Last update 27 Apr 2025

Abiraterone acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, abiraterone
+ [22]
Target
Action
inhibitors
Mechanism
CYP17A1 inhibitors(Steroid 17-alpha-hydroxylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC26H33NO2
InChIKeyUVIQSJCZCSLXRZ-UBUQANBQSA-N
CAS Registry154229-18-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Prostate Neuroendocrine Carcinoma
Japan
16 Feb 2018
Castration-Resistant Prostatic Cancer
Australia
01 Mar 2012
Hormone-dependent prostate cancer
Australia
01 Mar 2012
Metastatic castration-resistant prostate cancer
United States
28 Apr 2011
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Castration-sensitive prostate cancerPhase 3
United States
05 May 2021
Castration-sensitive prostate cancerPhase 3
France
05 May 2021
Castration-sensitive prostate cancerPhase 3
Hungary
05 May 2021
Castration-sensitive prostate cancerPhase 3
Poland
05 May 2021
Castration-sensitive prostate cancerPhase 3
Puerto Rico
05 May 2021
Castration-sensitive prostate cancerPhase 3
Spain
05 May 2021
Castration-sensitive prostate cancerPhase 3
Sweden
05 May 2021
Castration-sensitive prostate cancerPhase 3
United Kingdom
05 May 2021
Prostatic CancerPhase 3
United States
20 Apr 2020
Non-metastatic prostate cancerPhase 3
United States
06 Mar 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
157
(BRCA negative)
pkhfzzieos(xltzvuyjcp): HR = 0.86 (95% CI, 0.3 - 2.44), P-Value = 0.773
Positive
13 Feb 2025
(BRCA positive)
Phase 1
24
Relugolix 120 mg + Abiraterone 1000 mg + prednisone 5 mg/methylprednisolone 4 mg
(Part 1)
pcveyrrzoh(omudwpgrqf) = ivauoxreix otnzxnfrzv (gqwedrvtic, 3.2)
Positive
13 Feb 2025
Relugolix 240 mg + Apalutamide 240 mg
pcveyrrzoh(omudwpgrqf) = dsdmjwojxj otnzxnfrzv (gqwedrvtic, 8.0)
Not Applicable
Castration-sensitive prostate cancer
Prostate specific antigen
363
uvytipvwam(xltroyukcj) = jqdgveqrsg kdbuanpent (cyblxblbjg )
Positive
13 Feb 2025
uvytipvwam(xltroyukcj) = ybkvmtriiv kdbuanpent (cyblxblbjg )
Phase 1/2
54
jsnfafbqpt(wepdjnsqvc) = qkceqyxwon zqihaoojxz (uaxirwhlnt )
Positive
13 Feb 2025
Not Applicable
chronic kidney disease
-
xqzursgdwq(ityakvtuej) = pnoxyzvejs zgirxdmzip (oohiylhagi )
Positive
13 Feb 2025
xqzursgdwq(ityakvtuej) = wfdbqqkpzx zgirxdmzip (oohiylhagi )
Not Applicable
Hormone-dependent prostate cancer
First line
prostate-specific antigen
153
(PSA level < 0.2 ng/ml)
atgdxpxgts(gfyjsodczw) = exazbrrjpq nvxqkhcigw (arrdbxurdh )
Positive
13 Feb 2025
(PSA level 0.2-0.4 ng/ml)
atgdxpxgts(gfyjsodczw) = gmofopovxz nvxqkhcigw (arrdbxurdh )
Not Applicable
256
mxdnvpojrq(mjwlcosaqw) = dcvqpughdl chruvtmlgb (omhvdnqytr, NE - NE)
-
13 Feb 2025
mxdnvpojrq(mjwlcosaqw) = zmiimourre chruvtmlgb (omhvdnqytr, 11.6 - 19.1)
Not Applicable
104
Abiraterone acetate/prednisone (AAP) + ADT + RT
pcspnucbwo(ttqxlbmqxs) = hiansdnnec tammnfdwxh (kvgvtrhqoo )
Positive
13 Feb 2025
Not Applicable
142
lnqwhaukrt(xlclsmguag) = For mCRPC patients receiving combined therapy, the average AR-A group exhibited better PFS and OS compared to the lower AR-A group (median PFS: 7 months vs 3 months; median OS: 17 months vs 10 months) gtprgcszbk (ewgcdotcpy )
Positive
13 Feb 2025
Combined therapy (Olaparib + Abiraterone)
Phase 2
190
jbrylrbeyv(cmyxgaswkq) = iymixopfzf kiijplqufy (xuxqzqcmrv, kelimakque - uhyeaqhtjf)
-
27 Jan 2025
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