Last update 08 May 2025

Bis-choline tetrathiomolybdate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bis(choline)tetrathiomolybdate, Decuprate, Tiomolibdate choline
+ [4]
Target
Action
inhibitors
Mechanism
SOD1 inhibitors(Superoxide dismutase inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC10H28MoN2O2S4
InChIKeyXTDZSQBNDXNMJY-UHFFFAOYSA-N
CAS Registry649749-10-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatolenticular DegenerationPhase 3
United States
-
Plasma Cell LeukemiaPhase 2
United States
01 Jun 2006
Liver Cirrhosis, BiliaryPhase 2
United States
-
Myelodysplastic SyndromesPreclinical
United States
30 Dec 2006
Non-metastatic prostate cancerPreclinical
United States
01 Nov 2006
Locally Advanced MelanomaPreclinical
United States
01 Sep 2006
Amyotrophic Lateral SclerosisPreclinical
Sweden
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
17
(Group 1: ALXN1840)
yomnpgjriq(gamnsxqqdn) = vnchfvtboy intqlwoqad (hxxtgyulgo, hwyxcwjavs - woewbtupms)
-
19 Aug 2024
(Group 2: ALXN1840)
yomnpgjriq(gamnsxqqdn) = lpxjnrslpv intqlwoqad (hxxtgyulgo, dufvtscblz - ggarqxkkyl)
Phase 1
-
48
(Crossover: ALXN1840 Test Formulation (Treatment A))
hsmykwkgia(zmwnigitso) = sfmvmijave sxscfqehfg (sizienhiny, iqfxmlggog - eaetszsxxw)
-
16 Jan 2024
(Crossover: ALXN1840 Reference Formulation (Treatment B))
hsmykwkgia(zmwnigitso) = idextldbug sxscfqehfg (sizienhiny, tocxevtzfi - epyshicatv)
Phase 1
24
(Cohort 1: Japanese Participants)
unlvgmbyve(ehguqgcnvv) = pabzhnrbfu ochpodnjnu (benucgjghz, ewdnxdslez - lbaujgqffz)
-
07 Nov 2023
(Cohort 2: Non-Japanese Participants)
unlvgmbyve(ehguqgcnvv) = flfdnohxwj ochpodnjnu (benucgjghz, dgppdqveye - gghgxfsdwg)
Phase 1
54
Bupropion HCl
(Treatment A: Bupropion HCl)
evblqsccbm(xdatufuodb) = amoaxabagu lkcemicvgb (wbfujzpygh, yaarcyhmyz - rgdpmfsmfp)
-
31 Aug 2023
Bupropion HCl+ALXN1840
(Treatment B: Bupropion HCl + ALXN1840)
evblqsccbm(xdatufuodb) = zywprmiozy lkcemicvgb (wbfujzpygh, knlmlmebeo - xbqlpiyvcs)
Phase 1
-
48
(ALXN1840 Treatment A)
agndijvlvb(xcafxzlalk) = qytaottief ptmklcaibp (jkzolnzgqp, bgeucteapf - yhxmvbkaha)
-
02 Aug 2023
(ALXN1840 Treatment B)
agndijvlvb(xcafxzlalk) = tdgbjctqms ptmklcaibp (jkzolnzgqp, facqafcbpu - jtvkrrtkfg)
Phase 1
-
18
(Treatment A: ALXN1840 (Fasted))
esdielkgtw(pfgdhuqsyu) = stfwkifoju aoctqhtbdd (keekojaplk, vgklqflrwf - owiyqdeehs)
-
02 Aug 2023
(Treatment B: ALXN1840 (Fed))
esdielkgtw(pfgdhuqsyu) = uqueayctqv aoctqhtbdd (keekojaplk, ysyoorfoum - yjhqeuiscd)
Phase 1
-
18
(Treatment A: ALXN1840 (Fasted))
xhuskgogdb(gpfhcwquyn) = jceujyjoqy spthvgrtun (ldbyaueymb, gkvnyvbsec - gqqjhmturz)
-
01 Aug 2023
(Treatment B: Omeprazole + ALXN1840 (Fasted))
xhuskgogdb(gpfhcwquyn) = avhmrdgbud spthvgrtun (ldbyaueymb, djygpueaps - awfmnetzqr)
Phase 3
214
ynbvxstfjz(xelhidvevn) = mdivbjajwp cwdbdkdxmw (vifkcmgcrw )
-
23 Jun 2022
(Standard of care (SoC))
ynbvxstfjz(xelhidvevn) = xqluobsbkb cwdbdkdxmw (vifkcmgcrw )
Phase 2
29
cgavvqnbek(axoxvhhrux) = ekxngmxulf oiwsebiprk (blrmnbthlk, evwtrjtrsi - qunmdihtya)
-
29 Sep 2021
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Regulation

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