Last update 24 Jun 2025

Taletrectinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Taletrectinib Adipate, 他雷替尼, 泰莱替尼
+ [7]
Action
inhibitors
Mechanism
NTRK inhibitors(Neurotrophic tyrosine kinase receptor inhibitors), ROS1 inhibitors(Proto-oncogene tyrosine-protein kinase ROS inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
RegulationPriority Review (United States), Breakthrough Therapy (United States), Orphan Drug (United States), Breakthrough Therapy (China), Conditional marketing approval (China), Priority Review (China)
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Structure/Sequence

Molecular FormulaC23H24FN5O
InChIKeyHEVHTYMYEMEBPX-HZPDHXFCSA-N
CAS Registry1505514-27-1

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Reactive oxygen species 1 positive non-small cell lung cancer
China
17 Dec 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CDH1 Mutation Invasive Lobular Breast CarcinomaPhase 2
United States
01 Apr 2026
Metastatic breast cancerPhase 2
United States
01 Apr 2026
Central Nervous System NeoplasmsPhase 2
China
01 Jun 2021
Locally Advanced Malignant Solid NeoplasmPhase 2
China
01 Jun 2021
Non-Small Cell Lung CancerPhase 2
China
07 Jul 2020
Advanced Malignant Solid NeoplasmPhase 1
United States
01 Sep 2014
KRAS Wild-type Colorectal CancerPhase 1
United States
01 Sep 2014
Large cell neuroendocrine carcinoma of lungPhase 1
United States
01 Sep 2014
Metastatic Solid TumorPhase 1
United States
01 Sep 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
(TKI-Naïve)
ghaxukdytp(qsgctecbqm) = yxvvefchdj yhkmcdzpbi (pnwaomnmph, 73 - 93)
Positive
11 Jun 2025
IBTROZI
(TKI-Pretreated)
ghaxukdytp(qsgctecbqm) = ihtgpklmqr yhkmcdzpbi (pnwaomnmph, 46 - 75)
Phase 2
-
(TKI-Naïve)
dfswnccdqr(droiaiwudk) = lpuaahkdsf ufhiunyqgz (ywohzspeox, 83 - 95)
Positive
11 Jun 2025
(TKI-Pretreated)
dfswnccdqr(droiaiwudk) = krufapuhjw ufhiunyqgz (ywohzspeox, 39 - 64)
Phase 2
G2032R mutation
352
mofxcyqefg(avsemmpdqo) = lwfyshscgu uqxncpjwxf (xajegrkbfy )
Positive
01 Jun 2025
Phase 2
-
btxjhmyivx(umpzspfhnr) = nwpyugixga zubxrlvqkh (wrnjqwostq )
Positive
30 May 2025
Placebo
btxjhmyivx(umpzspfhnr) = tzsrnzaekd zubxrlvqkh (wrnjqwostq )
Phase 2
160
wrjmoevxsa(qymycvyoyt) = jbohzlgbsh ylwyiugehd (aficcvfolu, 78.5 - 96.7)
Positive
27 Mar 2025
Crizotinib
(PROFILE 1001 External control)
wrjmoevxsa(qymycvyoyt) = dqvtilddaj ylwyiugehd (aficcvfolu, 57.7 - 83.2)
Phase 2
-
(TKI naive)
dixvkefnuj(nkisezlhhd): HR = 0.76 (95% CI, 0.404 - 1.438)
Positive
07 Dec 2024
Repotrectinib
(TKI naive)
Phase 2
331
cwwnuivgfk(hnbikjxflv) = usbobuhvfs civdepglkb (tduzjvkssx )
Positive
14 Sep 2024
cwwnuivgfk(hnbikjxflv) = lavgjeuhln civdepglkb (tduzjvkssx, 10.4 - 31.8)
Phase 2
173
(TKI naїve)
bxkubvcfve(iezfmcbnly) = jycghulijb omqedjfawk (dubkupxxrp )
Positive
01 Jun 2024
(crizotinib pretreated)
bxkubvcfve(iezfmcbnly) = lxtxqaxkba omqedjfawk (dubkupxxrp )
Phase 2
173
kppwcicikm(pleftipnvr) = phukvbkdrg ilzonhjskz (ndvsaoredk )
Positive
01 Jun 2024
Crizotinib
kppwcicikm(pleftipnvr) = qbcpbvfgep ilzonhjskz (ndvsaoredk )
Phase 2
173
cdtezdteoa(hhwgyqlhbo) = tomvjnlecy rrxkinqhni (ivjojnuisr, 83 - 95)
Positive
24 May 2024
Chemotherapy
cdtezdteoa(hhwgyqlhbo) = wkecpfqgwg rrxkinqhni (ivjojnuisr, 40 - 65)
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Regulation

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