Delving into the Latest Updates on Allopurinol Sodium with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Aloprim

Target

XO

Action

inhibitors

Mechanism

XO inhibitors(Xanthine dehydrogenase inhibitors)

Therapeutic Areas

NeoplasmsImmune System DiseasesCongenital Disorders+ [4]

Active Indication

GoutHyperuricemiaLeukemia+ [2]

Inactive Indication-

Originator Organization

Mylan NV

Active Organization

Mylan Institutional LLCUDL Laboratories

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (17 May 1996),

GoutHyperuricemiaLeukemia+ [2]

RegulationOrphan Drug (European Union)

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Structure/Sequence

Molecular FormulaC5H4N4O

InChIKeyOFCNXPDARWKPPY-UHFFFAOYSA-N

CAS Registry315-30-0

View All Structures (2)

主要目的：评价健康中国受试者单次和多次静脉输注注射用别嘌醇钠后，别嘌醇及活性代谢物奥昔嘌醇的药代动力学特征，以了解其在中国人体内的吸收、分布与消除的规律；次要目的：评价注射用别嘌醇钠静脉给药的安全性和耐受性。

[Translation]

The primary objective was to evaluate the pharmacokinetic characteristics of allopurinol and its active metabolite oxypurinol after single and multiple intravenous infusions of allopurinol sodium for injection in healthy Chinese subjects, so as to understand the laws of its absorption, distribution and elimination in the Chinese body. The secondary objective was to evaluate the safety and tolerability of intravenous administration of allopurinol sodium for injection.

Start Date07 Nov 2018

Sponsor / Collaborator

Shandong Bestcomm Pharmaceutical Co., Ltd.

CTR20132332

/ CompletedNot Applicable

注射用别嘌醇人体药代动力学试验

[Translation] Pharmacokinetic study of allopurinol for injection in humans

进行健康受试者静脉注射注射用别嘌醇的药代动力学试验，测定主要成分别嘌醇和代谢物奥昔嘌醇的经时血药浓度和尿药浓度，估算主要药代动力学参数，了解注射用别嘌醇在人体吸收、分布、消除、代谢规律，为制定注射用别嘌醇II期临床试验方案提供试验依据。

[Translation]

A pharmacokinetic study of allopurinol for injection was conducted on healthy subjects after intravenous injection. The time-dependent blood and urine concentrations of the main component allopurinol and the metabolite oxypurinol were determined, the main pharmacokinetic parameters were estimated, and the absorption, distribution, elimination, and metabolism of allopurinol for injection in the human body were understood, providing an experimental basis for the formulation of a Phase II clinical trial plan for allopurinol for injection.

Start Date15 Aug 2012

Sponsor / Collaborator

Shandong Bestcomm Pharmaceutical Co., Ltd.

NCT00189007

/ Unknown statusPhase 3IIT

Does Antenatal Allopurinol Administration Reduce Post-hypoxic-ischemic Reperfusion Damage During Fetal Hypoxia in the Newborn?

A former study (submitted) in 32 severely asphyxiated infants participating in a randomized double blind study, in which early postnatal allopurinol or a placebo (within 4 hours after birth) was administered to reduce free radical formation and consequently reperfusion/reoxygenation injury to the newborn brain, showed an unaltered high mortality and no clinically relevant improvement in morbidity in infants treated with allopurinol. It was hypothesized that postnatal allopurinol treatment started too late to reduce reperfusion-induced free radical surge and that initiating allopurinol treatment of the fetus with (imminent) hypoxia already via the mother during labor will be more effective to reduce free radical-induced post-asphyxial brain damage.

Start Date01 Oct 2009

Sponsor / Collaborator

University Medical Center of Utrecht

100 Clinical Results associated with Allopurinol Sodium

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100 Translational Medicine associated with Allopurinol Sodium

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100 Patents (Medical) associated with Allopurinol Sodium

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5,571

Literatures (Medical) associated with Allopurinol Sodium

01 Apr 2025·Journal of Food Composition and Analysis

Identification of metabolite biomarkers for distinguishing Korean fresh/frozen and Chinese frozen yellow goosefish (Lophius litulon) using liquid chromatography-Orbitrap mass spectrometry

Author: Yang, Ji-young ; Yang, Junho ; Kang, Seokwon ; Shin, Jiyoung ; Nam, Gangmi

