Delving into the Latest Updates on Lysine Acetate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(S)-2,6-diaminohexanoic acid, (S)-lysine, (S)-α,ε-diaminocaproic acid

+ [9]

Target-

Action-

Mechanism

Amino acid replacements

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC8H18N2O4

InChIKeyRRNJROHIFSLGRA-JEDNCBNOSA-N

CAS Registry52315-76-1

View All Structures (2)

The prohibition of antibiotic growth promoters for animal production has created a demand to explore alternative feed additives to replace antibiotics.Monobutyrate has the potential to replace antibiotics.In this study, we investigated the effects of monobutyrate on broiler growth performance, intestinal development, and caecum microbiota.Total 240 1d-old Arbor Acres broilers were randomly divided into five groups.Each group had eight broilers, and the groups were replicated six times.The broilers were fed a basal diet (CK group), a basal diet containing 0.1% acetyl kitasamycin (Anti group), and basal diets containing 0.15‰, 0.30‰, and 0.45‰ monobutyrate (M1, M2 and M3 group) for 42 days.Compared with the CK group, F/G was significantly decreased in broilers in the M3 group (p <0.05).The relative length and weight of the duodenum were significantly higher in the M1, M2, and M3 groups than those in the CK group.Compared with the CK group, the relative ileum length was significantly increased in the M2 and M3 groups (p <0.05).Compared with those of the CK and Anti groups, Rikenellaceae, Alistipes, Sellimonas, and Ruminococcus_2 were enriched in the M3 group (p < 0.05).The results of this study indicated that monobutyrate promotes broiler growth performance, improves intestinal development, and regulates microbiota composition

01 Jul 2025·Separation and Purification Technology

Rational design and experimental evaluation of novel amino acid-based natural deep eutectic solvents for CO2 capture

Author: Chen, Guzhong ; Song, Zhen ; Wang, Jingwen ; Qi, Zhiwen ; Gu, Yuqi ; Qiu, Yuxin ; Cheng, Jie ; Chen, Jiahui

The inherent merits of natural deep eutectic solvents (NADESs) have endowed them as a class of promising solvents in many applications.In this study, amino acid-based DESs are applied as absorbent for CO₂ capture.A systematic method combining solid-liquid equilibrium (SLE) prediction, EHS-impacts (environmental, health, and safety) evaluation of the second components, and exptl. validation is employed to rationally identify promising CO₂ absorbents.The m.p. and fusion enthalpy of pure amino acid components are predicted by a recently proposed machine learning model, while COSMO-RS is used to predict the SLE of all possible combinations.Five key EHS-related properties of the second components are evaluated via the VEGA platform.From above, eight promising binary systems based on L-lysine and L-proline are screened from the initial pool of 2,500 combinations.The SLE, d., and viscosity are exptl. determined and the CO₂ absorption experiments are finally performed, identifying L-proline:nonanoic acid (1:4) as the most promising eutectic absorbent.

01 Jun 2025·Separation and Purification Technology

Lysine-coupled fly ash accelerated CO2 mineralization: Feasibility and reaction mechanism

Author: Zhao, Yongchun ; Wang, Chenglong ; Xiong, Zhuo ; Zhang, Tiantian ; Zhang, Junying ; Jiang, Huayu ; Wang, Yujie

CO2 mineralization using alk. solid waste is a promising technol. for integrated pollution reduction and carbon sequestration.This paper proposed an efficient and environmentally friendly method for lysine-coupled fly ash accelerated CO2 mineralization.And the feasibility of this process was preliminarily explored.The results showed that under mild operating conditions, the promotion of lysine achieved a carbon sequestration capacity of approx. 122.60 g-CO2/kg-FA, with a CO2 mineralization efficiency of 72.84%.Addnl., lysine acted as a crystal form regulator for CaCO3, resulting in vaterite CaCO3 at an appropriate lysine concentrationUsing 13C NMR (NMR), the carbamates, bicarbonates/carbonates, and Lys/protonated Lys at different reaction stages were considered to propose a novel reaction mechanism for the Lys-FA-H2O-CO2 system.It indicates that lysine accelerates key reaction steps in the fly ash carbonation process.Lysine, acting as a proton acceptor and promoting carbamate formation, accelerates the mass transfer of CO2 from the gas phase to the liquid phase.Meanwhile, the presence of lysine enhances the leaching capacity of Ca2+ by three times compared to H2O.

100 Deals associated with Lysine Acetate

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External Link

KEGG	Wiki	ATC	Drug Bank
D02278	Lysine Acetate	B05XB03	DB00123

R&D Status

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05210504 (CTgov)	Phase 1	Diabetes Mellitus, Type 2	23	L-Lysine+Normal Saline	wsajcpuulw(eqtnkdtkec) = ekrqrkebmj cxvwpcbutw (kzndrdamzn, vavcfujagm - meaftyftno) View more	-	05 Jun 2024
ASN2022	Not Applicable	Type 2 diabetes mellitus with established diabetic nephropathy	-	L-lysine chloride	bayettethh(vnekweukqj) = nkxopzlech wwmnfnzxgl (vtqgyixgtq, 197 ± 53)	-	05 Nov 2022
				L-lysine acetate	bayettethh(vnekweukqj) = qfydafsacv wwmnfnzxgl (vtqgyixgtq, 121 ± 6)
SNMMI2015	Not Applicable	-	-	L-Lysine	wydojwlsdi(ampkqxvsbl) = MTA was determined to be 18.6 to 24.2MBq 213Bi-DOTATATE with Lys pre-treatment ribdauyhde (rptlwcbsks ) View more	-	15 May 2015
				Placebo
ASTRO2013	Not Applicable	Stomatitis	-	L-lysine 1000 mg	katcxgaznc(nhroutrltz) = zgxcfqkqvu ujwisyxecu (tqxbmxtxhb, 3.4 - 19.0) View more	-	01 Oct 2013