haitian migrants in Chile have been exposed to hepatitis B infection. In this study the investigators aim to study the clinical and molecular characteristics of this infection and also to assess the serological response to an accelerated schedule of hepatitis B vaccination (0, 1 and 2 months).

Start Date01 Jun 2020

Sponsor / Collaborator

Pontificia Universidad Católica de Chile

NCT04398706

/ CompletedPhase 2

Safety and Immunogenicity of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants

Primary objectives:
* To assess the safety profile of each SP0202 formulation and Prevnar 13 in toddlers and infants (after each and any injection).
* To assess the immune response (serotype specific IgG concentration) of the SP0202 formulations and Prevnar 13 1 month after the administration of one dose in toddlers (Groups 1-4)
* To assess the immune response (serotype specific IgG concentration) of the SP0202 formulations and Prevnar 13 1 month after the administration of 3 doses in infants (Groups 5-8)
* To assess the immune response (serotype specific IgG concentration) of the SP0202 formulations and Prevnar 13 1 month after administration of a 4-dose schedule in infants (Groups 5-8)
Secondary objectives:
* To assess the immune response (serotype specific OPA titer) of the SP0202 formulations and Prevnar 13 1 month after the administration of one dose in toddlers (Groups 1-4)
* To assess the immune response (serotype specific OPA titer) of the SP0202 formulations and Prevnar 13 1 month after the administration of 3 doses in a subset of infants (Groups 5-8)
* To assess the immune response (serotype specific OPA titer) of the SP0202 formulations and Prevnar 13 1 month after administration of a 4-dose schedule in a subset of infants (Groups 5-8)
* In toddlers: to describe the Ab responses against Pentacel antigens before and 1 month following injection of Pentacel
* In infants: to describe the Ab responses against antigens of the routine pediatric vaccines (Pentacel, RotaTeq, ENGERIX-B, M-M-RII, and VARIVAX) when administered concomitantly with either SP0202 or Prevnar 13 (at pre-Dose 1 (as applicable) for RotaTeq, Diphteria, Tetanus and Pertussis antigens; at PD3 for ENGERIX-B, RotaTeq, and Pentacel; at PD4 for M-M-RII and VARIVAX])

Start Date22 May 2020

Sponsor / Collaborator

Sanofi Pasteur SA

100 Clinical Results associated with Hepatitis B vaccine(GlaxoSmithKline Plc)

100 Translational Medicine associated with Hepatitis B vaccine(GlaxoSmithKline Plc)

100 Patents (Medical) associated with Hepatitis B vaccine(GlaxoSmithKline Plc)

428

Literatures (Medical) associated with Hepatitis B vaccine(GlaxoSmithKline Plc)

01 Jul 2026·PROTEIN EXPRESSION AND PURIFICATION

Comparison of the efficacy of cell wall disruption methods for Saccharomyces cerevisiae INVSc1 cells expressing Toxoplasma gondii recombinant ROP6 protein

Article

Author: Döşkaya, Mert ; Döşkaya, Aysu Değirmenci ; Kantarcı, Ayşe Gülten ; Can, Hüseyin ; Gürüz, Adnan Yüksel ; Gül, Ceren ; Ovayurt, Tolga ; Karakavuk, Tuğba ; Yavuz, İrem ; Erel Akbaba, Gülşah ; Akbaba, Hasan ; Erkunt Alak, Sedef ; Kaplan Mansuroğlu, Seren ; Karakavuk, Muhammet ; Ün, Cemal ; Köseoğlu, Ahmet Efe ; Gül-Mete, Aytül

Toxoplasma gondii infects both humans and animals, causing severe clinical manifestations. Due to the lack of a safe vaccine, the development of a safe and effective vaccine against toxoplasmosis remains a significant need. Saccharomyces cerevisiae is a well-established recombinant protein expression system with Generally Recognized as Safe status. It supports post-translational glycosylation and is employed in several licensed vaccines, including hepatitis B (Engerix-B), human papillomavirus (Gardasil), and malaria (Mosquirix). Recombinant T. gondii proteins expressed in S. cerevisiae have been explored for use in vaccine formulations. However, cell disruption during downstream processing presents a major challenge due to the robust cell wall of yeast. In our previous work, T. gondii recombinant ROP6 protein was successfully expressed in S. cerevisiae INVSc1 cells for use as a vaccine antigen, and cell disruption was performed using a microfluidizer. In this study, we compared the efficiency of four disruption methods (microfluidizer, acid-washed glass beads, liquid nitrogen, and Y-PER reagent) for releasing recombinant protein. The results demonstrated that the microfluidizer and acid-washed glass bead methods achieved superior cell wall disruption efficiency, making them suitable for large-scale processing. The liquid nitrogen method caused excessive protein degradation and presents safety and scalability challenges. Although Y-PER reagent yielded lower amounts of rROP6 protein compared to microfluidizer and acid-washed glass bead methods, it provided good protein stability by reducing multimerization and degradation and offered operational simplicity. Overall, the choice of disruption method should be guided by the target protein's characteristics, production scale, and cost considerations to optimize yield and stability.

