The aim of the study is to investigate whether patients with moderate-to-severe VKC and keratitis will benefit from the addition of Diquafosol ophthalmic solution in terms of symptoms and signs of VKC, tear film metrics, ocular surface inflammation and quality of life. Potential beneficial effect of Diquafosol treatment on top of current standard use of topical immunosuppressant therapy in VKC would be studied.
Subject at least aged 6 and above with clinical diagnosis of vernal keratoconjunctivitis would be invited to join this study and perform the following assessments:
1. best corrected visual acuity,
2. slit lamp biomicroscope examination,
3. tear meniscus height and non-invasive keratographic tear breakup time(NIKBUT) measurement,
4. cornea fluorescein staining (CFS) and
5. Schirmer's I test. Doctor will prescribe eyedrop, 3% Diquafosol ophthalmic solution and 0.1% Cyclosporin A cationic ophthalmic emulsion or 0.1% Cyclosporin A cationic ophthalmic emulsion at the end of examination. Subjects will be followed up at 4 weeks, 8 weeks, 16 weeks after treatment.
All participants will be required to answer a standardised questionnaire relating to severity of VKC and dry eye disease.

Start Date09 Feb 2026

Sponsor / Collaborator

The University of Hong Kong

KCT0011521

/ Not yet recruitingPhase 4IIT

A multicenter, randomized, active-controlled, comparative clinical trial to evaluate the efficacy and safety of 5% Diquafosol ophthalmic solution in patients with short tear film break-up time(short BUT type) dry eye disease

Start Date02 Feb 2026

Sponsor / Collaborator

Chonnam National University Hospital

100 Clinical Results associated with Diquafosol Sodium

100 Translational Medicine associated with Diquafosol Sodium

100 Patents (Medical) associated with Diquafosol Sodium

248

Literatures (Medical) associated with Diquafosol Sodium

01 Sep 2026·EXPERIMENTAL EYE RESEARCH

The neuro-immune-epithelial axis in dry eye: From pathogenic crosstalk to neuromodulatory therapies

Review

Author: Zhang, Jiehao ; Li, Zhijie

Dry eye disease (DED) is commonly described through tear-film instability, tear deficiency, evaporative stress, and ocular surface inflammation. These models remain central to diagnosis and treatment, but they do not fully explain symptom-sign discordance, persistent discomfort after surface-directed therapy, epithelial disease with reduced corneal sensation, or variable treatment responses. In this structured narrative review, we synthesize DED-specific, phenotype-specific, adjacent ocular surface, and translational evidence relevant to a bidirectional neuro-immune-epithelial axis involving corneal sensory nerves, trigeminal-parasympathetic reflexes, epithelial and goblet-cell barrier function, and immune-cell activation. Available sensory evidence indicates that corneal sensory abnormalities in DED are heterogeneous: mechanical esthesiometry more often shows reduced sensitivity, whereas non-contact esthesiometry and pain-enriched cohorts may show hypersensitivity or mixed findings. In vivo confocal microscopy (IVCM) studies suggest concurrent changes in corneal nerve morphology and epithelial immune-cell density, but validated thresholds are not sufficient to define a routine neural DED subtype. Neural dysfunction is therefore considered a phenotype-dependent contributor or amplifier, rather than a universal nerve-first mechanism. Treatment implications are discussed according to evidence strength and directness. Varenicline nasal spray and acoltremon engage reflex or sensory tear pathways where approved; motugivatrep illustrates region-specific TRPV1 translation in Japan; diquafosol and rebamipide are epithelial/mucin-supportive therapies with indirect axis relevance; and cenegermin remains primarily a neurotrophic keratitis therapy with restricted relevance to selected DED phenotypes. Neuropeptide-specific targets, availability-limited device stimulation, and direct nerve-regenerative claims for photobiomodulation remain preliminary. This framework may support mechanism-based stratification and rational adjunctive therapy without replacing established DED classifications.

