IOMAB-ACT: a Phase Ib/II Multi-institutional Study of 131 I-Apamistamab Followed by CD19-targeted CAR-T Cell Therapy for Patients with Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)

This study is being done to determine the safety, efficacy and tolerability of a single 50 mCi dose of 131I-Apamistamab given prior to CAR-T cell infusion in patients with Relapsed or refractory (R/R) Diffuse large B-cell lymphoma (DLBCL).

Start Date01 Apr 2025

Sponsor / Collaborator

The University of Texas Southwestern Medical Center

[+1]

NCT04512716

/ RecruitingEarly Phase 1IIT

Iomab-ACT: a Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

This is a pilot study; patients will receive 131-I apamistamab prior to CAR T-cell infusion in order to determine the maximum tolerated dose of 131-I apamistamab is exceeded at 75 mCi, and if so, to assess the safety of a step-down dose of 50 mCi.

Start Date02 Feb 2021

Sponsor / Collaborator

Memorial Sloan Kettering Cancer Center

NCT02665065

/ Active, not recruitingPhase 3

A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplant Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (AML)

The primary objective of this study is to demonstrate the efficacy of Iomab-B, in conjunction with a Reduced Intensity Conditioning (RIC) regimen and protocol-specified allogeneic hematopoietic stem cell transplant (HCT), versus Conventional Care in patients with Active, Relapsed or Refractory Acute Myeloid Leukemia (AML).

Start Date01 Jun 2016

Sponsor / Collaborator

Actinium Pharmaceuticals, Inc.

100 Clinical Results associated with I-131-Apamistamab

100 Translational Medicine associated with I-131-Apamistamab

100 Patents (Medical) associated with I-131-Apamistamab

Literatures (Medical) associated with I-131-Apamistamab

10 Jan 2025·JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase III SIERRA Trial of ¹³¹ I-Apamistamab Before Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care for Relapsed/Refractory AML

Article

Author: Pandit-Taskar, Neeta ; Schuster, Michael ; Abboud, Camille ; Foran, James ; Larkin, Karilyn ; Reddy, Vijay ; Lazarus, Hillard M. ; Koshy, Nebu ; Jamieson, Katarzyna ; Choe, Hannah ; Haeuber, Elaina ; Law, Arjun Datt ; Gyurkocza, Boglarka ; Rowley, Scott D. ; Litzow, Mark R. ; Tomlinson, Benjamin ; Silverman, Margarida ; Seropian, Stuart ; Orozco, Johnnie J. ; McNamara, Kathleen ; MacDougall, James ; Sandmaier, Brenda M. ; Desai, Avinash ; Pagel, John M. ; Spross, Jennifer ; Levy, Moshe Y. ; Sabloff, Mitchell ; Munshi, Pashna ; Hari, Parameswaran ; Cook, Rachel ; Van Besien, Koen ; Stiff, Patrick ; Kebriaei, Partow ; Giralt, Sergio ; Abhyankar, Sunil ; Vusirikala, Madhuri ; Nahar, Akash ; Chen, George ; Al-Kadhimi, Zaid ; Nath, Rajneesh

PURPOSE:

Older patients with relapsed or refractory AML (RR AML) have dismal prognoses without allogeneic hematopoietic cell transplantation (alloHCT). SIERRA compared a targeted pretransplant regimen involving the anti-CD45 radioconjugate 131 I-apamistamab with conventional care.

METHODS:

SIERRA (ClinicalTrials.gov identifier: NCT02665065 ) was a phase III open-label trial. Patients age ≥55 years with active RR AML were randomly assigned 1:1 to either an 131 I-apamistamab–led regimen before alloHCT or conventional care followed by alloHCT if initial complete remission (CR)/CR with incomplete platelet recovery (CRp) occurred. Initial response was assessed 28-56 days after alloHCT in the 131 I-apamistamab group and 28-42 days after salvage chemotherapy initiation; patients without CR/CRp or with AML progression could cross over to receive 131 I-apamistamab followed by alloHCT. The primary end point was durable complete remission (dCR) lasting 180 days after initial CR/CRp. Secondary end points were overall survival (OS) and event-free survival (EFS), assessed hierarchically in the intention-to-treat (ITT) population.

RESULTS:

The ITT population included 153 patients ( 131 I-apamistamab [n = 76]; conventional care [n = 77]). In total, 44/77 conventional care arm patients crossed over and 40/77 (52%) received 131 I-apamistamab and alloHCT, with six patients (13.6%) experiencing a dCR. In the ITT population, the dCR rate was significantly higher with 131 I-apamistamab (17.1% [95% CI, 9.4 to 27.5]) than conventional care (0% [95% CI, 0 to 4.7]; P < .0001). The OS hazard ratio (HR) was 0.99 (95% CI, 0.70 to 1.41; P = .96), and the EFS HR was 0.23 (95% CI, 0.15 to 0.34), with HR <1 favoring 131 I-apamistamab. Grade ≥3 treatment-related adverse events occurred in 59.7% and 59.2% of the 131 I-apamistamab and conventional care groups, respectively.

CONCLUSION:

The 131 I-apamistamab–led regimen was associated with a higher dCR rate than conventional care in older patients with RR AML. 131 I-apamistamab was well tolerated and could address an unmet need in this population.

04 Jun 2009·BloodQ1 · MEDICINE

131I anti-CD45 radioimmunotherapy effectively targets and treats T-cell non-Hodgkin lymphoma

Q1 · MEDICINE

Article

Author: Press, Oliver W. ; Fromm, Jonathan R. ; Gopal, Ajay K. ; Pagel, John M. ; Wilbur, Shani

Abstract:

Radioimmunotherapy (RIT) options for T-cell non-Hodgkin lymphomas (T-NHLs) are limited. We evaluated anti-CD45-RIT in human (h) and murine (m) T-NHL. CD45 was highly expressed on hT-NHL patient samples (median, 2.3 × 105 antigen-binding capacity units/cell) and hT-NHL cell lines (3.4 × 105 CD45 antigen-binding capacity units/cell). Biodistribution studies in hTNHL xenografts showed that 131I-labeled BC8 (anti-hCD45) delivered 154% (P = .01) and 237% (P = .002) more radioiodine to tumor sites over control antibodies at 24 hours and 48 hours, respectively. Importantly, tumor sites targeted with 131I-BC8 exhibited 2.5-fold (P = .05), 3.0-fold (P = .007), and 3.6-fold (P = .07) higher 131I retention over the nontarget organs of lungs, liver, and kidneys, respectively (24 hours). Because the clinical use of anti-hCD45 would target both T-NHL and other hematolymphoid tissues, we evaluated the ability of anti-mCD45 to target mT-NHL. mT-NHL grafts targeted with anti-mCD45 correspondingly retained 5.3 (P < .001), 5.4 (P < .001), and 8.7 (P < .001) times the radioactivity in tumor sites compared with nontarget organs of lung, liver, and kidney. 131I-labeled BC8 therapy yielded improved complete remission rates (75% vs 0%, P < .001) and progression-free survivals (median, 23 days vs 4.5 days, P < .001) compared with controls. These data indicate that the high CD45 expression of T-NHL allows reliable tumor targeting and disease control supporting anti-CD45 RIT for T-NHL patients.

01 Oct 2006·Indian journal of experimental biology

Heat stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species.

Article

Author: Pardhasaradhi, B V V ; Kumari, A Leela ; Khar, Ashok ; Rangaraj, Nandini ; Varalakshmi, Ch

BC-8, a rat histiocytoma undergoes apoptosis after heat shock, which is due to lack of an effective heat shock response. Heat shock induced generation of free radicals, which in turn are involved in the induction of apoptotic death in BC-8 cells. Treatment of BC-8 cells with N-acetylcysteine partially inhibited the heat induced apoptosis. Introduction of Bcl-2 gene in these cells did not protect them from apoptotic death, whereas transfection with hsp-70 gene did render these cells resistant to heat induced apoptosis transiently. Heat shock also downregulated the expression of Bcl-2 and p53 in these cells. These observations suggested that the heat shock induced apoptosis was mediated through reactive oxygen species and controlled upstream of Bcl-2 check point.

News (Medical) associated with I-131-Apamistamab

14 Apr 2025

·www.prnewswire.com

ATNM Investors are Reminded of the Class Action Against Actinium Pharmaceuticals, Inc.: Contact Robbins LLP for Information About How to Become Lead Plaintiff for the Class

SAN DIEGO, April 14, 2025 /PRNewswire/ -- Robbins LLP reminds stockholders that a class action was filed on behalf of all persons and entities that purchased or otherwise acquired Actinium Pharmaceuticals, Inc. (NYSE: ATNM) securities between October 31, 2022 and August 2, 2024. Actinium is a late-stage biopharmaceutical company that develops targeted radiotherapies, such as Iomab-B, to treat people who have failed existing oncology therapies. For more information, submit a form, email attorney Aaron Dumas, Jr., or give us a call at (800) 350-6003. The Allegations: Robbins LLP is Investigating Allegations that Actinium Pharmaceuticals, Inc. (ATNM) Misled Investors Regarding FDA Approval of Iomab-B According to the complaint, during the class period, defendants misled investors to believe there was a very high likelihood that the FDA would review and approve the Company's Biologics License Application ("BLA") for Iomab-B. The complaint alleges that defendants (i) repeatedly touted the Sierra Trial's positive DCR data while downplaying the study's failure to generate statistically significant or clinically meaningful Overall Survival data; and (ii) misled investors about the importance of the Sierra Trial's poor Overall Survival data by claiming the FDA had blessed the design of the trial such that the lack of statistically significant or clinically meaningful OS data would not be a barrier to approval of the BLA. On August 5, 2024, Actinium announced "the FDA has now determined that the analyses from the Sierra trial do not adequately support a BLA filing for Iomab-B and requires an additional clinical study." On this new, the price of Actinium's common stock fell $3.69, or approximately to 60%, to close at $2.48 on August 5, 2024. What Now: You may be eligible to participate in the class action against Actinium Pharmaceuticals, Inc. Shareholders who want to serve as lead plaintiff for the class must file their papers with the court by May 26, 2025. A lead plaintiff is a representative party who acts on behalf of other class members in directing the litigation. You do not have to participate in the case to be eligible for a recovery. If you choose to take no action, you can remain an absent class member. For more information, click here. All representation is on a contingency fee basis. Shareholders pay no fees or expenses. About Robbins LLP: A recognized leader in shareholder rights litigation, the attorneys and staff of Robbins LLP have been dedicated to helping shareholders recover losses, improve corporate governance structures, and hold company executives accountable for their wrongdoing since 2002. To be notified if a class action against Actinium Pharmaceuticals, Inc. settles or to receive free alerts when corporate executives engage in wrongdoing, sign up for Stock Watch today. Attorney Advertising. Past results do not guarantee a similar outcome. SOURCE Robbins LLP WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Patent Infringement

28 Mar 2025

·www.prnewswire.com

Investor Alert: Robbins LLP Informs Stockholders of the Actinium Pharmaceuticals, Inc. Class Action Lawsuit

SAN DIEGO, March 28, 2025 /PRNewswire/ -- Robbins LLP informs stockholders that a class action was filed on behalf of all persons and entities that purchased or otherwise acquired Actinium Pharmaceuticals, Inc. (NYSE: ATNM) securities between October 31, 2022 and August 2, 2024. Actinium is a late-stage biopharmaceutical company that develops targeted radiotherapies, such as Iomab-B, to treat people who have failed existing oncology therapies. For more information, submit a form, email attorney Aaron Dumas, Jr., or give us a call at (800) 350-6003. The Allegations: Robbins LLP is Investigating Allegations that Actinium Pharmaceuticals, Inc. (ATNM) Misled Investors Regarding FDA Approval of Iomab-B According to the complaint, during the class period, defendants misled investors to believe there was a very high likelihood that the FDA would review and approve the Company's Biologics License Application ("BLA") for Iomab-B. The complaint alleges that defendants (i) repeatedly touted the Sierra Trial's positive DCR data while downplaying the study's failure to generate statistically significant or clinically meaningful Overall Survival data; and (ii) misled investors about the importance of the Sierra Trial's poor Overall Survival data by claiming the FDA had blessed the design of the trial such that the lack of statistically significant or clinically meaningful OS data would not be a barrier to approval of the BLA. On August 5, 2024, Actinium announced "the FDA has now determined that the analyses from the Sierra trial do not adequately support a BLA filing for Iomab-B and requires an additional clinical study." On this new, the price of Actinium's common stock fell $3.69, or approximately to 60%, to close at $2.48 on August 5, 2024. What Now: You may be eligible to participate in the class action against Actinium Pharmaceuticals, Inc. Shareholders who want to serve as lead plaintiff for the class must file their papers with the court by May 26, 2025. A lead plaintiff is a representative party who acts on behalf of other class members in directing the litigation. You do not have to participate in the case to be eligible for a recovery. If you choose to take no action, you can remain an absent class member. For more information, click here. All representation is on a contingency fee basis. Shareholders pay no fees or expenses. About Robbins LLP: A recognized leader in shareholder rights litigation, the attorneys and staff of Robbins LLP have been dedicated to helping shareholders recover losses, improve corporate governance structures, and hold company executives accountable for their wrongdoing since 2002. To be notified if a class action against Actinium Pharmaceuticals, Inc. settles or to receive free alerts when corporate executives engage in wrongdoing, sign up for Stock Watch today. Attorney Advertising. Past results do not guarantee a similar outcome. SOURCE Robbins LLP WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Patent Infringement

27 Mar 2025

·pipelinereview.com

Actinium Pharmaceuticals Announces ATNM-400 a Novel Non-PSMA Targeting First in Class Prostate Cancer Radiotherapy Leveraging Actinium-225

– 99.8% tumor growth inhibition achieved with a single dose of ATNM-400 in preclinical prostate cancer models – ATNM-400 accumulated in tumors for up to 144 hours and showed minimal uptake in healthy tissues in prostate cancer xenograft model – Initial ATNM-400 preclinical data to be presented at AACR including results in Pluvicto resistant prostate cancer models NEW YORK, NY, USA I March 27, 2025 I Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) (Actinium or the Company), a pioneer in the development of targeted radiotherapies, today announced ATNM-400, a novel, non-PSMA targeting, first in class radiotherapy for prostate cancer utilizing the Actinium-225 (Ac-225) radioisotope. Initial preclinical data from ATNM-400 will be presented at the American Association for Cancer Research (AACR) Annual Meeting being held on April 25 – 30, 2025, in Chicago, IL. The ATNM-400 AACR abstract will include the results from in vitro and in vivo studies including biodistribution imaging and efficacy analyses with various dose levels of ATNM-400. Actinium continues to advance ATNM-400 with additional data expected from Pluvicto-resistant prostate cancer models at AACR. Pluvicto (Lu-177-PSMA-617) is a prostate-specific membrane antigen (PSMA) directed targeted radiotherapy that uses the beta-particle emitting radioisotope Lutetitium-177 (Lu-177) that is approved for patients with metastatic prostate cancer. Pluvicto is marketed and sold by Novartis and generated sales of $1.39 billion in 2024. ATNM-400 is differentiated from Pluvicto as it targets a different marker than PSMA that has been shown to be overexpressed in patients with prostate cancer and uses the alpha-particle emitter Ac-225, which is more potent than Lu-177 but has a shorter path length, which could result in fewer off-target effects. Sandesh Seth, Actinium’s Chairman and CEO, said, “The current era of radiotherapy is built on the clinical and commercial success of Pluvicto in prostate cancer. The field is now looking to address patients that do not respond or progress after Pluvicto therapy. We believe ATNM-400 can address this high unmet need and we are incredibly excited by our data to date. As anticipated, we have seen robust tumor control and ATNM-400 has shown to be well tolerated in preclinical studies, which we believe is due to the precise and potent cell-killing of Ac-225. We are also highly excited by the results of our biodistribution studies that showed selective tumor uptake with minimal uptake in normal tissues. By focusing on a non-PSMA target, we also believe ATNM-400 has the potential to address some of the toxicities reported with Pluvicto and other PSMA targeting radiotherapies such as xerostomia. We are eager to present our ATNM-400 data at AACR and to continue to advance this highly novel prostate cancer candidate.” Highlights from the abstract include: ATNM-400 AACR Presentation Details Title: ATNM-400 is a novel Actinium-225 antibody radioconjugate with strong efficacy in preclinical models of prostate cancer Abstract Number: 578 Session: PO.ET08.01 – Theranostics and Radiotheranostics Date & Time: April 27, 2025 – 2:00 pm – 5:00 pm About Actinium Pharmaceuticals, Inc. Actinium is a pioneer in the development of targeted radiotherapies intended to meaningfully improve patient outcomes. Actinium is advancing its lead product candidate Actimab-A, a CD33 targeting therapeutic, as potential backbone therapy in acute myeloid leukemia (AML) and other myeloid malignancies leveraging the mutation agnostic alpha-emitter radioisotope payload Actinium-225 (Ac-225). Actimab-A has demonstrated potential activity in relapsed and refractory acute myeloid leukemia (r/r AML) patients in combination with the chemotherapy CLAG-M including high rates of Complete Remissions (CR) and measurable residual disease (MRD) negativity leading to improved survival outcomes and is being advanced to a pivotal Phase 2/3 trial. In addition, Actinium is engaged with the National Cancer Institute (NCI) under the Cooperative Research and Development Agreement (CRADA) for development of Actimab-A in AML and other myeloid malignancies. The first clinical trial under the CRADA will evaluate the triplet combination comprised of Actimab-A, Venetoclax (Abbvie/Roche) an oral Bcl-2 inhibitor and ASTX-727 (Taiho Oncology, an Otsuka holdings company) a novel oral hypomethylating agent (HMA) in frontline acute myeloid leukemia (AML) patients. Additionally, Actinium is developing Actimab-A as a potential pan tumor therapy in combination with PD-1 checkpoint inhibitors including KEYTRUDA ® and OPDIVO ® by depleting myeloid derived suppressor cells (MDSCs), which represents a potential multi-billion-dollar addressable market. Iomab-ACT, Actinium’s next generation conditioning candidate, is being developed with the goal of improving patient access and outcomes for potentially curative cell and gene therapies. Iomab-B is an induction and conditioning agent prior to bone marrow transplant in patients with r/r AML, which Actinium is seeking a potential strategic partner for the U.S. ATNM-400 is Actinium’s novel non-PSMA targeting Ac-225 radiotherapy for prostate cancer, which is supported by preclinical data and is being advanced to clinical trials. In addition, the company’s R&D efforts are primarily focused on advancing several preclinical programs for solid tumor indications. Actinium holds 230 patents and patent applications including several patents related to the manufacture of the isotope Ac-225 in a cyclotron. For more information, please visit: https://www.actiniumpharma.com/ SOURCE: Actinium Pharmaceuticals

AACRClinical StudyRadiation Therapy

100 Deals associated with I-131-Apamistamab

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Refractory acute myeloid leukemia	Phase 3	United States	Actinium Pharmaceuticals, Inc.	01 Jun 2016
Refractory acute myeloid leukemia	Phase 3	Canada	Actinium Pharmaceuticals, Inc.	01 Jun 2016
Relapsing acute myeloid leukemia	Phase 3	United States	Actinium Pharmaceuticals, Inc.	01 Jun 2016
Relapsing acute myeloid leukemia	Phase 3	Canada	Actinium Pharmaceuticals, Inc.	01 Jun 2016
Diffuse large B-cell lymphoma recurrent	Phase 2	United States	The University of Texas Southwestern Medical Center	01 Apr 2025
Diffuse large B-cell lymphoma recurrent	Phase 2	United States	Actinium Pharmaceuticals, Inc.	01 Apr 2025
Diffuse large B-cell lymphoma refractory	Phase 2	United States	Actinium Pharmaceuticals, Inc.	01 Apr 2025
Diffuse large B-cell lymphoma refractory	Phase 2	United States	The University of Texas Southwestern Medical Center	01 Apr 2025

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SNMMI2024	Not Applicable	-	-	Iomab-B	bhxqiiobgq(tfhmobmsnf) = cfoytmmudk wcpdlkluwn (ufxbdtutvm )	-	09 Jun 2024
NCT02665065 (SIERRA, EHA2024) Manual	Phase 3	Acute Myeloid Leukemia TP53 Mutation	153	Iomab-B with fludarabine and total body irradiation	mwseapjcqs(zytogcicmi) = mqskbqpuqd tahxhrtxtk (virjhcnxek ) View more	Positive	14 May 2024
				131I-APAMISTAMAB-LED (Conventional Care)	mwseapjcqs(zytogcicmi) = lkigtvucjj tahxhrtxtk (virjhcnxek ) View more
NCT02665065 (SIERRA, EHA2024) Manual	Phase 3	Acute Myeloid Leukemia CD45	153	Iomab-B with fludarabine and total body irradiation (2 Gy) followed by HCT	fypaoioxdq(noqtcmorzy) = lrnpqtgahc kpnbmtnzsw (waqvzgopga ) View more	Positive	14 May 2024
				131I-APAMISTAMAB-LED (Physician’s choice of conventional care (CC))	fypaoioxdq(noqtcmorzy) = qqahpekbug kpnbmtnzsw (waqvzgopga ) View more
NCT02665065 (SIERRA, EBMT2024) Manual	Phase 3	Acute Myeloid Leukemia TP53 Mutation	153	Iomab-B	uvpkmqpvmk(xtpfnzgsoz) = cbnxpmmolk zcpixdgwli (wqdxmprrok )	Positive	17 Apr 2024