31 Dec 2025·RENAL FAILURE

Optimizing hepatitis B vaccination in chronic kidney disease: a comprehensive scoping review of strategies across CKD stages, dialysis, and transplant populations

Article

Author: Leelahavanichkul, Asada ; Chancharoenthana, Wiwat ; Ronco, Claudio ; Traitanon, Opas

This scoping review aims to comprehensively map and critically analyze existing evidence regarding the optimal HBV vaccination strategies-including vaccine types, schedules, immunogenicity, duration of protection, factors influencing seroresponses, and safety-primarily in adults with pre-dialysis and dialysis-dependent chronic kidney disease (CKD) populations. Patients with CKD are at increased risk of hepatitis B virus (HBV) infection due to the immune dysfunction with frequent blood exposure during invasive procedures, including hemodialysis. Although HBV vaccination is crucial for CKD patients due to the high transmission efficacy of HBV, enhanced regimens or adjuvants are often required because of CKD-induced immune dysfunction. This scoping review followed Joanna Briggs Institute guidelines and the PRISMA-ScR checklist through searching on PubMed, EMBASE, and SCOPUS for English-language studies until August 2024, demonstrated 329 unique records, and 17 studies were included. Accordingly, 4 times of either double-dose simple recombinant vaccine (Engerix-B 40 mcg) or adjuvanted vaccines (e.g., Fendrix^®, Heplisav-B^® 20 mcg) demonstrated higher seroprotection rates than the standard conventional schedule (3 times of Engerix-B 20 mcg). Vaccination at pre-dialysis stages (eGFR > 15 mL/min/1.73 m²) yielded higher short-term seroprotection (SPR: 63-100% at 1-2 months after the last dose), than in dialysis patients (SPR: 50-89.3% at 1-2 months after the last dose) and the antibody titers were more prominent with adjuvant vaccines than with the nonadjuvant one. In conclusion, the higher doses of vaccination are required in adult patients with CKD; however, data on transplant recipients and pediatric patients are very limited. Large-scale, high-quality randomized controlled trials with long-term immunity monitoring are needed.

01 Dec 2025·OCCUPATIONAL MEDICINE-OXFORD

Management of non-response to Hepatitis B re-vaccination

Article

Author: Giri, Prosenjit ; Kroening, Helen L ; Adisesh, Anil

Abstract:

Background:

Bloodborne viruses, including Hepatitis B (HBV), are a known occupational hazard for healthcare workers (HCWs), particularly those involved in exposure-prone procedures. Whilst standard vaccines can provide immunity, 5–10% of people remain non-responders (anti-HBs titre <10IU/L) despite repeated vaccinations. Fendrix® (HBV recombinant DNA vaccine) has been shown to be highly effective in renal patients and those with human immunodeficiency virus, implying it may also have benefits for healthy non-responders.

Aims:

Our analysis set out to identify and compare response rates to re-vaccination (with Fendrix® or HBvaxPro40®) in HCWs with non-response to standard vaccination procedures.

Methods:

Between 1 March 2010 and 30 April 2024, either Fendrix® or HBvaxPro40® was offered to HCWs with inadequate response to two courses of Engerix B® standard vaccination. Antibody tests were performed 6 weeks post-final vaccine dose. Serological results from this period were retrospectively statistically analysed to compare differential vaccine responses.

Results:

Eighty-five HCWs were identified as non-responders and offered further vaccination (42 received Fendrix® and 43 received HBvaxPro40®). Fendrix® resulted in a seroconversion rate of 95% (40/42) compared to 72% (31/43) with HBvaxPro40®; a significantly higher number responded more strongly to Fendrix® (74% versus 23%).

