Delving into the Latest Updates on Nigella sativa seed extract with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

Nigella sativa seeds extract containing ointment intervention

Target-

Action-

Mechanism-

Therapeutic Areas

Infectious DiseasesRespiratory DiseasesEndocrinology and Metabolic Disease+ [2]

Active Indication-

Inactive Indication

Arsenical keratosisCOVID-19Diabetes Mellitus+ [4]

Originator Organization-

Active Organization-

Inactive Organization

University of Indonesia

Aga Khan University

Bangabandhu Sheikh Mujib Medical University

+ [2]

License Organization-

Drug Highest PhasePendingPhase 3

First Approval Date-

Regulation-

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The world is currently facing a crisis because of this potentially fatal situation of the COVID-19 epidemic without proven efficacy for any drug treatment, while the vaccination is not yet.
This epidemic is caused by a new betacorona virus, now called SARS-CoV-2. The most common symptoms reported are fever, cough or chest tightness, and dyspnea. Most cases have a mild course

Start Date01 Mar 2021

Sponsor / Collaborator

Hôpital Universitaire Sahloul

NCT04686461

/ Unknown statusNot ApplicableIIT

Effect of Thymoquinone Extracted From Nigella Sativa in the Treatment of Arsenical Keratosis

Prepare an ointment from Nigella sativa seeds extract and apply it over palmer arsenical keratosis patient for 12 weeks. After than the effect of the ointment will be observed by measuring the keratotic nodular size before and after the intervention.

Start Date20 Oct 2019

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

100 Clinical Results associated with Nigella sativa seed extract

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100 Translational Medicine associated with Nigella sativa seed extract

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100 Patents (Medical) associated with Nigella sativa seed extract

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236

Literatures (Medical) associated with Nigella sativa seed extract

01 Jun 2025·Current Medicinal Chemistry

Effect of Nigella sativa Consumption on Lipid Profile and Glycemic Index in Patients with Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Article

Author: Rajabian, Arezoo ; Ghavidel, Farideh ; Shabani, Maryam ; Homayouni-Tabrizi, Masoud ; Jamialahmadi, Tannaz ; Hosseini, Hossein ; Sahebkar, Amirhossein

Background::Metabolic syndrome is a multifactorial disorder and genetics, lifestyle, and aging play important roles in its prevalence. Nigella sativa has several pharmacological benefits, including anti-inflammatory, antitumor, anti-diabetic, antioxidant, and hypolipidemic effects. This meta-analysis of randomized controlled trials assesses the effect of N. sativa consumption on lipid profile and glycemic indices in patients with metabolic syndrome.Methods::We systematically researched Cochrane Library, PubMed, Scopus, and Web of Science databases. The literature research identified 171 studies with duplication. Of those, 73 articles were screened for titles and abstracts, and 7 studies were finally selected for the meta-analysis. Because of the high degree of heterogeneity, we performed subgroup analyses based on the dose of N. sativa (<=500 mg/day or >500 mg/day).Results::The results revealed that N. sativa intake significantly decreased total cholesterol (SMD: −0.71; 95% CI, -1.44 to -0.38; p = 0.00), LDL-C (SMD: −1.06; 95% CI, -1.45 to -0.66; p = 0.00) and HDL-C (SMD: −0.31; 95% CI, 0.09 to 0.53; p = 0.01) concentrations. In addition, N. sativa significantly decreased FBS (SMD: −0.8; 95% CI, -1.21 to -0.39; p = 0.00) and HbA1c (SMD: −0.37; 95% CI, -0.66 to -0.09; p = 0.01) concentrations. No publication bias was observed, and sensitivity analysis showed stable results.Conclusion::The current systematic review and meta-analysis indicates that N. sativa could improve lipid profile and glycemic index in patients with metabolic syndrome.

01 Apr 2025·Tropical Animal Health and Production

The supplementation of dietary black cumin (Nigella Sativa) seeds on performance, blood hematology, post-metabolic responses, antioxidant status, immunity, and inflammatory markers in pre-weaning calves

Article

Author: Al-Marakby, Khaled M ; Abdelnour, Sameh A ; Elsayed, Mamdouh ; Abdel Hafez, Sabry

