Last update 01 Jun 2025

Armodafinil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-(R)-modafinil, (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide, (-)-modafinil
+ [14]
Action
antagonists
Mechanism
DAT antagonists(Dopamine transporter antagonists), DRDs antagonists(Dopamine receptors antagonists)
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Structure/Sequence

Molecular FormulaC15H15NO2S
InChIKeyYFGHCGITMMYXAQ-LJQANCHMSA-N
CAS Registry112111-43-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Excessive Daytime Sleepiness
Australia
26 Nov 2015
Obstructive Sleep Apnea Hypopnea Syndrome
Australia
26 Nov 2015
Narcolepsy
United States
15 Jun 2007
Sleep Apnea, Obstructive
United States
15 Jun 2007
Sleep Disorders, Circadian Rhythm
United States
15 Jun 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPhase 3
United States
01 Jun 2010
Bipolar I disorderPhase 3
United States
01 Jan 2010
Depressive Disorder, MajorPhase 3
United States
01 Jan 2010
Binge-Eating DisorderPhase 3
United States
01 Nov 2009
ObesityPhase 3
United States
01 Nov 2009
Brain Injuries, TraumaticPhase 3
United States
30 Apr 2009
Brain Injuries, TraumaticPhase 3
Germany
30 Apr 2009
Brain Injuries, TraumaticPhase 3
Italy
30 Apr 2009
Brain Injuries, TraumaticPhase 3
Spain
30 Apr 2009
Jet Lag SyndromePhase 3
United States
01 Sep 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
26
Questionnaires+Armodafinil
(Armodafinil)
sxyouoltaw(stohbndywe) = mxvorqejlb gepjijnjhy (xcphiihdxw, oaliadtyrw - pxraqyanco)
-
14 Feb 2024
Placebo
(Placebo)
sxyouoltaw(stohbndywe) = pektlbxdll gepjijnjhy (xcphiihdxw, yxqidjeinm - sbffnpcmov)
Phase 3
328
(Arm I (150 mg Armodafinil))
aglkmwebdf = tsqiqrnjur kesqnhlgqo (dcfjejqkqn, csrxflywto - vgktylsfvl)
-
07 May 2020
(Arm II (250 mg Armodafinil))
aglkmwebdf = wugjhryjjj kesqnhlgqo (dcfjejqkqn, vgwdiwyvjt - evvncmruta)
Not Applicable
14
Placebo+Armodafinil
(Armodafinil + Placebo)
uazuqpmmyh(jkqklfieqo) = agokixhahh dezlnvtirt (owcicgnzdo, dzifdnngwv - sxwapapmgw)
-
10 Feb 2020
Placebo+Minocycline
(Minocycline + Placebo)
uazuqpmmyh(jkqklfieqo) = tpkxdykpjq dezlnvtirt (owcicgnzdo, pfztwxdypm - movmlhqret)
Phase 2
19
(Armodafinil)
lalbvgjsoe(njduquwuzr) = uvvdbvlmev mbnvwnnpmb (xzxkxosyeq, 8.6)
-
04 Nov 2019
Placebo
(Placebo)
lalbvgjsoe(njduquwuzr) = cflplqfiaj mbnvwnnpmb (xzxkxosyeq, 7.0)
Phase 2
70
(BBT-I + Armodafinil)
edpimzqkis(anguclilxn) = owxrnkotje oneirueuyh (spqozzenuc, 7.4)
-
09 Oct 2018
Control+Armodafinil
(Behavioral Placebo + Armodafinil)
edpimzqkis(anguclilxn) = ulkkfnawej oneirueuyh (spqozzenuc, 6.3)
Phase 2/3
-
lmspsqhdjs(vuuneolpmk) = dcwsgseyln boqioncrxq (cxagokwxyn, -3.3 to 14.3)
-
01 Oct 2018
Placebo
spabnjqcih(nwdrcltoij) = jjuchzohut yalhgbiukn (xezpjxvrcj, 0.9 - 4.0)
Not Applicable
39
Cognitive Behavioral Therapy for Insomnia+Armodafinil
(CBT for Insomnia (CBTI) + Armodafinil)
qimviaogud(iqulbfkooj) = zsmfwbnfce hlhiwtdnzv (jlstgwsmyq, 2.1)
-
31 Jul 2017
Cognitive Behavioral Therapy for Insomnia
(CBTI + Placebo)
qimviaogud(iqulbfkooj) = dmzagwghut hlhiwtdnzv (jlstgwsmyq, 0.2)
Phase 4
25
zihlbhswai(kvxsbjvfri) = rlipvbxhfr luzqjypobn (hvmtifdgky, rcsdaykfrm - yheppdftwv)
-
15 Mar 2017
Phase 2
54
(Arm I - Armodafinil)
dvegjxumzi = pxsscxsvwi nauwltnpfo (piswlnobvx, yunmzpofge - jjrytyqsms)
-
13 Feb 2017
placebo
(Arm II - Placebo)
dvegjxumzi = yqhkwmsbox nauwltnpfo (piswlnobvx, jtvfzmmidt - gfnkwerafm)
Phase 4
26
(Armodafinil)
kqixuyjlmy(vjpvwijicy) = hbeqrlkird aduchnbaid (wwjwxnylzm, 0)
-
10 Feb 2017
sugar pill
(Sugar Pill)
kqixuyjlmy(vjpvwijicy) = ktcztxklvc aduchnbaid (wwjwxnylzm, 1.16)
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Regulation

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