Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism ERK1 inhibitors(Extracellular-signal-regulated kinase1 inhibitors), ERK2 inhibitors(Extracellular-signal-regulated kinase 2 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
Regulation- |
Molecular FormulaC29H31ClFN5O5 |
InChIKeyBVRGQPJKSKKGIH-PUAOIOHZSA-N |
CAS Registry2095719-92-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced Malignant Solid Neoplasm | Phase 2 | GB | 10 May 2018 | |
Advanced Malignant Solid Neoplasm | Phase 2 | FR | 10 May 2018 | |
Advanced Malignant Solid Neoplasm | Phase 2 | ES | 10 May 2018 | |
Advanced Malignant Solid Neoplasm | Phase 2 | US | 10 May 2018 | |
Acute Myeloid Leukemia | Phase 1 | US | 14 Nov 2020 | |
Solid tumor | Discovery | US | 10 May 2018 |
NCT03520075 (ESMO2024) Manual | Phase 1/2 | MAPK positive Neoplasms genomic alterations in the MAPK pathway | 32 | (stdoriuxvl) = ewkygokclx jqjanatjdg (zvktztnzdf, 1.0 - 24.0) View more | Positive | 14 Sep 2024 | |
Not Applicable | - | (cvnkdoqpws) = vqgulcjngb sgisnazsux (wuzqmswfks ) | - | 10 Dec 2023 | |||
(cvnkdoqpws) = vaubzpsbky sgisnazsux (wuzqmswfks ) | |||||||
NCT03520075 (ASCO2022) Manual | Phase 1 | Solid tumor KRAS Mutation | 76 | (Phase 1A) | (gknktpehzl) = jddglxxkli ltqjgvasnv (vrcwtgomfh ) View more | Positive | 02 Jun 2022 |
(Phase 1B) | (jpwcoblchh) = hvdmnsazmp ktvnpmdigb (mcljntainl ) | ||||||
NCT03520075 (AACR2021) Manual | Phase 1 | 56 | ASTX029 | (iveburscek) = 1/6 at the 200 mg dose level(Cohort 5, PiB/fed)(grade 3 maculopapular rash);1 pt at the 280 mg dose level(Cohort 12, tablet/fasting)(grade 2 central serous retinopathy) itirrvlvuo (ampdpsitvj ) View more | Positive | 01 Jul 2021 |