Conclusions:

Our results demonstrate the rationale for offering additional vaccination with Fendrix® to HCWs when standard vaccination and repeated administration has not elicited an adequate immune response. Multi-centre evaluation of this vaccination strategy for non-responder HCWs should be considered to generate evidence for the most acceptable and efficacious approach.

News (Medical) associated with Hepatitis B vaccine(GlaxoSmithKline Plc)

27 Mar 2026

·www.fiercepharma.com

Fierce Pharma Asia—Takeda’s $1.3B reorg; India’s GLP-1 floodgates; Gilead’s $2.2B buy of a China NewCo

Takeda's $1.3 billion restructuring plan, semaglutide generic launches in India and Gilead's $2.2 billion Ouro acquisition made our news this week. Takeda is launching a restructuring, targeting nearly $1.3 billion in annual savings. Generic versions of Novo Nordisk's semaglutide reached India in chaotic fashion. Gilead Sciences is paying up to $2.2 billion to purchase a Chinese "NewCo." And more.1. Takeda targets $1.3B in cost savings in further restructuringTakeda is launching another round of restructuring, aiming to achieve 200 billion Japanese yen ($1.26 billion) in annual gross savings by its 2028 fiscal year. Resources will be reallocated to support upcoming launches, late-stage programs and strategic technology investments. To achieve increased efficiency, the company expects to incur 150 billion yen in restructuring expenses in fiscal 2026. 2. With Novo's semaglutide going off patent, Indian drugmakers set to launch their cheaper genericsGenerics to Novo Nordisk’s semaglutide have launched in India. More than 10 brands have launched online, and shortages have already happened despite inventory build-ups by companies, according to a March 26 note by Jefferies. For injectable versions, the monthly prices range between 1,290 rupees ($13.7) to 4,500 rupees ($47.8). “Companies are testing the waters with demand and supply, and they expect the market to settle down in the next few months,” Jefferies’ analysts said.3. Gilead's $2.2B Ouro buyout delivers autoimmune T-cell engager, new purpose for GalapagosGilead Sciences is paying $1.675 billion upfront for Ouro Medicines, a “NewCo” built on ex-China rights to a BCMAxCD3 T-cell engager from China’s Keymed Biosciences and funding from GSK and Monograph Capital. Known as gamgertamig, or OM336, the drug is being studied for autoimmune disorders. Gilead is planning for its partner Galapagos to essentially absorb Ouro.4. Novartis joins Lilly, AZ in China expansion with $480M commitment to boost manufacturing, R&DNovartis said it will invest 1.5 billion yuan ($220 million) to upgrade its manufacturing facility in Beijing and will spend another 1.8 billion yuan to initiate a second phase of its Shanghai R&D campus. “China is crucial to Novartis’ long-term development and innovation,” CEO Vas Narasimhan said at the 2026 China Development Forum.5. Dizal's Zegfrovy clinches landmark phase 3 win in NSCLC subtype, setting up challenge to J&J's RybrevantA global phase 3 trial of Dizal’s Zegfrovy has met its primary endpoint of progression-free survival in first-line EGFR exon 20-mutated non-small cell lung cancer, the Chinese biotech announced. The oral drug—as a monotherapy—beat chemo where Johnson & Johnson’s injectable Rybrevant achieved in combination with chemo. 6. Novo Nordisk prepares to go global as triple-G prospect passes midphase diabetes test in ChinaThe United Laboratories, licensor of Novo Nordisk’s GLP-1/GIP/glucagon triple agonist, reported a Chinese midphase win against semaglutide in Type 2 diabetes. After 24 weeks of once-weekly injections, levels of HbA1c fell up to 2.16% in the UBT251 cohorts, compared to declines of 1.77% for semaglutide. Novo plans to start a global phase 2 trial in diabetes this year.Other News of Note: 7. Biogen pays $20M upfront to tap into Alteogen's subQ delivery tech8. Massive class action seeking RICO penalties against Takeda, Lilly presses forward with SCOTUS order9. Innovent delivers first year of net profit amid growing sales, global partnerships (release)10. InnoCare achieves profitability for the first time thanks to 2 BD deals (release)11. Hengrui posts 13% annual revenue growth, but quarterly profit misses forecasts (Reuters)12. Sino Biopharm touts 26% sales growth from innovative drugs (release)13. Innovent sees path to China approval after eye disease drug matches Eylea in phase 314. WuXi Bio's record number of new projects in 2025 leaned heavily on US clients15. Akeso advances oncology strategy as revenue jumps 44% (release, PDF)16. Shionogi pays Apnimed $100M for joint venture to awaken sleep disorder dream17. BrightGene's oral dual agonist sees up to 8% weight loss at 8 weeks in slice of early data18. GSK partners with Shanghai Pharma to bring hepatitis B vaccine back to China (Yicai)

