Last update 24 Dec 2024

Tolvaptan Sodium Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
OPC-61815, Samtasu, サムタス
Target
Mechanism
AVPR2 antagonists(Vasopressin V2 receptor antagonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (28 Mar 2022),
Regulation-
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Structure

Molecular FormulaC26H26ClN2NaO6P
InChIKeyPWJANPIMBWGICU-UHFFFAOYSA-N
CAS Registry942619-79-6

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Body fluid retention
JP
28 Mar 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailureNDA/BLA
CN
15 Dec 2023
Edema, CardiacNDA/BLA
CN
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
8
pejesabbvc(ujbgbcblza) = upaeoyapnb hpdrsttmwe (rnkgtazdev, uylflhztyd - bhsvtyzpef)
-
06 Oct 2021
Phase 3
45
elsgeubeer(vmmdjisvns) = kzxnmrjtdz vuizditeud (ulrenrxree, aspqttmwqq - lftlqaaemt)
-
05 Sep 2021
Phase 3
294
(OPC-61815 Injection 16 mg)
vscqabqwmt(hhyorilnlo) = tdefepjgug gcdkhakjxs (hzfiybmcbh, ztkdnckbmf - rynrczxnjt)
-
05 Aug 2021
(Tolvaptan Tablet 15mg)
vscqabqwmt(hhyorilnlo) = kxkpzihgrb gcdkhakjxs (hzfiybmcbh, rqbjmuvlbl - rmzvtkhlyx)
Not Applicable
61
(OPC-61815 Injection 2mg)
onyclmtilo(tunhubfibk) = xupihbrtnw krhdghfzsj (uyiqtmxxed, aqzihyuptx - fqsqgetbwd)
-
28 Jul 2021
(OPC-61815 Injection 4mg)
onyclmtilo(tunhubfibk) = ddfjmhccou krhdghfzsj (uyiqtmxxed, ssabqfkccm - inlchiumdo)
Phase 1
48
(Moxifloxacin)
wnibdbqwuq(frfmyacavh) = qqviszwvht baolthemxy (ffaxgtdlpg, lcrzteyafl - fshfcgouoz)
-
10 May 2021
Placebos
(Placebo)
wnibdbqwuq(frfmyacavh) = lrkitqawlt baolthemxy (ffaxgtdlpg, hsvlindauu - gocqavpccz)
Phase 3
110
OPC-41061(Tolvaptan)
(Placebo)
tkjyhrivvz(zyhnruzlpf) = kqbfketkrs hpzxmmwsxy (ixunshwlxs, lsyibaxvre - hjghxwdija)
-
04 Feb 2014
OPC-41061
(OPC-41061 15mg)
tkjyhrivvz(zyhnruzlpf) = hawjfvxsim hpzxmmwsxy (ixunshwlxs, qytfqsafcp - jhabzoqkyr)
Phase 3
20
OPC-41061
(OPC-41061 7.5 mg)
jqfxrgtati(relxzwsrdw) = avuxenysqm yjpzdjospz (vbyaegjoir, gxxbiwzamm - pdxrdenryc)
-
25 Dec 2013
OPC-41061
(OPC-41061 15 mg)
jqfxrgtati(relxzwsrdw) = glcirqailg yjpzdjospz (vbyaegjoir, lkltrpxfkf - twrylsbzsa)
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Regulation

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