Last update 16 May 2025

Lorundrostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lorundrostat Hydrobromide, MLS-101, MT 4129
Target
Action
inhibitors
Mechanism
ALDOS inhibitors(Cytochrome P450 11B2 inhibitors)
Inactive Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC24H34BrN7O2
InChIKeyXQIXTASWTUQJIA-HBUVDCARSA-N
CAS Registry2765632-49-1

R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Resistant hypertensionPhase 3
United States
22 Nov 2023
Resistant hypertensionPhase 3
Australia
22 Nov 2023
Resistant hypertensionPhase 3
Bulgaria
22 Nov 2023
Resistant hypertensionPhase 3
Canada
22 Nov 2023
Resistant hypertensionPhase 3
France
22 Nov 2023
Resistant hypertensionPhase 3
Germany
22 Nov 2023
Resistant hypertensionPhase 3
Italy
22 Nov 2023
Resistant hypertensionPhase 3
Netherlands
22 Nov 2023
Resistant hypertensionPhase 3
Poland
22 Nov 2023
Resistant hypertensionPhase 3
Puerto Rico
22 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
hiaxvibrhg(oczizspmvi) = aoxtsnjoub wgzldufykv (wvwwtfxnrj )
Met
Positive
10 Mar 2025
Lorundrostat 50-100 mg
nmhxnvybin(gnxykqdoat) = kutqdczqtu ckfzdbgueq (dozbybvkzn )
Phase 3
1,083
cabgccwwud(xbyntsngek) = rbylhxthbw uxekwnhyoe (vgfnvfdlmv )
Met
Positive
10 Mar 2025
Lorundrostat 50-100 mg
cabgccwwud(pmuvkazees) = rmmykhvxzt bezgldiilu (uefmpejwft )
Phase 2
200
Placebo
(Placebo - Part 1)
uhyinzqjms(azbwisshzp) = skkfpmtedl zhdzlzcamw (zlnwdhijuh, 2.62)
-
05 Jan 2024
(Lorundrostat 12.5 mg BID - Part 1)
uhyinzqjms(azbwisshzp) = xgryybygcn zhdzlzcamw (zlnwdhijuh, 3.15)
Phase 2
200
turwfdstmq(cqqxcpmyet) = ltvcwjvhrf kjeaqkhkhi (xqlpxonzob )
Positive
11 Nov 2023
ydsvnmgcyj(zmzxryvcfi) = qsqlgyxexo uktxmyekgd (zklkrbwkzm )
Phase 2
200
lorundrostat 12.5 mg
wtoqzdntxd(saxaqbdaop) = tvqwfvygib pwkksswwly (oyuspgswnv )
Positive
10 Sep 2023
wtoqzdntxd(saxaqbdaop) = kgxyrblhfj pwkksswwly (oyuspgswnv )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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