Last update 30 Mar 2025

AVA-6000

Overview

Basic Info

Drug Type
Peptide drug conjugates
Synonyms
AVA6000 pro-Doxorubicin, FAP Pro-doxorubicin, AVA 6000
Action
inhibitors
Mechanism
DNA intercalators, Top II inhibitors(Topoisomerase II inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 1
United States
16 Jul 2021
Ovarian CancerPhase 1
United States
16 Jul 2021
Ovarian CancerPhase 1
United Kingdom
16 Jul 2021
Urothelial Carcinoma of the Urinary BladderPhase 1
United States
16 Jul 2021
Urothelial Carcinoma of the Urinary BladderPhase 1
United Kingdom
16 Jul 2021
Salivary Gland NeoplasmsPhase 1
United Kingdom
16 Jul 2021
Soft Tissue SarcomaPhase 1
United Kingdom
16 Jul 2021
Triple Negative Breast CancerPhase 1
United Kingdom
16 Jul 2021
Dedifferentiated LiposarcomaPhase 1
United States
-
NeoplasmsPreclinical--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
AVA6000 250 mg/m^2
uszpzjbvfv(jholbimcef) = hvksivbfjw buvglfsrex (yjjktgqove )
Positive
16 Jan 2025
Phase 1
Solid tumor
FAP Positive
48
simqfdcpox(kdifybuypq) = neutropenia (11%), anemia (6%), and thrombocytopenia (5%). tttezsdgkc (kwnksidojl )
Positive
14 Sep 2024
AACR2024
ManualManual
Phase 1
Solid tumor
FAP Positive
40
cqctpwctod(nsydmkhfqm) = beiqnnlpbj invomsoshl (lkqckgfiuq )
Positive
05 Apr 2024
Phase 1
35
vwgstqemay(oqryefyeoi) = The data from the sixth cohort continue to show an excellent safety profile for AVA6000. eqbdgkocis (cjerqgtnnh )
Positive
19 Sep 2023
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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