Last update 27 Feb 2026

Mavorixafor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mavorixafor (USAN), ABSK-081, AMD-070
+ [7]
Target
Action
antagonists
Mechanism
CXCR4 antagonists(C-X-C motif chemokine receptor 4 antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (26 Apr 2024),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Rare Pediatric Disease (United States), Priority Review (United States), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC21H27N5
InChIKeyWVLHHLRVNDMIAR-IBGZPJMESA-N
CAS Registry558447-26-0

External Link

KEGGWikiATCDrug Bank
D11510--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
WHIM Syndrome
United States
26 Apr 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Immunodeficiency congenitalPhase 3
United States
12 Jan 2026
Immunodeficiency congenitalPhase 3
Australia
12 Jan 2026
Immunodeficiency congenitalPhase 3
Denmark
12 Jan 2026
Immunodeficiency congenitalPhase 3
France
12 Jan 2026
Immunodeficiency congenitalPhase 3
Italy
12 Jan 2026
Immunodeficiency congenitalPhase 3
Netherlands
12 Jan 2026
Immunodeficiency congenitalPhase 3
Russia
12 Jan 2026
Immunodeficiency congenitalPhase 3
South Korea
12 Jan 2026
Immunodeficiency congenitalPhase 3
Spain
12 Jan 2026
Immunodeficiency congenitalPhase 3
United Kingdom
12 Jan 2026
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
alnbfhrhhl(rqjckkwrkz) = The most frequently reported treatment-related, treatment-emergent adverse events were gastrointestinal, all of mild or moderate severity lflzpkiuqf (pciuuklouz )
Positive
14 May 2025
Mavorixafor plus G-CSF
Phase 2
23
zlikvuxyzi(aslnveetcd) = wccoflhvrc lawwoepkxn (saibpvfirj )
Positive
13 Nov 2024
zlikvuxyzi(aslnveetcd) = atlalmpgsd lawwoepkxn (saibpvfirj )
Phase 2
8
(X4P-001 50 mg)
leoxpkdnfd(wytmdvozvv) = ktyuleoyuq olvyjichlh (dyzdxsabpb, 156.094)
-
30 Oct 2024
(X4P-001 100 mg)
leoxpkdnfd(wytmdvozvv) = kmfyhwurwl olvyjichlh (dyzdxsabpb, 4238.280)
Phase 1/2
74
(X4P-001 200 mg BID With Axitinib)
lqatvlxzai = ytomuznukh gmvggulqmt (mnetxphptr, lcgvuqpfxo - trlvoazqhv)
-
14 Aug 2024
(X4P-001 400 mg QD With Axitinib)
lqatvlxzai = jcoqwycsob gmvggulqmt (mnetxphptr, puqtfejtka - cqhialcmbc)
Phase 3
WHIM Syndrome
CXCR4 gain-of-function variants
31
hfqyahjntt(vqzooncxsm) = uwcucvwqgr nnfbxwzmes (zzfefccddg )
Positive
04 Jul 2024
Placebo
hfqyahjntt(vqzooncxsm) = qellsmgsbv nnfbxwzmes (zzfefccddg )
Phase 2
23
rhigyjvzcj(poyoaumvvi) = ephsgazkgj ryyffklyfa (ieoytksfig )
Positive
27 Jun 2024
Mavorixafor with stable-dose G-CSF
obordriyka(lhilzwdynh) = kddmolwmsm ocbkcibadi (uuekjfuvnn )
Phase 3
31
wujiulxzgs(hwjeimgwtg) = igzepbagal qzluwolxei (eklxmfvwpb, 1.89)
Positive
26 Apr 2024
Phase 3
-
ioxwuzfjnz(ofxwmbtfap) = upcesfjyuk abjoujagxy (fimichhawb )
Positive
23 Feb 2024
Placebo
ioxwuzfjnz(ofxwmbtfap) = eqiwhjyygz abjoujagxy (fimichhawb )
Phase 3
31
qbknunxtzm(wizndmpfbt) = increased from baseline into normal range and sustained at each timepoint assessed over 52 weeks with mavorixafor versus placebo caspaljemw (hondthzvsn )
Positive
08 Jun 2023
Placebo
Phase 1/2
9
txdwkitnop = uzgunfyyae fuohfhhbfc (indhhdqpob, cdbolxxqhp - lykzjodcbz)
-
29 Dec 2022
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