AbstractPre-weaning feeding is critical for calf growth, laying the foundation for future productivity and health. Nigella sativa seeds (NS) are rich in bioactive compounds with numerous beneficial effects on health and various pharmacological properties. This study aimed to investigate the supplementation of NS powder on performance, post-metabolic attributes, immunity, antioxidant capacity, and inflammatory responses in pre-weaning Friesian calves. Twenty-four Friesian male calves at 4 days of age with a similar genetic line, weighing 33.67 ± 0.6 kg, were randomly allocated to three groups (8 animals per group). The study comprised three groups: a control group (NS0) receiving no supplementation, and two experimental groups received either 1% (NS1) or 3% (NS3) NS supplementation for 84 days. All levels of NS supplementation significantly improved the final body weight and body weight gain in a linear manner (P < 0.001), while the highest total dry matter intake was observed in NS1 group (quadratic; P < 0.001). White blood cells (quadratic, P = 0.026), lymphocytes (quadratic, P = 0.012), and monocytes (linear effect; P = 0.001) significantly decreased, whereas red blood cells (linear; P = 0.004), hematocrit (linear; P = 0.002), mean corpuscular volume (MCV, linear; P = 0.003), and mean corpuscular hemoglobin concentration (MCHC, quadratic, P = 0.007), platelets (linear; P < 0.001) increased in calves fed NS. Feeding calves diets supplemented with NS led to a significant linear decrease in plasma creatinine and liver enzymes (AST and ALT) compared to the control diet (P < 0.01). Calves fed 3% of NS in their diets had lower plasma cholesterol (linear; P < 0.001) and triglyceride levels (linear; P = 0.002) compared to calves in NS0 and NS1 groups. Polynomial analysis indicated a quadratic decrease in direct bilirubin (P = 0.006), and a quadratic increase in immunoglobulin G (IgG, P = 0.014) and M (IgM, P = 0.032) in the calves fed the NS diet. All NS-supplemented groups showed a significant increase in IL-10 (linear; P < 0.001), TAC (linear; P = 0.006), and CAT (linear; P < 0.001), and a significant decrease in IL-4 levels (linear; P < 0.001) of the plasma of pre-weaning calves. As expected, pre-weaning calves fed diets containing NS (1% or 3%) exhibited a quadratic decrease in plasma malondialdehyde (MDA, P < 0.001) levels compared to those fed diets without NS. Our findings suggest that incorporating up to 3% Nigella sativa into pre-weaning calf diets can enhance growth, bolster immune function, and mitigate oxidative stress, offering a promising strategy for improving health and sustainability on dairy farms.

01 Jan 2025·Open Veterinary Journal

The effect of black cumin (Nigella sativa L.) on the number of glial cells in white rats (Rattus norvegicus) exposed to cigarette smoke

Article

Author: Plumeriastuti, Hani ; Amalia, Amirul ; Hamid, Iwan Sahrial ; Rachmawati, Kadek ; Wahyunengtiyas, Marita ; Hendrawan, Viski Fitri ; Widjiati, Widjiati ; Warsito, Sunaryo Hadi

Background: Cigarette smoke is known to have harmful effects on the brain, particularly on glial cells, which play a crucial role in maintaining the health and functionality of the central nervous system. Nigella sativa (black cumin) has been reported to have neuroprotective properties, but its effects on glial cells in the cerebellum and cerebrum when exposed to cigarette smoke are not well understood. Aim: This study aimed to determine the benefits of N. sativa on the number of glial cells in the cerebellum and cerebrum of white rats (Rattus norvegicus) exposed to cigarette smoke. Methods: Thirty white rats weighing approximately 105 grams were divided into five groups: K (control group, no exposure to cigarette smoke and without given Nigella sativa), K+ (exposed to cigarette smoke, 2 cigarettes/day, and 0.5% CMC), and three treatment groups (P1, P2, and P3) exposed to cigarette smoke, 2 cigarettes/day, with Nigella sativa dosages of 300, 600, and 1200 mg/kg BW, respectively. The number of glial cells in the cerebellum and cerebrum was examined under a microscope at 400x magnification. Data were analyzed using a One-Way ANOVA test, followed by the Post Hoc Duncan test. Results: Significant difference (p<0.05) in the number of glial cells in both the cerebellum and cerebrum between the control and treatment groups. Conclusion: The administration of N. sativa, particularly at a dosage of 1200 mg/kg BW/day, significantly increased and maintained the number of glial cells in the cerebellum and cerebrum of rats exposed to cigarette smoke.

100 Deals associated with Nigella sativa seed extract

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
COVID-19	Phase 3	Pakistan	Sheikh Zayed Federal Postgraduate Medical Institute	05 Mar 2021
Arsenical keratosis	Phase 3	Bangladesh	Bangabandhu Sheikh Mujib Medical University	20 Oct 2019
Dyslipidemias	Phase 3	Indonesia	University of Indonesia	01 Sep 2011
Hypertension	Phase 3	Indonesia	University of Indonesia	01 Jul 2011
Diabetes Mellitus	Phase 3	Pakistan	Aga Khan University	01 Feb 2006
Hypercholesterolemia	Phase 3	Pakistan	Aga Khan University	01 Feb 2006
Metabolic Syndrome	Phase 3	Pakistan	Aga Khan University	01 Feb 2006