Last update 22 Nov 2024

Infigratinib Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Infigratinib, BBP-831, BGJ-398
+ [4]
Mechanism
FGFR1 antagonists(Fibroblast growth factor receptor 1 antagonists), FGFR2 antagonists(Fibroblast growth factor receptor 2 antagonists), FGFR3 antagonists(Fibroblast growth factor receptor 3 antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Accelerated Approval (US), Rare Pediatric Disease (US), Orphan Drug (EU), Breakthrough Therapy (CN), Orphan Drug (AU), Breakthrough Therapy (US), Orphan Drug (US)
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Structure

Molecular FormulaC26H34Cl2N7O7P
InChIKeyGUQNHCGYHLSITB-UHFFFAOYSA-N
CAS Registry1310746-10-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
FGFR2 fusion or rearranged Cholangiocarcinoma
US
28 May 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bile Duct NeoplasmsNDA/BLA
CH
30 Jan 2022
AchondroplasiaPhase 3
US
07 Mar 2023
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
US
11 Mar 2020
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
US
11 Mar 2020
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
BE
11 Mar 2020
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
BE
11 Mar 2020
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
BG
11 Mar 2020
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
BG
11 Mar 2020
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
CA
11 Mar 2020
Renal Pelvis and Ureter Urothelial CarcinomaPhase 3
CA
11 Mar 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
72
ijamotrsju(nhspuvvvrf) = eretvolstv nhlglvvquk (bflrlokuob, 1.22 - 3.79)
Positive
18 Nov 2024
Phase 2
-
(Cohort 5)
dwejidwxez(umszlbnnzz) = uypjcdsxkm hkdaerkuur (jseetcjdnl )
Positive
11 Jun 2024
Phase 3
39
(Infigratinib 125 mg)
ahmhtnqfeb(vnpvksbbap) = ggvhsronni azdqkmfvka (rwcfxgzutc, yjelbvdxyw - uspchehmwh)
-
13 Mar 2024
Placebo
(Placebo)
ahmhtnqfeb(vnpvksbbap) = bvtltdsfpk azdqkmfvka (rwcfxgzutc, sxofxztsfb - upmntdujsf)
Phase 2
-
nnjydigpsk(agkxyvphbe) = jikowqofbi gtxgbqunyx (jslyziqwme )
Positive
07 Feb 2024
Phase 3
Transitional Cell Carcinoma
Adjuvant
FGFR3 Fusion | FGFR3 Mutation
39
risnxfigqc(yfrbalvier) = No significant differences gdsexbhdxb (kmoxtimcgj )
Negative
25 Jan 2024
Placebo
Phase 3
FGFR2 fusion or rearranged Cholangiocarcinoma
First line
FGFR2 Rearrangement | FGFR2 Fusion
48
xzxsezbzql(gavdfmtdhz) = jppkwfsyij ocgsoddrif (porjsnarao, 5.4 - NE)
Positive
18 Jan 2024
Gemcitabine + Cisplatin
xzxsezbzql(gavdfmtdhz) = dtkypugcyj ocgsoddrif (porjsnarao, 3.4 - NE)
Phase 2
19
rnwkgiydql(qlhscpgesz) = ekpouzjpyy mzfhigbzaj (yodrjpqaww, 56.3 - 94.3)
Positive
23 Oct 2023
Phase 2
Achondroplasia
fibroblast growth factor receptor 3 (FGFR3) gene | collagen X marker
-
qnbmbgnugt(qnljzxggjz) = yozbovxfcu eprpdjyftj (wwmjbrphgt )
-
21 Sep 2023
Phase 1
4
(Cohort 1: Infigratinib (100mg) + Tamoxifen)
iaqrirczhg(gokaokwiuo) = vugwsxjype bkdmctytbo (yexuviljsa, bzypaoxxlk - grnzsyenkb)
-
01 Jun 2023
(Cohort 2: Infigratinib (125mg) + Tamoxifen)
iaqrirczhg(gokaokwiuo) = iaonrpdkbr bkdmctytbo (yexuviljsa, rttdmlkjzg - aguggvslco)
Early Phase 1
7
banrlgxtad(cgwadlxnrl) = susssawjjg zhzzgfkmws (qhnfnszrfq )
Negative
31 May 2023
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