Phase 3AcquisitionClinical ResultVaccinePhase 2

14 Jan 2026

·www.biospace.com

JPM26: Sanofi’s CEO Keen To Buy the Dip as Vaccine Rhetoric Impacts Short-Term Sales

iStock, nito100 Buying vaccine biotech Dynavax was an easy choice for Sanofi despite antivaccine moves by the Trump administration. “It’s a good time to do vaccine BD and M&A,” according to Sanofi CEO Paul Hudson. While vaccine sentiment is suffering amid the Trump administration’s rhetoric, Hudson says he’s playing the long game with Sanofi’s acquisition of Dynavax . “With the uncertainty, if you’re a short-term thinker, you don’t move. If you’re a long-term thinker—which is what we have to be—then there are less people to compete against to make acquisitions,” Hudson told reporters at a media breakfast in San Francisco on day three of the J.P. Morgan Healthcare Conference. To end 2025, Sanofi offered $2.2 billion to buy Dynavax. The center of that deal is the hepatitis B vaccine Heplisav-B. That the vaccine is for adults could help Sanofi overcome some of the vaccine hesitancy that is rising, particularly in America, Hudson said. “We know that the sensitivities are less in the adult context.” And it was those sensitivities that set the stage for the French drugmaker to pay what Hudson called an “appropriate price” for Dynavax. Elsewhere on the company’s business development (BD) bingo card, he also pointed to Sanofi’s July 2025 acquisition of Vicebio for $1.6 billion, scooping up a combination vaccine for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). “Those things will launch 5, 6, 7, 8 years from now. And so we have to assume that there’ll be a new administration or two between now and then,” Hudson said. “We don’t know what their sensitivities will be, but it’s okay, as long as there’s some objectivity in the regulator.” Hudson hinted that there could be more deals to come in the vaccine space. Sanofi’s legacy vaccine sales fell 8% in the third quarter and Hudson is predicting similar “softness” in the quarters to come. Hudson reiterated that the sales decline can be pinned on the “misinformation that is going around.” He noted the rise in measles cases as people opt out of vaccines. “We think it will settle down and we’ll move through it,” Hudson said. Sanofi has not provided guidance for 2026 yet. Hudson also spoke to recent vaccine schedule updates and other antivaccine actions at the Department of Health and Human Services (HHS). The CEO suggested that people are capable of educating themselves when it comes to vaccines in partnership with their care providers. “The vast majority of people understand the benefit of vaccines and their lives and generations of their family have been protected that way,” Hudson said. “Not everybody looks to the top of the HHS to get people with their guidance on how to live their lives.” He continued: “So I think people should be respectful of all guidance given, but I think talking to their own healthcare professional is still probably the best thing to do.” Vaccines Pesky ‘Macro Factors’—aka RFK Jr.—Come for Vaccine Pharmas’ Wallets Following restricted vaccine approvals and changes to CDC immunization schedules, Merck, Pfizer, GSK and Sanofi are all suffering revenue hits to their vaccine programs. November 7, 2025 · 4 min read · Annalee Armstrong Read more The Next Moment Vicebio and Dynavax’s programs may be years out from FDA review, but Sanofi’s flu-COVID combo, licensed from Novavax, is not. Hudson expects regulatory review to happen in 2027 or 2028. That shot is “going to be the next moment, I think, for an acceleration on vaccine utilization,” Hudson said. The product will offer convenience with a one-and-done approach for both infectious diseases. And it will be the only non-mRNA COVID shot available in the U.S. for those who do not want to receive a shot featuring that technology. “We think people are still very vaccine literate. We think they understand the reactogenicity or the tolerability challenges of mRNA,” Hudson said. Those post-vaccine reactions may have been tolerated during the global pandemic, but that’s not the case anymore, the CEO explained. He expects Sanofi will garner the over-55 and over-65 markets, particularly as the combo can offer a high dose needed for older people, who are at higher risk of death from the flu. “While there may be debates on Facebook and other places, the over-65s, I think, are highly motivated to get protected,” Hudson said, “because they know they are the ones that are most vulnerable.”

