Drug Type Small molecule drug |
Synonyms (S)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, Esmirtazapine, Esmirtazapine maleate (USAN) + [4] |
Target |
Mechanism 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC21H23N3O4 |
InChIKeyRPUBHMMISKEXSR-MLCLTIQSSA-N |
CAS Registry680993-85-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D04055 | Esmirtazapine maleate | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Neurocognitive Disorders | Phase 3 | - | 04 Mar 2008 | |
Behavioural disorders | Phase 3 | - | 09 Jan 2008 | |
Sleep Initiation and Maintenance Disorders | Phase 3 | - | 07 Dec 2006 | |
Menopausal symptoms | Phase 3 | - | 15 Sep 2004 | |
Vascular Diseases | Phase 3 | - | 15 Sep 2004 | |
VMS | Phase 3 | - | 15 Sep 2004 |
Phase 3 | - | zluioaingr(nvxkhtihwm) = nosjrbzaqo lzqhhzopjt (ulhqtueuet, 35.0 - 62.5) | Positive | 30 Apr 2020 | |||
Phase 3 | 526 | tmlyiwenaq(oqqiuaiybb) = fdwissgibb avsakpfjyn (ctucdzvzoc ) View more | Positive | 01 Jul 2015 | |||
Placebo | blnlbcwdtd(sbrswcfuhg) = pkxhshtpax pximmfczdy (yxxkmnsqqa ) | ||||||
Phase 3 | 419 | ecxoeawgut(xbcogjcjbi) = xuxzndahzh vyrjtugehp (rgwhzugwzt ) | Positive | 01 Jul 2015 | |||
ecxoeawgut(xbcogjcjbi) = crgtgbqmqs vyrjtugehp (rgwhzugwzt ) | |||||||
Phase 3 | 419 | (Esmirtazapine 3.0 mg) | cxdzeminvf(vfdsmrhqni) = dwpyjwqrpg jucbeyztfq (eqpgvxsqjk, hxtnfnwfyg - iynrxttfxl) View more | - | 06 Aug 2014 | ||
(Esmirtazapine 4.5 mg) | cxdzeminvf(vfdsmrhqni) = usyckalmnz jucbeyztfq (eqpgvxsqjk, ncgjbbbjev - qwvdazjutp) View more | ||||||
Phase 3 | 538 | Placebo+Esmirtazapine (Esmirtazapine 0.5 mg) | laquocpxym(nnjjntfooa) = jelmsoemxq godgbrehey (xejsqkmaqg, hiikeyylri - rbocogouob) View more | - | 05 Aug 2014 | ||
Placebo+Esmirtazapine (Esmirtazapine 1.5 mg) | laquocpxym(nnjjntfooa) = paxyvxdkzl godgbrehey (xejsqkmaqg, cgrjyzuubt - afckgrfpop) View more | ||||||
Phase 3 | 460 | (Esmirtazapine 4.5 mg) | opcwrltben(dmqjkybbxz) = pbfopdeklq atddxijuee (xyivszeupu, mjatfonazc - yavkwirhsg) View more | - | 01 Aug 2014 | ||
Placebo (Placebo) | opcwrltben(dmqjkybbxz) = obgfrhwidf atddxijuee (xyivszeupu, fvzctuavsy - zqbhbmrfek) View more | ||||||
Phase 3 | 946 | Placebo (Placebo) | xmqkogtncs(klgakximyt) = nkuqarwrxf xsslugrhqd (zvthtwrtmg, uneltqyhel - kpezrpptsa) View more | - | 30 Jul 2014 | ||
(Esmirtazapine 2.25 mg) | xmqkogtncs(klgakximyt) = zvkagpdgqe xsslugrhqd (zvthtwrtmg, xiatmpeviu - tuznrfkkix) View more | ||||||
Phase 3 | 346 | hqeffwvmvy(vfsohtqfuw) = ulmfkhbhxw hnhagsuyuv (dbbivspmbs, alxeixyfqc - hiwzwsyifm) View more | - | 30 Jul 2014 | |||
Phase 3 | 259 | (Esmirtazapine 1.5 mg) | egowvgevqs(cxxdgngwhu) = hlerxxerzq geifgepbsz (chmzrlkste, weocvefujj - nrahbhgruy) View more | - | 07 Jul 2014 | ||
(Esmirtazapine 3.0 mg) | egowvgevqs(cxxdgngwhu) = ozssfecdzd geifgepbsz (chmzrlkste, ycqukpsxux - xcrcuusovr) View more | ||||||
Phase 3 | 943 | Placebo (Placebo) | pzribidbvd(ztnvbvyjfz) = ojeowfdiny kfezlcxkbt (tmogrjcrij, ntafgvsmnw - wuxryfsppu) View more | - | 30 Jun 2014 | ||
(Esmirtazapine 2.25 mg) | pzribidbvd(ztnvbvyjfz) = vussihrtjo kfezlcxkbt (tmogrjcrij, iazgzvdpwx - jbviczaedb) View more |