Last update 04 Dec 2024

Dorzolamide Hydrochloride/Timolol Maleate/Brimonidine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Brimonidine/dorzolamide/timolol, Krytantek PF, PRO-122
+ [2]
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), CAs inhibitors(Carbonic anhydrases inhibitors), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
MX (01 Sep 2007),
Regulation-
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Structure

Molecular FormulaC10H17ClN2O4S3
InChIKeyOSRUSFPMRGDLAG-QMGYSKNISA-N
CAS Registry130693-82-2
View All Structures (3)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
MX
01 Sep 2007
Ocular Hypertension
MX
01 Sep 2007
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glaucoma, Open-AnglePhase 3-01 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
(PRO-122)
tjzkojpqqv(dmktxeuzym) = gouoqyyddv hocmrbqfoo (hgdywrnfip, ggovxxclwp - rnwepjgkpa)
-
13 Dec 2019
(Krytantek Ofteno®)
tjzkojpqqv(dmktxeuzym) = crholrkmmj hocmrbqfoo (hgdywrnfip, nkmevuxnac - kpnqbmvqmj)
Phase 2
124
Timolol+Brimonidine+Dorzolamide
(A (Triple Therapy))
vhslqjuahj(acqdrhnfdg) = sjqahttlcj hzrziqjhpc (fcudlmaqta, qmxnnhouxq - ebrxwdlfoo)
-
01 Aug 2019
timolol+dorzolamide
(B (Doble Therapy))
vhslqjuahj(acqdrhnfdg) = jbshqlztxw hzrziqjhpc (fcudlmaqta, vqdubfakjv - pnakuyvqji)
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Regulation

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