01 Aug 2026·JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Efficacy of Topical Cyclosporine Versus Topical Diquafosol in Treating Dry Eye Disease: A Systematic Review and Meta-Analysis

Review

Author: Chen, Kai-Yang ; Chan, Chi-Ming ; Chang, Hua-Ching

Purpose::

This study compared the clinical efficacy of cyclosporine A (CsA) and diquafosol (DQS) in improving outcomes for patients with dry eye disease (DED).

Methods::

We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for studies published before July 13, 2025. Eligible studies included randomized controlled trials (RCTs) and non-RCTs comparing the clinical efficacy of CsA and DQS in treating DED. The primary outcomes were changes in subjective and objective ocular examination results for DED. A random-effects model was used for meta-analysis.

Results::

We included nine studies in the systematic review and finally included six studies (three RCTs and three non-RCTs) in the meta-analysis. These studies analyzed 724 patients, with 367 receiving CsA and 357 receiving DQS. Pooled results revealed no significant differences in improvement of corneal staining scores, conjunctival staining scores, and tear break-up time between the two treatment groups. Subgroup analyses stratified by 1- and 3-month follow-up periods yielded consistent results. However, CsA treatment demonstrated a borderline significant improvement in the Schirmer test ( P = 0.046) compared with DQS, whereas DQS treatment yielded greater improvement in the Ocular Surface Disease Index compared with CsA (mean difference = 3.413; 95% CI = 0.700–6.126; P = 0.014).

Conclusion::

This study revealed that CsA and DQS did not differ significantly in their efficacy in improving most objective clinical indices for DED over 1–3 months of treatment. However, DQS demonstrated greater improvement in subjective patient-reported outcomes. Future RCTs should explore the long-term efficacy of these treatments.

01 Jul 2026·JOURNAL OF AAPOS

Efficacy of diquafosol 3% in preventing and treating dry eye associated with pediatric orthokeratology

Article

Author: Hou, Wenbin ; Fan, Xinyi ; Li, Yingli ; Gao, Na ; Ying, Peixi ; Zhou, Lili

PURPOSE:

To evaluate the efficacy of diquafosol 3% in preventing and treating dry eye associated with orthokeratology in children.

METHODS:

First-time pediatric orthokeratology wearers were enrolled in this prospective, randomized clinical trial. Participants were randomized into the treatment group (3% diquafosol sodium four times daily from the prefitting period) and control group (no additional treatment). Noninvasive tear film parameters (first break-up time [NIBUT], average NIBUT, tear meniscus height, and lipid layer thickness), corneal staining grade, uncorrected visual acuity (UCVA), and Ocular Surface Disease Index (OSDI) were compared at baseline, before lens wear, and at 1 week, 1 month, and 3 months.

RESULTS:

A total of 64 children (128 eyes) completed the study. During the prefitting period, all tear film parameters improved significantly in the treatment group (all P < 0.001). At 3 months, the treatment group demonstrated significantly higher first NIBUT, average NIBUT, tear meniscus height, and lipid layer thickness (all P < 0.001), with lower OSDI scores (P < 0.05) and higher UCVA (P < 0.001). Corneal staining was significantly lower in the treatment group at 1 week (P < 0.05) but not at 1 or 3 months. Mild adverse events included transient discharge (3 children, treatment group) and conjunctival congestion (5 eyes, control group). There were no serious adverse events.

CONCLUSIONS:

Prophylactic and therapeutic use of diquafosol 3% improved tear film stability, tear secretion, and dry eye symptoms in children undergoing orthokeratology. Early initiation during the prefitting period may establish a more favorable ocular surface before lens wear.

