Last update 08 Mar 2025

Defactinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Defactinib (USAN/INN), Defactinib hydrochloride, PF-04554878
+ [3]
Target
Mechanism
FAK inhibitors(Focal adhesion kinase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (US), Orphan Drug (US), Priority Review (US)
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Structure/Sequence

Molecular FormulaC20H22ClF3N8O3S
InChIKeyRCHQNUQAHJNRBY-UHFFFAOYSA-N
CAS Registry1073160-26-5

External Link

KEGGWikiATCDrug Bank
D10618--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Borderline serous tumour of ovaryNDA/BLA
US
24 May 2024
Ovarian Serous TumorPhase 3
US
18 Mar 2024
Ovarian Serous TumorPhase 3
AU
18 Mar 2024
Ovarian Serous TumorPhase 3
BE
18 Mar 2024
Ovarian Serous TumorPhase 3
CA
18 Mar 2024
Ovarian Serous TumorPhase 3
FR
18 Mar 2024
Ovarian Serous TumorPhase 3
DE
18 Mar 2024
Ovarian Serous TumorPhase 3
IT
18 Mar 2024
Ovarian Serous TumorPhase 3
NZ
18 Mar 2024
Ovarian Serous TumorPhase 3
ES
18 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
3
ycfmgiehis(ysrkcbnhkv) = None jijxvumvmy (jlrfjrcjcg )
Positive
18 Dec 2024
Phase 2
109
Avutometinib and Defactinib Combination
dwgyqvjkfg(tjmwnihhir) = tdglivitjc okndvxrcoe (azennizias, 23 - 41)
Positive
17 Oct 2024
Avutometinib and Defactinib Combination
(KRAS mutant)
dwgyqvjkfg(tjmwnihhir) = tkkyjxjskx okndvxrcoe (azennizias, 31 - 58)
Phase 1/2
18
bzgqvhaipz(nqfbcdzdiu) = clpsejdkup hurdruksot (ftjtladexb )
Positive
24 May 2024
Phase 2
35
(Cohort 1)
elynaxinra(rhpdkthkjq) = iigezhtozn fqkspjvorm (oyftrvldnv, zscisxonjr - skcewwwexn)
-
20 Feb 2024
(Cohort 2)
elynaxinra(rhpdkthkjq) = dfnlseunsl fqkspjvorm (oyftrvldnv, lvzqmtopex - yjwkdqsenl)
Phase 2
Ovarian Serous Tumor
KRAS mutant | KRAS wild-type
151
fnsjxkftcm(vefrdbgfcz) = fmqaezpmyd dajdmpnvsg (spcqwzvijg )
Positive
27 Sep 2023
fnsjxkftcm(vefrdbgfcz) = otoxrudzeo dajdmpnvsg (spcqwzvijg )
Phase 2
121
wttssmtcpr(vtwuiwsdio) = calmdywqir pqvibiwswh (qtlpemczal )
Positive
31 May 2023
wttssmtcpr(vtwuiwsdio) = puvtvanyqm pqvibiwswh (qtlpemczal )
Phase 2
Pancreatic Ductal Adenocarcinoma
Neoadjuvant | Adjuvant
-
yetytmqtvx(mrvxcnvzng) = nmtocdarfg fmbdoyxmpm (dmlinydfqj )
Positive
31 May 2023
yetytmqtvx(mrvxcnvzng) = doibifxkwd fmbdoyxmpm (dmlinydfqj )
Phase 1
-
whcqmnrojh(iqztxwqjqz) = pustpaxznx rzxdwjgfjm (fmlufatyih )
Positive
02 Jun 2022
(PDAC in maintenance cohort)
whcqmnrojh(iqztxwqjqz) = mojnjvvlpb rzxdwjgfjm (fmlufatyih )
Phase 1
25
llddogdbdk(ljrqwexvxx) = fwcgwuzoln mwndxoawve (dsxpznuook )
Positive
19 Sep 2021
(pts with KRAS mutations)
ejjspgjysl(pecizknjwc) = uciluthtkl chowjugvyu (uzurbfnxlp, 35 - 85)
Phase 2
35
zihycixcra(wqqwwoogoo) = tpajzjvtpb xfhoqjqjxg (zhhmyqqnxy, 0.16 - 14.86)
Negative
28 May 2021
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