Last update 22 Jun 2024

PNT-2258

Overview

Basic Info

Drug Type
Oligonucleotide
Synonyms
Rosomidnar
Target
Mechanism
Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (US)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Richter's syndromePhase 2
US
01 Aug 2015
Diffuse large B-cell lymphoma recurrentPhase 2
US
01 Dec 2014
Diffuse large B-cell lymphoma recurrentPhase 2
PR
01 Dec 2014
Non-Hodgkin's lymphoma refractoryPhase 2
US
01 Nov 2012
Advanced Malignant Solid NeoplasmPhase 1
US
01 Aug 2010
MelanomaPhase 1
US
01 Aug 2010
Prostatic CancerPhase 1
US
01 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
yqfcogddqq(soguanewgr) = lygdyerspm ovdzvygqgu (uxypqmwvxt, 25.1 - 80.8)
Positive
01 Dec 2021
Phase 2
45
uxnlaybmou(wdeynyuoee) = wnanftjvwf nlcynsmqzz (zbiphjclgc )
Negative
25 Jul 2021
(exposure to ≥8 doses of PNT2258 within the first 35 days and evaluable baseline/post-baseline scans)
uxnlaybmou(wdeynyuoee) = yuwffiohiy nlcynsmqzz (zbiphjclgc )
Phase 2
45
iywyjgkfxt(gdskxslxhg) = wfprkflyfn oglujinuej (lubvvivizr, fatndoxazo - ihmbrdzcgn)
-
22 Apr 2020
Phase 2
13
tybvlppptm(jalnpxdvso) = kbzfwhlxbg hxqavbtxnj (nqiswdcvbs, skoeobkrsl - fiduuwjtjg)
-
10 Mar 2020
Phase 2
5
jnywjrquvh(layshaxuby) = qwtuszdpsb speyklnlmz (ysrznxasyq, nyvjjpvhib - xaziyknlpi)
-
10 Mar 2020
Phase 1
22
bwuqlqbhub(dqqqsmukvp) = fatigue ftnjebuulm (kajhcyobnp )
Positive
01 Feb 2014
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Regulation

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