News (Medical) associated with Diquafosol Sodium

23 May 2023

·www.prnewswire.com

DelveInsight Evaluates a Robust Dry Eye Disease Clinical Trial Pipeline as 60+ Influential Pharma Players to Set Foot in the Domain

The prevalence of dry eye disease has been rising over the past few years, which prompts the growing demand for treatment options. The increasing prevalence of dry eye disease and the growing research and development activities to develop novel therapies to treat dry eye disease to drive the market. The companies developing the potential therapies in the last stage of development include Aldeyra Therapeutics, RegeneRx Biopharmaceuticals, Mitotech, and several others. LAS VEGAS, May 23, 2023 /PRNewswire/ -- DelveInsight's ' Dry Eye Disease Pipeline Insight – 2023 ' report provides comprehensive global coverage of pipeline dry eye disease therapies in various stages of clinical development, major pharmaceutical companies working to advance the pipeline space, and the future growth potential of the dry eye disease pipeline domain. Key Takeaways from the Dry Eye Disease Pipeline Report DelveInsight's dry eye disease pipeline report depicts a robust space with 50+ active players working to develop 60+ pipeline therapies for dry eye disease treatment. Key dry eye disease companies such as TearSolutions, Novaliq, HanAll Biopharma, Aldeyra Therapeutics, RegeneRx Biopharmaceuticals, Mitotech, Aerie Pharmaceuticals, Azura Ophthalmics, Stuart Therapeutics, Surface Ophthalmics, Glaukos Corporation, BRIM Biotechnology Inc., Dompé Farmaceutici S.p.A, Okyo Pharma Ltd, AxeroVision, Inc., Palatin Technologies, Seikagaku Corporation, Invirsa, Inc., Allysta Pharmaceutical, Taejoon Pharmaceutical Co., Ltd., Ocular Therapeutix, Inc., Dreamhawk Vision Biotech, Inc., Yuyu Pharma, Inc., Novartis Pharmaceuticals, VivaVision Biotech, Inc, Huons Co., Ltd., and others are evaluating new dry eye disease drugs to improve the treatment landscape. Promising dry eye disease pipeline therapies in various stages of development include Reproxalap, Timbetasin, Visomitin, HL036, CyclASol, Lacripep, AR15512, AZR MD 001, ST-100, SURF-100, SURF-200, GLK-301, BRM421, Oxervate, OK-101, AXR 159, AXR 270, PL9643, SI-614, INV-102, ALY688, TJO-083, OTX-CSI, OTX-DED, SHJ002, YP-P10, ECF843, VVN001, HU007 and others. In March 2023, Selagine, Inc., a spin-out company from the University of Illinois at Chicago (UIC), announced that it has entered into a research, development, and sublicense agreement with Grifols (Nasdaq: GRFS), a global leader in plasma-derived medicines, for the development and commercialization of immunoglobulin eye drops for dry eye disease.Under the agreement, Selagine will receive an upfront payment and annual collaboration fee. In addition, Grifols has committed to fund the development of immunoglobulin eye drops through FDA approval, which will be managed collaboratively by Grifols and Selagine, including the clinical, manufacturing and regulatory activities required for FDA approval for dry eye disease indication. In February 2023, Aldeyra Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for topical ocular reproxalap, a first-in-class investigational new drug candidate, for the treatment of the signs and symptoms of dry eye disease. The FDA assigned a Prescription Drug User Fee Act (PDUFA) date of November 23, 2023. The FDA noted that no potential filing review issues have been identified, and that an advisory committee meeting is not currently planned. In February 2023, Novaliq, announced its plans for filing a Marketing Authorisation Application (MAA) for CyclASol® (ciclosporin ophthalmic solution), a first-of-its-kind anti-inflammatory product for the treatment of dry eye disease (DED) in the