Last update 01 Nov 2024

Arsenical keratosis

Last update 01 Nov 2024

Basic Info

Synonyms

Arsenical Keratosis, Arsenical keratosis, Arsenical keratosis (disorder)

+ [7]

Introduction

A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic.

Drugs associated with Arsenical keratosis

Nigella sativa seed extract

Target-

Mechanism-

Active Org.

Cairo University

Originator Org.-

Active Indication

Chronic sinusitis

Inactive Indication

Arsenical keratosis [+6]

Drug Highest PhaseClinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Solasodine

Target

Class I PI3K

Mechanism

Class I PI3K inhibitors

Active Org.-

Originator Org.

Bangabandhu Sheikh Mujib Medical University

Active Indication-

Inactive Indication

Arsenical keratosis

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Eggplant peel extract

Target-

Mechanism-

Active Org.-

Originator Org.

Bangabandhu Sheikh Mujib Medical University

Active Indication-

Inactive Indication

Arsenical keratosis

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Arsenical keratosis

NCT04686474 / Unknown statusNot ApplicableIIT

Effect of the Compound Extracted From Azadirachta Indica Leaves in the Treatment of Arsenical Keratosis

Prepare an ointment from Azadirachta indica leaves extract and its apply on palmer arsenical keratosis patient, for 12 weeks. After intervention, effect of the ointment will be observed by measuring the nodule (before and after apply the ointment)

Start Date20 Oct 2019

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

NCT04686461 / Unknown statusNot ApplicableIIT

Effect of Thymoquinone Extracted From Nigella Sativa in the Treatment of Arsenical Keratosis

Prepare an ointment from Nigella sativa seeds extract and apply it over palmer arsenical keratosis patient for 12 weeks. After than the effect of the ointment will be observed by measuring the keratotic nodular size before and after the intervention.

Start Date20 Oct 2019

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

NCT04608461 / Unknown statusPhase 2IIT

Effect of Pumpkin Seeds in the Treatment of Moderate to Severe Palmar Arsenical Keratosis

Arsenicosis is a major health problem in Bangladesh. Long term exposure of arsenic causes keratosis of palm which reduce working capacity of patient. It also causes massive skin lesions like Bowen's disease which has a risk to develop squamous cell carcinoma. Pumpkin seed is well known for its antioxidant and anticancer properties. So this study will be conducted to identify the compound from pumpkin seeds and to see its outcome on keratosis.

Start Date17 Sep 2019

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

100 Clinical Results associated with Arsenical keratosis

100 Translational Medicine associated with Arsenical keratosis

0 Patents (Medical) associated with Arsenical keratosis

114

Literatures (Medical) associated with Arsenical keratosis

01 Sep 2024·Skin Research and Technology

Arsenical keratosis in China: A case report and review of the literature

Review

Author: Wang, Ruojun ; Tao, Rong

AbstractBackgroundArsenical keratosis is a precancerous dermatosis which could be induced by long‐term exposure to arsenic poisoning. Arsenic is often added to traditional Chinese medicine in a non‐compliant manner to increase the effectiveness of psoriasis treatment, which is often the main cause of arsenic poisoning in Chinese patients with psoriasis.ObjectivesWe performed a systemic review of arsenic keratosis during the past 32 years to better understand the sources, treatment, and prognosis of arsenic keratosis in China.MethodsWe searched Medline/PubMed, Embase, CNKI, and Wanfang databases for research studies published between 1992 and 2024. A total of 64 papers with 78 individual Chinese of arsenical keratosis were included in this analysis.ResultsOf the patients included in the analysis, 92.21% of arsenic poisoning was due to iatrogenic factors: Chinese traditional medicine. Seventy‐six patients (98.70%) had skin manifestation of hyperkeratotic papules and plaques, 68 patients (88.31%) had hyperpigmentation, 43 cases (55.84%) had hypopigmentation, and only 4 had a clear indication of Mees' lines in nails. A total of 52.63% of patients presented with tumors, including squamous cell carcinoma, Bowen's disease, and basal cell carcinoma. For patients with tumors, 20 opted for surgery, 6 for radiotherapy, and 3 for PDT. All patients with only cutaneous tumors are currently well‐controlled. Death occurred in one patient with metastatic squamous cell carcinoma. Keratinizing papules improved significantly in 70.59% of patients treated with Acitretin Capsules.ConclusionsIn this study, arsenic sources in Chinese patients were mainly from traditional Chinese medicine, and there were no reports of exposure to water sources or occupational sources in the past 32 years. Most of the patients showed keratinizing papules and pigmentation, and more than 1/2 of the patients showed skin tumors, mainly squamous cell carcinoma. The treatments of tumors are mainly surgical treatment, PDT and radiotherapy can also be selected. The improvement in keratinizing rash was greater than 70% with acitretin capsules. Patients with this disease should be regularly followed up for early detection and timely treatment of potential malignant tumors.

01 Sep 2024·Mayo Clinic Proceedings

Arsenical Keratosis in Chronic Arsenic Intoxication

Article

Author: Weng, Pei-Chun ; Cheng, Chun-Yu

01 Apr 2024·Photodiagnosis and Photodynamic Therapy

Hematoporphyrin injection mediated photodynamic therapy for secondary squamous cell carcinoma of arsenical keratosis: A case report

Article

Author: Feng, Hao ; Shen, Bo ; Fu, Tao ; Liu, Xiguang ; Li, Linwei ; Ma, Guozhang

Hematoporphyrin injection (HpD) mediated photodynamic therapy (PDT) has demonstrated efficacy in treating various types of Bowen's disease, including basal-cell carcinoma, squamous cell carcinoma, extramammary Paget's disease, and actinic keratosis. We present a case of a male patient who developed squamous cell carcinoma as a result of repeated instances of arsenic-induced keratosis on both his hands and feet. Due to the involvement of the joint in both hands, the patient declined the conventional surgical resection treatment since it could potentially impact normal physiological function. Instead, the patient chose to undergo hemoporphyrin photodynamic therapy. After the treatment, the rash was entirely eliminated and there were no restrictions in the movement of the joint. Nevertheless, a local recurrence was detected throughout the two-year monitoring period. Arsenical keratosis carries a substantial likelihood of recurring. However, we believe that hemoporphyrin photodynamic therapy is effective in treating this condition.

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Arsenical keratosis

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