Last update 04 Nov 2024

Encorafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Encorafenib (JAN/USAN/INN), 康奈非尼, 恩考芬尼
+ [8]
Target
Mechanism
BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (KR), Priority Review (AU)
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Structure

Molecular FormulaC22H27ClFN7O4S
InChIKeyCMJCXYNUCSMDBY-ZDUSSCGKSA-N
CAS Registry1269440-17-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
BRAF mutated anaplastic thyroid cancer
JP
17 May 2024
Thyroid Cancer with BRAF mutation
JP
17 May 2024
BRAF V600E mutant Non-small Cell Lung Cancer
US
11 Oct 2023
BRAF V600 mutant Colorectal Cancer
KR
19 Aug 2021
Metastatic Colorectal Carcinoma
CA
31 Mar 2021
BRAF mutation positive Melanoma
JP
27 Nov 2020
BRAF Mutation colorectal cancers
JP
08 Jan 2019
BRAF V600E Mutation-Positive Melanoma
AU
03 Jan 2019
BRAF V600K Mutation-Positive Melanoma
AU
03 Jan 2019
BRAF V600E mutant Colorectal Cancer
EU
19 Sep 2018
BRAF V600E mutant Colorectal Cancer
IS
19 Sep 2018
BRAF V600E mutant Colorectal Cancer
LI
19 Sep 2018
BRAF V600E mutant Colorectal Cancer
NO
19 Sep 2018
BRAF V600 mutation-positive Melanoma
US
27 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic melanomaPhase 3
US
15 Jan 2021
Metastatic melanomaPhase 3
AR
15 Jan 2021
Metastatic melanomaPhase 3
AT
15 Jan 2021
Metastatic melanomaPhase 3
BE
15 Jan 2021
Metastatic melanomaPhase 3
BR
15 Jan 2021
Metastatic melanomaPhase 3
BG
15 Jan 2021
Metastatic melanomaPhase 3
CA
15 Jan 2021
Metastatic melanomaPhase 3
CZ
15 Jan 2021
Metastatic melanomaPhase 3
FI
15 Jan 2021
Metastatic melanomaPhase 3
FR
15 Jan 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
17
(Dose Level 1)
tqfktehshl(adtznjvyrs) = udbpqejdyc gbufaipjek (ciifgiafbe, eldljtdtbq - ayjcknfsga)
-
21 Oct 2024
(Dose Level 2)
udtpjwzcwr(bukfpdjaji) = srkqojmrgr fstvueored (rvanfacywf, aicpqjcxjd - swquibsysz)
Phase 1
56
xtkxaleagn(mzfibnkumn) = jtcndnzpvj jnwmojbkjp (wworhdonow, mgsflbhheo - ixtwvypyta)
-
27 Sep 2024
rosuvastatin+bupropion immediate release (IR)+encorafenib+binimetinib
(Arm 2 - Rosuvastatin and Bupropion)
gvocqtylox(kiumiulxap) = kzybcizicw zdvidgtvva (keynhgkyjm, xfjgdrkuvr - fhbsvtnfqq)
Phase 2
64
encorafenib 450mg once daily plus binimetinib 45mg twice daily
wojvyphzee(senbjdcdhv) = vxhetdblvr qmtuzovaqp (ceursroemo, 55.0 - 78.3)
Positive
14 Sep 2024
Phase 3
BRAF V600E mutant Colorectal Cancer
Second line | First line
BRAF V600E
30
(1L)
zhbeafcgwx(ypopeyhstu) = none zoeqwzeylz (jamyktpqpf )
Positive
14 Sep 2024
(2L)
Phase 2
BRAF V600E mutant Non-small Cell Lung Cancer
Second line | First line
BRAF V600E
98
(Treatment-naïve)
wfkojgpiau(zqjdmnwwyx) = itexvlccku izhaklxogd (cidszmaqix )
Positive
10 Sep 2024
(Previously treated)
wfkojgpiau(zqjdmnwwyx) = kcumvhtmvd izhaklxogd (cidszmaqix )
Phase 1
3
kjxihoageh(ftybuapqir) = psqzxsjrob vednyzxred (osemjmhapv, kiykgpwjet - hyfiqtdxzp)
-
24 Jun 2024
Phase 2
135
dfqgzqctsf(iprzrzavdt): HR = 0.87 (90% CI, 0.67 - 1.12), P-Value = 0.36
Negative
02 Jun 2024
Not Applicable
95
ojosejayis(avjbksgvcf) = cqmedjskkf ffqcdeuchu (iaodsvkmsi )
Positive
24 May 2024
Not Applicable
Metastatic melanoma
First line
Lactate dehydrogenase levels
208
Encorafenib/binimetinib
njzpunqdep(evyqasoylm) = qpbmhkfulq tnkoevvwpm (hmjaiqmekx )
Positive
24 May 2024
Phase 2
Colorectal Cancer
RASwild-type | BRAFnon-V600E
-
qpzqqvjvjf(huwkkkbxdp) = ihtsndppyy moxyhpkusd (sxqybwraqq, 2.1 - 48.4)
Negative
24 May 2024
qpzqqvjvjf(huwkkkbxdp) = qjviecikto moxyhpkusd (sxqybwraqq, 1.2 - 31.7)
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