European Union. The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) determined that CyclASol® is eligible to be reviewed in a centralized procedure to receive a Union Marketing Authorisation for the European Economic Area (EEA). In January 2023, Bausch + Lomb Corporation and Novaliq GmbH, announced that Ophthalmology, the peer-reviewed journal of the American Academy of Ophthalmology, has published results from the pivotal Phase 3 trial GOBI, which is one of two pivotal Phase 3 trials for NOV03 (perfluorohexyloctane). NOV03 is being investigated to treat the signs and symptoms of dry eye disease (DED) associated with Meibomian gland dysfunction (MGD).In the study, NOV03 was well tolerated with few subjects experiencing ocular adverse events (AEs) (9.6% NOV03 group, 7.5% control group) or treatment-related ocular AEs (6.3% NOV03 group, 3.1% control group). In August 2022, Alcon and Aerie Pharmaceuticals, Inc. announced the companies have entered into a definitive merger agreement through which Alcon acquired Aerie. The transaction affirmed Alcon's commitment to the ophthalmic pharmaceutical space and is expected to add broader pharmaceutical R&D capabilities to Alcon's existing commercial expertise, maximizing the value of its diversified portfolio. Through the transaction, Alcon added the commercial products Rocklatan® (netarsudil and latanoprost ophthalmic solution) 0.02%/0.005% and Rhopressa® (netarsudil ophthalmic solution) 0.02%, as well as AR-15512, a Phase 3 product candidate for dry eye disease, and a pipeline of several clinical and preclinical ophthalmic pharmaceutical product candidates. In May 2022, Yuyu Pharmaceutical presented a poster study for YP-P10, its new dry eye syndrome treatment, during the 2022 ARVO (Association for Research in Vision and Ophthalmology) conference. YP-P10 is a new biopharmaceutical using synthetic peptides, aiming to relieve signs and symptoms of dry eye syndrome caused by inflammation by administering the treatment twice a day. According to preclinical trial results unveiled at the conference, Yuyu confirmed that the candidate had an excellent anti-inflammatory mechanism and corneal epithelial cell healing effect compared to existing drugs. Request a sample and discover the recent advances in dry eye disease drug treatment @ Dry Eye Disease Pipeline Report The dry eye disease pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage dry eye disease drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the dry eye disease clinical trial landscape. Dry Eye Disease Overview Dry eye disease is characterized as a multifactorial disease of the tears and ocular surface that causes symptoms such as pain, visual disruption, and tear film instability, as well as potential ocular surface damage. It is accompanied by increased tear osmolarity and transient ocular surface irritation. When tear production and drainage are out of balance, dry eyes can result. People with dry eyes either do not produce enough tears or have poor-quality tears. Dry eyes can occur for various reasons, including age, gender, drugs, and medical disorders. Dry eye disease symptoms include redness, stinging, itching, or burning sensations, light sensitivity, watery eyes, stringy mucus near the eye, and blurred vision. A thorough eye examination can detect dry eyes. Dry eye disease treatments seek to restore or maintain the usual number of tears in the eye in order to reduce dryness and associated discomfort and to maintain eye health. The basic approaches used to manage and treat dry eyes include adding tears with over-the-counter artificial tear solutions, conserving tears, boosting tear production, and treating the inflammation of the eyelids or eye surface that contributes to