Clemastion Fumarate Liniment was prepared and quality control standards were formulated.With clemastine fumarate as the main ding, Clemastine Fumarate Liniments was preparedQuality control carried out by hight performance liquid chromatog. (HPLC).The quality of prepared liniment was stable, operation method was simple and quality control was accurate and reliable.The average recovery of clemastine fumarate was 99.63%, RSD was 0.83% (n=9).The preparation process was simple, determination method was simple, accurate, and it was suitable for the preparation and quality control of Clemastine Fumarate Liniment.