Delving into the Latest Updates on Lysine Acetate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(S)-2,6-diaminohexanoic acid, (S)-lysine, (S)-α,ε-diaminocaproic acid

+ [9]

Target-

Action-

Mechanism

Amino acid replacements

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC8H18N2O4

InChIKeyRRNJROHIFSLGRA-JEDNCBNOSA-N

CAS Registry52315-76-1

View All Structures (2)

The prohibition of antibiotic growth promoters for animal production has created a demand to explore alternative feed additives to replace antibiotics.Monobutyrate has the potential to replace antibiotics.In this study, we investigated the effects of monobutyrate on broiler growth performance, intestinal development, and caecum microbiota.Total 240 1d-old Arbor Acres broilers were randomly divided into five groups.Each group had eight broilers, and the groups were replicated six times.The broilers were fed a basal diet (CK group), a basal diet containing 0.1% acetyl kitasamycin (Anti group), and basal diets containing 0.15‰, 0.30‰, and 0.45‰ monobutyrate (M1, M2 and M3 group) for 42 days.Compared with the CK group, F/G was significantly decreased in broilers in the M3 group (p <0.05).The relative length and weight of the duodenum were significantly higher in the M1, M2, and M3 groups than those in the CK group.Compared with the CK group, the relative ileum length was significantly increased in the M2 and M3 groups (p <0.05).Compared with those of the CK and Anti groups, Rikenellaceae, Alistipes, Sellimonas, and Ruminococcus_2 were enriched in the M3 group (p < 0.05).The results of this study indicated that monobutyrate promotes broiler growth performance, improves intestinal development, and regulates microbiota composition

01 Dec 2025·Functional & Integrative Genomics

Genomics-assisted stacking of waxy1, opaque2, and crtRB1 genes for enhancing amylopectin in biofortified maize for industrial utilization and nutritional security

Article

Author: Gopinath, Ikkurti ; Zunjare, Rajkumar U ; Hossain, Firoz ; Kasana, Ravindra K ; Chhabra, Rashmi ; Devi, Elangbam L ; Talukder, Zahirul A ; Bhatt, Vinay ; Kumar, Jitender ; Sarika, Konsam ; Mehta, Brijesh K ; Guleria, Satish K ; Mishra, Subhra J ; Muthusamy, Vignesh ; Sarma, Govinda Rai ; Katral, Ashvinkumar

Waxy maize is highly preferred diet in developing countries due to its high amylopectin content. Enriching amylopectin in biofortified maize meets food security and fulfils the demand of rising industrial applications, especially bioethanol. The mutant waxy1 (wx1) gene is responsible for increased amylopectin in maize starch, with a wide range of food and industrial applications. Conventional maize has a modest amount of amylopectin (70-75% of starch), but waxy maize, with favourable wx1 allele, has ~ 95-100% amylopectin. In this study, the wx1 allele was introgressed into the multi-nutrient-rich maize parental inbreds (PMI-PV9 and PMI-PV5) of APQH8, a multi-nutrient rich maize hybrid having high lysine, tryptophan, and provitamin-A nutritionally superior over the traditional hybrids. Gene-specific markers specific for o2 and crtRB1 were employed to select desirable gene segregants from BC₁F₁, BC₂F₁, and BC₂F₂. Background selection was employed with > 90 SSR markers. Selected backcross progenies showed high recovery of recurrent parent genomes (RPG: 94.8-96.8%). The reconstituted waxy hybrids exhibited an increase in amylopectin (mean: 98.4%) compared to the original hybrid (mean: 72.7%). The reconstituted hybrids also recorded enhanced lysine (mean: 0.382%), tryptophan (mean: 0.092%), and provitamin-A (mean: 10.36 ppm), respectively, than normal maize, however similar to the original hybrid with high lysine: 0.330%, tryptophan: 0.079% and provitamin-A: 10.42 ppm. Furthermore, MAS-derived genotypes showed similar agro-morphological traits and grain yield. These biofortified waxy maize hybrids, rich in provitamin-A, lysine, and tryptophan with enhanced amylopectin hold great potential in diverse industrial applications and nutritional security.

01 Dec 2025·Functional & Integrative Genomics

Comparison of the rhizospheric soil bacteriomes of Oryza sativa and Solanum melongena crop cultivars reveals key genes and pathways involved in biosynthesis of ectoine, lysine, and catechol meta-cleavage

Article

Author: Mandal, Shyamapada ; Mandal, Manisha ; Ghosh, Biswajit

Rice (Oryza sativa L.), Poaceae family, forms staple diet of half of world's population, and brinjal (Solanum melongena L.), an important solanaceous crop, are consumed worldwide. Rhizosphere research is gaining importance towards application of knowledge for improving productivity, sustainable agricultural practice, and rhizoremediation for nature restoration. While there are reports on rhizobacteriome of rice, studies comparing structural, functional and metabolomic traits of microbial communities in rhizospheres of rice and brinjal are not yet available. We demonstrated, in Oryza sativa (1144-Hybrid, Dhiren, Local Saran cultivars) and Solanum melongena (Jhiloria, Chandtara, Jotshna cultivars) rhizospheres from Malda, India, using integrated approach of 16 S ribosomal sequencing, shotgun metagenomics, and microbial metabolomics to decipher microbial diversity, association with soil physicochemical characteristics, key genes and pathways. Ectoine biosynthesis was significantly expressed in brinjal (Jhiloria), but not in rice rhizosphere. The dominant brinjal rhizobacteriome-specific bacteria comprised Thermus sp., Petrobacter succinatimandens, Thermoanaerobacter sp., and Diaphorobacter sp., that were involved in house-keeping functions including pentose phosphate pathway, biosynthesis of amino acids, lipopolysaccharide, and photosynthesis. The dominant bacteria unique to rice rhizobacteriome (Local Saran) consisted of Aeromonas sp., associated with catechol meta-cleavage, while Clostridium sp., Faecalibacterium prausnitzii, and Roseburia sp. were involved with lysine biosysnthesis in rice (1144-Hybrid). Our results imply novel information for improved breeding of brinjal specific cultivar with enhanced ectoine production associated with osmotic stress tolerance, rice specific cultivars with enhanced lysine production significant to human nutrition and catechol removal for the maintenance of environmental quality.

100 Deals associated with Lysine Acetate

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External Link

KEGG	Wiki	ATC	Drug Bank
D02278	Lysine Acetate	B05XB03	DB00123

R&D Status

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2022	Not Applicable	Type 2 diabetes mellitus with established diabetic nephropathy	-	L-lysine chloride	xipohegheq(rwtsnksmps) = vckvglpayl llvryqiuve (bnnuixeuwk, 197 ± 53)	-	05 Nov 2022
				L-lysine acetate	xipohegheq(rwtsnksmps) = sclzpralyr llvryqiuve (bnnuixeuwk, 121 ± 6)
SNMMI2015	Not Applicable	-	-	L-Lysine	kclisioxpe(gqoxrwbmwq) = MTA was determined to be 18.6 to 24.2MBq 213Bi-DOTATATE with Lys pre-treatment okguvzlbzg (gddmrfoecp ) View more	-	15 May 2015
				Placebo
ASTRO2013	Not Applicable	Stomatitis	-	L-lysine 1000 mg	dmkwpnggjn(ywfmjraihp) = kdqeanywob sicwffkrqh (nkyuzuhvkv, 3.4 - 19.0) View more	-	01 Oct 2013