dry eyes. Find out more about drugs for dry eye disease @ New Dry Eye Disease Drugs A snapshot of the Dry Eye Disease Pipeline Drugs mentioned in the report: Learn more about the emerging dry eye disease pipeline therapies @ Dry Eye Disease Clinical Trials Dry Eye Disease Therapeutics Assessment The dry eye disease pipeline report proffers an integral view of dry eye disease emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Dry Eye Disease Pipeline Report Coverage: Global Dry Eye Disease Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Dry Eye Disease Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Dry Eye Disease Therapeutics Assessment By Route of Administration: Intra-articular, Intraocular, Intrathecal, Intravenous, Ophthalmic, Oral, Parenteral, Subcutaneous, Topical, Transdermal Dry Eye Disease Therapeutics Assessment By Molecule Type: Oligonucleotide, Peptide, Small molecule Dry Eye Disease Therapeutics Assessment By Mechanism of Action: Malondialdehyde inhibitors, Actin modulators, Amyloid inhibitors, Angiogenesis inducing agents, Apoptosis inhibitors, Cell movement activators, Collagen stimulants, Heat-shock protein modulators, MicroRNA modulators, Nerve growth factor stimulants, NF-kappa B inhibitors, Stem cell stimulants, Antioxidants, Electron transport chain complex protein modulators, Lipid modulators, Tumour necrosis factor alpha inhibitors, Eye protein modulators, TRPM8 protein stimulants, Glucocorticoid receptor agonists, Inosine monophosphate dehydrogenase inhibitors, Muscarinic receptor agonists Key Dry Eye Disease Companies: TearSolutions, Novaliq, HanAll Biopharma, Aldeyra Therapeutics, RegeneRx Biopharmaceuticals, Mitotech, Aerie Pharmaceuticals, Azura Ophthalmics, Stuart Therapeutics, Surface Ophthalmics, Glaukos Corporation, BRIM Biotechnology Inc., Dompé Farmaceutici S.p.A, Okyo Pharma Ltd, AxeroVision, Inc., Palatin Technologies, Seikagaku Corporation, Invirsa, Inc., Allysta Pharmaceutical, Taejoon Pharmaceutical Co., Ltd., Ocular Therapeutix, Inc., Dreamhawk Vision Biotech, Inc., Yuyu Pharma, Inc., Novartis Pharmaceuticals, VivaVision Biotech, Inc, Huons Co., Ltd., and others. Key Dry Eye Disease Pipeline Therapies: Reproxalap, Timbetasin, Visomitin, HL036, CyclASol, Lacripep, AR15512, AZR MD 001, ST-100, SURF-100, SURF-200, GLK-301, BRM421, Oxervate, OK-101, AXR 159, AXR 270, PL9643, SI-614, INV-102, ALY688, TJO-083, OTX-CSI, OTX-DED, SHJ002, YP-P10, ECF843, VVN001, HU007, and others. Dive deep into rich insights for new drugs for dry eye disease treatment; visit @ Dry Eye Disease Medications Table of Contents For further information on the dry eye disease pipeline therapeutics, reach out @ Dry Eye Disease Drug Treatment Related Reports Dry Eye Disease Market Dry Eye Disease Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key dry eye disease companies, including Oyster Point Pharma, Aerie Pharmaceuticals, Azura Ophthalmics, Stuart Therapeutics, Surface Ophthalmics, Glaukos Corporation, among others. Dry Eye Disease Epidemiology Forecast Dry Eye Disease Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and dry eye disease epidemiology trends. Mild Dry Eye Market Mild Dry Eye Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key mild dry eye companies, including Allergan Plc., Novartis AG., Otsuka Pharmaceutical Co. Ltd., Santen Pharmaceutical Co. Ltd., among others. Moderate Dry Eye Market Moderate Dry Eye Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key moderate dry eye companies, including Santen Pharmaceutical Co. Ltd., OASIS Medical, Alcon Inc., Bausch Health Companies Inc., AbbVie Inc., among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur [email protected] +1(919)321-6187 Logo: SOURCE DelveInsight Business Research, LLP

