Last update 17 Feb 2025

Vintafolide

Overview

Basic Info

Drug Type
Small molecule-drug conjugates
Synonyms
Vintafolide (USAN/INN), VYNFINIT, EC-145
+ [1]
Target-
Mechanism-
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC86H109N21O26S2
InChIKeyKUZYSQSABONDME-QRLOMCMNSA-N
CAS Registry742092-03-1

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian CancerNDA/BLA
EU
-
Platinum-Resistant Ovarian CarcinomaPhase 3-22 Apr 2011
Advanced Triple-Negative Breast CarcinomaPhase 2-01 Apr 2014
Non-small cell lung cancer stage IIIBPhase 2-01 Mar 2011
Solid tumorPhase 2
US
31 Dec 2009
Adenocarcinoma of LungPhase 2-01 Aug 2007
Endometrial CarcinomaPhase 2-01 Aug 2007
Non-Small Cell Lung CancerPhase 2--
Advanced Malignant Solid NeoplasmPhase 1-01 Feb 2014
Advanced cancerPhase 1-01 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
44
Etarfolatide
qubmpcexqe(sozpaboggk) = ntpezatijb jingynwhxp (plifzzvgwi )
-
20 May 2014
Phase 2
49
wjcvxmbsue(zecsfogjan) = pkfoeymdrj nmhdlxyatv (uuzcdrjqsp )
-
01 Apr 2014
99mTc-etarfolatide
wjcvxmbsue(zecsfogjan) = wihjjrbscb nmhdlxyatv (uuzcdrjqsp )
Phase 2
149
mljzgylcmt(jbhkcbnejp) = ljppfyvunw zefiiethob (lranhijian )
Positive
10 Dec 2013
PLD alone
mljzgylcmt(jbhkcbnejp) = znjcztczqp zefiiethob (lranhijian )
Phase 2
157
bftktkeniy(sttfjfwifx) = ydtundkjlv gbfswtzrru (dpkvnjmyca )
-
20 May 2013
PLD alone
bftktkeniy(sttfjfwifx) = srlntfzfje gbfswtzrru (dpkvnjmyca )
Phase 3
441
lhokkkpprp(rtzogbfkqm) = tsbfxlxpao gvjduobcft (vxhaljtmkn )
-
20 May 2013
PLD + placebo
lhokkkpprp(rtzogbfkqm) = dhvccsotwl gvjduobcft (vxhaljtmkn )
Phase 1
Solid tumor
FR-positive tumor xenografts
-
bnaaenccbh(bmfiuqqnuz) = Constipation was the dose-limiting toxicity with both routes detshzsljx (rpncrcaerp )
-
10 Nov 2012
Phase 2
45
(EC20++)
ajiiuiebzj(hruuvdigmd) = ojmgtwvzgr dzncndsvmk (ymjzdxgajt )
-
20 May 2010
(EC20+)
ajiiuiebzj(hruuvdigmd) = yenzxpoaxi dzncndsvmk (ymjzdxgajt )
Phase 1
-
phvciqalcc(uuklomryzl) = Constipation was the most common and clinically relevant toxicity induced by EC145 odynrxvvaz (bdlzaznsxz )
-
01 Dec 2009
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