Last update 01 Nov 2024

Beroterkib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mechanism
ERK1 inhibitors(Extracellular-signal-regulated kinase1 inhibitors), ERK2 inhibitors(Extracellular-signal-regulated kinase 2 inhibitors)
Therapeutic Areas
Inactive Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC29H31ClFN5O5
InChIKeyBVRGQPJKSKKGIH-PUAOIOHZSA-N
CAS Registry2095719-92-7

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
GB
10 May 2018
Advanced Malignant Solid NeoplasmPhase 2
FR
10 May 2018
Advanced Malignant Solid NeoplasmPhase 2
ES
10 May 2018
Advanced Malignant Solid NeoplasmPhase 2
US
10 May 2018
Acute Myeloid LeukemiaPhase 1
US
14 Nov 2020
Solid tumorDiscovery
US
10 May 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
MAPK positive Neoplasms
genomic alterations in the MAPK pathway
32
(stdoriuxvl) = ewkygokclx jqjanatjdg (zvktztnzdf, 1.0 - 24.0)
Positive
14 Sep 2024
Not Applicable
-
(cvnkdoqpws) = vqgulcjngb sgisnazsux (wuzqmswfks )
-
10 Dec 2023
(cvnkdoqpws) = vaubzpsbky sgisnazsux (wuzqmswfks )
Phase 1
Solid tumor
KRAS Mutation
76
(Phase 1A)
(gknktpehzl) = jddglxxkli ltqjgvasnv (vrcwtgomfh )
Positive
02 Jun 2022
(Phase 1B)
(jpwcoblchh) = hvdmnsazmp ktvnpmdigb (mcljntainl )
Phase 1
56
ASTX029
(iveburscek) = 1/6 at the 200 mg dose level(Cohort 5, PiB/fed)(grade 3 maculopapular rash);1 pt at the 280 mg dose level(Cohort 12, tablet/fasting)(grade 2 central serous retinopathy) itirrvlvuo (ampdpsitvj )
Positive
01 Jul 2021
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Clinical Trial

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Approval

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Regulation

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