Phase 3Clinical ResultAcquisition

27 Apr 2023

·www.biospace.com

Yuyu Pharma, Dry Eye Pipeline Mechanism of Action and Pre-clinical Results Published

SEOUL, South Korea, April 27, 2023 /PRNewswire/ -- At ARVO 2023, Yuyu Pharma unveiled the results of its mechanism of action and head-to- head studies for its dry eye treatment peptide (project name: YP-P10). ARVO is the world's largest ophthalmic society and held its annual meeting in New Orleans, Louisiana, USA in April of this year. A study conducted by Dr. Virginia Calder of the University College London (UCL) found that YP-P10 significantly reduces inflammatory Th2 and Th17 cells. In particular, the YP-P10 model reduced Th17 cells 25% more effectively when compared to the control group. The YP-P10 pre-clinical head-to-head study, jointly conducted by five people including Dr. Kyungho Park of Naason Science, showed statistically significant reduction of corneal damage by measuring Corneal Fluorescein Staining (CFS). The study compared the efficacy of YP-P10 to that of several competing dry eye treatment products such as Lifitegrast, Cyclosporine, Diquafosol, and Hyaluronic Acid. The results showed that YP-P10 had 12% better efficacy than Lifitegrast, 7% better than Cyclosporine, 9 % better than Hyaluronic Acid, and showed similar efficacy to Diquafosol. Yuyu Pharma's Director of Business Development, Laxmikant Neil Gharat said, "Through this ARVO presentation, ophthalmologists and global pharmaceutical companies have once again confirmed their interest in YP-P10. We plan to announce the results of YP-P10's phase 2 clinical trial in the first half of this year." Yuyu Pharma anticipates that YP-P10 will be an effective treatment and has completed patent registration in 4 countries (USA, Korea, Australia, Russia) with patent applications pending in 11 other countries. About YP-P10 Ophthalmic Solution YP-P10 is a novel, patented, synthetic peptide with anti-inflammatory properties being explored for the potential treatment of dry eye disease (DED). In April 2022, Yuyu received clearance from the U.S. Food & Drug Administration (FDA) that enabled the company to initiate the phase 2 clinical study, ICECAP, to evaluate the safety, tolerability and efficacy of YP-P10 Ophthalmic Solution in patients with DED. ICECAP is Yuyu's first biopharmaceutical clinical trial within the United States. About Yuyu Pharma With over 80 years in the healthcare industry, Yuyu Pharma (KRX: 000220) is a rapidly scaling global pharmaceutical company founded in Seoul, South Korea. Yuyu is committed to developing innovative therapeutics in the areas of neurology, dermatology, urology, and ophthalmology. For additional information about Yuyu Pharma and YP-P10, please visit YuyupharmaUS.com. Media contact: Sean Yoon, hjyoon@yuyu.co.kr View original content to download multimedia: SOURCE Yuyu Pharma Company Codes: Korea:000220

