Shandong Bestcomm Pharmaceutical Co., Ltd.

Main purpose To compare the differences in the extent and rate of absorption of Vardenafil Hydrochloride Tablets (20 mg) provided by Shandong Bainuo Pharmaceutical Co., Ltd. and Vardenafil Hydrochloride Tablets (20 mg, trade name: Levitra®) licensed by Bayer AG in healthy adults under fasting and postprandial administration conditions, and to evaluate their bioequivalence. Secondary purpose To evaluate the safety of Vardenafil Hydrochloride Tablets (20 mg) provided by Shandong Bainuo Pharmaceutical Co., Ltd. and Vardenafil Hydrochloride Tablets (20 mg, trade name: Levitra®) licensed by Bayer AG in healthy adults under fasting and postprandial administration conditions.

The main purpose of the study is to study the pharmacokinetics of the test preparation sildenafil citrate dry suspension (specification: 10 mg/mL, produced by Shandong Langnuo Pharmaceutical Co., Ltd.) and the reference preparation sildenafil citrate dry suspension (Revatio®) (specification: 10 mg/mL, produced by Fareva Amboise) in healthy subjects after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two preparations in the fasting and fed state. Secondary purpose of the study: to evaluate the safety of the test preparation sildenafil citrate dry suspension (specification: 10 mg/mL) and the reference preparation sildenafil citrate dry suspension (Revatio®) (specification: 10 mg/mL) in healthy subjects.

Primary objective: To evaluate the bioavailability of the test and reference preparations in healthy subjects after a single oral administration of the test and reference preparations in fasting and postprandial states, using Etogliflozin Tablets produced by Shandong Langnuo Pharmaceutical Co., Ltd. as the test preparation (T) and Etogliflozin Tablets (trade name: Steglatro®/Jianoto®) produced by Pfizer Manufacturing Deutschland GmbH as the reference preparation (R). Secondary objective: To evaluate the safety of the test and reference preparations in healthy subjects.