Delving into the Latest Updates on Glutamic Acid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(2S)-2-Aminopentanedioic acid, (S)-2-Aminopentanedioic acid, (S)-Glutamic acid

+ [12]

Target

GRIA2

Action

agonists

Mechanism

GRIA2 agonists(glutamate ionotropic receptor AMPA type subunit 2 agonists), Amino acid replacements

Therapeutic Areas

Nervous System DiseasesDigestive System DisordersEndocrinology and Metabolic Disease

Active Indication

Hepatic Encephalopathy

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC5H9NO4

InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N

CAS Registry56-86-0

Effect of oral intake of branched-chain amino acids in nursing mothers on the concentration of glutamic acid in breast milk - leucine as a representative substance - Effect of oral intake of branched-chain amino acids in nursing mothers on the concentration of glutamic acid in breast milk - leucine as a representative substance

Start Date06 Sep 2022

Sponsor / Collaborator

Shiga University of Medical Science

NCT05221892

/ CompletedPhase 4IIT

Double Blind Evaluation of Gamma-aminobutyric Acid Tartarate 100 mg, Glutamic Acid 100 mg, Dibasic Calcium Phosphate 50 mg, Thiamine Nitrate 25 mg, Pyridoxine Chloride 10 mg and Cyanocobalamin 5 mcg Versus Ginger for Vertigo-kinetosis

The goal of this clinical trial is to assess the efficacy and safety of a combination of aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine and cyanocobalamin as adjuvant therapy for vertigo comparatively to ginger under a double-blind randomized study design.

Start Date22 Nov 2021

Sponsor / Collaborator

Fundação Educacional Serra dos Órgãos

ACTRN12612000826842

/ CompletedNot ApplicableIIT

Effects of small intestinal L-glutamate and L-glutamine infusions on antropyloroduodenal motility, gut hormone release, blood glucose control and energy intake in healthy, normal weight subjects.

Start Date18 Oct 2012

Sponsor / Collaborator-

100 Clinical Results associated with Glutamic Acid

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100 Translational Medicine associated with Glutamic Acid

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100 Patents (Medical) associated with Glutamic Acid

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153,808

Literatures (Medical) associated with Glutamic Acid

31 Dec 2025·International Journal of Food Properties

FTIR characteristics of sweet flour as affected by particle size distribution and in vitro digestibility of gluten-free sweet potato noodles

Author: Mohamed Ahmed, Isam A. ; Qureshi, Tahir Mahmood ; Wadood, Syed Abdul ; Azeem, Muhammad ; Ali, Asmahan A. ; Anees Ur Rehman, Muhammad ; Aljobair, Moneera O.

There is a need to explore the influence of particle size of sweet potato flour on physicochem. properties and in vitro starch digestibility of gluten free sweet potato noodles.The aim of this work was to examine the influence of purple-fleshed sweet potato flour (PFSPF) having different particle size distribution (355 μm to 75μ m) on physicochem. properties and in vitro starch digestibility of gluten-free purple sweet potato noodles.Pasting properties and sugar contents were pos. correlated toward the finest particle fraction.The hardness of noodles was pos. and significantly correlated to the finest particle size fraction.Sweet potato flour (SPF) noodles prepared with particle size of 75 μm retained lower hardness 5.74 N.An abrupt increase in yellowness was observed with decreasing particle size that might be attributed to the reduction of protein.The results of FTIR suggested that with the reduction of particle size, protein and carbohydrates decreased that much associated with crystallization and retrogradation of starch.Among all the amino acids, aspartic acid and glutamic acid were observed to be more abundant, i.e. approx. 13.33 and 29.05‰, resp.In this way, PFSPF with particle size 75 μm exhibited significant application potential for producing gluten free noodles due to high resistant starch and lower hardness.It may be concluded that particle sizes of sweet potato flour influenced pasting properties, textural characteristics, sugar contents, protein contents, amino acid contents, carbohydrate contents of prepared noodles.

01 Dec 2025·Nano-Micro Letters

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Article

Author: Shi, Jue ; He, Jing ; Hong, Gaoying ; Liu, Nian ; Xie, Zhijian ; Yuan, Ximin ; Xia, Pengcheng ; Hu, Zihe ; Yao, Ke ; Li, Yuanrong ; He, Yong ; Chen, Yuewei ; Zhou, Yanyan ; Kong, Weicheng

AbstractHydrogel scaffolds have numerous potential applications in the tissue engineering field. However, tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties. Inspired by Chinese ramen, we propose a universal fabricating method (printing-P, training-T, cross-linking-C, PTC & PCT) for tough hydrogel scaffolds to fill this gap. First, 3D printing fabricates a hydrogel scaffold with desired structures (P). Then, the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance (T). Finally, the training results are fixed by photo-cross-linking processing (C). The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa (622-fold untreated) and have excellent biocompatibility. Furthermore, this scaffold possesses functional surface structures from nanometer to micron to millimeter, which can efficiently induce directional cell growth. Interestingly, this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt, and many hydrogels, such as gelatin and silk, could be improved with PTC or PCT strategies. Animal experiments show that this scaffold can effectively promote the new generation of muscle fibers, blood vessels, and nerves within 4 weeks, prompting the rapid regeneration of large-volume muscle loss injuries.