Clinical ResultPhase 2Phase 1

21 Jun 2022

·www.biospace.com

Opus Genetics Appoints Ben Yerxa, Ph.D., as Permanent Chief Executive Officer

Industry veteran and experienced CEO will continue to lead the company as its AAV-based gene therapies for inherited retinal diseases approach the clinic RESEARCH TRIANGLE PARK, N.C., June 21, 2022 (GLOBE NEWSWIRE) -- Opus Genetics, a patient-first gene therapy company developing treatments for inherited retinal diseases, today announced the appointment of Ben Yerxa, Ph.D., as Chief Executive Officer (CEO). Dr. Yerxa previously served as acting CEO of Opus, in addition to former roles as CEO of the Foundation Fighting Blindness and the Retinal Degeneration (RD) Fund, the venture arm of the Foundation focused on making venture philanthropy investments to further the Foundation’s mission of accelerating research for preventing, treating and curing blinding diseases. Opus is the first spin-off company internally conceived and launched by the RD Fund, and combines unparalleled insight and commitment to patient need with wholly owned AAV-based gene therapy programs in inherited retinal diseases, while creating novel manufacturing scale and efficiencies tailored for producing rare disease therapeutics. “I’m exceptionally proud of the progress we’ve made toward our mission during my nearly five years at the Foundation, including the launch of the RD Fund to further the Foundation’s mission through venture philanthropy,” said Dr. Yerxa. “Stepping into the permanent CEO role at Opus Genetics – a company that we created and launched through the RD Fund – enables me to be on the front line of bringing potentially life-changing treatments to the patients who so urgently need them.” Dr. Yerxa continued, “More than 280 genes are known to cause inherited retinal diseases, and it’s estimated that over 180,000 patients are waiting for treatments for their individual genetic conditions. Opus is combining the best instruments of science with patient need to grow and advance our pipeline of AAV-based gene therapies for inherited retinal diseases, and I’m pleased to continue leading the Opus team in this important work.” Dr. Yerxa has more than 25 years’ experience in biotechnology, nonprofit and drug development and in translating promising research discoveries into clinical milestones and commercial launches in the ophthalmology, pulmonary, rare disease, cardiovascular and HIV fields. He has been involved with the discovery and development of nine investigational new drugs, four Phase 3 clinical programs, two new drug applications and two drug approvals. Prior to joining the Foundation, Dr. Yerxa served as president and co-founder of Envisia Therapeutics, a company focused on developing novel ocular sustained delivery therapies for the front and back of the eye. He also has previously held founding and executive positions in several ophthalmology-based R&D organizations, including Liquidia Technologies, Clearside Biomedical, Parion Sciences and Inspire Pharmaceuticals. “Opus is entering a pivotal time in its evolution as our first program, OPGx-001 to address mutations in the LCA5 gene, is expected to enter the clinic this year, bringing a potential treatment another step closer to patients in need,” said Jean Bennett, M.D., Ph.D., Opus scientific founder, board director and scientific advisory board member. “As a founder of the RD Fund and Opus, Ben is uniquely well-suited to realize Opus’ potential to tackle some of the most neglected forms of inherited blindness and make a real difference in the lives of patients.” Dr. Yerxa holds 60 U.S. patents and is an inventor of DIQUAS™, an innovative treatment for dry eye approved in Japan. Dr. Yerxa earned his Ph.D. in organic chemistry from University of California, Irvine, and BA in chemistry from the University of California, San Diego. About Opus Genetics Opus Genetics is a groundbreaking gene therapy company for inherited retinal diseases with a unique model and purpose. Backed by Foundation Fighting Blindness’s venture arm, the RD Fund, Opus combines unparalleled insight and commitment to patient need with wholly owned programs in numerous orphan retinal diseases. Its AAV-based gene therapy portfolio tackles some of the most neglected forms of inherited blindness while creating novel orphan manufacturing scale and efficiencies. Based in Research Triangle Park, N.C., the company leverages knowledge of the best science and the expertise of pioneers in ocular gene therapy to transparently drive transformative treatments to patients. For more information, visit . Media Contact: Heather Anderson 6 Degrees 919-827-5539 handerson@6degreespr.com

Gene Therapy

100 Deals associated with Diquafosol Sodium

External Link

KEGG	Wiki	ATC	Drug Bank
D03864	Diquafosol Sodium	S02AA	DB15919

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Dry Eye Syndromes	South Korea	Santen Pharmaceutical Co., Ltd.	30 Dec 2011
Xerophthalmia	Japan	Santen Pharmaceutical Co., Ltd.	16 Apr 2010

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Kerato conjunctivitis sicca	Phase 3	-	Merck Sharp & Dohme Corp.	01 Apr 2002
Cataract	Phase 2	Indonesia	Santen Pharmaceutical Co., Ltd.	02 Oct 2022
Bronchitis	Phase 2	United States	-	-
Corneal Ulcer	Phase 2	United States	-	-
Cystic Fibrosis	Phase 1	United States	-	-
Cystic Fibrosis	Phase 1	United Kingdom	-	-
Pulmonary Disease, Chronic Obstructive	Phase 1	United States	-	-
Pulmonary Disease, Chronic Obstructive	Phase 1	United Kingdom	-	-

Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05682547 (Pubmed \| Ophthalmol Ther)	Not Applicable	Dry Eye Syndromes \| Diabetes Mellitus	198	3% Diquafosol Ophthalmic Solution	baddwcmqiw(avyhunkjuo) = kzmhitcmlf ghkzngdupd (lhdwxpwtla, 0.88) View more	Positive	01 Oct 2025
				0.1% Hyaluronic Acid	baddwcmqiw(avyhunkjuo) = okrnzymvcj ghkzngdupd (lhdwxpwtla, 1.35) View more
NCT06146881 (ThIRST DED, ARVO2024)	Phase 2	Xerophthalmia	70	地夸磷索	taqexxulfh(orhshrolwo) = uaeaujnzqr qklvvflida (lzjpkwcsyk ) View more	Positive	07 May 2024
				玻璃酸钠	taqexxulfh(orhshrolwo) = gwqfpxnbeq qklvvflida (lzjpkwcsyk ) View more
NCT05193331 (Pubmed \| J Ocul Pharmacol Ther)	Not Applicable	Dry Eye Syndromes Matrix metalloproteinase-9 (MMP-9)	-	3% Diquafosol Sodium ophthalmic solution	rokfvbhgat(tbarcqisfi) = uartttxlxx uwujwzqtmo (ewmipwcuwg ) View more	Positive	13 Dec 2023
NCT04980144 (Pubmed \| J Ocul Pharmacol Ther)	Not Applicable	Xerophthalmia \| Diabetes Mellitus, Type 2	30	Diquafosol ophthalmic solution	kikfoumhpq(lwzgsfaddu) = ilcrokyuxp ruihveeiji (gbvnpqacvj ) View more	Positive	19 Jan 2022
				Hyaluronate	kikfoumhpq(lwzgsfaddu) = dmfbsceagn ruihveeiji (gbvnpqacvj ) View more
NCT04980144 \| NCT05193331 \| NCT05682547 (Pubmed \| Clin Ophthalmol)	Not Applicable	Dry Eye Syndromes \| Meibomian Gland Dysfunction	-	Topical 3% diquafosol sodium	ytsbqoosci(trufeusrdj) = mfnqyiaeck trrtbyyobm (esixexrksw )	-	01 Jan 2017
NCT02608489 (CTgov)	Not Applicable	Dry Eye Syndromes	86	Diquas (Diqufosol)	xlidanufgl(ndxfhxghhf) = enkfnhuhcg xgjqptbwzh (kipdracflp, 3.86) View more	-	17 Oct 2016
				Sodium Hyaluronate (Hyaluronate)	xlidanufgl(ndxfhxghhf) = wiafdsxace xgjqptbwzh (kipdracflp, 2.66) View more
NCT01101984 (Pubmed \| Br J Ophthalmol) Manual	Not Applicable	Dry Eye Syndromes	497	diquafosol ophthalmic solution	kadujjozgz(ibkcdgrsyt) = qfomqpqkzn bdmikutcxx (ewhdgzmiat, 1.5) View more	Positive	01 Jul 2015
				sodium hyaluronate ophthalmic solution	xjgrhpfpzw(hjgilxlrng) = tdcrfekbcp ceamqlwego (qffetuuomp ) View more
NCT01240382 (CTgov)	Phase 3	Dry Eye Syndromes	332	3% DE-089 ophthalmic solution (3% DE-089)	sxlsyfllvv(ttuzvgvkqd) = xccjfhyvdd yvbwydlcxt (wscnivorch, 1.66) View more	-	08 Aug 2014
				0.1% sodium hyaluronate ophthalmic solution (0.1% HA)	sxlsyfllvv(ttuzvgvkqd) = mghwxmppqs yvbwydlcxt (wscnivorch, 1.52) View more
NCT01189032 (CTgov)	Phase 2	Dry Eye Syndromes	320	Placebo ophthalmic solution (Placebo)	btswjyuuxf(mxavqbjsni) = pcwvadzkdy tijwmnyxut (tzmvtiirsj, 1.33) View more	-	08 Aug 2014
				DE-089 (Low Concentration)	btswjyuuxf(mxavqbjsni) = rfqkfuhcey tijwmnyxut (tzmvtiirsj, 1.43) View more
NCT00404131 \| NCT00403715 \| NCT00403975 (ARVO2007)	Phase 3	Dry Eye Syndromes	-	Diquafosol	qvhdpnsbtg(pkfxaxgxum) = dekjvwwhhp dxtmakciaq (imelrouizf ) View more	Positive	01 May 2007

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Clinical Trial

Identify the latest clinical trials across global registries.

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Approval

Accelerate your research with the latest regulatory approval information.

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Regulation

Understand key drug designations in just a few clicks with Synapse.

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Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis