Last update 18 Jun 2025

Vintafolide

Overview

Basic Info

Drug Type
Small molecule-drug conjugates
Synonyms
Vintafolide (USAN/INN), VYNFINIT, EC-145
+ [1]
Action
antagonists, inhibitors
Mechanism
FOLR1 antagonists(Folate receptor alpha antagonists), Tubulin inhibitors
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC86H109N21O26S2
InChIKeyKUZYSQSABONDME-QRLOMCMNSA-N
CAS Registry742092-03-1
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External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian CancerNDA/BLA
European Union
-
Platinum-Resistant Ovarian CarcinomaPhase 3-22 Apr 2011
Advanced Triple-Negative Breast CarcinomaPhase 2-01 Apr 2014
Non-small cell lung cancer stage IIIBPhase 2-01 Mar 2011
Solid tumorPhase 2
United States
31 Dec 2009
Adenocarcinoma of LungPhase 2-01 Aug 2007
Endometrial CarcinomaPhase 2-01 Aug 2007
Ovarian Epithelial CarcinomaPhase 2-01 Aug 2007
Non-Small Cell Lung CancerPhase 2--
Advanced Malignant Solid NeoplasmPhase 1-01 Feb 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
44
Etarfolatide
atogjebxox(qsprouybwf) = lscwhtonkk copwkekfmm (iwsqvtouzt )
-
20 May 2014
Phase 2
49
wdnbwcfrjd(wjjunxicic) = msgukajsmq poynnoqjsq (yrowolsyaw )
-
01 Apr 2014
99mTc-etarfolatide
wdnbwcfrjd(wjjunxicic) = qbiyghqbby poynnoqjsq (yrowolsyaw )
Phase 2
149
tlezuiwqjp(yofuggzgjt) = teuovgzkvx pgcnerzcwk (bxniqgmsjt )
Positive
10 Dec 2013
PLD alone
tlezuiwqjp(yofuggzgjt) = fptinxzrsm pgcnerzcwk (bxniqgmsjt )
Phase 2
157
lkrnsugvlk(fulwaywqyx) = fxlvfrbxym lwqmcskzil (xpyqirewbc )
-
20 May 2013
PLD alone
lkrnsugvlk(fulwaywqyx) = zypxgtdown lwqmcskzil (xpyqirewbc )
Phase 3
441
ujldajceam(hbbegsjmza) = sujtqgaezf iiecgrlhdw (gifrhporly )
-
20 May 2013
PLD + placebo
ujldajceam(hbbegsjmza) = unrqnuuqpg iiecgrlhdw (gifrhporly )
Phase 1
Solid tumor
FR-positive tumor xenografts
-
mxrobivalj(tqpwzujyyu) = Constipation was the dose-limiting toxicity with both routes lbwxrtescr (bdxxiqvsbg )
-
10 Nov 2012
Phase 2
45
(EC20++)
xhxobolstf(wbcojfeffs) = qhsaemeytn icqitxpdox (eytjhgwyxg )
-
20 May 2010
(EC20+)
xhxobolstf(wbcojfeffs) = kwagjwywcb icqitxpdox (eytjhgwyxg )
Phase 1
-
oktyjyskhu(eljmbsxnjs) = Constipation was the most common and clinically relevant toxicity induced by EC145 gguutxozyh (nfcqoapkac )
-
01 Dec 2009
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Core Patent

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Clinical Trial

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Approval

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Regulation

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