OBJECTIVES: I. Determine the bacteriological activity of amithiozone against Mycobacterium avium complex (MAC) pulmonary disease.
II. Define the ability of amithiozone to improve clinical outcomes in patients with MAC infection.
III. Determine the safety and tolerance of amithiozone with chronic dosing in these patients.
IV. Assess the contribution of clarithromycin, streptomycin, rifampin, ethambutol, kanamycin, and amithiozone in the treatment of pulmonary MAC infection.

Start Date01 Jan 1991

Sponsor / Collaborator

National Jewish Health, Inc.

100 Clinical Results associated with Thioacetazone

100 Translational Medicine associated with Thioacetazone

100 Patents (Medical) associated with Thioacetazone

1,119

Literatures (Medical) associated with Thioacetazone

01 Mar 2025·Food Chemistry

Insight into the mechanism of Maillard reaction and lipids mutually contribute to the flavor release of squid fillets during the drying process

Article

Author: Xue, Changhu ; Liu, Yanjun ; Zeng, Junpeng ; Meng, Nan ; Xu, Jie ; Jiang, Xiaoming ; Song, Yu ; Cong, Peixu ; Fan, Xiaowei

Dried squid fillet is a popular seafood product with a unique flavor. However, its flavor release mechanism is unclear. In this study, volatile compounds (VOCs) were dynamically monitored in thawed squid (TS), salted squid (SS) and dried squid for 6 h (D6) and 24 h (D24). Subsequently, the Maillard reaction (MR) substrate, lipid oxidation index, free fatty acids and lipid profiles were detected. The results showed that the number of VOCs increased from 11 in TS (114.26 μg/kg) to 19 in D24 (1257.89 μg/kg). Besides, MR between glucose/ribose and amino acids (methionine, arginine, etc.) contributed to 3-methyl-butanal, methional and 2,3-butanedione. Meanwhile, lipid oxidation index, lipidomics and correlation analysis indicated that lipids (phosphatidylcholines and triglycerides) containing polyunsaturated fatty acids (C18:2, C20:4, C20:5 and C22:6) were precursors of 3-methyl-butanal, nonanal, heptanal, dodecane and tetradecane. Briefly, lipid hydrolysis, oxidation and MR mutually contributed to the flavor during the drying process of squid fillets.

01 Nov 2024·Radiation Physics and Chemistry

Effect of gamma irradiation on sensory and aroma compounds of soaked bayberry jiu

Author: Wang, Shanshan ; Chen, Zhijun ; Zhang, Ci ; Tian, Wenhui ; Zhang, Yi ; Qi, Wenyuan ; Zheng, Qi ; Kong, Qiulian ; Yan, Weiqiang ; Yue, Ling

Soaked bayberry jiu is a homely fruit alc. beverage that produced by soaking bayberry in Baijiu, a traditional Chinese distilled spirit.To investigate the changes in the sensory and aroma compounds of soaked bayberry jiu following gamma irradiation, the sensory evaluation, electron nose, electron tongue, and headspace solid-phase microextraction gas chromatog. mass spectrometry (HS-SPME-GC-MS) were conducted.The results showed that the different irradiation doses of samples could be well separatedThe taste and smell of 6 kGy irradiated soaked bayberry jiu were significantly improved, but the color of irradiated samples was deteriorated.Moreover, a total of 53 differential products (21 decreased and 32 increased products) were detected compared 6 kGy irradiated soaked bayberry jiu to unirradiated sample, including some important aroma compounds of Baijiu, indicating that the active free radicals produced by gamma irradiation promote the oxidation-reduction reaction in soaked bayberry jiu and lead to the mutual transformation and equilibrium among the compoundsThese findings suggest that gamma irradiation can improve the quality of soaked bayberry jiu.

01 Oct 2024·Journal of Biological Chemistry

Mechanistic insights and in vivo efficacy of thiosemicarbazones against methicillin-resistant Staphylococcus aureus

Article

Author: Gaudreau, Avery ; El-Halfawy, Omar M ; Roy, Paroma ; Flannagan, Ronald S ; Watson, David W ; Beavers, William N ; Shen, Chenfangfei ; Heinrichs, David E ; Abdelmoneim, Ahmed ; Gillies, Elizabeth R

Staphylococcus aureus poses a significant threat in both community and hospital settings due to its infective and pathogenic nature combined with its ability to resist the action of chemotherapeutic agents. Methicillin-resistant S. aureus (MRSA) represents a critical challenge. Metal-chelating thiosemicarbazones (TSCs) have shown promise in combating MRSA and while previous studies hinted at the antimicrobial potential of TSCs, their mechanisms of action against MRSA are still under investigation. We screened a chemical library for anti-staphylococcal compounds and identified a potent molecule named R91 that contained the NNSN structural motif found within TSCs. We identified that R91 and several structural analogs exhibited antimicrobial activity against numerous S. aureus isolates as well as other Gram-positive bacteria. RNAseq analysis revealed that R91 induces copper and oxidative stress responses. Checkerboard assays demonstrated synergy of R91 with copper, nickel, and zinc. Mutation of the SrrAB two-component regulatory system sensitizes S. aureus to R91 killing, further linking the oxidative stress response to R91 resistance. Moreover, R91 was found to induce hydrogen peroxide production, which contributed to its antimicrobial activity. Remarkably, no mutants with elevated R91 resistance were identified, despite extensive attempts. We further demonstrate that R91 can be used to effectively treat an intracellular reservoir of S. aureus in cell culture and can reduce bacterial burdens in a murine skin infection model. Combined, these data position R91 as a potent TSC effective against MRSA and other Gram-positive bacteria, with implications for future therapeutic development.

100 Deals associated with Thioacetazone

External Link

KEGG	Wiki	ATC	Drug Bank
D08584	Thioacetazone	J04AK07	DB12829

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Indication	Country/Location	Organization	Date
Pulmonary Tuberculosis	China	Shandong Boshan Pharmaceutical Co., Ltd.	-
Tuberculosis	China	Shandong Boshan Pharmaceutical Co., Ltd.	-

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