Shandong Bestcomm Pharmaceutical Co., Ltd.

Main study objectives: To study the pharmacokinetics of the test preparation dapagliflozin metformin extended-release tablets (I) (Specification: 10 mg/1000 mg, provided by Shandong Baino Pharmaceutical Co., Ltd. and produced by Fosun Pharmaceutical (Xuzhou) Co., Ltd.) and the reference preparation dapagliflozin metformin extended-release tablets (I) (Anda-Rel®, Specification: 10 mg/1000 mg, licensed by AstraZeneca AB and produced by AstraZeneca Pharmaceuticals LP) in healthy adult subjects after single oral administration in fasting and fed state, and to evaluate the bioequivalence of the two preparations in fasting and fed state. Secondary study objectives: To evaluate the safety of the test preparation dapagliflozin metformin extended-release tablets (I) (Specification: 10 mg/1000 mg) and the reference preparation dapagliflozin metformin extended-release tablets (I) (Anda-Rel®, Specification: 10 mg/1000 mg) in healthy adult subjects.

Primary objective: To compare the differences in absorption extent and rate between ilaprazole enteric-coated tablets (5 mg) of Shandong Bainuo Pharmaceutical Co., Ltd. and ilaprazole enteric-coated tablets (5 mg, trade name: Yilian) certified by Livzon Pharmaceutical Factory of Livzon Group in healthy adults under fasting and postprandial administration conditions, and to evaluate their bioequivalence. Secondary objective: To evaluate the safety of ilaprazole enteric-coated tablets (5 mg) of Shandong Bainuo Pharmaceutical Co., Ltd. and ilaprazole enteric-coated tablets (5 mg, trade name: Yilian) certified by Livzon Pharmaceutical Factory of Livzon Group in healthy adults under fasting and postprandial administration conditions.

Main purpose To compare the differences in the extent and rate of absorption of Vardenafil Hydrochloride Tablets (20 mg) provided by Shandong Bainuo Pharmaceutical Co., Ltd. and Vardenafil Hydrochloride Tablets (20 mg, trade name: Levitra®) licensed by Bayer AG in healthy adults under fasting and postprandial administration conditions, and to evaluate their bioequivalence. Secondary purpose To evaluate the safety of Vardenafil Hydrochloride Tablets (20 mg) provided by Shandong Bainuo Pharmaceutical Co., Ltd. and Vardenafil Hydrochloride Tablets (20 mg, trade name: Levitra®) licensed by Bayer AG in healthy adults under fasting and postprandial administration conditions.