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Q3: continued sales and earnings progress Paris, October 24, 2025 Q3 sales growth of 7.0% at CER1 and business earnings per share (EPS)2 of €2.91 Pharma launches increased sales by 57.1%, reaching €1.0 billion, driven by ALTUVIIIO and Ayvakit Dupixent sales increased by 26.2% to €4.2 billion, first time above €4 billion in a quarter Vaccines sales decreased by 7.8% to €3.4 billion, from lower influenza sales Research and Development expenses were €1.8 billion, an increase of 4.9% Selling, general and administrative expenses were €2.3 billion, up 7.1% to support launches Business EPS was €2.91, up 13.2% at CER and 7.0% at actual exchange rates, delivering profitable growth; IFRS EPS was €2.30 Pipeline progress Two regulatory approvals: Wayrilz (US) in ITP, a rare disease, and Tzield (China) for delaying onset of stage 3, type 1 diabetes Two positive phase 3 readouts: amlitelimab’s first phase 3 study in atopic dermatitis and Fluzone HD in influenza 50+ years Eight regulatory submission acceptances, three phase 3 study starts, and three regulatory designations (fast track, orphan) Capital allocation Completion of the Vigil Neuroscience acquisition, adding to the early-stage pipeline Additional commitment of $625 million to Sanofi Ventures, investing in innovative biotech and digital health companies Sanofi intends to complete its €5 billion share buyback program in 2025. 86.1% has been executed to date Sustainability Global Health Unit: one million patients have now received treatments for non-communicable diseases since 2021 Insulins Valyou Savings Program: improving access to reliable and affordable supply of critical medicines in the US Guidance unchanged In 2025, sales are anticipated to grow by a high single-digit percentage at CER. Sanofi confirms the expectation of a strong business EPS rebound with growth at a low double-digit percentage at CER (before share buyback)3 Paul Hudson, Chief Executive Officer: “We continued executing on our strategy and the growth momentum continued in Q3 with sales up by 7.0% over a high base of comparison last year. Newly launched medicines and vaccines grew by 40.8%. Dupixent grew by 26.2% and exceeded for the first time both four billion euros in quarterly global sales and three billion euros in the US, despite an unfavorable currency impact. As expected, our flu vaccines business declined because of increased price competition and lower vaccination rate. Business EPS increased by 13.2%, supported by disciplined spending, R&D prioritization, and operational efficiency. After three quarters of profitable growth, we reiterate our 2025 guidance. Our strategic focus on science, patients, and pipeline delivered important milestones in the quarter, including positive phase 3 data for amlitelimab in atopic dermatitis with all primary and key secondary endpoints met, increasing efficacy over time, and a patient-friendly quarterly dosing. We obtained two regulatory approvals: Wayrilz in the US for the rare disease immune thrombocytopenia and Tzield in China to delay the onset of stage 3, type 1 diabetes. We submitted eight regulatory applications, initiated three new phase 3 studies, and received three new regulatory designations. The acquisition of Vigil Neuroscience closed in August, and we will complete our share buyback program by the end of the year. Sanofi will strategically deploy capital towards growth and differentiated science with expected attractive financial returns. As we are looking forward to 2026, we are confident in our ability to pursue our current trajectory of profitable growth.” Q3 2025 Change Change at CER YTD 2025 Change Change at CER IFRS net sales reported €12,434m +2.3% +7.0% €32,323m +5.9% +8.7% IFRS net income reported €2,802m -0.5% — €8,614m +70.2% — IFRS EPS reported €2.30 +2.2% — €7.04 +73.8% — Free cash flow4 €2,994m -6.1% — €5,452m +50.8% — Business operating income €4,445m +2.7% +8.5 % €9,808m +5.9% +9.7% Business net income €3,547m +4.0% +9.8 % €7,699m +5.9% +9.8% Business EPS €2.91 +7.0% +13.2% €6.30 +8.4% +12.4% 1 Changes in net sales are at constant exchange rates (CER) unless stated otherwise (definition in Appendix 9). 2 To facilitate an understanding of operational performance, Sanofi comments on the business net income, a non-IFRS financial measure (definition in Appendix 9). The income statement is in Appendix 3 and a reconciliation of net income as reported under IFRS to business net income is in Appendix 4. 3 Applying October 2025 average currency exchange rates, the currency impacts are estimated at c.-4% on sales and at c.-6% on business EPS. 4 Free cash flow is a non-IFRS financial measure (definition in Appendix 9). Attachment Press release

Sanofi on Friday reported a sharp decline in quarterly vaccine sales, a development the French company partially tied to lower immunization rates in the U.S.In its latest earnings report, Sanofi said that its overall vaccine sales fell by 7.8% to 3.4 billion, or $3.9 billion, between July and September. The pullback was largely driven by a slowdown in influenza shots, which, combined with the revenue Sanofi derives from Novavaxs COVID-19 vaccine Nuvaxovid, decreased by 16.8%, to 1.5 billion. Sanofis COVID-19 and influenza vaccine sales are down a total of 14% this year, the company said.In prepared remarks and on an earnings call with analysts, Sanofi executives claimed the lower numbers were expected. CEO Paul Hudson cited price competition in Germany and a slowdown in the U.S.It's early. We're still in October. But I think it's fair that with the first few weeks that we observed a little bit of vaccination rate on the soft side when it comes to flu vaccination, particularly in the U.S., Thomas Triomphe, Sanofis head of vaccines R&D, told analysts.Vaccines have faced heightened commercial pressure in the U.S. since the confirmation of Health and Human Services Secretary Robert F. Kennedy, Jr. Kennedy overhauled a key committee guiding U.S. vaccine policy, replacing themwith a handpicked groupmore aligned with his skeptical views on immunizations.The Food and Drug Administration has also set in place a stricter framework for COVID-19 shots, leading to narrower clearances than in years past.Over that time, vaccination rates for routine childhood immunizations have declined, even as a measles outbreak has taken hold. Rates of flu shots have also been in a prolonged downswing in the U.S., according to a report earlier this year from the nonprofit group PLOS Global Health.Sanofi, one of the worlds preeminent vaccine makers, continues to invest in the space, however. The company, for instance, has multiple combination shots for influenza and other viruses in development.Sanofi has a proud legacy of flu vaccines, and we remain committed on bringing innovation to strengthen our leadership in flu and to provide better protection for patients, Hudson said Friday.Despite the slowdown in vaccine sales, Sanofis overall revenue rose by 2.3%, boosted in part by revenue for its blockbuster anti-inflammatory drug Dupixent. Sales of Dupixent surged by 26.2% to 4.2 billion, a quarterly record that beat consensus estimates, wrote Leerink Partners analyst David Risinger.Sanofis Beyfortus, a preventive drug for respiratory syncytial virus in infants, also bested Wall Street projections. Sales jumped 14.6% to 739 million, or about $860 million, between April and June.Newer drug launches which include the hemophilia medication Altuviiio and Ayvakit, a rare disease therapy acquired in Sanofis buyout of Blueprint Medicines climbed 57.1%, reaching 1 billion for the quarter. '