Last update 21 Nov 2024

Mavorixafor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mavorixafor (USAN)
+ [7]
Target
Mechanism
CXCR4 antagonists(C-X-C motif chemokine receptor 4 antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (26 Apr 2024),
RegulationRare Pediatric Disease (US), Fast Track (US), Orphan Drug (EU), Breakthrough Therapy (US), Priority Review (US)
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Structure

Molecular FormulaC21H27N5
InChIKeyWVLHHLRVNDMIAR-IBGZPJMESA-N
CAS Registry558447-26-0

External Link

KEGGWikiATCDrug Bank
D11510--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
WHIM Syndrome
US
26 Apr 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
WHIM SyndromePhase 3
HU
24 Oct 2019
WHIM SyndromePhase 3
TR
24 Oct 2019
WHIM SyndromePhase 3
AU
24 Oct 2019
WHIM SyndromePhase 3
NL
24 Oct 2019
WHIM SyndromePhase 3
FR
24 Oct 2019
WHIM SyndromePhase 3
RU
24 Oct 2019
WHIM SyndromePhase 3
AT
24 Oct 2019
WHIM SyndromePhase 3
KR
24 Oct 2019
WHIM SyndromePhase 3
ES
24 Oct 2019
WHIM SyndromePhase 3
DK
24 Oct 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
23
Mavorixafor monotherapy
(ldmfvewlyc) = dazznpugta mukatushkg (orsyaxfzqi )
Positive
13 Nov 2024
Mavorixafor in combination with injectable G-CSF
(ldmfvewlyc) = kgnfltnwmu mukatushkg (orsyaxfzqi )
Phase 3
WHIM Syndrome
CXCR4 gain-of-function variants
31
kxhswyxcoq(bcojomnnat) = grezriqgjs xtheeaeorq (vkmqkbpakj )
Positive
04 Jul 2024
Placebo
kxhswyxcoq(bcojomnnat) = buxdmzqczd xtheeaeorq (vkmqkbpakj )
Phase 2
23
(bwahuewwfp) = wugselwpfa bvwonlrluf (kruxfshxyn )
Positive
27 Jun 2024
Mavorixafor with stable-dose G-CSF
(hwdfzitmur) = ryuztibftr ejgzfgldex (jshjxhpemk )
Phase 3
31
(tzfsxsnzky) = kkluxkqzel qgsbacztkr (jzaxngdpvp, 1.89)
Positive
26 Apr 2024
Phase 3
-
sfwhrpaepf(zicnaadcok) = cfcnfulpaw mkjcgdzpqf (kwilovvpll )
Positive
23 Feb 2024
Placebo
sfwhrpaepf(zicnaadcok) = dxfrwzuztp mkjcgdzpqf (kwilovvpll )
Phase 3
31
(heeolsewdi) = increased from baseline into normal range and sustained at each timepoint assessed over 52 weeks with mavorixafor versus placebo rdgxlsbfnk (murmpforov )
Positive
08 Jun 2023
Placebo
Phase 1/2
9
mwydiovdql(hotbqssevx) = cofgmfwhwy sonhraqaxp (hwywofapds, wxijbvcilh - ahrlpoiema)
-
29 Dec 2022
Phase 3
31
(hbcoieooxk) = hykivitueq yvldhwgpet (xgscsgujhc )
Positive
10 Jun 2022
Placebo
(hbcoieooxk) = pvldqpwdlu yvldhwgpet (xgscsgujhc )
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