This study aimed to identify metabolite biomarkers to distinguish yellow goosefish based on their distribution origin (Korean or Chinese) and freshness, using liquid chromatog.-Orbitrap mass spectrometry.Fresh and frozen fish samples from both origins were analyzed, resulting in the identification of 213 putative metabolites.Principal component anal. with hierarchical clustering was initially performed to compare all fish groups, focusing on the effects of distribution conditions by comparing fresh and frozen Korean fish.Subsequently, t-test and orthogonal partial least squares discrimination anal. were conducted to calculate the variable importance in projection (VIP) scores of metabolites and evaluate their ability to distinguish between Korean and Chinese fish.The anal. demonstrated an excellent model for distinguishing Korean fresh fish from Chinese frozen fish, with an area under the curve (AUC) ranging from 0.98 to 1.00.Eight compounds exhibited significant differences between Korean and Chinese fish (p < 0.05, VIP > 1.0), with anserine identified as the most robust biomarker for distinguishing between the two groups.The high AUC value of 0.98, derived from the receiver operating characteristic curve, confirmed the effectiveness of anserine as a biomarker.Anserine is proposed as a reliable biomarker for distinguishing yellow goosefish based on their geog. origin.

01 Apr 2025·Biocatalysis and Agricultural Biotechnology

Characterization of enzymatic and metabolic of a biocomposite based on Trichoderma koningiopsis and chlorella biomass

Author: Kubeneck, Simone ; Longo, Vitoria Dassoler ; Pagno, Carlos Henrique ; Treichel, Helen ; Camargo, Aline Frumi ; Romani, Larissa Capeletti ; Rodrigues, Eliseu ; Bazoti, Suzana Fatima ; Nerling, Julia Pieper

The gradual concern with promoting sustainability has encouraged the search for new methodologies for obtaining bioproducts.This study, therefore, analyzed the generation of a fungal biocomposite using Trichoderma koningiopsis and biomass of the microalgae Chlorella sp. from swine wastewater, aiming at a product with potential for environmental and agronomic application.The process involved submerged fermentation in an Airlift bioreactor, using microalgal biomass as the substrate and Trichoderma koningiopsis, such as fermentative microorganisms.Afterward, the enzymic activity and stability were evaluated, and the stability was monitored for 90 days at different storage temperatures (20°C, 4°C, and -80°C).The results demonstrated considerable enzymic activity of the biocomposite, mainly for catalase (1274,79μmol/min.mL), peroxidase (52,08 U/mL), and protease (97,50 U/mL), with good stability over time.By analyzing the organic compounds before and after fermentation using UHPLC-ESI-qTOF-MS/MS, the production of metabolites such as tyrosine and leucine which have herbicidal potential, koningins a, b, and d, trichodermin, which are considered antifungal agents and of relevance in the health area, in addition to primary metabolites such as fructose, organic acids, and ethanol, was observedTherefore, through this study, it was possible to highlight the potential of the biocomposite obtained as a matrix of products aimed at the environment and agricultural level through enzymes and metabolites of interest for producing bioinputs and removing contaminants in effluents.

01 Apr 2025·Food Chemistry

Physicochemical characteristics and metabolite composition of fish sauce made from large yellow croaker roe enzymatic hydrolysates based on three fermentation temperatures

Article

Author: Zhong, Rongbin ; Shi, Feifei ; Yang, Qian ; Liang, Peng ; Wu, Hua ; Du, Yanyu ; Zheng, Tingting

Large yellow croaker roes were used to make fish sauce using enzymolysis method, and the impact of different fermentation temperatures (25, 32 and 40 °C) on the physicochemical characteristics and metabolite composition was revealed. Results indicated that compared with 25 and 32 °C, the higher contents of total acidity, amino nitrogen, total soluble nitrogen, and the deepening of the nonenzymatic browning degree of fish sauce fermented at 40 °C were obtained. The total volatile basic nitrogen content at 40 °C was lower than 32 °C. The ideal fermentation temperature should be 40 °C. The metabolomics analysis of fish sauce showed that 40 °C significantly increased the abundance of hippuric acid, 3-hydroxy hippuric acid, hydrocinnamic acid and heptanoic acid compared with other temperatures, but decreased trimethylamine N-oxide, 15-methyl palmitic acid, N6-succinyl adenosine and nicotinamide. These results expand the utilization pathways of low-value fish roes, and provide a promising reference for the manufacturing of high-quality fish sauce.

100 Deals associated with Allopurinol Sodium

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External Link

KEGG	Wiki	ATC	Drug Bank
D07564	Allopurinol Sodium	M04AA01	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Gout	United States	UDL Laboratories	17 May 1996
Hyperuricemia	United States	UDL Laboratories	17 May 1996
Leukemia	United States	Mylan Institutional LLC	17 May 1996
Lymphoma	United States	Mylan Institutional LLC	17 May 1996
Solid tumor	United States	Mylan Institutional LLC	17 May 1996