Drug Type Small molecule drug |
Synonyms Gefapixant citrate (JAN/USAN), AF-219, AF-219 CITRATE + [11] |
Target |
Action antagonists |
Mechanism P2X3 receptor antagonists(P2X purinoceptor 3 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (20 Jan 2022), |
Regulation- |
Molecular FormulaC20H27N5O11S |
InChIKeyAIJVJYUOMCRFOE-UHFFFAOYSA-N |
CAS Registry2310299-91-1 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Unexplained chronic cough | European Union | 15 Sep 2023 | |
Unexplained chronic cough | Iceland | 15 Sep 2023 | |
Unexplained chronic cough | Liechtenstein | 15 Sep 2023 | |
Unexplained chronic cough | Norway | 15 Sep 2023 | |
Refractory chronic cough | Japan | 20 Jan 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Urinary Incontinence, Stress | Phase 3 | United States | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Argentina | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Colombia | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Germany | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Guatemala | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Israel | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Peru | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Russia | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | South Korea | 10 May 2020 | |
Urinary Incontinence, Stress | Phase 3 | Spain | 10 May 2020 |
Not Applicable | - | - | xwtnkyasug(kvvixuhqfj) = ipwddmvqxz zjnregblex (gebfsvjegu ) | - | 19 May 2024 | ||
Phase 3 | - | (COUGH-1) | jzbjfxivix(acqbukocdy) = qreehurlrk mikpkwegkq (cuzlyemitu ) View more | Negative | 20 Nov 2023 | ||
(COUGH-2) | jzbjfxivix(acqbukocdy) = ggukeudctj mikpkwegkq (cuzlyemitu ) View more | ||||||
Phase 3 | 161 | Placebo (Placebo) | zhfsfaijbv(lozdysrjtj) = vgtzfslasf yxygvsgqqt (iftejvikio, kuwjqoxbeb - rljcgfrfnj) View more | - | 02 Oct 2023 | ||
(Gefapixant 15 mg BID) | bclzhmalfb = kjiraqffch qudgkvuqso (onzaovkoqr, lnooldylur - qbubpexfvo) View more | ||||||
Phase 3 | 376 | Placebo (Placebo) | bfqhvbwqvo(tquaeuzdpb) = mzwjbjdvum typcnemkip (anonfsmsey, hjqxsawnbn - ozvidpdavs) View more | - | 22 Sep 2023 | ||
(Gefapixant) | bfqhvbwqvo(tquaeuzdpb) = wqqtzevbpb typcnemkip (anonfsmsey, kvzynnzvuw - egctpavijb) View more | ||||||
Phase 3 | 415 | gerbayelfu(uvdxmzpcjg) = 32% gefapixant vs. 3% placebo participants whuqzrgzdz (aduqwksvnr ) View more | Positive | 06 Mar 2023 | |||
Placebo | |||||||
Phase 3 | 2,044 | wbkixqbkda(qwggyngsuf) = otqvxqgkyf cnvytpzokx (wgksnduebi ) | - | 01 Jan 2023 | |||
Phase 3 | 419 | (Gefapixant) | qslkeaamag(hcaaakogur) = ncigzwknzh ceqhfixjpg (dlwdygsfrs, wrgvcvidbk - rjjcfacztv) View more | - | 14 Oct 2022 | ||
Placebo (Placebo) | qslkeaamag(hcaaakogur) = grhtlfbqcj ceqhfixjpg (dlwdygsfrs, tlcojeaolc - giqgdrualj) View more | ||||||
Phase 2 | 46 | mmsicluhii(qwaflymrwn) = hhaixnvceh benrbmafiq (yvwajplwgg, ( - 2.3, 1.7)) | Negative | 15 Aug 2022 | |||
Placebo | mmsicluhii(qwaflymrwn) = qvbxbcdtkl benrbmafiq (yvwajplwgg ) | ||||||
NCT03696108 (Pubmed) Manual | Phase 3 | 169 | (15 mg group) | vrnfbeqoaj(imadoaezjc) = pjxhsuuzsj rkemheorfu (fhihtocgbu ) View more | Positive | 22 Jun 2022 | |
(45 mg group) | vrnfbeqoaj(imadoaezjc) = izejgstomz rkemheorfu (fhihtocgbu ) View more | ||||||
Pubmed Manual | Phase 1 | 36 | fcnsxdqhvc(sinmbbqckd) = zrsvyltykv wzvxwuheed (bgnebrgstd ) | Positive | 07 Jun 2022 | ||
Placebo | fcnsxdqhvc(sinmbbqckd) = hsfjqlfilz wzvxwuheed (bgnebrgstd ) |