VaccineAcquisitionmRNA

29 Dec 2025

·www.pharmaceutical-technology.com

Sanofi buys hep B vaccine maker for $2.2bn

Sanofi’s executive vice president of vaccines Thomas Triomphe said the deal “brings new option to our portfolio”. Image credit: Below the Sky via Shutterstock.com. Sanofi has agreed to acquire hepatitis B vaccine manufacturer Dynavax for an equity value of around $2.2bn, bolstering the former’s pipeline amid significant vaccine policy changes in the US. The transaction, for a price of $15.50 per share in cash, is expected to close in the first quarter of 2026. Through the deal, Sanofi will acquire Dynavax’s hepatitis B vaccine HEPLISAV-B. The product won approval in the US and Europe in 2017 and 2021, respectively. Sanofi does not currently have a hepatitis B vaccine in its portfolio. The French drugmaker previously won approval for a hepatitis B vaccine in a joint venture with MSD, though the latter company now commercialises the jab, which is known under the HBVaxPro and Recombivax HB brand names in Europe and the US, respectively. Heplisav-B is administered via a two-dose regimen delivered within one month, unlike GSK’s Engerix-B and MSD’s Recombivax HB. These rival products are given in three doses over six months. With the Dynavax acquisition, Sanofi is adding a strong revenue avenue for the virus that causes serious liver infection. HEPLISAV-B generated sales of $268.4m in 2024, with Dynavax forecasting net product revenue of between $305m and $325m for 2025. GlobalData forecasts HEPLISAV-B will reach $677m in annual sales in 2031. GlobalData is the parent company of Pharmaceutical Technology . GlobalData Strategic Intelligence US Tariffs are shifting - will you react or anticipate? Don’t let policy changes catch you off guard. Stay proactive with real-time data and expert analysis. By GlobalData Learn more about Strategic Intelligence William Blair analyst Matt Phipps said: “While the deal value does come slightly below our net present value for Heplisav of $2.6bn, we believe the acquisition makes sense given growing regulatory concerns around vaccines and investor questions on management’s strategy for value creation.” Earlier in December, the US Centers for Disease and Prevention (CDC) changed its guidance to no longer recommend that all US newborns receive the hepatitis B vaccine. The significant policy changes have created volatility in the infectious disease vaccine sector, along with catalysing backlash from several medical bodies . The jewel in Dynavax’s pipeline is its shingles vaccine candidate, currently in a Phase I/II trial. In results announced in August 2025, the jab, dubbed Z-1018, demonstrated comparable efficacy to GSK’s blockbuster Shingrix – a product that dominates the shingles market. However, Z-1018 had fewer local and systemic post-injection reactions, which might give it a market advantage on tolerability. About one in three people in the US develop shingles at least once in their lives, according to the CDC. Shingrix generated £3.4bn globally for GSK in 2024, representing the size of the shingles market. Sanofi’s executive vice president of vaccines Thomas Triomphe said: “Dynavax’s marketed adult hepatitis B vaccine and shingles candidate bring new options to our portfolio and underscore our commitment to providing vaccine protection across the lifespan.” Phipps commented that: “Sanofi is a logical acquisition partner for Dynavax given the company has extensive vaccine capabilities but the portfolio does not have an adult hepatitis B or shingles programme.” Pharmaceutical Technology Excellence Awards - Nominations Closed Nominations are now closed for the Pharmaceutical Technology Excellence Awards . A big thanks to all the organisations that entered – your response has been outstanding, showcasing exceptional innovation, leadership, and impact. Excellence in Action Awarded the 2025 Pharmaceutical Technology Excellence Award for Business Expansion in Integrated Manufacturing , Upperton Pharma Solutions is rapidly expanding its UK GMP and sterile manufacturing footprint. Find out how Upperton’s integrated CDMO model helps pharma companies move from early development to clinical and niche commercial supply with fewer handovers and faster timelines. Discover the Impact

VaccineDrug ApprovalAcquisitionClinical Result

100 Deals associated with Hepatitis B vaccine(GlaxoSmithKline Plc)

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KEGG	Wiki	ATC	Drug Bank
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Indication	Country/Location	Organization	Date
Hepatitis B	United States	GlaxoSmithKline LLC	28 Aug 1989