01 Sep 2025·Neural Regeneration Research

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Article

Author: Zhang, Yanyu ; Zhang, Meiyu ; Zeng, Yan ; Huang, Taiqi ; Su, Chonglin ; Chen, Xingxing

The hypothalamic–pituitary–adrenal axis regulates the secretion of glucocorticoids in response to environmental challenges. In the brain, a nuclear receptor transcription factor, the glucocorticoid receptor, is an important component of the hypothalamic–pituitary–adrenal axis’s negative feedback loop and plays a key role in regulating cognitive equilibrium and neuroplasticity. The glucocorticoid receptor influences cognitive processes, including glutamate neurotransmission, calcium signaling, and the activation of brain-derived neurotrophic factor–mediated pathways, through a combination of genomic and non-genomic mechanisms. Protein interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor, thereby affecting the hypothalamic–pituitary–adrenal axis and stress-related cognitive functions. An appropriate level of glucocorticoid receptor expression can improve cognitive function, while excessive glucocorticoid receptors or long-term exposure to glucocorticoids may lead to cognitive impairment. Patients with cognitive impairment–associated diseases, such as Alzheimer’s disease, aging, depression, Parkinson’s disease, Huntington’s disease, stroke, and addiction, often present with dysregulation of the hypothalamic–pituitary–adrenal axis and glucocorticoid receptor expression. This review provides a comprehensive overview of the functions of the glucocorticoid receptor in the hypothalamic–pituitary–adrenal axis and cognitive activities. It emphasizes that appropriate glucocorticoid receptor signaling facilitates learning and memory, while its dysregulation can lead to cognitive impairment. This provides clues about how glucocorticoid receptor signaling can be targeted to overcome cognitive disability-related disorders.

1

News (Medical) associated with Glutamic Acid

19 Oct 2022

·www.sciencedaily.com

Storing hydrogen fuel in salts -- a step toward 'cleaner' energy production

Hydrogen gas could someday replace fossil fuels as a 'clean' energy source, producing only water and energy. However, handling large quantities of gaseous hydrogen is cumbersome, and converting it to a liquid requires vessels that can withstand extremely high pressures. Now, researchers have developed a method to store and release highly pure hydrogen with salts in the presence of amino acids. Hydrogen gas could someday replace fossil fuels as a "clean" energy source, producing only water and energy. However, handling large quantities of gaseous hydrogen is cumbersome, and converting it to a liquid requires vessels that can withstand extremely high pressures. Now, researchers reporting in ACS Central Science have developed a method to store and release highly pure hydrogen with salts in the presence of amino acids. The reversible storage of hydrogen in solid salts has emerged as one potential way to make the fuel easier to transport and handle, but the reactions to do this require precious metals as catalysts and may produce carbon dioxide as an unwanted byproduct. So, Henrik Junge, Matthias Beller and colleagues developed effective storage-release systems with both bicarbonate and carbonate salts, as well as manganese, which is a more widely available metal catalyst. The researchers found that converting bicarbonate and hydrogen into formate, and vice versa, was most effective with potassium salts, a manganese-based catalyst and lysine -- an amino acid that acted as an additional promoter and reacted with carbon dioxide to capture it -- at reaction temperatures below 200 F. After five storage-release cycles, the reaction system produced hydrogen with a high yield (80%) and purity (99%). The team also showed that carbonate salts and glutamic acid can be part of the reusable storage-release system with hydrogen yields up to 94%. This technique paves the way for large-scale hydrogen storage in solids, the researchers say. The authors acknowledge funding from the State of Mecklenburg-Vorpommern and European Union, the Leibniz-Program Cooperative Excellence K308/2020 (project "SUPREME") and the European CO2PERATE project.

100 Deals associated with Glutamic Acid

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External Link

KEGG	Wiki	ATC	Drug Bank
D00007	Glutamic Acid	A09AB01	DB00142

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hepatic Encephalopathy	China	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00369564 (CTgov)	Phase 3	Nerve injury \| Sarcoma \| Neurotoxicity Syndromes \| Leukemia \| Peripheral Nervous System Diseases \| Kidney Neoplasms \| Lymphoma	250	glutamic acid (Arm I Glutamic Acid)	aquwxpexhr(rtxdjnjgwa) = pgtlppzbhg rewlthitkc (auqkaaqkzl, luptmifhda - grkuokteko) View more	-	14 Mar 2014
				placebo (Arm II Placebo)	aquwxpexhr(rtxdjnjgwa) = yszvtuysww rewlthitkc (auqkaaqkzl, onzuftibxy - wvaremjpdv) View more
SFN2002	Not Applicable	Ganglion Cysts	-	L-glutamate	tefktkldgk(lgqkciatsj) = dhjybqrbli bcxmahhqtg (bjklrzyrvw, 6.2)	-	03 Nov 2002
				ACh	tefktkldgk(lgqkciatsj) = munhdqazer bcxmahhqtg (bjklrzyrvw, 5.2)
SFN2001	Not Applicable	-	-	Aminoguanidine	(fjueiggnsj) = atfmqtkihi gjrygpgepd (ovmfdohnbk, 3)	-	14 Nov 2001
				L-NAME	(fjueiggnsj) = lomuwzbdtm gjrygpgepd (ovmfdohnbk, 7)