NCT02665065 (SIERRA, Biospace) Manual	Phase 3	Acute Myeloid Leukemia TP53 Mutation	54	Iomab-B	tqlmiyhrde(fmvtrmqxuw) = zdtugaphyv kifrctopux (mlegqvxjee ) View more	Positive	26 Feb 2024
				Crossover	tqlmiyhrde(fmvtrmqxuw) = iqmhucdkqr kifrctopux (mlegqvxjee ) View more
NCT02665065 (SIERRA, Tandem Meetings ASTCT and CIBMTR2024) Manual	Phase 3	Acute Myeloid Leukemia TP53 Mutation	153	Iomab-B with fludarabine and total body irradiation	farkwhvskf(ywgqwndmru) = rqpjayjsre mufjtybodo (ltpswwkveh ) View more	Positive	01 Feb 2024
				Apamistamab (Conventional Care)	farkwhvskf(ywgqwndmru) = fkwnckpmxl mufjtybodo (ltpswwkveh ) View more
NCT02665065 (SIERRA, Tandem Meetings ASTCT and CIBMTR2024) Manual	Phase 3	Acute Myeloid Leukemia CD45	153	Iomab-B with fludarabine and total body irradiation (2 Gy)	eyuwocomko(qeebjjapgh) = bydfxhrhvt mlrtlvdjcf (rooxpslawo, 9.7 - 33.1) View more	Positive	01 Feb 2024
				I-Apamistamab (Conventional Care (CC))	eyuwocomko(qeebjjapgh) = owbaxdljaw mlrtlvdjcf (rooxpslawo ) View more
NCT02665065 (SIERRA, Biospace) Manual	Phase 3	Acute Myeloid Leukemia TP53 Mutation	153	Iomab-B (Crossover + TP53 Mutation)	ttefcpmvab(jaolavhpjz) = yfzzzhwfrl vljtkcvupq (rimalbszxf ) View more	Positive	11 Dec 2023
				Control Arm (TP53 Mutation)	ttefcpmvab(jaolavhpjz) = kpsfxgsthn vljtkcvupq (rimalbszxf ) View more
NCT02665065 (SIERRA, ASH2023)	Phase 3	Acute Myeloid Leukemia TP53 mutation positive	153	131I-apamistamab led induction and conditioning followed by alloHCT	kmtrffmmuw(xindoetiby) = gfsnvgmoqm umwtnodndj (lhdxerfdpp, 12.29 - 34.73) View more	Positive	10 Dec 2023
				physician’s choice of conventional care	xcdotihzzg(eyohpatsww) = jqfgmliasw zqgkdxqqii (lyimrgznvj )
NCT02665065 (SIERRA, ASH2023)	Phase 3	Acute Myeloid Leukemia	153	131I-apamistamab with fludarabine and total body irradiation	evmqtabyfi(wymlyqqoda) = lazmxnausw wrlmsloeex (weswujcyuv, 11.5 - 22.3) View more	Positive	10 Dec 2023

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