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01311674 (CTgov)	Phase 3	Hepatitis B	141	hepatitis B vaccine (Schedule 1- Standard Dose Primary Vaccination Series)	lrrnnrhqmt(rfcegjsfpl) = tpspcazpeh gmxpiztrpa (ukkrpccshj, 3065.6) View more	-	17 Aug 2021
NCT01311674 (CTgov)	Phase 3	Hepatitis B	141	hepatitis B vaccine (Schedule 2 - High Dose Primary Vaccination Series)	lrrnnrhqmt(rfcegjsfpl) = hdghjonjwt gmxpiztrpa (ukkrpccshj, 1097.3) View more	-	17 Aug 2021
NCT02003703 (Pubmed \| JAMA Netw Open)	Phase 3	HIV Infections	107	Hepatitis B Revaccination (High-dose HBV vaccination)	pjdrzgjnew(lhjffibqhj) = ktsuupjzav jsxmichpuq (ubljxrgfqw ) View more	-	02 Aug 2021
NCT02003703 (Pubmed \| JAMA Netw Open)	Phase 3	HIV Infections	107	Hepatitis B Revaccination (Standard-dose HBV vaccination)	pjdrzgjnew(lhjffibqhj) = fqiufrcmbc jsxmichpuq (ubljxrgfqw ) View more	-	02 Aug 2021
NCT03393754 (PROTECT, EASL2020)	Phase 3	Hepatitis B	1,607	Engerix-B (Sci-B-Vac 10 Î¼g)	yogjvjukgm(dzdafehwrc) = pslelkulvg yjjiyvpngk (swhwohjply ) View more	Positive	27 Aug 2020
NCT03393754 (PROTECT, EASL2020)	Phase 3	Hepatitis B	1,607	Engerix B 20 Î¼g	yogjvjukgm(dzdafehwrc) = ouipjhijsq yjjiyvpngk (swhwohjply ) View more	Positive	27 Aug 2020
NCT02169674 (CTgov)	Phase 4	Hepatitis B	359	EngerixB, GlaxoSmithKline Vaccines (10-11 Year-olds)	tjhmdzvcad = ctbhzlqogy wvpamhtzco (rmnenptguw, hcawihslgp - guvmpgxuwt) View more	-	21 Mar 2019
NCT02169674 (CTgov)	Phase 4	Hepatitis B	359	EngerixB, GlaxoSmithKline Vaccines (15-16 Year-olds)	tjhmdzvcad = ayafkosgif wvpamhtzco (rmnenptguw, qmrdxtincx - qlsstpjoar) View more	-	21 Mar 2019
NCT02798952 (CTgov)	Phase 4	Hepatitis B	302	Engerix-B Kinder+Infanrix hexa	eklodozzmp(ijtxwovqnw) = tbhspqafsg wxnuozgskp (vcxxwmuhdw, daplxgvtwb - htmpehpliz) View more	-	01 Feb 2019
ASN2018	Not Applicable	anti-HBsAg titer	28	Standard Double-Dose Intramuscular Vaccine	lzjvvvtznf(snpghsfacp) = There were no reports of adverse events associated with intradermal dosing bqbiewyzro (eurfprnsva )	Positive	23 Oct 2018
NCT02901951 (CTgov)	Phase 4	Hepatitis B	106	Engerix-B	crcwooexvu = xzbfxlrdkd kvgrcirdkk (emkabxodyl, qdrkgopkhr - wpremvcnhq) View more	-	03 Aug 2018
NCT01817725 (CTgov)	Phase 1	Hepatitis B, Chronic	20	Engerix B	slwlufcpjf(gwdpnkuall) = xullobqgyg uttmkepcwg (vsdlmtwrgn, 0.48) View more	-	02 May 2017
NCT01847430 (Pubmed \| Vaccine)	Phase 4	Hepatitis B	303	Hepatitis B vaccine challenge dose	xkhstjvcjn(lapjdypmex) = iekbwrfdmy kuiudlxmmt (wevcyencne, 94.2 - 98.6) View more	-	23 May 2016
NCT01847430 (CTgov)	Phase 4	Hepatitis B	303	Engerix™-B Kinder	amwuxngdqy = tdcirdponb pifcxtslvt (gzcwwgzocb, xdmemjtxyr - trpceqdsoz) View more	-	02 Mar 2016

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